Relationship among plasma endothelin, calcitonin gene-related peptide and blood flow rate of bilateral vertebral arteries in patients with cervical vertigo

Objective： To investigate the relationship among plasma endothelin（ET）, calcitonin gene-related peptide（CGRP） and blood flow rate of bilateral vertebral arteries in patients with cervical vertigo（CV） and to assess the effect of ET and CGRP on the onset of CV. Methods：The concentration of ET and CGRP in 64 patients with CV and 30 controls was determined by radioimmunity method. The average blood flow velocity （Vm） of bilateral vertebral arteries was detected by Transcranial Doppler（TCD）. Results：Plasma concen- tration ofET（91.48 ± 9.08 pg/ml） and ET/CGRP ratio value（2.88 ± 0.52） in vertebrobasilar arteriospasm group were both higher than those in vertebrobasilar non-arteriospasm group and in controls, while CGRP concentration（30.66 ± 6.05 pg/ml） in vertebrobasilar arteriospasm group was lower than that in vertebrobasilar non-arteriospasm group and controls respectively. The Vm of bilateral verte- bral arteries in vertebrobasilar arteriospasm group（67.97 ± 11.64 cm/s ） was higher than that in vertebrobasilar non-arteriospasm group and controls respectively, having a positive correlation with ET concentration and ET/CGRP ratio value（r1=0.52, P 〈 0.05; r2=0.59, P 〈 0.05）, but a negative correlation with CGRP concentration（r3=-0.54, P 〈 0.05）. There was no significant difference in ET and CGRP concentration, ET/CGRP ratio value and the Vm of bilateral vertebral arteries between vertebrobasilar non-arteriospasm group and the control group. Conclusion： All the results indicate that ET and CGRP are possibly the most important substance factors at the onset of CV with vertebrobasilar arteriospasm, and their imbalance of regulating vertebrobasilar arterial contraction and relaxation may play an important role in the onset of CV with vertebrobasilar arteriospasm.

Treatment of Cervical Vertigo of Atlanto-occipital Type with Massotherapy

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CERVICAL PLEXUS PUNCTURING PLUS MOXIBUSTION FOR TREATMENT OF 78 CASES OF CERVICAL VERTIGO

Objective: To observe the effect of puncturing cervical plexus plus moxibustion in treatment of cervical vertigo. Methods: 78 inpatients were randomly divided into acupuncture + moxibustion (acumoxi) group (n = 40) and Western medicine (control) group (n =38). Acupuncture needles were inserted separately into the points about 0. 5 cun beside the spinous processes of the cervical vertebral1-7. Results: The cure rates and total effective rates of acumoxi group and control group were 70.00%, 95.00%, 31 . 58% and 92% respectively, with the cure rate of the acumoxi group being significantly higher than that of control group (P<0.05). After treatment, the mean velocity of blood flow of the vertebral artery and basal artery decreased significantly (P <0.05, 0.01) . Conclusion: Acupuncture of cervical plexus plus moxibustion is effective definitely in treatment of cervical vertigo and superior to that of control group.

Analysis on Risk Factors of Cervical Vertigo

Objective:Through the real-world electronic medical record information system,the medical records of patients with cervical vertigo were sorted and statistically analyzed to explore the risk factors of patients with cervical vertigo.Method:Retrospective case-control study was adopted.The general status and accompanying symptoms,medical history,auxiliary examination and other medical records of the patients were subject to statistical analysis,and risk factors were determined from logistic regression analysis.Results:The results of imaging examination showed that the risk of vertigo in patients with abnormal cervical physiological curvature was 2.607 times higher than that in patients with normal cervical physiological curvature,and the risk of vertigo in patients with narrowed intervertebral space was 0.431 times higher than that in patients with normal intervertebral space.Conclusion:There were differences in gender,cervical physiological curvature,intervertebral space and other clinical indexes between patients with cervical vertigo and patients without cervical vertigo.Abnormal cervical physiological curvature and narrowing of intervertebral space were significantly correlated with vertigo.

Effect of three vertigo-stopping needles on neurohumor of patients with cervical vertigo:a controlled trial

Objective To observe the effect of three vertigo-stopping needles on the contents of neuropeptide Y （NPY）, endothelin （ET） and calcitonin gene-related peptide （CGRP） in plasma of patients with cervical vertigo, and to explore its mechanism of treatment. Methods One hundred and eighty patients with cervical vertigo were divided into group A [acupuncture at R6nyfng （人迎ST 9） and Fengchi （风池 GB 20）, and frontal line], group B [acupuncture at Jing jiaji （颈夹脊）, GB 20 and Baihui （百会 GV 20）] and group C [intravenous infusion with ligustrazine and oral administration with flunarizine] according to simple randomization, with 60 cases in each group. For the patients in group A and group B, the treatment was conducted once a day, and ten times were considered as one course of treatment. Two days were free of treatment between two courses, and two courses were needed. For the patients in group C, the treatment was conducted for fifteen days. The contents of NPY, ET and CGRP in plasma before and after treatment were detected in patients with cervical vertigo. Results The contents of NPY in plasma of patients in the three groups after treatment were markedly lower than that before treatment （all P〈0.01）, and the differences were not statistically significant when compared the descending degrees among three groups （P〉0.05）. The contents of ET in plasma of patients in the three groups after treatment were markedly lower than that before treatment （P〈0.05, P〈0.01）, the descending degree in group A was greater than that in group B and group C, and the difference was statistically significant （P〈0.O1, P〈O.05）; while the difference was not statistically significant when compared the descending degrees between group B and group C （P〉0.05）. The contents of CGRP in plasma of patients in the three groups after treatment were markedly higher than that before treatment （P〈0.05, P〈O.O1）, the increasing degree in group A was greater than that in group B and group C, and the difference was statistically significant （both P〈0.05）; while the difference was not statistically significant when compared the increasing degrees between group B and group C （P〉0.05）. Conclusion Three vertigo-stopping needles, acupuncture and medication can regulate the contents of NPY, ET and CGRP in plasma of patients with cervical vertigo, while three vertigo-stopping needles is significantly superior to acupuncture and medication in reducing ET and increasing CGRP.

Sixty-five cases of cervical vertigo treated by needling Jǐngjiájǐ points in combination with acupressure

Objective To observe the clinical efficacy of needling Jingjiaji points in combination with acupressure for cervical vertigo, and provide a better therapy. Methods Sixty-five cases of patients with cervical vertigo were punctured on the points Jingjiaji and Fengchi （风池GB 20） bilaterally, from Qiangjian （强间 GV 18） to Naohu （脑户 GV 17）, from Yuzhan （玉枕 BL 9） to Tianzhu （天柱 BL 10） with penetrating methods, besides, acupressure was also used on these points. It was given once a day, and 16 times constituted one course with 2 courses altogether, and then the clinical efficacy was observed. Results Twenty-five cases were cured accounting to 38.5%; 18 remarkably improved accounting to 27.7%; 19 improved accounting to 29.2%; 3 ineffective accounting to 4.6%. The total effective rate was 95.4%. Conclusion Needling Jingjiaji points in combination with acupressure can alleviate the clinical symptoms of cervical vertigo and is worthy of being promoted.

Sixty-five cases of cervical vertigo treated by needling cervical jiaji points in combination with acupoint pressing

Objective To observe the clinical efficacy of needling cervical Jiaji points in combination with acupoint pressing for cervical vertigo, and provide a better therapy for the clinical treatment of this disease. Methods Sixty-five patients with cervical vertigo were punctured at the points Cervical jiaji and Fengchi （风池 GB 20） bilaterally, from Qiangjian （强间 GV 18） to Naohu （脑户 GV 17）, from Yuzhen （玉枕 BL 9） to Tianzhu （天柱 BL 10） with penetrating methods, besides, acupoint pressing was also used on these points. It was given once a day, and 16 times constituted one course with 2 courses together, and then the clinical efficacy was observed. Results Twenty-five cases were cured accounting to 38.5%; 18 remarkably improved accounting to 27.7%; 19 improved accounting to 29.2%; 3 ineffective accounting to 4.6%. The total effective rate was 95.4%. Conclusion Needling cervical Jiaji points in combination with acupoint pressing can alleviate the clinical symptoms of cervical vertigo and worthy of being promoted.

OBSERVATION ON THE TREATMENT OF VERTEBROARTERY TYPE CERVICAL SPONDYLOPATHY INDUCED VERTIGO WITH HYDRO-ACUPUNCTURE THERAPY

Objective: To observe the therapeutic effect of hydro acupuncture therapy for treatment of vertigo induced by vertebroartery type cervical spondylopathy and to study its action mechanisms. Methods: A total of 54 cases of vertebroartery type cervical spondylopathy patients were observed in the present study. Fengfu (GV 16) and Jiaji (EX B 2) near the regenerated cervical vertebral body were used for injection of Ligustrazine injectio, 1 mL every acupoint, once every other day, with 7 sessions being a therapeutic course. Before and after treatment, cerebral blood flow volume was determined using a Doppler velocimeter. Results: After 2 weeks’ treatment, of the 54 cases, 28 (51.9%) had their vertigo disappeared, 13 (24.1%) had remarkable improvement, 10 (18.5%) had improvement and 3 (5.5%) failed in the treatment, with an effective rate of 94.5%. After treatment, the peak and mean values of the blood flow velocity of the bilateral vertebral arteries and the basilar artery increased significantly in comparison with pre treatment ( P <0.01). Conclusion: Hydro acupuncture therapy has an obvious therapeutic effect for relieving vertebroartery type vertigo and ameliorating cerebral blood supply.