BACKGROUND Epithelioid trophoblastic tumor(ETT) is the rarest type of gestational trophoblastic tumor(GTT). It has been reported that more than 50% of ETTs arise in the uterine cervix or the lower uterine segment. Her...BACKGROUND Epithelioid trophoblastic tumor(ETT) is the rarest type of gestational trophoblastic tumor(GTT). It has been reported that more than 50% of ETTs arise in the uterine cervix or the lower uterine segment. Here, we report a case of ETT within the lower uterine segment and cervical canal and discuss its manifestations,possible causes, and related influencing factors.CASE SUMMARY A 35-year-old woman(gravida 7, miscarriage 3, induction 2 with 1 being twins,para 2 of cesarean section, live 2), who had amenorrhea for 9 mo after breastfeeding for 22 mo after the last cesarean section, was diagnosed with ETT. The lesion was present in the lower uterine segment and endocervical canal with severe involvement of the anterior wall of the lower uterine segment and the front wall of the lower uterine segment where the cesarean incisions were made.Laboratory tests showed slight elevation of serum beta-human chorionic gonadotropin. Intraoperative exploration showed the presence of a normal-sized uterus body with an enlarged tumor in the lower uterine segment. The surface of the lower uterine segment was light blue, the entire lesion was approximately about 8cm × 8 cm × 9 cm, with compression and displacement of the surrounding tissue.Histological examination diagnosed ETT. Immunohistochemical analysis showed positive expression of p63, with a Ki-67 proliferation index of 40%.CONCLUSION A search of the PubMed database using the search terms "cesarean section" and "epithelioid trophoblastic tumor" retrieved nine articles, including 13 cases of ETT and ETT-related lesions, all 13 cases had a history of cesarean section, and the lesions were all located at the cesarean section incision on the anterior wall of the lower uterine segment. The present case is the 14th reported case of ETT after cesarean section. Therefore, we deduced that cesarean section trauma had an important effect on the occurrence of ETT at this site.展开更多
目的:探讨子宫下段全层缝合术在剖宫产中的应用及对子宫切口憩室(PCSD)形成的影响。方法:选取2020年6月—2022年6月于我院行剖宫产产妇78例,按随机数字表法分为两组,各39例。对照组予以子宫下段分层缝合术,观察组予以子宫下段全层缝合...目的:探讨子宫下段全层缝合术在剖宫产中的应用及对子宫切口憩室(PCSD)形成的影响。方法:选取2020年6月—2022年6月于我院行剖宫产产妇78例,按随机数字表法分为两组,各39例。对照组予以子宫下段分层缝合术,观察组予以子宫下段全层缝合术。比较两组手术相关指标、术后并发症、PCSD发生率、PCSD容积及周围厚度。结果:两组手术时间、24h出血量、恶露持续天数及产后血红素相比,差异无统计学意义(P>0.05);观察组术后并发症总发生率、PCSD发生率较对照组低(P<0.05);观察组子宫切口憩室容积为(0.31±0.04)mm2,低于对照组的(0.45±0.06)mm2,子宫切口憩室周围厚度为(7.35±0.76)mm,高于对照组的(6.02±0.62)mm( P <0.05)。 结论: 子宫下段全层缝合术在剖宫产术中应用效果更佳,可降低并发症风险,减少PCSD形成。展开更多
文摘BACKGROUND Epithelioid trophoblastic tumor(ETT) is the rarest type of gestational trophoblastic tumor(GTT). It has been reported that more than 50% of ETTs arise in the uterine cervix or the lower uterine segment. Here, we report a case of ETT within the lower uterine segment and cervical canal and discuss its manifestations,possible causes, and related influencing factors.CASE SUMMARY A 35-year-old woman(gravida 7, miscarriage 3, induction 2 with 1 being twins,para 2 of cesarean section, live 2), who had amenorrhea for 9 mo after breastfeeding for 22 mo after the last cesarean section, was diagnosed with ETT. The lesion was present in the lower uterine segment and endocervical canal with severe involvement of the anterior wall of the lower uterine segment and the front wall of the lower uterine segment where the cesarean incisions were made.Laboratory tests showed slight elevation of serum beta-human chorionic gonadotropin. Intraoperative exploration showed the presence of a normal-sized uterus body with an enlarged tumor in the lower uterine segment. The surface of the lower uterine segment was light blue, the entire lesion was approximately about 8cm × 8 cm × 9 cm, with compression and displacement of the surrounding tissue.Histological examination diagnosed ETT. Immunohistochemical analysis showed positive expression of p63, with a Ki-67 proliferation index of 40%.CONCLUSION A search of the PubMed database using the search terms "cesarean section" and "epithelioid trophoblastic tumor" retrieved nine articles, including 13 cases of ETT and ETT-related lesions, all 13 cases had a history of cesarean section, and the lesions were all located at the cesarean section incision on the anterior wall of the lower uterine segment. The present case is the 14th reported case of ETT after cesarean section. Therefore, we deduced that cesarean section trauma had an important effect on the occurrence of ETT at this site.
文摘目的:探讨子宫下段全层缝合术在剖宫产中的应用及对子宫切口憩室(PCSD)形成的影响。方法:选取2020年6月—2022年6月于我院行剖宫产产妇78例,按随机数字表法分为两组,各39例。对照组予以子宫下段分层缝合术,观察组予以子宫下段全层缝合术。比较两组手术相关指标、术后并发症、PCSD发生率、PCSD容积及周围厚度。结果:两组手术时间、24h出血量、恶露持续天数及产后血红素相比,差异无统计学意义(P>0.05);观察组术后并发症总发生率、PCSD发生率较对照组低(P<0.05);观察组子宫切口憩室容积为(0.31±0.04)mm2,低于对照组的(0.45±0.06)mm2,子宫切口憩室周围厚度为(7.35±0.76)mm,高于对照组的(6.02±0.62)mm( P <0.05)。 结论: 子宫下段全层缝合术在剖宫产术中应用效果更佳,可降低并发症风险,减少PCSD形成。
