AIM: To validate accuracy of a novel chair-side test for matrix metalloproteinase(MMP)-8 as compared to enzyme-linked immunosorbent assay(ELISA) in Periodontal health and disease.METHODS: Gingival crevicular fluid was...AIM: To validate accuracy of a novel chair-side test for matrix metalloproteinase(MMP)-8 as compared to enzyme-linked immunosorbent assay(ELISA) in Periodontal health and disease.METHODS: Gingival crevicular fluid was collected from 150 subjects, Group 1(healthy)- 50 subjects, Group 2(gingivitis)- 50 subjects and Group 3(chronic periodontitis)- 50 subjects. A chair-side test strip was indigenously prepared using polyclonal antibodies(principle of immunochromatography) to detect the MMP-8 levels. The detection accuracy(sensitivity and specificity) of the MMP-8 levels by chair-side test kit were compared with ELISA at baseline and 3 mo after scaling and root planing among the study population.RESULTS: The novel chair side test detected MMP-8 levels in accordance with ELISA which at baseline were higher in Group 2 and Group 3 as compared to controls(P < 0.05), and these enzyme levels decreased after therapy(P < 0.05). The chair-side test could differentiate healthy, gingivitis and periodontitis. The detection accuracy of the chair-side test strip were on par with ELISA(sensitivity 92.9% and specificity of 100%) which were statistically significant(P < 0.05). A desire to arouse interest about periodontal health and maintenance in the Indian population provided a strong rationale for us to develop our chair-side test strips to suit our economy. Moreover, this was the first ever effort to develop and validate a chair-side test strip to detect MMP-8 levels in the Indian population. This test can be used on a large scale in private dental practice for the early detection of disease, tapping the sites at risk for disease, alongside helps in patient education and motivation for maintenance.CONCLUSION: This study shows that the novel chair side test kit detects MMP-8 levels a biomarker of periodontal disease progression accurately making it a good chair side diagnostic tool. Further, it is cost effective and time saving which can make it applicable in private dental practice on a large scale for the early detection of periodontal disease.展开更多
Introduction: Several techniques have been described by which a pair of dentures may be replicated. Case Report: The method described in this paper used materials readily available in a private practice to generate a ...Introduction: Several techniques have been described by which a pair of dentures may be replicated. Case Report: The method described in this paper used materials readily available in a private practice to generate a pair of duplicate dentures for a 74-year-old Black male, which captured all of the features of the patients’ existing pair. These were modified chair-side and used to capture vital information on fit, occlusion and aesthetics, forming a template which was transferred to the laboratory and used to generate new dentures via the traditional laboratory process. The same template was also used to generate a pair of “AvaDent Digital Dentures” by digital scanning and production of a digital denture template for try and then fabrication of the digital denture. Conclusion: The results of this pilot study show that this simple chair-side method of fabricating duplicate dentures can be incorporated successfully into the AvaDent Digital Denture fabrication process to generate a pair of dentures with comparability if not superior fit and aesthetics to a pair fabricated from the same template via the traditional laboratory process.展开更多
目的 本研究通过比较瓷睿刻椅旁系统三种生物再造设计功能[复制(BC)、自定义(BI)、参考(BR)]生成全冠的咬合面及邻面接触穿透区面积,从而指导临床医师选择合适的椅旁全冠设计策略。方法 制取6名志愿者的全口石膏模型,按全瓷冠标准预备...目的 本研究通过比较瓷睿刻椅旁系统三种生物再造设计功能[复制(BC)、自定义(BI)、参考(BR)]生成全冠的咬合面及邻面接触穿透区面积,从而指导临床医师选择合适的椅旁全冠设计策略。方法 制取6名志愿者的全口石膏模型,按全瓷冠标准预备模型右侧上颌中切牙,口内扫描仪扫描模型。分别使用BC、BI和BR三种模式生成虚拟全冠。计算全冠咬合面及邻面接触穿透区的面积,统计分析三种模式之间的差异(随机区组设计的方差分析,检验水平α=0.05)。结果 BC组咬合面接触穿透区面积与BR组、BI组之间的差异有统计学意义( P <0.05);BR组咬合面接触穿透区面积与BI组之间的差异无统计学意义( P >0.05)。三组邻面接触穿透区面积间的差异均无统计学意义( P >0.05)。结论 对于上颌中切牙形态完整、自然且对称的患者,BC模式生成全冠的咬合关系最佳;3种模式生成的全冠邻接关系无显著差异。展开更多
目的:分析数字化椅旁计算机辅助设计/计算机辅助制造(computer-aided design/computer-aided manufacturing,CAD/CAM)系统制作高嵌体修复后牙牙体缺损的临床应用价值。方法:研究对象为2016年1月~2018年1月在川北医学院附属医院口腔科接...目的:分析数字化椅旁计算机辅助设计/计算机辅助制造(computer-aided design/computer-aided manufacturing,CAD/CAM)系统制作高嵌体修复后牙牙体缺损的临床应用价值。方法:研究对象为2016年1月~2018年1月在川北医学院附属医院口腔科接受CAD/CAM系统制作高嵌体修复后牙牙缺损的1100例患者,共计1249颗患牙;分别于修复后即刻、修复后6个月时采用按照改良的美国公共卫生协会(United States Public Health Service,USPHS)评价标准评价疗效。结果:数字化椅旁CAD/CAM系统制作高嵌体1249个,经修复治疗后均成功回访;修复后即刻修完整性、边缘密合性、牙周状态、修复体固位达A级比重分别为90.07%、98.64%、100.00%、95.28%,且未发生边缘着色及继发龋。修复6个月后,修复体在完整性、修复体颜色匹配度上与修复后即刻比较,差异均无统计学意义(P>0.05);但边缘密合性、牙周状态、修复体固位较修复后即刻均有显著改善(P<0.05)。且完整性、边缘密合性、修复体固位达B级患者中修复体厚度<1 mm比重及髓高嵌体余留牙壁厚度<1 mm比重均显著高于A级(P<0.05)。结论:数字化椅旁CAD/CAM系统制作高嵌体修复后牙牙体缺损具良好的临床获益,部分修复体完整性、边缘密合性、固位欠佳或与修复体厚度、髓高嵌体余留牙壁厚度有关,值得临床重视。展开更多
文摘AIM: To validate accuracy of a novel chair-side test for matrix metalloproteinase(MMP)-8 as compared to enzyme-linked immunosorbent assay(ELISA) in Periodontal health and disease.METHODS: Gingival crevicular fluid was collected from 150 subjects, Group 1(healthy)- 50 subjects, Group 2(gingivitis)- 50 subjects and Group 3(chronic periodontitis)- 50 subjects. A chair-side test strip was indigenously prepared using polyclonal antibodies(principle of immunochromatography) to detect the MMP-8 levels. The detection accuracy(sensitivity and specificity) of the MMP-8 levels by chair-side test kit were compared with ELISA at baseline and 3 mo after scaling and root planing among the study population.RESULTS: The novel chair side test detected MMP-8 levels in accordance with ELISA which at baseline were higher in Group 2 and Group 3 as compared to controls(P < 0.05), and these enzyme levels decreased after therapy(P < 0.05). The chair-side test could differentiate healthy, gingivitis and periodontitis. The detection accuracy of the chair-side test strip were on par with ELISA(sensitivity 92.9% and specificity of 100%) which were statistically significant(P < 0.05). A desire to arouse interest about periodontal health and maintenance in the Indian population provided a strong rationale for us to develop our chair-side test strips to suit our economy. Moreover, this was the first ever effort to develop and validate a chair-side test strip to detect MMP-8 levels in the Indian population. This test can be used on a large scale in private dental practice for the early detection of disease, tapping the sites at risk for disease, alongside helps in patient education and motivation for maintenance.CONCLUSION: This study shows that the novel chair side test kit detects MMP-8 levels a biomarker of periodontal disease progression accurately making it a good chair side diagnostic tool. Further, it is cost effective and time saving which can make it applicable in private dental practice on a large scale for the early detection of periodontal disease.
文摘Introduction: Several techniques have been described by which a pair of dentures may be replicated. Case Report: The method described in this paper used materials readily available in a private practice to generate a pair of duplicate dentures for a 74-year-old Black male, which captured all of the features of the patients’ existing pair. These were modified chair-side and used to capture vital information on fit, occlusion and aesthetics, forming a template which was transferred to the laboratory and used to generate new dentures via the traditional laboratory process. The same template was also used to generate a pair of “AvaDent Digital Dentures” by digital scanning and production of a digital denture template for try and then fabrication of the digital denture. Conclusion: The results of this pilot study show that this simple chair-side method of fabricating duplicate dentures can be incorporated successfully into the AvaDent Digital Denture fabrication process to generate a pair of dentures with comparability if not superior fit and aesthetics to a pair fabricated from the same template via the traditional laboratory process.
文摘目的 本研究通过比较瓷睿刻椅旁系统三种生物再造设计功能[复制(BC)、自定义(BI)、参考(BR)]生成全冠的咬合面及邻面接触穿透区面积,从而指导临床医师选择合适的椅旁全冠设计策略。方法 制取6名志愿者的全口石膏模型,按全瓷冠标准预备模型右侧上颌中切牙,口内扫描仪扫描模型。分别使用BC、BI和BR三种模式生成虚拟全冠。计算全冠咬合面及邻面接触穿透区的面积,统计分析三种模式之间的差异(随机区组设计的方差分析,检验水平α=0.05)。结果 BC组咬合面接触穿透区面积与BR组、BI组之间的差异有统计学意义( P <0.05);BR组咬合面接触穿透区面积与BI组之间的差异无统计学意义( P >0.05)。三组邻面接触穿透区面积间的差异均无统计学意义( P >0.05)。结论 对于上颌中切牙形态完整、自然且对称的患者,BC模式生成全冠的咬合关系最佳;3种模式生成的全冠邻接关系无显著差异。
文摘目的:分析数字化椅旁计算机辅助设计/计算机辅助制造(computer-aided design/computer-aided manufacturing,CAD/CAM)系统制作高嵌体修复后牙牙体缺损的临床应用价值。方法:研究对象为2016年1月~2018年1月在川北医学院附属医院口腔科接受CAD/CAM系统制作高嵌体修复后牙牙缺损的1100例患者,共计1249颗患牙;分别于修复后即刻、修复后6个月时采用按照改良的美国公共卫生协会(United States Public Health Service,USPHS)评价标准评价疗效。结果:数字化椅旁CAD/CAM系统制作高嵌体1249个,经修复治疗后均成功回访;修复后即刻修完整性、边缘密合性、牙周状态、修复体固位达A级比重分别为90.07%、98.64%、100.00%、95.28%,且未发生边缘着色及继发龋。修复6个月后,修复体在完整性、修复体颜色匹配度上与修复后即刻比较,差异均无统计学意义(P>0.05);但边缘密合性、牙周状态、修复体固位较修复后即刻均有显著改善(P<0.05)。且完整性、边缘密合性、修复体固位达B级患者中修复体厚度<1 mm比重及髓高嵌体余留牙壁厚度<1 mm比重均显著高于A级(P<0.05)。结论:数字化椅旁CAD/CAM系统制作高嵌体修复后牙牙体缺损具良好的临床获益,部分修复体完整性、边缘密合性、固位欠佳或与修复体厚度、髓高嵌体余留牙壁厚度有关,值得临床重视。
