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A Research Progress of CO_(2)-Responsive Plugging Channeling Gels
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作者 Yang Xiong Jianxin Liu +4 位作者 Xianhao Yi Bangyan Xiao Dan Wu Biao Wu Chunyu Gao 《Energy Engineering》 EI 2024年第7期1759-1780,共22页
In the heterogeneous reservoirs,CO_(2) flooding easily leads to CO_(2) gas channeling,which can seriously affect sweeping efficiency and reduce oil recovery.After thoroughly investigating the advantages and shortcomin... In the heterogeneous reservoirs,CO_(2) flooding easily leads to CO_(2) gas channeling,which can seriously affect sweeping efficiency and reduce oil recovery.After thoroughly investigating the advantages and shortcomings of various CO_(2) plugging technologies,this paper focuses on the feasibility of improving conventional water-alternating gas(WAG)through CO_(2)-responsive gel materials.Based on the different chemical reaction mechanisms between the unique chemical structure and CO_(2),changes in the material’s physical and chemical properties can respond to CO_(2).The feasibility of utilizing these property changes for CO_(2)-responsive plugging is explored.Various CO_(2)-responsive gels and gel nanoparticles have been extensively researched in different fields,such as energy,medicine,and biology.This paper surveys the molecular structures,chemical compositions,response mechanisms,and changes of these CO_(2)-responsive gels,aiming to draw insights into the carbon dioxide-enhanced oil recovery(CO_(2)-EOR)field.Finally,the key issues and future development direction of CO_(2)-responsive plugging gels were analyzed. 展开更多
关键词 Gas channeling sweep efficiency CO_(2)-responsive gel CO_(2)-EOR
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Gas channeling control with an in-situ smart surfactant gel during water-alternating-CO_(2) enhanced oil recovery
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作者 Xin-Jie Luo Bing Wei +6 位作者 Ke Gao Bo Jing Bo Huang Ping Guo Hong-Yao Yin Yu-Jun Feng Xi Zhang 《Petroleum Science》 SCIE EI CSCD 2023年第5期2835-2851,共17页
Undesirable gas channeling always occurs along the high-permeability layers in heterogeneous oil reservoirs during water-alternating-CO_(2)(WAG)flooding,and conventional polymer gels used for blocking the“channeling... Undesirable gas channeling always occurs along the high-permeability layers in heterogeneous oil reservoirs during water-alternating-CO_(2)(WAG)flooding,and conventional polymer gels used for blocking the“channeling”paths usually suffer from either low injectivity or poor gelation control.Herein,we for the first time developed an in-situ high-pressure CO_(2)-triggered gel system based on a smart surfactant,N-erucamidopropyl-N,N-dimethylamine(UC22AMPM),which was introduced into the aqueous slugs to control gas channeling inWAG processes.The water-like,low-viscosity UC22AMPM brine solution can be thickened by high-pressure CO_(2) owing to the formation of wormlike micelles(WLMs),as well as their growth and shear-induced structure buildup under shear flow.The thickening power can be further potentiated by the generation of denser WLMs resulting from either surfactant concentration augmentation or a certain range of heating,and can be impaired via pressurization above the critical pressure of CO_(2) because of its soaring solvent power.Core flooding tests using heterogeneous cores demonstrated that gas channeling was alleviated by plugging of high-capacity channels due to the in-situ gelation of UC22AMPM slugs upon their reaction with the pre-or post-injected CO_(2) slugs under shear flow,thereupon driving chase fluids into unrecovered low-permeability areas and producing an 8.0% higher oil recovery factor than the conventional WAG mode.This smart surfactant enabled high injectivity and satisfactory gelation control,attributable to low initial viscosity and the combined properties of one component and CO_(2)-triggered gelation,respectively.This work could provide a guide towards designing gels for reducing CO_(2) spillover and reinforcing the CO_(2) sequestration effect during CO_(2) enhanced oil recovery processes. 展开更多
关键词 CO_(2)flooding Enhanced oil recovery Gas channeling Water-alternating-CO_(2) Smart surfactant GEL
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Analysis of Channeling-Path Phenomena in a Complex Fault-Block Reservoir with Low Recovery Factor and High Water-Cut Ratio
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作者 Qunyi Wang Xiaoli Ma +4 位作者 Yongbin Bi Haiyan He Xiao Gu Tongjing Liu Lekun Zhao 《Fluid Dynamics & Materials Processing》 EI 2023年第2期361-377,共17页
Current methods for the analysis of channeling-path phenomena in reservoirs cannot account for the influence of time and space on the actual seepage behavior.In the present study,this problem is addressed considering ... Current methods for the analysis of channeling-path phenomena in reservoirs cannot account for the influence of time and space on the actual seepage behavior.In the present study,this problem is addressed considering actual production data and dynamic characteristic parameters quantitatively determined in the near wellbore area by fitting the water-cut curve of the well.Starting from the dynamic relationship between injection and production data,the average permeability is determined and used to obtain a real-time quantitative characterization of the seepage behavior of the channeling-path in the far wellbore area.For the considered case study(Jidong oilfield),it is found that the seepage capacity of the channeling-path in the far wellbore area is far less(10 times smaller)than that of the channeling-path in the near wellbore area.The present study and the proposed model(combining near wellbore area and far wellbore area real-time data)have been implemented to support the definition of relevant adjustment measures to ultimately improve oil recovery. 展开更多
关键词 Complex fault-block reservoirs channeling path quantitative identification characteristic parameters dynamic inversion
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非熟练外语学习者交际中Back-channeling现象的分析研究 被引量:4
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作者 黄清贵 林丽霞 +1 位作者 林敦川 黄丽 《青海师范大学学报(哲学社会科学版)》 2008年第6期111-114,共4页
要全面客观地评估"非熟练外语学习者"在Back-channeling策略的运用上是否受所学外语的影响而产生语用迁移,就要从其所使用的Back-channels在频率、位置、形式及功能方面加以综合考量。利用会话分析理论及所收集到的语料,我们... 要全面客观地评估"非熟练外语学习者"在Back-channeling策略的运用上是否受所学外语的影响而产生语用迁移,就要从其所使用的Back-channels在频率、位置、形式及功能方面加以综合考量。利用会话分析理论及所收集到的语料,我们观察到"非熟练外语学习者"在会话中最经常使用"点头"与"Yes/yeah"这两种Back-channels。经过认真的对比分析,我们认为"非熟练外语学习者"在其Back-channeling策略的运用上并未发生真正意义上的语用迁移。同时,我们还结合社会心理学相关研究成果,对他们在会话中所使用的Back-channeling策略背后的动机进行了初步的探讨。 展开更多
关键词 非熟练外语学习者 Back—channeling策略 合作 竞争 语用迁移
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CO_2-triggered gelation for mobility control and channeling blocking during CO_2 flooding processes 被引量:5
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作者 De-Xiang Li Liang Zhang +2 位作者 Yan-Min Liu Wan-Li Kang Shao-Ran Ren 《Petroleum Science》 SCIE CAS CSCD 2016年第2期247-258,共12页
CO2 flooding is regarded as an important method for enhanced oil recovery (EOR) and greenhouse gas control. However, the heterogeneity prevalently dis- tributed in reservoirs inhibits the performance of this technol... CO2 flooding is regarded as an important method for enhanced oil recovery (EOR) and greenhouse gas control. However, the heterogeneity prevalently dis- tributed in reservoirs inhibits the performance of this technology. The sweep efficiency can be significantly reduced especially in the presence of "thief zones". Hence, gas channeling blocking and mobility control are important technical issues for the success of CO2 injection. Normally, crosslinked gels have the potential to block gas channels, but the gelation time control poses challenges to this method. In this study, a new method for selectively blocking CO2 channeling is proposed, which is based on a type of CO2-sensitive gel system (modified polyacry- lamide-methenamine-resorcinol gel system) to form gel in situ. A CO2-sensitive gel system is when gelation or solidification will be triggered by CO2 in the reservoir to block gas channels. The CO2-sensitivity of the gel system was demonstrated in parallel bottle tests of gel in N2 and CO2 atmospheres. Sand pack flow experiments were con- ducted to investigate the shutoff capacity of the gel system under different conditions. The injectivity of the gel system was studied via viscosity measurements. The results indi- cate that this gel system was sensitive to CO2 and had good performance of channeling blocking in porous media. Advantageous viscosity-temperature characteristics were achieved in this work. The effectiveness for EOR in heterogeneous formations based on this gel system was demonstrated using displacement tests conducted in double sand packs. The experimental results can provide guideli- nes for the deployment of theCO2-sensitive gel system for field applications. 展开更多
关键词 CO2 flooding Gas channeling - CO2sensitivity - Sweep efficiency Enhanced oil recoveryMobility control
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THE DAMAGE MEASUREMENT OF ION- IMPLANTED COMPOUND SEMICONDUCTOR GaAs BY PIXE-CHANNELING TECHNIQUE
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作者 刘惠珍 盛康龙 +4 位作者 朱德彰 杨国华 朱福英 曹建清 唐立军 《Nuclear Science and Techniques》 SCIE CAS CSCD 1990年第3期156-160,共5页
A combined PIXE-RBS channeling measurement system to examine Ⅲ-Ⅴ compound semiconductors has been established. Preliminary results on studying Si+ and Te+ implanted GaAs have been presented and discussed.
关键词 Ion implantation Compound semiconductor GAAS PIXE- channeling TECHNIQUE
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Optimization of laser focused atomic deposition by channeling
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作者 陈杰 刘杰 +3 位作者 朱立 邓晓 陈鑫彬 李同保 《Chinese Physics B》 SCIE EI CAS CSCD 2020年第2期177-182,共6页
Laser focused atomic deposition is a unique and effective way to fabricate highly accurate pitch standards in nanometrology.However,the stability and repeatability of the atom lithography fabrication process remains a... Laser focused atomic deposition is a unique and effective way to fabricate highly accurate pitch standards in nanometrology.However,the stability and repeatability of the atom lithography fabrication process remains a challenging problem for massive production.Based on the atom-light interaction theory,channeling is utilized to improve the stability and repeatability.From the comparison of three kinds of atom-light interaction models,the optimal parameters for channeling are obtained based on simulation.According to the experimental observations,the peak to valley height of Cr nano-gratings keeps stable when the cutting proportion changes from 15%to 50%,which means that the channeling shows up under this condition.The channeling proves to be an effective method to optimize the stability and repeatability of laser focused Cr atomic deposition. 展开更多
关键词 laser FOCUSED ATOMIC DEPOSITION nano-grating length transition STANDARDS channeling
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LATTICE LOCATION DETERMINATION OF TRACE AMOUNT CARBON IN GALLIUM ARSENIDE BY THEORETICAL CALCULATION OF CPAA WITH CHANNELING
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作者 韦伦存 包尚联 +1 位作者 杨其湘 杨熙宏 《Nuclear Science and Techniques》 SCIE CAS CSCD 1991年第4期211-219,共9页
Combining the charged particle activation analysis (CPAA) and the (?)hanneling technique, partial concentrations of carbon on different crystal lattice locations of GaAs were calculated. The results show that at lower... Combining the charged particle activation analysis (CPAA) and the (?)hanneling technique, partial concentrations of carbon on different crystal lattice locations of GaAs were calculated. The results show that at lower total concentration (≈0.3 ppm), carbon atoms occupy principally the octahedral and displaced octahedral interstitial positions, but at higher total concentration (≈2 ppm), the substitutional carbon plays a principal role. 展开更多
关键词 CPAA channeling technique IMPURITY carbon GAAS
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Dependence of Dechanneling on Individual Layer Thicknesses in Strained-Layer Superlattices
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作者 PAN Chuankang JIANG Fengyi 《Chinese Physics Letters》 SCIE CAS CSCD 1994年第10期626-629,共4页
We show our new channeling measurement results on ZnSe/Zns and GaSb/AlSb superlattices,which are different from the channeling results on strained-layer superlattices in the early publications.A new concept of“effect... We show our new channeling measurement results on ZnSe/Zns and GaSb/AlSb superlattices,which are different from the channeling results on strained-layer superlattices in the early publications.A new concept of“effective channel”,and a calculation formula of“effective channel geometry width”have been presented and derived,the theoretical analysis is in good agreement with the experiment results. 展开更多
关键词 CHANNEL channeling GASB
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Channeling of fast ions through the bent carbon nanotubes: The extended two-fluid hydrodynamic model
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作者 Lazar Karbunar Dusko Borka +1 位作者 Ivan Radovic Zoran L Miskovic 《Chinese Physics B》 SCIE EI CAS CSCD 2016年第4期274-283,共10页
We investigate the interactions of charged particles with straight and bent single-walled carbon nanotubes (SWNTs) under channeling conditions in the presence of dynamic polarization of the valence electrons in carb... We investigate the interactions of charged particles with straight and bent single-walled carbon nanotubes (SWNTs) under channeling conditions in the presence of dynamic polarization of the valence electrons in carbon, This polarization is described by a cylindrical, two-fluid hydrodynamic model with the parameters taken from the recent modelling of several independent experiments on electron energy loss spectroscopy of carbon nano-structures. We use the hydrodynamic model to calculate the image potential for protons moving through four types of SWNTs at a speed of 3 atomic units. The image potential is then combined with the Doyle-Turner atomic potential to obtain the total potential in the bent carbon nanotubes. Using that potential, we also compute the spatial and angular distributions of protons channeled through the bent carbon nanotubes, and compare the results with the distributions obtained without taking into account the image potential. 展开更多
关键词 NANOTUBES channeling dynamic polarization
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Characterization of tetragonal distortion in a thick Al_(0.2)Ga_(0.8)N epilayer with an AlN interlayer by Rutherford backscattering/channeling
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作者 王欢 姚淑德 《Chinese Physics B》 SCIE EI CAS CSCD 2014年第9期354-357,共4页
An Al0.2Ga0.8N/AlN/Al0.2Ga0.8N heterostructure was grown by metalorganic chemical vapor deposition on a sapphire (0001) substrate with a thick (〉 1 μm) GaN intermediate layer. The Al composition was determined b... An Al0.2Ga0.8N/AlN/Al0.2Ga0.8N heterostructure was grown by metalorganic chemical vapor deposition on a sapphire (0001) substrate with a thick (〉 1 μm) GaN intermediate layer. The Al composition was determined by Rutherford backscattering (RBS). Using the channeling scan around an off-normal [1213] axis in the (1010) plane of the Al0.2Ga0.8N layer, the tetragonal distortion eT, which is caused by the elastic strain in the epilayer, is investigated. The results show that eT in the high-quality Al0.2Ga0.8N layer is dramatically released by the AIN interlayer from 0.66% to 0.27%. 展开更多
关键词 ALGAN Rutherford backscattering/channeling elastic strain
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A Method for Identifying Channeling Paths in Low-Permeability Fractured Reservoirs
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作者 Zhenfeng Zhao Bin Li +6 位作者 Zubo Su Lijing Chang Hongzheng Zhu Ming Liu Jialing Ma Fan Wang Qianwan Li 《Fluid Dynamics & Materials Processing》 EI 2022年第6期1781-1794,共14页
Often oilfield fractured horizontal wells produce water flowing in multiple directions.In this study,a method to identify such channeling paths is developed.The dual-medium model is based on the principle of inter-wel... Often oilfield fractured horizontal wells produce water flowing in multiple directions.In this study,a method to identify such channeling paths is developed.The dual-medium model is based on the principle of inter-well connectivity and considers the flow characteristics and related channeling terms.The Lorentz curve is drawn to qualitatively discern the geological type of the low-permeability fractured reservoir and determine the channeling direction and size.The practical application of such an approach to a sample oilfield shows that it can accurately identify the channeling paths of the considered low-permeability fractured reservoir and predict production performances according to the inter-well connectivity model.As a result,early detection of water channeling becomes possible,paving the way to real-time production system optimization in low-permeability fractured reservoirs. 展开更多
关键词 Low-permeability fractured reservoir fracturing horizontal well interwell connectivity dual media channeling paths
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Study of depth-dependent tetragonal distortion of quaternary AlInGaN epilayer by Rutherford backscattering/channeling
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作者 G.Husnain 陈田祥 +1 位作者 法涛 姚淑德 《Chinese Physics B》 SCIE EI CAS CSCD 2010年第8期563-566,共4页
A 240-nm thick Al0.4In0.02Ga0.58N layer is grown by metal organic chemical vapour deposition, with an over 1-μm thick GaN layer used as a buffer layer on a substrate of sapphire (0001). Rutherford backscattering an... A 240-nm thick Al0.4In0.02Ga0.58N layer is grown by metal organic chemical vapour deposition, with an over 1-μm thick GaN layer used as a buffer layer on a substrate of sapphire (0001). Rutherford backscattering and channeling are used to characterize the microstructure of AlInGaN. The results show a good crystalline quality of AIInGaN (χmin = 1.5%) with GaN buffer layer. The channeling angular scan around an off-normal {1213} axis in the {1010} plane of the AlInGaN layer is used to determine tetragonal distortion eT, which is caused by the elastic strain in the AIInGaN. The resulting AlInGaN is subjected to an elastic strain at interracial layer, and the strain decreases gradually towards the near-surface layer. It is expected that an epitaxial AlInGaN thin film with a thickness of 850 nm will be fully relaxed (^eT = 0). 展开更多
关键词 Ⅲ-Ⅴ semiconductors Rutherford backscattering and channeling tetragonal distortion
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Channeling in Bent Crystallites: A New Method to Enhance the Radiation Shielding Efficiency
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作者 Mukhtar Ahmed Rana 《Modern Instrumentation》 2018年第3期35-41,共7页
A new method is proposed here aiming at designing a shielding wall with the efficiency significantly higher than that of traditional designs. This new design arises from the idea of using channeling in multilayered sh... A new method is proposed here aiming at designing a shielding wall with the efficiency significantly higher than that of traditional designs. This new design arises from the idea of using channeling in multilayered shielding wall structure, each layer composed of bent crystallites distributed in a way that each layer covers a small section of 2π angular range of which wall is exposed. Part of the incident charged particles will get channeled in bent crystallites in each layer. Bending of channeled particles in bent crystallites will change their directions in the wall increasing their path lengths in the wall which would enhance its shielding efficiency for charged particle radiations. Proposed design is useful for radiation shielding in fission power plants, future fusion reactors and air travel. 展开更多
关键词 Radiation SHIELDING BENT Crystals channeling Nuclear and Thermonuclear Reactors COSMIC RAYS
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Channeling Sealing Technique with QN-70 Agent
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《China Oil & Gas》 CAS 1997年第2期98-98,共1页
关键词 QN channeling Sealing Technique with QN-70 Agent
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Low-energy ion channeling in nanocubes
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作者 Shiva Choupanian Wolfhard Möller +1 位作者 Martin Seyring Carsten Ronning 《Nano Research》 SCIE EI CSCD 2023年第1期1522-1526,共5页
Focused ion beam(FIB)processing with low-energy ions has become a standard technique for the manipulation of nanostructures.Many underlying ion beam effects that deviate from conventional high-energy ion irradiation o... Focused ion beam(FIB)processing with low-energy ions has become a standard technique for the manipulation of nanostructures.Many underlying ion beam effects that deviate from conventional high-energy ion irradiation of bulk systems are considered today;however,ion channeling with its consequence of significant deeper penetration depth has been only theoretically investigated in this regime.We present here an experimental approach to determine the channeling of low-energy ions in crystalline nanoparticles by measuring the sputter yield derived from scanning electron microscopy(SEM)images taken after irradiation under various incident ion angles.Channeling maps of 30 and 20 keV Ga+ions in Ag nanocubes have been identified and fit well with the theory.Indeed,channeling has a significant impact on the transport of energetic ions in crystals due to the large critical angle at low ion energies,thus being relevant for any FIB-application.Consequently,the obtained sputter yield clearly differs from amorphous materials;therefore,it is recommended not to rely only on,e.g.,ion distribution depths predicted by standard Monte-Carlo(MC)algorithms for amorphous materials. 展开更多
关键词 ion nanostructure interaction ion channeling metallic nanoparticles focused ion beam
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Two-Staged Method for Ice Channel Identification Based on Image Segmentation and Corner Point Regression 被引量:1
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作者 DONG Wen-bo ZHOU Li +2 位作者 DING Shi-feng WANG Ai-ming CAI Jin-yan 《China Ocean Engineering》 SCIE EI CSCD 2024年第2期313-325,共13页
Identification of the ice channel is the basic technology for developing intelligent ships in ice-covered waters,which is important to ensure the safety and economy of navigation.In the Arctic,merchant ships with low ... Identification of the ice channel is the basic technology for developing intelligent ships in ice-covered waters,which is important to ensure the safety and economy of navigation.In the Arctic,merchant ships with low ice class often navigate in channels opened up by icebreakers.Navigation in the ice channel often depends on good maneuverability skills and abundant experience from the captain to a large extent.The ship may get stuck if steered into ice fields off the channel.Under this circumstance,it is very important to study how to identify the boundary lines of ice channels with a reliable method.In this paper,a two-staged ice channel identification method is developed based on image segmentation and corner point regression.The first stage employs the image segmentation method to extract channel regions.In the second stage,an intelligent corner regression network is proposed to extract the channel boundary lines from the channel region.A non-intelligent angle-based filtering and clustering method is proposed and compared with corner point regression network.The training and evaluation of the segmentation method and corner regression network are carried out on the synthetic and real ice channel dataset.The evaluation results show that the accuracy of the method using the corner point regression network in the second stage is achieved as high as 73.33%on the synthetic ice channel dataset and 70.66%on the real ice channel dataset,and the processing speed can reach up to 14.58frames per second. 展开更多
关键词 ice channel ship navigation IDENTIFICATION image segmentation corner point regression
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Channel Correlation Based User Grouping Algorithm for Nonlinear Precoding Satellite Communication System 被引量:1
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作者 Ke Wang Baorui Feng +5 位作者 Jingui Zhao Wenliang Lin Zhongliang Deng Dongdong Wang Yi Cen Genan Wu 《China Communications》 SCIE CSCD 2024年第1期200-214,共15页
Low Earth Orbit(LEO)multibeam satellites will be widely used in the next generation of satellite communication systems,whose inter-beam interference will inevitably limit the performance of the whole system.Nonlinear ... Low Earth Orbit(LEO)multibeam satellites will be widely used in the next generation of satellite communication systems,whose inter-beam interference will inevitably limit the performance of the whole system.Nonlinear precoding such as Tomlinson-Harashima precoding(THP)algorithm has been proved to be a promising technology to solve this problem,which has smaller noise amplification effect compared with linear precoding.However,the similarity of different user channels(defined as channel correlation)will degrade the performance of THP algorithm.In this paper,we qualitatively analyze the inter-beam interference in the whole process of LEO satellite over a specific coverage area,and the impact of channel correlation on Signal-to-Noise Ratio(SNR)of receivers when THP is applied.One user grouping algorithm is proposed based on the analysis of channel correlation,which could decrease the number of users with high channel correlation in each precoding group,thus improve the performance of THP.Furthermore,our algorithm is designed under the premise of co-frequency deployment and orthogonal frequency division multiplexing(OFDM),which leads to more users under severe inter-beam interference compared to the existing research on geostationary orbit satellites broadcasting systems.Simulation results show that the proposed user grouping algorithm possesses higher channel capacity and better bit error rate(BER)performance in high SNR conditions relative to existing works. 展开更多
关键词 channel correlation inter-beam interference multibeam satellite Tomlinson-Harashima precoding user grouping
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Cascaded ELM-Based Joint Frame Synchronization and Channel Estimation over Rician Fading Channel with Hardware Imperfections 被引量:1
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作者 Qing Chaojin Rao Chuangui +2 位作者 Yang Na Tang Shuhai Wang Jiafan 《China Communications》 SCIE CSCD 2024年第6期87-102,共16页
Due to the interdependency of frame synchronization(FS)and channel estimation(CE),joint FS and CE(JFSCE)schemes are proposed to enhance their functionalities and therefore boost the overall performance of wireless com... Due to the interdependency of frame synchronization(FS)and channel estimation(CE),joint FS and CE(JFSCE)schemes are proposed to enhance their functionalities and therefore boost the overall performance of wireless communication systems.Although traditional JFSCE schemes alleviate the influence between FS and CE,they show deficiencies in dealing with hardware imperfection(HI)and deterministic line-of-sight(LOS)path.To tackle this challenge,we proposed a cascaded ELM-based JFSCE to alleviate the influence of HI in the scenario of the Rician fading channel.Specifically,the conventional JFSCE method is first employed to extract the initial features,and thus forms the non-Neural Network(NN)solutions for FS and CE,respectively.Then,the ELMbased networks,named FS-NET and CE-NET,are cascaded to capture the NN solutions of FS and CE.Simulation and analysis results show that,compared with the conventional JFSCE methods,the proposed cascaded ELM-based JFSCE significantly reduces the error probability of FS and the normalized mean square error(NMSE)of CE,even against the impacts of parameter variations. 展开更多
关键词 channel estimation extreme learning machine frame synchronization hardware imperfection nonlinear distortion synchronization metric
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Na^(+)/K^(+)-ATPase:ion pump,signal transducer,or cytoprotective protein,and novel biological functions 被引量:1
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作者 Songqiang Huang Wanting Dong +1 位作者 Xiaoqian Lin Jinsong Bian 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第12期2684-2697,共14页
Na^(+)/K^(+)-ATPase is a transmembrane protein that has important roles in the maintenance of electrochemical gradients across cell membranes by transporting three Na^(+)out of and two K^(+)into cells.Additionally,Na^... Na^(+)/K^(+)-ATPase is a transmembrane protein that has important roles in the maintenance of electrochemical gradients across cell membranes by transporting three Na^(+)out of and two K^(+)into cells.Additionally,Na^(+)/K^(+)-ATPase participates in Ca^(2+)-signaling transduction and neurotransmitter release by coordinating the ion concentration gradient across the cell membrane.Na^(+)/K^(+)-ATPase works synergistically with multiple ion channels in the cell membrane to form a dynamic network of ion homeostatic regulation and affects cellular communication by regulating chemical signals and the ion balance among different types of cells.Therefo re,it is not surprising that Na^(+)/K^(+)-ATPase dysfunction has emerged as a risk factor for a variety of neurological diseases.However,published studies have so far only elucidated the important roles of Na^(+)/K^(+)-ATPase dysfunction in disease development,and we are lacking detailed mechanisms to clarify how Na^(+)/K^(+)-ATPase affects cell function.Our recent studies revealed that membrane loss of Na^(+)/K^(+)-ATPase is a key mechanism in many neurological disorders,particularly stroke and Parkinson's disease.Stabilization of plasma membrane Na^(+)/K^(+)-ATPase with an antibody is a novel strategy to treat these diseases.For this reason,Na^(+)/K^(+)-ATPase acts not only as a simple ion pump but also as a sensor/regulator or cytoprotective protein,participating in signal transduction such as neuronal autophagy and apoptosis,and glial cell migration.Thus,the present review attempts to summarize the novel biological functions of Na^(+)/K^(+)-ATPase and Na^(+)/K^(+)-ATPase-related pathogenesis.The potential for novel strategies to treat Na^(+)/K^(+)-ATPase-related brain diseases will also be discussed. 展开更多
关键词 ANTIBODY biological functions cellular communication electrochemical gradient ion balance ion channels Na^(+)/K^(+)-ATPase neurological diseases neurotransmitter release signal transduction
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