PRELIMINARY STUDIES ON THE SYNTHESIS AND CHARACTERIZATION OF OXY-AND THIO-DIACETIC ACID HYDRAZITION AND THEIR FIRST-ROW TRANSITION METAL COMPLEXES

It has been made certain that thio-and oxy-diacetic acid hydrazides are potential anticancer compounds.However,their ability to form complexes with transition metals and the properties of the complexes thus formed have not been studied.Employing a new potential anticancer ligand 1,2-bis(thioacetic acid hydrazide)ethane prepared in our lab,along with ligands oxydiacetic hydrazide and 1,2-bis(oxyacetic acid hydrazide) ethane,a series of 11 new first-row transition metal(M=Zn^(2+),Cu^(2+),Co^(2+), Ni^(2+))complexes with each of the above three ligands have been synthesized and characterized by means of elemental analyses,IR,TG and X-ray powder diffraction.

The characteristics of driver lane-changing behaviour in congested road environments

Lane-changing behaviour is one of the complex|driving behaviours.The lane-changing behaviour of drivers may exacerbate congestion,however driver behavioural characteristics are difficult to accurately acquire and quantify,and thus tend to be simplified or ignored in existing lane-changing models.In this paper,the Bik-means clustering algorithm is used to analyse the urban road congestion state discrimination method.Then,simulated driving tests were conducted for different traffic congestion conditions.Through the force feedback system and infrared camera,the data of driver lane-changing behaviours at different traffic congestion levels are obtained separately,and the definitions of the start and end points of a vehicle changing lanes are determined.Furthermore,statistical analysis and discussion of key feature parameters including driver lane-changing behaviour data and visual data under different levels of traffic congestion were conducted.It is found that the average lane-change intention times in each congestion state are 2 s,4 s,6 s and 7 s,while the turn-signal duration and the number of rear-view mirror observations have similar patterns of change to the data on lane-changing intention duration.Moreover,drivers’pupil diameters become smaller during the lane-changing intention phase,and then relatively enlarge during lane-changing;the range of pupil variation is roughly 3.5 mm to 4 mm.The frequency of observing the vehicle in front of the target lane increased as the level of congestion increased,and the frequency of observation in the driver’s mirrors while changing lanes approximately doubled compared to driving straight ahead,and this ratio increased as the level of congestion increased.

Characterization and phase transition study for vesicles of fluorocarbon amphiphiles with 1,3-disubstituted glycerol structure

This paper presents the preparations and characterization of vesicles of four new fluoro- carbon amphiphiles with 1,3-disubstituted glycerol structure in common and different headgroups (OH, 1; CO_2H, 2; quaternary ammonium salt, 3; and pyridinium salt, 4). These vesicles have higher transition temperature due to the stronger hydrophobic interaction between fluorocarbon chains. Addition of fluorocarbon additives with carboxylic acid or quaternary ammonium salt head group respectively shows different influences on phase behavior of vesicles of 2. These results are discussed based on the interaction within headgroup, hydrophobicity and specific mutahydrophobic interaction between fluoro- and hydrocarbon chains.

Simultaneous size characterization and mass quantification of the in vivo core-biocorona structure and dissolved species of silver nanoparticles

Size characterization of silver nanoparticles with biomolecule corona（AgNP@BCs） and mass quantification of various silver species in organisms are essential for understanding the in vivo transformation of Ag NPs. Herein, we report a versatile method that allows simultaneous determination of the size of AgNP@BCs and mass concentration of various silver species in rat liver. Both particulate and ionic silver were extracted in their original forms from the organs by alkaline digestion, and analyzed by size exclusion chromatography combined with inductively coupled plasma mass spectrometry（SEC-ICP-MS）. While the silver mass concentrations were quantified by ICP-MS with a detection limit of 0.1 μg/g, the effective diameter of AgNP@BCs was determined based on the retention time in SEC separation with size discrimination of 0.6-3.3 nm. More importantly, we found that the BC thickness of AgNP@BCs is core size independent, and a linear correlation was found between the effective diameter and core diameter of AgNP@BCs in extracted tissues, which was used to calibrate the core diameter with standard deviations in the range of 0.2-1.1 nm. The utility of this strategy was demonstrated through application to rat livers in vivo. Our method is powerful for investigating the transformation mechanism of Ag NPs in vivo.