AIM: The healthy ranges for serum alanine aminotransferase(ALT) levels are less well studied. The aim of this study was to define the upper limit of normal (ULN) for serum ALT levels, and to assess factors associated ...AIM: The healthy ranges for serum alanine aminotransferase(ALT) levels are less well studied. The aim of this study was to define the upper limit of normal (ULN) for serum ALT levels, and to assess factors associated with serum ALT activity in apparently healthy blood donors. METHODS: A total of 1 939 blood donors were included.ALT measurements were performed for all cases using the same laboratory method. Healthy ranges for ALT levels werecomputed from the population at the lowest risk for liver disease. Univariate and multivariate analyses were performed to evaluate associations between clinical factors and ALT levels.RESULTS: Serum ALT activity was independently associated with body mass index (BMI) and male gender, but not associated with age. Association of ALT with BMI was more prominent in males than in females. Upper limit of normal for non-overweight women (BMI of less than 25) was 34 U/L,and for non-overweight men was 40 U/L.CONCLUSION: Serum ALT is strongly associated with sex and BMI. The normal range of ALT should be defined for male and female separately.展开更多
目的总结幼儿心脏死亡器官捐献(donation after cardiac death,DCD)单侧供肾成人肾移植的手术经验,探讨其临床效果及安全性。方法 1例5岁8个月幼儿DCD提供了两个供肾,分别为两例成人受者做肾移植手术。总结术中、术后管理经验,随访1年,...目的总结幼儿心脏死亡器官捐献(donation after cardiac death,DCD)单侧供肾成人肾移植的手术经验,探讨其临床效果及安全性。方法 1例5岁8个月幼儿DCD提供了两个供肾,分别为两例成人受者做肾移植手术。总结术中、术后管理经验,随访1年,监测移植肾功能、移植肾大小的变化及并发症的发生情况。结果供肾大小:右肾长径8.0cm、短径3.0cm、宽径4.0cm,左肾长径8.2cm、短径3.1cm、宽径4.3cm。2例受者均为50kg以下的女性。采用单肾右髂窝移植,手术方式及术后免疫抑制方案与成人供肾移植相同。受者的血清肌酐(Scr)分别于术后10d和30d降至正常水平,估算肾小球滤过率分别于术后15d和50d增加至稳定水平(>50ml/min),移植肾各径长度在2周内达到稳定水平并接近成人肾大小。随访至交稿日,两受体的肾功能、尿量均正常,无发生蛋白尿及并发症。结论 5岁左右的幼儿DCD单侧供肾用于成人肾移植,在选择合适受者的前提下具有良好的临床效果和安全性。展开更多
文摘AIM: The healthy ranges for serum alanine aminotransferase(ALT) levels are less well studied. The aim of this study was to define the upper limit of normal (ULN) for serum ALT levels, and to assess factors associated with serum ALT activity in apparently healthy blood donors. METHODS: A total of 1 939 blood donors were included.ALT measurements were performed for all cases using the same laboratory method. Healthy ranges for ALT levels werecomputed from the population at the lowest risk for liver disease. Univariate and multivariate analyses were performed to evaluate associations between clinical factors and ALT levels.RESULTS: Serum ALT activity was independently associated with body mass index (BMI) and male gender, but not associated with age. Association of ALT with BMI was more prominent in males than in females. Upper limit of normal for non-overweight women (BMI of less than 25) was 34 U/L,and for non-overweight men was 40 U/L.CONCLUSION: Serum ALT is strongly associated with sex and BMI. The normal range of ALT should be defined for male and female separately.
