An authoritative parenting style has been shown to promote children’s emotion regulation in European-American family studies.However,little is known about how sleep problems and the child’s sibling status in Chinese...An authoritative parenting style has been shown to promote children’s emotion regulation in European-American family studies.However,little is known about how sleep problems and the child’s sibling status in Chinese families affect this relationship.Based on family system theory,this study attempts to better understand the relationship between authoritative parenting style and emotion regulation.Mothers of preschool children in Chinese kindergartens completed questionnaires about their children’s sleep habits,their authoritative parenting styles,and children’s emotion regulation.A total of 531 children participated in this study.Results showed that authoritative parenting was positively associated with emotional regulation.Sleep problems mediated the effects of authoritative parenting style on emotion regulation.The child’s sibling status moderated the mediating effects of sleep problems in authoritative parenting and emotion regulation relationships.Specifically,the relationship between the authoritative parenting style and sleep problems was significant for only children,while birth order had no significant influence on the authoritative parenting style and sleep problems in two-child families.These findings suggest that a lowauthoritative parenting style predicts low emotion regulation through sleep problems,and this depends on the child’s sibling status,indicating that children without siblings may impair emotion regulation due to increased sleep problems.展开更多
Diarrhea is a frequent symptom in postoperative patients with Crohn’s diseases(CD),and several different mechanisms likely account for postoperative diarrhea in CD.A targeted strategy based on a comprehensive underst...Diarrhea is a frequent symptom in postoperative patients with Crohn’s diseases(CD),and several different mechanisms likely account for postoperative diarrhea in CD.A targeted strategy based on a comprehensive understanding of postoperative diarrhea is helpful for better postoperative recovery.展开更多
This paper aims to study the functions of two different points of view from the perspective of narratology,namely,the point of view of the adult and the one of the child,in two of Herman Melville’s early stories.By c...This paper aims to study the functions of two different points of view from the perspective of narratology,namely,the point of view of the adult and the one of the child,in two of Herman Melville’s early stories.By contrasting these two functions of the different perspectives,the author of this paper draws the conclusion that the child has a unique and significant perspective in Melville’s works.展开更多
The Great Plague:The Diary of Alice Paynton,London 1665-1666 adopts the realistic painting style and direct writing to the painful experience,describes the situation of the Great Plague in London truly from the perspe...The Great Plague:The Diary of Alice Paynton,London 1665-1666 adopts the realistic painting style and direct writing to the painful experience,describes the situation of the Great Plague in London truly from the perspective of children,and breaks people’s cognitive expectation of children’s literature,the construction of children’s Gray inner world is completed behind the true description of the Great Plague in London with the true brushwork,which presents a different world of childlike innocence.Despite the importance of epidemics writing in literature,the child’s diary perspective of them is one of the least developed of Plague Narrative.Only when authenticity and the child’s grey interior are integrated will we reveal a true picture of society as it was.展开更多
BACKGROUND Post-cholecystectomy diarrhea(PCD)frequently occurs in patients following gallbladder removal.PCD is part of the post-cholecystectomy(PC)syndrome,and is difficult to treat.After cholecystectomy,bile enters ...BACKGROUND Post-cholecystectomy diarrhea(PCD)frequently occurs in patients following gallbladder removal.PCD is part of the post-cholecystectomy(PC)syndrome,and is difficult to treat.After cholecystectomy,bile enters the duodenum directly,independent of the timing of meals.The interaction between the bile acids and the intestinal microbes is changed.Therefore,the occurrence of PCD may be related to the change in microbiota.However,little is known about the relationship between the gut microbiota and PCD.AIM To better understand the role of the gut microbiota in PCD patients.METHODS Fecal DNA was isolated.The diversity and profiles of the gut microbiota were analyzed by performing high-throughput 16S rRNA gene sequencing.The gut microbiota were characterized in a healthy control(HC)group and a PC group.Subsequently,the PC group was further divided into a PCD group and a postcholecystectomy non-diarrhea group(PCND)according to the patients’clinical symptoms.The composition,diversity and richness of microbial communities were determined and compared.RESULTS In the PC and HC groups,720 operational taxonomic units(OTUs)were identified.The PC group had fewer OTUs than the HC group.β-diversity was decreased in the PC group.This indicated decreased microbial diversity in the PC group.Fifteen taxa with differential abundance between the HC and PC groups were identified.In the PCD group compared to the PCND group,significant decreases in microbial diversity,Firmicutes/Bacteroidetes ratio,and richness of probiotic microbiota(Bifidobacterium and Lactococcus),and an increase in detrimental microbiota(Prevotella and Sutterella)were observed.Moreover,a negative correlation was found between Prevotella and Bifidobacterium.Using a Kyoto Encyclopedia of Genes and Genomes functional analysis,it was found that the abundances of gut microbiota involved in lipid metabolism pathways were markedly lower in the PCD group compared to the PCND group.CONCLUSION This study demonstrated that gut dysbiosis may play a critical role in PCD,which provides new insights into therapeutic options for PCD patients.展开更多
INTRODUCTIONA major function of the intestinal epithelium is to controlthe amount of fluid entering into and being absorbed fromthe lumen.In healthy conditions,net fluid movementfollows an absorptive vector,although s...INTRODUCTIONA major function of the intestinal epithelium is to controlthe amount of fluid entering into and being absorbed fromthe lumen.In healthy conditions,net fluid movementfollows an absorptive vector,although significant secretionalso takes place to subserve digestive function.Thus。展开更多
It is reported that a pancreatic disease may precede the diagnosis of inflammatory bowel disease(IBD) both in children and in adults.Idiopathic chronic pancreatitis,however,occasionally co-exists with the IBD,mainly a...It is reported that a pancreatic disease may precede the diagnosis of inflammatory bowel disease(IBD) both in children and in adults.Idiopathic chronic pancreatitis,however,occasionally co-exists with the IBD,mainly at pediatric age.We report a case of a patient who progressively developed the features of a chronic pancreatitis,before the diagnosis of Crohn's Disease(CD).Ten months after the onset of the first episode of pancreatitis the patient developed bloody diarrhea,mucus stools and biochemical findings of inflammation.The colonoscopy revealed a diffuse colitis without involvement of the last loop and the gastroscopy showed inflammation of the iuxta-papillary area.The histological findings confirmed the diagnosis of CD that involved the colon and the duodenum.In conclusion,in children the idiopathic chronic pancreatitis may be an unusual presentation of CD.Thus,if other known cause of chronic pancreatitis are not found,a not invasive work up to exclude the IBD should be warranted.An early coincidental diagnosis of the IBD may delay the progression of the pancreatic disease.展开更多
Objective: To evaluate the suitability of educational videos produced in Brazil that addressed aspects related to prevention and/or management of infant diarrhea according to content;language;graphic illustrations;sti...Objective: To evaluate the suitability of educational videos produced in Brazil that addressed aspects related to prevention and/or management of infant diarrhea according to content;language;graphic illustrations;stimulation for learning/motivation and cultural fit. Method: Documentary study, which evaluated six educational videos from an adapted and validated tool, the Suitability Assessment of Materials. Three nurses evaluated the videos. Data were processed using the Statistical Package for the Social Sciences, version 17.0, and presented in tables and graphics. Results: It was found that 4 (66.6%) of the educational videos were classified as appropriate, ranging from 60% to 63.3% of full approval, and 2 (33.3%) were assessed as higher, reaching up to 83.3% to 90% approval. Considering the socioeconomic and cultural contexts of the videos to the audience, they assigned notes ranging from 6 to 9 in a rating ranging from 0, the minimum score, to 10, the highest score. Conclusion: The educational videos were considered adequate, with positive results about the content on the prevention and management of infant diarrhea, being appropriate for the target audience. As a result, greater credibility is ratified as the use thereof, since these resources can contribute to health promotion and prevention of diarrhea in children.展开更多
Objective:To obtain the prevalence with clinical symptoms of Cyclospora cayetanensis(C.cayetanensis),a coceidian protozoan parasite,in Thailand which is the cause of an intestinal infection characterized by sporadic-t...Objective:To obtain the prevalence with clinical symptoms of Cyclospora cayetanensis(C.cayetanensis),a coceidian protozoan parasite,in Thailand which is the cause of an intestinal infection characterized by sporadic-to-frequent explosive diarrhea.Methods:In a field surveyconducted by the Faculty of Tropical Medicine.Mahidol Lniversity.as part of the existing parasite-control program,a total of 2 540 faecal samples from villagers in Nan Province,Thailand,were collected and examined to determine the prevalence and clinical characteristics of parasitic infections.Results:Twelve cases of C.cayetanensis infection were found duritig faecal examination of schoolchildren aged 5-12 years.None exhibited obvious clinical symptoms,especially evidence of diarrhea:5 of 12 had loose faeces,one reported frequent symptoms of abdominal discomfort,and another had pale conjunctiva with low hematocrit.The children were generally asymptomatic.Conclusions:This finding confirms a public-health issue with potentially serious consequences whereby children can be exposed to an environment contaminated with food-und water-borne transmitted oocysts,anil can hence become infected with C.cayetunensis.展开更多
Bile acid diarrhea results from excessive amounts of bile acids entering the colon due to hepatic overexcretion of bile acids or bile acid malabsorption in the terminal ileum. The main therapies include bile acid sequ...Bile acid diarrhea results from excessive amounts of bile acids entering the colon due to hepatic overexcretion of bile acids or bile acid malabsorption in the terminal ileum. The main therapies include bile acid sequestrants, such as colestyramine and colesevelam, which may be given in combination with the opioid receptor agonist loperamide. Some patients are refractory to conventional treatments. We report the use of the farnesoid X receptor agonist obeticholic acid in a patient with refractory bile acid diarrhea and subsequent intestinal failure. A 32-year-old woman with quiescent colonic Crohn's disease and a normal terminal ileum had been diagnosed with severe bile acid malabsorption and complained of watery diarrhea and fatigue. The diarrhea resulted in hypokalemia and sodium depletion that made her dependent on twice weekly intravenous fluid and electrolyte infusions. Conventional therapies with colestyramine, colesevelam, and loperamide had no effect. Second-line antisecretory therapies with pantoprazole, liraglutide, and octreotide also failed. Third-line treatment with obeticholic acid reduced the number of stools from an average of 13 to an average of 7 per 24h and improved the patient's quality of life. The fluid and electrolyte balances normalized. The effect was sustained during follow-up for 6 mo with treatment at a daily dosage of 25 mg. The diarrhea worsened shortly after cessation of obeticholic acid. This case report supports the initial report that obeticholic acid may reduce bile acid production and improve symptoms in patients with bile acid diarrhea.展开更多
BACKGROUND There is a small and poorly studied population of patients with mild and limited Crohn’s disease(CD),who either spontaneously enter remission and can discontinue therapy,or be maintained on milder anti-inf...BACKGROUND There is a small and poorly studied population of patients with mild and limited Crohn’s disease(CD),who either spontaneously enter remission and can discontinue therapy,or be maintained on milder anti-inflammatory treatment.AIM To identify a group of children with mild CD who were not escalated to immunomodulators(azathioprine,mercaptopurine,or methotrexate)or biologics(infliximab or adalimumab)within the first two years after their Crohn’s diagnosis and outline the natural history and phenotypic features of these patients.METHODS In a retrospective chart review of the inflammatory bowel disease database at Boston Children’s Hospital we reviewed all the mild CD patient’s clinic visits,laboratory studies,and procedures for the duration of time they were followed at the center.Patients were included if they had clear diagnosis of Crohn’s disease,and they were not escalated to immunosuppressive therapies for at least 2 years after the date of diagnosis.These mild CD patients were compared to controls diagnosed at a similar time,that were treated with immunomodulators or biologics.Data that was abstracted included:Age at diagnosis,sex,disease location utilizing the Paris classification,medical treatment,surgical treatment,endoscopic findings,histology,and hospitalizations.We also analyzed differences in the phenotypic features between those with mild CD and those with moderate to severe disease.RESULTS Out of 1205 patients with CD diagnosed between 1990 and 2013,we identified 29 patients that met the inclusion criteria,and they were matched with 58 controls.There were no significant differences between the disease behaviors at presentation,with approximately 90%of patients in each group having inflammatory disease.However,patients with mild disease were more likely to have disease limited to the colon(31%vs 12%,P=0.03).In contrast,patients with moderate to severe disease(aka control group)were more likely to have ileocolonic disease(70%vs 45%in the mild group,P=0.02).Of the 29 patients,only 8 required medication escalation to immunomodulators during the period of follow-up.The primary indication for escalation to immune suppressive therapies was corticosteroid dependence.We also found that patients treated without immunomodulators or biologics for mild CD continue to exhibit histologic intestinal inflammation.Of the 29 patients,three developed significant complications of ileal disease,though only one required surgical intervention during the period of follow-up.CONCLUSION We identified a cohort of children with mild CD,who were able to avoid the institution of immune suppressive therapies for several years,and generally had good outcomes during the period of follow-up.While a subset of these patients will eventually require either immunosuppression or surgery,the majority of them have a good quality of life despite having low-grade intestinal inflammation.Importantly,this subset of patients has managed to avoid the potential toxicities of immune suppression for several years.The majority of these patients have either colonic disease with minimal small bowel involvement or limited ileal disease.展开更多
基金supported by the Guangdong Province Philosophy and Social Science Project(Grant No.GD22CJY12)the Young Innovation Talent Project of Guangdong Province(Grant No.2022WTSCX112)the Key Construction Discipline of Guangdong Province(Grant No.2022ZDJS061)to Yan Jin.
文摘An authoritative parenting style has been shown to promote children’s emotion regulation in European-American family studies.However,little is known about how sleep problems and the child’s sibling status in Chinese families affect this relationship.Based on family system theory,this study attempts to better understand the relationship between authoritative parenting style and emotion regulation.Mothers of preschool children in Chinese kindergartens completed questionnaires about their children’s sleep habits,their authoritative parenting styles,and children’s emotion regulation.A total of 531 children participated in this study.Results showed that authoritative parenting was positively associated with emotional regulation.Sleep problems mediated the effects of authoritative parenting style on emotion regulation.The child’s sibling status moderated the mediating effects of sleep problems in authoritative parenting and emotion regulation relationships.Specifically,the relationship between the authoritative parenting style and sleep problems was significant for only children,while birth order had no significant influence on the authoritative parenting style and sleep problems in two-child families.These findings suggest that a lowauthoritative parenting style predicts low emotion regulation through sleep problems,and this depends on the child’s sibling status,indicating that children without siblings may impair emotion regulation due to increased sleep problems.
基金Supported by Jiangsu Provincial Health Commission,No.M2021013the Science Foundation of Jinling Hospital,No.YYMS2021035。
文摘Diarrhea is a frequent symptom in postoperative patients with Crohn’s diseases(CD),and several different mechanisms likely account for postoperative diarrhea in CD.A targeted strategy based on a comprehensive understanding of postoperative diarrhea is helpful for better postoperative recovery.
文摘This paper aims to study the functions of two different points of view from the perspective of narratology,namely,the point of view of the adult and the one of the child,in two of Herman Melville’s early stories.By contrasting these two functions of the different perspectives,the author of this paper draws the conclusion that the child has a unique and significant perspective in Melville’s works.
文摘The Great Plague:The Diary of Alice Paynton,London 1665-1666 adopts the realistic painting style and direct writing to the painful experience,describes the situation of the Great Plague in London truly from the perspective of children,and breaks people’s cognitive expectation of children’s literature,the construction of children’s Gray inner world is completed behind the true description of the Great Plague in London with the true brushwork,which presents a different world of childlike innocence.Despite the importance of epidemics writing in literature,the child’s diary perspective of them is one of the least developed of Plague Narrative.Only when authenticity and the child’s grey interior are integrated will we reveal a true picture of society as it was.
文摘BACKGROUND Post-cholecystectomy diarrhea(PCD)frequently occurs in patients following gallbladder removal.PCD is part of the post-cholecystectomy(PC)syndrome,and is difficult to treat.After cholecystectomy,bile enters the duodenum directly,independent of the timing of meals.The interaction between the bile acids and the intestinal microbes is changed.Therefore,the occurrence of PCD may be related to the change in microbiota.However,little is known about the relationship between the gut microbiota and PCD.AIM To better understand the role of the gut microbiota in PCD patients.METHODS Fecal DNA was isolated.The diversity and profiles of the gut microbiota were analyzed by performing high-throughput 16S rRNA gene sequencing.The gut microbiota were characterized in a healthy control(HC)group and a PC group.Subsequently,the PC group was further divided into a PCD group and a postcholecystectomy non-diarrhea group(PCND)according to the patients’clinical symptoms.The composition,diversity and richness of microbial communities were determined and compared.RESULTS In the PC and HC groups,720 operational taxonomic units(OTUs)were identified.The PC group had fewer OTUs than the HC group.β-diversity was decreased in the PC group.This indicated decreased microbial diversity in the PC group.Fifteen taxa with differential abundance between the HC and PC groups were identified.In the PCD group compared to the PCND group,significant decreases in microbial diversity,Firmicutes/Bacteroidetes ratio,and richness of probiotic microbiota(Bifidobacterium and Lactococcus),and an increase in detrimental microbiota(Prevotella and Sutterella)were observed.Moreover,a negative correlation was found between Prevotella and Bifidobacterium.Using a Kyoto Encyclopedia of Genes and Genomes functional analysis,it was found that the abundances of gut microbiota involved in lipid metabolism pathways were markedly lower in the PCD group compared to the PCND group.CONCLUSION This study demonstrated that gut dysbiosis may play a critical role in PCD,which provides new insights into therapeutic options for PCD patients.
基金grants from the National Institute of Health(USA):DK28305,DK53480 and DK35108 Unit 5
文摘INTRODUCTIONA major function of the intestinal epithelium is to controlthe amount of fluid entering into and being absorbed fromthe lumen.In healthy conditions,net fluid movementfollows an absorptive vector,although significant secretionalso takes place to subserve digestive function.Thus。
文摘It is reported that a pancreatic disease may precede the diagnosis of inflammatory bowel disease(IBD) both in children and in adults.Idiopathic chronic pancreatitis,however,occasionally co-exists with the IBD,mainly at pediatric age.We report a case of a patient who progressively developed the features of a chronic pancreatitis,before the diagnosis of Crohn's Disease(CD).Ten months after the onset of the first episode of pancreatitis the patient developed bloody diarrhea,mucus stools and biochemical findings of inflammation.The colonoscopy revealed a diffuse colitis without involvement of the last loop and the gastroscopy showed inflammation of the iuxta-papillary area.The histological findings confirmed the diagnosis of CD that involved the colon and the duodenum.In conclusion,in children the idiopathic chronic pancreatitis may be an unusual presentation of CD.Thus,if other known cause of chronic pancreatitis are not found,a not invasive work up to exclude the IBD should be warranted.An early coincidental diagnosis of the IBD may delay the progression of the pancreatic disease.
文摘Objective: To evaluate the suitability of educational videos produced in Brazil that addressed aspects related to prevention and/or management of infant diarrhea according to content;language;graphic illustrations;stimulation for learning/motivation and cultural fit. Method: Documentary study, which evaluated six educational videos from an adapted and validated tool, the Suitability Assessment of Materials. Three nurses evaluated the videos. Data were processed using the Statistical Package for the Social Sciences, version 17.0, and presented in tables and graphics. Results: It was found that 4 (66.6%) of the educational videos were classified as appropriate, ranging from 60% to 63.3% of full approval, and 2 (33.3%) were assessed as higher, reaching up to 83.3% to 90% approval. Considering the socioeconomic and cultural contexts of the videos to the audience, they assigned notes ranging from 6 to 9 in a rating ranging from 0, the minimum score, to 10, the highest score. Conclusion: The educational videos were considered adequate, with positive results about the content on the prevention and management of infant diarrhea, being appropriate for the target audience. As a result, greater credibility is ratified as the use thereof, since these resources can contribute to health promotion and prevention of diarrhea in children.
基金partially supported by a grant from the Faculty of Tropical Medicine,Mahidol University
文摘Objective:To obtain the prevalence with clinical symptoms of Cyclospora cayetanensis(C.cayetanensis),a coceidian protozoan parasite,in Thailand which is the cause of an intestinal infection characterized by sporadic-to-frequent explosive diarrhea.Methods:In a field surveyconducted by the Faculty of Tropical Medicine.Mahidol Lniversity.as part of the existing parasite-control program,a total of 2 540 faecal samples from villagers in Nan Province,Thailand,were collected and examined to determine the prevalence and clinical characteristics of parasitic infections.Results:Twelve cases of C.cayetanensis infection were found duritig faecal examination of schoolchildren aged 5-12 years.None exhibited obvious clinical symptoms,especially evidence of diarrhea:5 of 12 had loose faeces,one reported frequent symptoms of abdominal discomfort,and another had pale conjunctiva with low hematocrit.The children were generally asymptomatic.Conclusions:This finding confirms a public-health issue with potentially serious consequences whereby children can be exposed to an environment contaminated with food-und water-borne transmitted oocysts,anil can hence become infected with C.cayetunensis.
文摘Bile acid diarrhea results from excessive amounts of bile acids entering the colon due to hepatic overexcretion of bile acids or bile acid malabsorption in the terminal ileum. The main therapies include bile acid sequestrants, such as colestyramine and colesevelam, which may be given in combination with the opioid receptor agonist loperamide. Some patients are refractory to conventional treatments. We report the use of the farnesoid X receptor agonist obeticholic acid in a patient with refractory bile acid diarrhea and subsequent intestinal failure. A 32-year-old woman with quiescent colonic Crohn's disease and a normal terminal ileum had been diagnosed with severe bile acid malabsorption and complained of watery diarrhea and fatigue. The diarrhea resulted in hypokalemia and sodium depletion that made her dependent on twice weekly intravenous fluid and electrolyte infusions. Conventional therapies with colestyramine, colesevelam, and loperamide had no effect. Second-line antisecretory therapies with pantoprazole, liraglutide, and octreotide also failed. Third-line treatment with obeticholic acid reduced the number of stools from an average of 13 to an average of 7 per 24h and improved the patient's quality of life. The fluid and electrolyte balances normalized. The effect was sustained during follow-up for 6 mo with treatment at a daily dosage of 25 mg. The diarrhea worsened shortly after cessation of obeticholic acid. This case report supports the initial report that obeticholic acid may reduce bile acid production and improve symptoms in patients with bile acid diarrhea.
文摘BACKGROUND There is a small and poorly studied population of patients with mild and limited Crohn’s disease(CD),who either spontaneously enter remission and can discontinue therapy,or be maintained on milder anti-inflammatory treatment.AIM To identify a group of children with mild CD who were not escalated to immunomodulators(azathioprine,mercaptopurine,or methotrexate)or biologics(infliximab or adalimumab)within the first two years after their Crohn’s diagnosis and outline the natural history and phenotypic features of these patients.METHODS In a retrospective chart review of the inflammatory bowel disease database at Boston Children’s Hospital we reviewed all the mild CD patient’s clinic visits,laboratory studies,and procedures for the duration of time they were followed at the center.Patients were included if they had clear diagnosis of Crohn’s disease,and they were not escalated to immunosuppressive therapies for at least 2 years after the date of diagnosis.These mild CD patients were compared to controls diagnosed at a similar time,that were treated with immunomodulators or biologics.Data that was abstracted included:Age at diagnosis,sex,disease location utilizing the Paris classification,medical treatment,surgical treatment,endoscopic findings,histology,and hospitalizations.We also analyzed differences in the phenotypic features between those with mild CD and those with moderate to severe disease.RESULTS Out of 1205 patients with CD diagnosed between 1990 and 2013,we identified 29 patients that met the inclusion criteria,and they were matched with 58 controls.There were no significant differences between the disease behaviors at presentation,with approximately 90%of patients in each group having inflammatory disease.However,patients with mild disease were more likely to have disease limited to the colon(31%vs 12%,P=0.03).In contrast,patients with moderate to severe disease(aka control group)were more likely to have ileocolonic disease(70%vs 45%in the mild group,P=0.02).Of the 29 patients,only 8 required medication escalation to immunomodulators during the period of follow-up.The primary indication for escalation to immune suppressive therapies was corticosteroid dependence.We also found that patients treated without immunomodulators or biologics for mild CD continue to exhibit histologic intestinal inflammation.Of the 29 patients,three developed significant complications of ileal disease,though only one required surgical intervention during the period of follow-up.CONCLUSION We identified a cohort of children with mild CD,who were able to avoid the institution of immune suppressive therapies for several years,and generally had good outcomes during the period of follow-up.While a subset of these patients will eventually require either immunosuppression or surgery,the majority of them have a good quality of life despite having low-grade intestinal inflammation.Importantly,this subset of patients has managed to avoid the potential toxicities of immune suppression for several years.The majority of these patients have either colonic disease with minimal small bowel involvement or limited ileal disease.