Objectives Phenotypic switching of smooth muscle cells(SMCs) plays a critical role in the pathogenesis of atherosclerotic lesions such as coronary artery disease (CAD).Accumulating evidence demonstrates(hat a cellular...Objectives Phenotypic switching of smooth muscle cells(SMCs) plays a critical role in the pathogenesis of atherosclerotic lesions such as coronary artery disease (CAD).Accumulating evidence demonstrates(hat a cellular repressor of E1A-stimulated genes(CREG) plays a role in the maintenance of the mature phenotype of vascular SMCs. The purpose of the present study was to assess the possible association between CREG and CAD in the Han population of North China.Methods The promoter region of CREG by direct sequencing was conducted in 48 subjects.Then SNP rs2995073 and another 4 tagSNPs(rs4657669,rs3767443, rsl6859185,rs3753921) were selected for the association study.All five selected SNPs were determined in 1161 patients with angiographically proven CAD and 960 controls with normal coronary angiograms to investigate the possible involvement of CREG in CAD.Results Genotype frequencies of the five examined polymorphisms were similarly distributed between CAD group and controls(P】0.05).Further haplotype analysis also found no significant differences in the distributions between CAD group and controls(P】0.05). Conclusions This study did not show an association between common variants of CREG and CAD in the northern Chinese Han population.展开更多
Stature estimation is widely used for individual identification in forensic field.Previous studies have proposed several regression equations derived from a single population for this purpose.However,this may not be s...Stature estimation is widely used for individual identification in forensic field.Previous studies have proposed several regression equations derived from a single population for this purpose.However,this may not be suitable for other populations because of different hereditary and environmental conditions.In this study,stature estimation equations for southern China Han population have been provided.The study was conducted on a sample population of 121 men and women aged 18–25 years.A total of 19 parameters,including stature,head,torso,and parts of upper limbs and lower limbs,were measured according to standard anthropometric procedures.Herein,the anterior superior spine–malleolus medialis line showed the highest correlation coefficient(r=0.817)and was the most reliable predictor(R^(2)=0.667)in men,while the best predictor for women was total leg length(R^(2)=0.746)with the highest correlation coefficient(r=0.863).The regression analysis results via multiple predictors showed a high accuracy in stature estimation.Moreover,the analysis of multiple regression predictors showed that the dimensions of lower limbs were more reliable for stature estimation compared to head,torso,and upper limb measurements.This study provided equations of stature estimation for southern China Han population which can be useful in cases of dismembered body.展开更多
Papillary thyroid carcinoma （PTC） is one of the most common tumors of the thyroid gland. The common risk factors of PTC include ionizing radiation, positive family history, and thyroid nodular disease. PTC was ident...Papillary thyroid carcinoma （PTC） is one of the most common tumors of the thyroid gland. The common risk factors of PTC include ionizing radiation, positive family history, and thyroid nodular disease. PTC was identified in Europeans by conducting a genome-wide association study, and a strong association signal with PTC was observed in rs944289 and NKX2-1 （located at the 14q13.3 locus）, which was probably the genetic risk factor of PTC. This study aimed to examine the association of this gene with PTC in Chinese. A total of 354 patients with PTC and 360 healthy control subjects from the Han population of Northern China were recruited in the study. These individuals were genotyped to determine rs12589672, rs12894724, rs2076751, and rs944289. The association of rs944289 with PTC was obtained （C vs. T, P= 0.027, OR= 1.264, 95% CI = 1.026-1.557; and C/C-C/T vs. T/T, P= 0.034, OR= 1.474, 95% CI = 1.028-2.112）. Conducting a subgroup analysis, we found a marginal difference in the allele frequency distribution of rs944289 （adjusted P = 0.062） between the patients with PTC and multi-nodular goiter and the control subjects. We also observed an interaction （P= 0.029; OR = 2.578, 95% CI=1.104-6.023） between rs944289 and diabetes in patients with PTC. In conclusion, rs944289 was associated with an increased risk of PTC in the Han population of Northern China, but no clear association was observed in either of the tag single nucleotide polymorphisms of NKX2-1.展开更多
文摘Objectives Phenotypic switching of smooth muscle cells(SMCs) plays a critical role in the pathogenesis of atherosclerotic lesions such as coronary artery disease (CAD).Accumulating evidence demonstrates(hat a cellular repressor of E1A-stimulated genes(CREG) plays a role in the maintenance of the mature phenotype of vascular SMCs. The purpose of the present study was to assess the possible association between CREG and CAD in the Han population of North China.Methods The promoter region of CREG by direct sequencing was conducted in 48 subjects.Then SNP rs2995073 and another 4 tagSNPs(rs4657669,rs3767443, rsl6859185,rs3753921) were selected for the association study.All five selected SNPs were determined in 1161 patients with angiographically proven CAD and 960 controls with normal coronary angiograms to investigate the possible involvement of CREG in CAD.Results Genotype frequencies of the five examined polymorphisms were similarly distributed between CAD group and controls(P】0.05).Further haplotype analysis also found no significant differences in the distributions between CAD group and controls(P】0.05). Conclusions This study did not show an association between common variants of CREG and CAD in the northern Chinese Han population.
基金This study was supported by the National Natural Science Foundation of China(Grant No.81871526)the National Students’Innovative and Entrepreneurship Training Program(No.20181212112X).
文摘Stature estimation is widely used for individual identification in forensic field.Previous studies have proposed several regression equations derived from a single population for this purpose.However,this may not be suitable for other populations because of different hereditary and environmental conditions.In this study,stature estimation equations for southern China Han population have been provided.The study was conducted on a sample population of 121 men and women aged 18–25 years.A total of 19 parameters,including stature,head,torso,and parts of upper limbs and lower limbs,were measured according to standard anthropometric procedures.Herein,the anterior superior spine–malleolus medialis line showed the highest correlation coefficient(r=0.817)and was the most reliable predictor(R^(2)=0.667)in men,while the best predictor for women was total leg length(R^(2)=0.746)with the highest correlation coefficient(r=0.863).The regression analysis results via multiple predictors showed a high accuracy in stature estimation.Moreover,the analysis of multiple regression predictors showed that the dimensions of lower limbs were more reliable for stature estimation compared to head,torso,and upper limb measurements.This study provided equations of stature estimation for southern China Han population which can be useful in cases of dismembered body.
文摘Papillary thyroid carcinoma （PTC） is one of the most common tumors of the thyroid gland. The common risk factors of PTC include ionizing radiation, positive family history, and thyroid nodular disease. PTC was identified in Europeans by conducting a genome-wide association study, and a strong association signal with PTC was observed in rs944289 and NKX2-1 （located at the 14q13.3 locus）, which was probably the genetic risk factor of PTC. This study aimed to examine the association of this gene with PTC in Chinese. A total of 354 patients with PTC and 360 healthy control subjects from the Han population of Northern China were recruited in the study. These individuals were genotyped to determine rs12589672, rs12894724, rs2076751, and rs944289. The association of rs944289 with PTC was obtained （C vs. T, P= 0.027, OR= 1.264, 95% CI = 1.026-1.557; and C/C-C/T vs. T/T, P= 0.034, OR= 1.474, 95% CI = 1.028-2.112）. Conducting a subgroup analysis, we found a marginal difference in the allele frequency distribution of rs944289 （adjusted P = 0.062） between the patients with PTC and multi-nodular goiter and the control subjects. We also observed an interaction （P= 0.029; OR = 2.578, 95% CI=1.104-6.023） between rs944289 and diabetes in patients with PTC. In conclusion, rs944289 was associated with an increased risk of PTC in the Han population of Northern China, but no clear association was observed in either of the tag single nucleotide polymorphisms of NKX2-1.
