Multisensory mechanisms of gait and balance in Parkinson’s disease:an integrative review

Understanding the neural underpinning of human gait and balance is one of the most pertinent challenges for 21st-century translational neuroscience due to the profound impact that falls and mobility disturbances have on our aging population.Posture and gait control does not happen automatically,as previously believed,but rather requires continuous involvement of central nervous mechanisms.To effectively exert control over the body,the brain must integrate multiple streams of sensory information,including visual,vestibular,and somatosensory signals.The mechanisms which underpin the integration of these multisensory signals are the principal topic of the present work.Existing multisensory integration theories focus on how failure of cognitive processes thought to be involved in multisensory integration leads to falls in older adults.Insufficient emphasis,however,has been placed on specific contributions of individual sensory modalities to multisensory integration processes and cross-modal interactions that occur between the sensory modalities in relation to gait and balance.In the present work,we review the contributions of somatosensory,visual,and vestibular modalities,along with their multisensory intersections to gait and balance in older adults and patients with Parkinson’s disease.We also review evidence of vestibular contributions to multisensory temporal binding windows,previously shown to be highly pertinent to fall risk in older adults.Lastly,we relate multisensory vestibular mechanisms to potential neural substrates,both at the level of neurobiology(concerning positron emission tomography imaging)and at the level of electrophysiology(concerning electroencephalography).We hope that this integrative review,drawing influence across multiple subdisciplines of neuroscience,paves the way for novel research directions and therapeutic neuromodulatory approaches,to improve the lives of older adults and patients with neurodegenerative diseases.

Review on Practical Models of Urban-Rural Integration in China

Urban-rural integration is important for urbanization and strengthening of urban and rural development in China. Since the third session of the 16th National Committee, the model is still at experimental stage, although with some progress. Hence, it is necessary to make a summary on some typical experience of urban-ru- ral integration, in order to provide references for further exploration.

Research on Enterprise Finance Integration Model Based on Financial Sharing

This article elaborates on the necessity of promoting the integration of business and finance based on financial sharing,analyzes the measures and effects of implementing business and finance integration in enterprises,points out the existing problems,and proposes strategies to optimize the integration from three aspects:building big data platforms,improving talent training plans,and improving financial shared information management platforms.

Port Integration in China: Temporal Pathways, Spatial Patterns and Dynamics

Over the past two decades, numerous ports located in China have participated in port integration strategies, thus influencing the entire port system. The current research is initiated in order to examine the nature of port integration in China, including associated temporal pathways, spatial patterns and dynamics. Results indicate that port integration in China has been characterized by a significant increase at the turn of the 21 st century, comprising thirteen distinguishable pathways typified by differing dynamics, particularly between the northern and southern ports. Pathways were found to include 44 seaports and river ports, chiefly concentrated in the Bohai Rim, Yangtze(Changjiang) River Delta, Beibu Gulf and the southeastern Fujian, thus representing significant spatial regions. Categorically larger seaports have become the primary beneficiaries of port integration. Integration cases were divided into four categories based upon quantified dynamic magnitude including the government-driven mode, market-driven mode, government/market-driven mode and strategic alliance, and into five further categories based upon spatial extent including port internal integration, jurisdictional port integration, port integration across neighbor region, regional port integration and hub-feeder port integration. Results suggest that several factors have effectively driven port integration in China, including legislative tools and spatial planning, optimization of shoreline resources and port functionality, and port competition with the same hinterland.

Discussion on Cultural Integration and Educational Services for International Students from the Perspective of Situational Communication

From the perspective of situational communication,this paper aims to explore how to promote cultural integration and provide better educational services for international students in China.This paper first analyzes the basic assumptions and key factors of situational communication based on international students in China.Secondly,the relationship between situational communication and cultural integration and educational services for international students in China is discussed in depth.Additionally,the role of situational communication in educational services for international students in China,such as promoting cross-cultural communication,solving language barriers,and enhancing mutual understanding,is proposed.Lastly,from the perspective of situational communication,an optimization path of educational services and cultural integration for international students in China is proposed,including the provision of diversified educational resources,the enhancement of cross-cultural communication,and the establishment of an effective communication mechanism.This study expands the perspective of educational services for international students in China,provides a new theoretical framework and practical path,and offers a reference for promoting cultural integration and improving educational services for international students in China.

Satisfaction of Village Doctors with the Township and Village Health Services Integration Policy in the Western Minority-inhabited Areas of China

Township and Village Health Services Integration Management（TVHSIM） is an essential form of China＇s two-tiered health service integration plan at the township and village level. Its main purpose, also one of the target goals in China＇s new healthcare reform, is to gradually integrate rural health services and appropriately allocate rural health resources. This study aims to assess the village doctors＇ satisfaction with the TVHSIM and provide scientific base to further improve TVHSIM. A cross-sectional study was carried out in which 162 village doctors from Qinghai, Inner Mongolia and Xinjiang in western China were interviewed. Descriptive analysis, independent t-test, one-way ANOVA, Spearman rank correlation and multiple linear regression were used to analyze the difference and relevance between village doctors＇ personal characteristics and their satisfaction with TVHSIM and six subscales. Village doctors with different years of practice, social insurance status and essential medical knowledge level showed statistically significant differences in their satisfaction levels（all P〈0.05）. Age（P〈0.05） and years of practice（P〈0.01） were negatively correlated with Drug and Medical Device Management and Financing Management. Essential medical knowledge level（P〈0.05） was negatively correlated with Operations Management as well. However, social insurance status（P〈0.05） was positively correlated with Human Resources Management and Drug and Medical Device management. Gender, age and years of practice respectively had significant influence on village doctors＇ satisfaction with TVHSIM（P〈0.01）. In conclusion, in order to further promote TVHSIM policy in rural China, a well-rounded social insurance model for village doctors is urgently needed. In addition, the development of TVHSIM is regionally imbalanced. Efficient and effective measures aiming at rationalizing gender and age structure and enhancing essential medical training should be carefully considered.

The Research of the Balanced Development of China's Urban-rural Spatial Integration Based on the Evolution of Regional Spatial Structure

The general law of regional spatial evolution is researched.In the process of the evolution of four stages,namely the early stage of traditional agriculture and industrialization,the middle stage of industrialization,the later stage of industrialization and post-industrialization,the types of space are homogenized space,polarized space,pole-axis space and integrated space respectively;the choosing of the spatial location is influenced by economy,society and environment,and the spatial structure extends along with three-dimensional space.Based on the fact that China's urban-rural spatial structure evolution develops rapidly,and the outstanding characteristics of dual structure becomes the main obstacle to urban-rural balanced development,the thesis poses the countermeasures of China's urban-rural spatial integrated balanced development.It points out that the healthy development of socio-economy is the external environment of realizing urban-rural spatial integration;the urban-rural coordinated planning is the prerequisite of realizing urban-rural spatial integration;fulfilling the governmental function is the key to realizing urban-rural spatial integration;promoting agricultural industrialization is the approach to realizing urban-rural spatial integration;perfecting social security system is the basis of realizing urban-rural spatial integration.

Study on the Strategy of Rural Industry Development in the Central China under the Background of Urban-Rural Integration

Taking the rural areas in the central China s the target,the representative achievements and difficulties faced by rural industries in the process of urban-rural integration were sorted out systematically in this article. In the new stage of development,it is necessary to adjust the development strategy,focus on tapping the rural characteristic industries,accelerate the upgrading of agricultural products,aim at market demand,and implement multi-channel marketing strategies to expand the influence of agricultural brands. The government must actively promote the integration of urban and rural industries and the development of division of labor,actively cultivate and develop rural characteristic industrial clusters,and encourage farmers to explore various types of rural industrial models.

Resource integration of regional economic development in northwest China

Northwestern area is the most arid and underdeveloped area in China. Lots of researches have been doneto find the approaches to alleviate poverty. But there are some problems, for example, how to invest, how to use capital,and why the utilization rate is ambiguous. Water, capital and human resources are analyzed in this paper to be comparedwith their Utilization rates. As a result, according to the dependences of economic growth on those resources, a newapproach has been selected to organize the integration ways among these resources for economic development innorthwestern China. The efficient ways to develop northwestern China are: firstly, use the wanting resources mosteffectively to make an efficient integration model of multiple resources. For example, enhance the utilization rate of waterto raise the value of other resources. Secondly, invest more in basic factors for economic development to upgrade thecompetitiveness in the western China. For example, invest more in primary education and sustainable development ofbasic natural resources in order to have more power for sustainable development.

China Should Adopt Integration Policies to Reduce Energy Waste

China should pilot renewable energy integration policies similar to those adopted in Germany and Texas in the Beijing-Tianjin-Hebei region to transmit excess energy and reduce wasted wind power.Renewable energy integration will be fundamental to China?s transition to a low-carbon economy.Although China now leads the world in terms

The Use of Curriculum Integration in ELT within Secondary Schools in China

CTMRC - Curriculum and Teaching Materials Reform Commission; CTMRI - Curriculum and Teaching Materials Research Institute; ELT - English Language Teaching; MOE - Ministry of Education;

Study on the Current Situation of Urban Integration of Aboveground Space and Underground Space:Under the Background of China’s Land Spatial Planning

Urban underground public space has a synergistic effect with its surrounding urban aboveground functions or facilities,which reflects the complementarity between underground functions and urban functions.The research analyses the degree of integration through the case study of urban aboveground space and underground space in China.The research method of this paper will give different evaluation criteria to public transport and public space and the influencing factors of space integration.The indicators of public transport include the number of subway lines and underground parking spaces.The evaluation standard of public space is the area of underground space and the number of floors of underground space.The subway entrance and exits are selected as the evaluation index for the aboveground and underground transition space.Through the specific analysis of 7 selected cases,it provides arguments for the research.The average rent in the case is taken as the dependent variable.Through the regression model,the influencing factors of the integration of aboveground and underground space are determined.The purpose of the study is to explore the influencing factors of the integration of aboveground space and underground space,and how to optimize the integration of aboveground and underground space.

Influence of Sino-US Agricultural Trade on China’s Total Agricultural Output Value Based on Cointegration Model

According to the data of the total trade of agricultural products between China and the United States from 2009 to 2018 and the general description of agriculture in China,this paper adopts the method of econometric model to make a detailed analysis of the agricultural trade between China and the United States by using cointegration analysis,Granger causality test and error correction model in order to explore the impact of agricultural trade between China and the United States on China’s agricultural development. The results of empirical analysis show that there is a balanced relationship between the trade of agricultural products between China and the United States and the development of agriculture in China. The total trade of agricultural products between China and the United States affects the development of China’s agriculture.In addition,in the short term,if the short-term fluctuation deviates from the long-term equilibrium,then the error correction term will reverse it with strength of 0. 378,so that the non-equilibrium state will gradually return to the equilibrium state.

Towards an Integration of the Behaviorist,the Cognitivist and the Interactionist Models in SLA in China

Introduction English Language teaching as a profession has enjoyed a long history.And ever since itsinitiation,people have investigated different models in language acquisition/learning andteaching,although only in recent years has attention been paid to the studies of SLA.In theChinese setting,research in foreign language teaching(TEFL)has been made in the fashionof the theories of first language acguisition or SLA,for it is believed that the contributions tostudies of the input provided by mothers(i.e motherese) in L1 acquisition and teachers inter-locuters in SLA are necessarily important for understanding the direction that TEEL researchhas followed,as they have provided both a methodololgy for investigating input and the re-search questions.The behaviorist,the cognitivist and the interactionist approaches have putforward different models in interpreting L1 acquisition and SLA,which obviously have theirown merits and demerits,depending on the level at which they are employed and the purposethey

Prevalence of vegetation browning in China’s drylands under climate change

Vegetation greening has long been acknowledged,but recent studies have pointed out that vegetation greening is possibly stalled or even reversed.However,detailed analyses about greening reversal or increased browning of vegetation remain scarce.In this study,we utilized the normalized difference vegetation index(NDVI)as an indicator of vegetation to investigate the trends of vegetation greening and browning(monotonic,interruption,and reversal)through the breaks for the additive season and trend(BFAST)method across China’s drylands from 1982 to 2022.It also reveals the impacts of ecological restoration programs(ERPs)and climate change on these vegetation trends.We find that the vegetation displays an obvious pattern of east-greening and west-browning in China’s drylands.Greening trends mainly exhibits monotonic greening(29.8%)and greening with setback(36.8%),whereas browning shows a greening to browning reversal(19.2%).The increase rate of greening to browning reversal is 0.0342/yr,which is apparently greater than that of greening with setback,0.0078/yr.This research highlights that,under the background of widespread vegetation greening,vegetation browning is pro-gressively increasing due to the effects of climate change.Furthermore,the ERPs have significantly increased vegetation coverage,with the increase rate in 2000-2022 being twice as much as that of 1982-1999 in reveg-etation regions.Vegetation browning in southwestern Qingzang Plateau is primarily driven by adverse climatic factors and anthropogenic disturbances,which offset the efforts of ERPs.

Influence of Human Activity Intensity on Habitat Quality in Hainan Tropical Rainforest National Park,China

Due to long-term human activity interference,the Hainan Tropical Rainforest National Park(HTRNP)of China has experienced ecological problems such as habitat fragmentation and biodiversity loss,and with the expanding scope and intensity of human activity impact,the regional ecological security is facing serious challenges.A scientific assessment of the interrelationship between human activity intensity and habitat quality in the HTRNP is a prerequisite for achieving effective management of ecological disturbances caused by human activities and can also provide scientific strategies for the sustainable development of the region.Based on the land use change data in 2000,2010,and 2020,the spatial and temporal variations and the relationship between habitat quality(HQ)and human activity intensity(HAI)in the HTRNP were explored using the integrated valuation of ecosystem services and trade-offs(InVEST)model.System dynamics and land use simulation models were also combined to conduct multi-scenario simulations of their relationships.The results showed that during 2000–2020,the habitat quality of the HTRNP improved,the intensity of human activities decreased each year,and there was a negative correlation between the two.Second,the system dynamic model could be well coupled with the land use simulation model by combining socio-economic and natural factors.The simulation scenarios of the coupling model showed that the harmonious development(HD)scenario is effective in curbing the increasing trend of human activity intensity and decreasing trend of habitat quality,with a weaker trade-off between the two compared with the baseline development(BD)and investment priority oriented(IPO)scenarios.To maintain the authenticity and integrity of the HTRNP,effective measures such as ecological corridor construction,ecological restoration,and the implementation of ecological compensation policies need to be strengthened.

On the Devonian-Carboniferous Boundary in Neritic Facies Areas of South China:A Viewpoint of Integrated StratigraPhy

Biostratigraphical data indicate that in the neritic facies areas of South China, the Devonian -Carboniferous boundary (DCB), matching the boundary between conodont Siphonodella praesulcata zone and S. sulcata zone, should be drawn between rugose coral Cystophrentis zone and Pseudouralina zone, i.e. the Cystophrentis\ Pseudouralina inter val-zone. The top of the sea level fall event bed near the DCB is lower than the boundary between S. praesulcata and S. sulcata zones, but higher than the top of the Cysto phrentis zone. Sequence stratigraphical study shows that the sea level fall event bed near the DCB constitutes the shelf margin system tract (SMST) of a depositional sequence (SQ1) in both neritic and pelagic facies areas. The top surfaces of SMST of SQ1 is slightly lower than the base of S. sulcata zone in the pelagic facies areas. In neritic facies areas of South China, therefore, the Devonian - Carboniferous boundary is marked by the most distinct transgressive surface within the Cystophrentis\ Pseudouralina interval-zone, i.e. the base of the TST of SQ1. This boundary coincides with the top surface of the event bed resulted from the eustatic fall, and approximately corresponds to the base of Pseudouralina assemblage zone.

Study on Characteristics of 3-D Translating-Pulsating Source Green Function of Deep-Water Havelock Form and Its Fast Integration Method

The singularities, oscillatory performances and the contributing factors to the 3-＇D translating-pulsating source Green function of deep-water Havelock form which consists of a local disturbance part and a far-field wave-like part, are analyzed systematically. Relative numerical integral methods about the two parts are presented in this paper. An improved method based on LOBATTO rule is used to eliminate singularities caused respectively by infinite discontinuity and jump discontinuous node from the local disturbance part function, which makes the improvement of calculation efficiency and accuracy possible. And variable substitution is applied to remove the singularity existing at the end of the integral interval of the far-field wave-like part function. Two auxiliary techniques such as valid interval calculation and local refinement of integral steps technique in narrow zones near false singularities are applied so as to avoid unnecessary integration of invalid interval and improve integral accordance. Numerical test results have proved the efficiency and accuracy in these integral methods that thus can be applied to calculate hydrodynamic performance of floating structures moving in waves.

Integrated Indicators-based Gradation of Cultivated Land Quality in Mountainous Region of Southwestern China

The gradation of cultivated land is to assess the suitability of cultivated land for agricultural production in terms of natural and economic properties of land. It can be used to evaluate sustainability of land use and soil management practices. Formal and informal surveys, Delphi and comprehensive index method are adopted to identify appropriate integrated indicators, and measure the gradation of cultivated land quality. The determination of integrated indicators presents three basic features of cultivated land quality： stable plant productivity, social acceptability and maintenance of environmental quality. Pronounced concentration-dissipation law of total function score value occurs in paddy field units, with three ranges, i.e., 79-68.5, 68.5-59 and 59-51. Total function score value in dryland units mainly ranges from 40 to 70, but slight concentration-dissipation law of each unit is still observed, with four ranges, i.e., 79-68, 68-51, 51-37 and 37-15. Paddy field quality is divided into three gradations, and the scales are 18 220.9 ha, 5410.6 ha and 2890.9 ha. Dryland quality is classified into four gradations, and the scales are 1548.6 ha, 8153.8 ha, 3316.3 ha and 685.2 ha. The total function score value of every gradation unit is conformed to the results of farmers＇ assessment. Research results meet with the needs of accurate degree of the gradation of cultivated land quality. Integrated indicators-based gradation of cultivated land assessment accords with the characteristics of land resources and human preference in the mountains of southwestern China. This study will be useful to promote the monitoring of cultivated land quality, and to supply fine ground and knowledge for establishing appropriate cultivated land management practices in Southwestern China.