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A U-Shaped Network-Based Grid Tagging Model for Chinese Named Entity Recognition
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作者 Yan Xiang Xuedong Zhao +3 位作者 Junjun Guo Zhiliang Shi Enbang Chen Xiaobo Zhang 《Computers, Materials & Continua》 SCIE EI 2024年第6期4149-4167,共19页
Chinese named entity recognition(CNER)has received widespread attention as an important task of Chinese information extraction.Most previous research has focused on individually studying flat CNER,overlapped CNER,or d... Chinese named entity recognition(CNER)has received widespread attention as an important task of Chinese information extraction.Most previous research has focused on individually studying flat CNER,overlapped CNER,or discontinuous CNER.However,a unified CNER is often needed in real-world scenarios.Recent studies have shown that grid tagging-based methods based on character-pair relationship classification hold great potential for achieving unified NER.Nevertheless,how to enrich Chinese character-pair grid representations and capture deeper dependencies between character pairs to improve entity recognition performance remains an unresolved challenge.In this study,we enhance the character-pair grid representation by incorporating both local and global information.Significantly,we introduce a new approach by considering the character-pair grid representation matrix as a specialized image,converting the classification of character-pair relationships into a pixel-level semantic segmentation task.We devise a U-shaped network to extract multi-scale and deeper semantic information from the grid image,allowing for a more comprehensive understanding of associative features between character pairs.This approach leads to improved accuracy in predicting their relationships,ultimately enhancing entity recognition performance.We conducted experiments on two public CNER datasets in the biomedical domain,namely CMeEE-V2 and Diakg.The results demonstrate the effectiveness of our approach,which achieves F1-score improvements of 7.29 percentage points and 1.64 percentage points compared to the current state-of-the-art(SOTA)models,respectively. 展开更多
关键词 chinese named entity recognition character-pair relation classification grid tagging U-shaped segmentation network
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Improved Prefix Based Format-Preserving Encryption for Chinese Names 被引量:2
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作者 Junwei Zou Peng Wang Hong Luo 《China Communications》 SCIE CSCD 2018年第3期78-90,共13页
In the era of big data, government, business and personal digital information will be possible for data mining. Data mining requires massive data as a support. However, the direct release of the original mass data, wh... In the era of big data, government, business and personal digital information will be possible for data mining. Data mining requires massive data as a support. However, the direct release of the original mass data, which usually contain some sensitive information of personal or analysis, will result in leakage of user privacy. Therefore, it is becoming increasingly important to protect privacy information in data publishing. In this paper, we focus on the multi-type self-identified format-preserving encryption. First, we introduce a multi-type self-identified format-preserving encryption system and discuss the encryption of various types of data in this system. Then, for the format preserving encryption(FPE) about Chinese name, we study from the encryption model construction and basic encryption scheme. The format-preserving encryption model about Chinese name is constructed and the concept of the name library is presented. Based on this, it is used to not only limit the message space to reduce complexity, but also ensure the cipher in accordance with the Chinese naming habits. In addition, according to the encryption and decryption model, format-preserving encryption process of Chinese name is designed. In order to add new names, the algorithm of name space expansion is proposed. Based on the Prefix, this paper put forward an algorithm named Cycle-Prefix, which enhances the security and dynamics of FPE by using two adjustment factors and the circular encryption. Compared with the traditional Prefix algorithm, experiments show that Cycle-Prefix can not only complete the task of FPE for Chinese name, but also encrypt same plain text into different ciphers under the premise of similar efficiency with Prefix. 展开更多
关键词 chinese name format-preservingencryption name library encryption model
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On Generalities of Chinese Names and English Names
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作者 唐志娟 《海外英语》 2010年第10X期273-275,共3页
Name system has developed simultaneously with the change of world language.Generalities of Chinese names and English names are discussed from 8 aspects.Meanwhile,the structural changes of names in Chinese and English ... Name system has developed simultaneously with the change of world language.Generalities of Chinese names and English names are discussed from 8 aspects.Meanwhile,the structural changes of names in Chinese and English are also contrasted in order to make some further exploration.Readers may more deeply understand the specific regularity of the individual languages after knowing several generalities. 展开更多
关键词 generalities chinese nameS ENGLISH nameS
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Should the Writing of Chinese Names in Pinyin Be Standardized?
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《ChinAfrica》 2012年第11期12-13,共2页
With international exchanges and gatherings becoming more common, Chinese in pinyin, mainly the names of people and places has become more and more common. Pinyin is a system for transliterating Chinese characters int... With international exchanges and gatherings becoming more common, Chinese in pinyin, mainly the names of people and places has become more and more common. Pinyin is a system for transliterating Chinese characters into the Roman alphabet and was officially adopted by the People's Republic of China in 1979. 展开更多
关键词 Should the Writing of chinese names in Pinyin Be Standardized BE
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China ABC A Chinese Name
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《China Today》 1996年第12期11-11,共1页
ChinaABCAChineseNameCHINAISaunifiedmulti-nationalstatewith55ethnicminoritiesinadditiontotheHanChinese.Theful... ChinaABCAChineseNameCHINAISaunifiedmulti-nationalstatewith55ethnicminoritiesinadditiontotheHanChinese.ThefullnameofaHanChines... 展开更多
关键词 China ABC A chinese name
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Chinese Named Entity Recognition with Character-Level BLSTM and Soft Attention Model 被引量:1
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作者 Jize Yin Senlin Luo +1 位作者 Zhouting Wu Limin Pan 《Journal of Beijing Institute of Technology》 EI CAS 2020年第1期60-71,共12页
Unlike named entity recognition(NER)for English,the absence of word boundaries reduces the final accuracy for Chinese NER.To avoid accumulated error introduced by word segmentation,a deep model extracting character-le... Unlike named entity recognition(NER)for English,the absence of word boundaries reduces the final accuracy for Chinese NER.To avoid accumulated error introduced by word segmentation,a deep model extracting character-level features is carefully built and becomes a basis for a new Chinese NER method,which is proposed in this paper.This method converts the raw text to a character vector sequence,extracts global text features with a bidirectional long short-term memory and extracts local text features with a soft attention model.A linear chain conditional random field is also used to label all the characters with the help of the global and local text features.Experiments based on the Microsoft Research Asia(MSRA)dataset are designed and implemented.Results show that the proposed method has good performance compared to other methods,which proves that the global and local text features extracted have a positive influence on Chinese NER.For more variety in the test domains,a resume dataset from Sina Finance is also used to prove the effectiveness of the proposed method. 展开更多
关键词 chinese named ENTITY recognition(NER) character-level BIDIRECTIONAL long SHORT-TERM memory SOFT attention model
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In Silico Screening of Potential Inhibitors against dPLA2 from Named Chinese Herbs for Identification of Compounds with Antivenom Effects Due to Deinagkistrodon acutus Snake Bites
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作者 Xingyang Xiao Mengyi Lai +3 位作者 Zechang Rao Jianzhong Huang Yiwei Xie Hongbin Zhang 《American Journal of Molecular Biology》 CAS 2024年第3期107-125,共19页
Phospholipase A2 (PLA2) is the key enzyme to the venom from Deinagkistrodon acutus which is one of the highly venomous snakes in China. In addition to being a catalyst for the hydrolysis of phospholipases A2 from snak... Phospholipase A2 (PLA2) is the key enzyme to the venom from Deinagkistrodon acutus which is one of the highly venomous snakes in China. In addition to being a catalyst for the hydrolysis of phospholipases A2 from snake venom, its well known that it possesses a broad spectrum of pharmacological activities, such as myotoxicity, neurotoxicity, cardiotoxicity, and hemolytic, anticoagulant and antiplatelet activities. However, snakebites are not efficiently treated by conventional serum therapy. Acute wounds can still cause poisoning and death. In order to find effective inhibitors of Deinagkistrodon venom acid phospholipase A2 (dPLA2), we obtained 385 compounds in 9 Chinese herbs from the TCMSP. These compounds were further performed to virtual screen using in silico tools like ADMET analysis, molecular docking and molecular dynamics (MD) simulation. After Pharmacokinetics analysis, we found 7 candidate compounds. Besides, analysis of small molecule interactions with dPLA2 confirmed that the amino acid residues HIS47 and GLY29 are key targets. Because they bind not only to the natural substrate phosphatidylcholine and compounds known for having inhibitory functions, but also for combining with potential antidote molecules in Chinese herbal medicine. This study is the first to report experience with virtual screening for possible inhibitor of dPLA2, such as the interaction spatial structure, binding energy and binding interaction analysis, these experiences not only provide reference for further experimental research, but also have a guideline for the study of drug molecular mechanism of action. 展开更多
关键词 chinese Herbal Medicine Phospholipase A2 Inhibitor Molecular Docking Molecular Mechanism
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Data Masking for Chinese Electronic Medical Records with Named Entity Recognition 被引量:1
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作者 Tianyu He Xiaolong Xu +3 位作者 Zhichen Hu Qingzhan Zhao Jianguo Dai Fei Dai 《Intelligent Automation & Soft Computing》 SCIE 2023年第6期3657-3673,共17页
With the rapid development of information technology,the electronifi-cation of medical records has gradually become a trend.In China,the population base is huge and the supporting medical institutions are numerous,so ... With the rapid development of information technology,the electronifi-cation of medical records has gradually become a trend.In China,the population base is huge and the supporting medical institutions are numerous,so this reality drives the conversion of paper medical records to electronic medical records.Electronic medical records are the basis for establishing a smart hospital and an important guarantee for achieving medical intelligence,and the massive amount of electronic medical record data is also an important data set for conducting research in the medical field.However,electronic medical records contain a large amount of private patient information,which must be desensitized before they are used as open resources.Therefore,to solve the above problems,data masking for Chinese electronic medical records with named entity recognition is proposed in this paper.Firstly,the text is vectorized to satisfy the required format of the model input.Secondly,since the input sentences may have a long or short length and the relationship between sentences in context is not negligible.To this end,a neural network model for named entity recognition based on bidirectional long short-term memory(BiLSTM)with conditional random fields(CRF)is constructed.Finally,the data masking operation is performed based on the named entity recog-nition results,mainly using regular expression filtering encryption and principal component analysis(PCA)word vector compression and replacement.In addi-tion,comparison experiments with the hidden markov model(HMM)model,LSTM-CRF model,and BiLSTM model are conducted in this paper.The experi-mental results show that the method used in this paper achieves 92.72%Accuracy,92.30%Recall,and 92.51%F1_score,which has higher accuracy compared with other models. 展开更多
关键词 named entity recognition chinese electronic medical records data masking principal component analysis regular expression
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Five commonly used traditional Chinese medicine formulas in the treatment of ulcerative colitis:A network meta-analysis 被引量:2
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作者 Zhi-Hui Zhao Yi-Hang Dong +5 位作者 Xin-Qi Jiang Jing Wang Wan-Li Qin Zhang-Yi Liu Xiao-Qing Zhang Yu-Jie Wei 《World Journal of Clinical Cases》 SCIE 2024年第22期5067-5082,共16页
BACKGROUND Currently,traditional Chinese medicine(TCM)formulas are commonly being used as adjunctive therapy for ulcerative colitis in China.Network meta-analysis,a quantitative and comprehensive analytical method,can... BACKGROUND Currently,traditional Chinese medicine(TCM)formulas are commonly being used as adjunctive therapy for ulcerative colitis in China.Network meta-analysis,a quantitative and comprehensive analytical method,can systematically compare the effects of different adjunctive treatment options for ulcerative colitis,providing scientific evidence for clinical decision-making.AIM To evaluate the clinical efficacy and safety of commonly used TCM for the treatment of ulcerative colitis(UC)in clinical practice through a network metaanalysis.METHODS Clinical randomized controlled trials of these TCM formulas used for the adjuvant treatment of UC were searched from the establishment of the databases to July 1,2022.Studies that met the inclusion criteria were screened and evaluated for literature quality and risk of bias according to the Cochrane 5.1 standard.The methodological quality of the studies was assessed using ReviewManager(RevMan)5.4,and a funnel plot was constructed to test for publication bias.ADDIS 1.16 statistical software was used to perform statistical analysis of the treatment measures and derive the network relationship and ranking diagrams of the various intervention measures.RESULTS A total of 64 randomized controlled trials involving 5456 patients with UC were included in this study.The adjuvant treatment of UC using five TCM formulations was able to improve the clinical outcome of the patients.Adjuvant treatment with Baitouweng decoction(BTWT)showed a significant effect[mean difference=36.22,95%confidence interval(CI):7.63 to 65.76].For the reduction of tumor necrosis factor in patients with UC,adjunctive therapy with BTWT(mean difference=−9.55,95%CI:−17.89 to−1.41),Shenlingbaizhu powder[SLBZS;odds ratio(OR)=0.19,95%CI:0.08 to 0.39],and Shaoyao decoction(OR=−23.02,95%CI:−33.64 to−13.14)was effective.Shaoyao decoction was more effective than BTWT(OR=0.12,95%CI:0.03 to 0.39),SLBZS(OR=0.19,95%CI:0.08 to 0.39),and Xi Lei powder(OR=0.34,95%CI:0.13 to 0.81)in reducing tumor necrosis factor and the recurrence rate of UC.CONCLUSION TCM combined with mesalazine is more effective than mesalazine alone in the treatment of UC. 展开更多
关键词 Network meta-analysis Traditional chinese medicine Ulcerative colitis MESALAZINE TREATMENT
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Synergistic effects of carbon cycle metabolism and photosynthesis in Chinese cabbage under salt stress 被引量:1
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作者 Hao Liang Qiling Shi +8 位作者 Xing Li Peipei Gao Daling Feng Xiaomeng Zhang Yin Lu Jingsen Yan Shuxing Shen Jianjun Zhao Wei Ma 《Horticultural Plant Journal》 SCIE CAS CSCD 2024年第2期461-472,共12页
Chinese cabbage(Brassica rapa ssp. pekinensis) has a long cultivation history and is one of the vegetable crops with the largest cultivation area in China. However, salt stress severely damages photosynthesis and horm... Chinese cabbage(Brassica rapa ssp. pekinensis) has a long cultivation history and is one of the vegetable crops with the largest cultivation area in China. However, salt stress severely damages photosynthesis and hormone metabolism, nutritional balances, and results in ion toxicity in plants. To better understand the mechanisms of salt-induced growth inhibition in Chinese cabbage, RNA-seq and physiological index determination were conducted to explore the impacts of salt stress on carbon cycle metabolism and photosynthesis in Chinese cabbage. Here, we found that the number of thylakoids and grana lamellae and the content of starch granules and chlorophyll in the leaves of Chinese cabbage under salt stress showed a time-dependent response, first increasing and then decreasing. Chinese cabbage increased the transcript levels of genes related to the photosynthetic apparatus and carbon metabolism under salt stress, probably in an attempt to alleviate damage to the photosynthetic system and enhance CO_(2) fixation and energy metabolism. The transcription of genes related to starch and sucrose synthesis and degradation were also enhanced;this might have been an attempt to maintain intracellular osmotic pressure by increasing soluble sugar concentrations. Soluble sugars could also be used as potential reactive oxygen species(ROS) scavengers, in concert with peroxidase(POD)enzymes, to eliminate ROS that accumulate during metabolic processes. Our study characterizes the synergistic response network of carbon metabolism and photosynthesis under salt stress. 展开更多
关键词 chinese cabbage Salt stress Carbon metabolism PHOTOSYNTHESIS CHLOROPLAST
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Knee osteoarthritis:A review of animal models and intervention of traditional Chinese medicine 被引量:1
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作者 Xuyu Song Ying Liu +5 位作者 Siyi Chen Lei Zhang Huijie Zhang Xianhui Shen Hang Du Rong Sun 《Animal Models and Experimental Medicine》 CAS CSCD 2024年第2期114-126,共13页
Background:Knee osteoarthritis(KOA)characterized by degeneration of knee cartilage and subsequent bone hyperplasia is a prevalent joint condition primarily affecting aging adults.The pathophysiology of KOA remains poo... Background:Knee osteoarthritis(KOA)characterized by degeneration of knee cartilage and subsequent bone hyperplasia is a prevalent joint condition primarily affecting aging adults.The pathophysiology of KOA remains poorly understood,as it involves complex mechanisms that result in the same outcome.Consequently,researchers are interested in studying KOA and require appropriate animal models for basic research.Chinese herbal compounds,which consist of multiple herbs with diverse pharmacological properties,possess characteristics such as multicomponent,multipathway,and multitarget effects.The potential benefits in the treatment of KOA continue to attract attention.Purpose:This study aims to provide a comprehensive overview of the advantages,limitations,and specific considerations in selecting different species and methods for KOA animal models.This will help researchers make informed decisions when choosing an animal model.Methods:Online academic databases(e.g.,PubMed,Google Scholar,Web of Science,and CNKI)were searched using the search terms“knee osteoarthritis,”“animal models,”“traditional Chinese medicine,”and their combinations,primarily including KOA studies published from 2010 to 2023.Results:Based on literature retrieval,this review provides a comprehensive overview of the methods of establishing KOA animal models;introduces the current status of advantages and disadvantages of various animal models,including mice,rats,rabbits,dogs,and sheep/goats;and presents the current status of methods used to establish KOA animal models.Conclusion:This study provides a review of the animal models used in recent KOA research,discusses the common modeling methods,and emphasizes the role of traditional Chinese medicine compounds in the treatment of KOA. 展开更多
关键词 animal models knee osteoarthritis system review traditional chinese medicine
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Advances in the treatment of diabetic peripheral neuropathy by modulating gut microbiota with traditional Chinese medicine 被引量:1
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作者 Ye-Yao Li Rui-Qian Guan +2 位作者 Zhi-Bo Hong Yao-Lei Wang Li-Min Pan 《World Journal of Diabetes》 SCIE 2024年第8期1712-1716,共5页
Diabetic peripheral neuropathy(DPN)is one of the strongest risk factors for diabetic foot ulcers(neuropathic ulcerations)and the existing ulcers may further deteriorate due to the damage to sensory neurons.Moreover,th... Diabetic peripheral neuropathy(DPN)is one of the strongest risk factors for diabetic foot ulcers(neuropathic ulcerations)and the existing ulcers may further deteriorate due to the damage to sensory neurons.Moreover,the resulting numbness in the limbs causes difficulty in discovering these ulcerations in a short time.DPN is associated with gut microbiota dysbiosis.Traditional Chinese medicine(TCM)compounds such as Shenqi Dihuang Decoction,Huangkui Capsules and Qidi Tangshen Granules can reduce the clinical symptoms of diabetic nephropathy by modulating gut microbiota.The current review discusses whether TCM compounds can reduce the risk of DPN by improving gut microbiota. 展开更多
关键词 DIABETES Peripheral neuropathy Traditional chinese medicine Gut microbiota Diabetic foot ulcer TREATMENT
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Understandings of Urban Sustainability in China:a Bibliometric Analysis Using Chinese Literatures 被引量:1
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作者 WU Shuang YUE Yang LI Xuesong 《Journal of Geodesy and Geoinformation Science》 CSCD 2024年第1期105-122,共18页
Cities hold a critical responsibility for achieving the Sustainable Development Goals(SDGs)due to their high population density,extensive resource consumption,and significant economic contributions.To examine the pres... Cities hold a critical responsibility for achieving the Sustainable Development Goals(SDGs)due to their high population density,extensive resource consumption,and significant economic contributions.To examine the present state of understandings regarding urban sustainability(SDG 11:Sustainable Cities and Communities)within Chinese research communities,this study collected 15950 papers from 1994 to 2022 on the 12 indicators of SDG 11,from the China National Knowledge Infrastructure(CNKI),a hub of Chinese academic papers,that directly relate to policymaking.Significant research topics on SDG 11 were identified for each indicator using bibliometrics analysis approaches.The high-frequency keywords and clusters of keywords over the last three decades reveal that existing studies primarily concentrated on the physical aspects,such as transportation and environment,while there is a lack of consideration of societal aspects.This indicates a limited and biased understanding of the urban sustainability within the Chinese academic community.Hence,it is crucial to prioritize the societal aspects in order to develop a research agenda that further advances urban sustainability. 展开更多
关键词 urban sustainability SDG 11 BIBLIOMETRIC chinese research communities
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Exploring the transformative impact of traditional Chinese medicine on depression:Insights from animal models 被引量:1
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作者 Yan Yang Yan-Kun Chen Meng-Zhou Xie 《World Journal of Psychiatry》 SCIE 2024年第5期607-623,共17页
Depression,a prevalent and complex mental health condition,presents a significant global health burden.Depression is one of the most frequent mental disorders;deaths from it account for 14.3%of people worldwide.In rec... Depression,a prevalent and complex mental health condition,presents a significant global health burden.Depression is one of the most frequent mental disorders;deaths from it account for 14.3%of people worldwide.In recent years,the integration of complementary and alternative medicine,including traditional Chinese medicine(TCM),has gained attention as a potential avenue for addressing depression.This comprehensive review critically assesses the efficacy of TCM interventions in alleviating depressive symptoms.An in-depth look at different research studies,clinical trials,and meta-analyses is used in this review to look into how TCM practices like herbal formulations,acupuncture,and mindbody practices work.The review looks at the quality of the evidence,the rigor of the methods,and any possible flaws in the current studies.This gives us an idea of where TCM stands right now in terms of treating depression.This comprehensive review aims to assess the efficacy of TCM interventions in alleviating depressive symptoms.In order to learn more about their possible healing effects,the study also looks into how different types of TCM work,such as herbal formulas,acupuncture,and mind-body practices. 展开更多
关键词 Traditional chinese medicine DEPRESSION EFFICACY Treatment Holistic approach
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Whole-genome analysis reveals distinct adaptation signatures to diverse environments in Chinese domestic pigs
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作者 Zhen Wang Bangmin Song +4 位作者 Jianyu Yao Xingzheng Li Yan Zhang Zhonglin Tang Guoqiang Yi 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2024年第5期1866-1880,共15页
Background Long-term natural and artificial selection has resulted in many genetic footprints within the genomes of pig breeds across distinct agroecological zones.Nevertheless,the mechanisms by which these signatures... Background Long-term natural and artificial selection has resulted in many genetic footprints within the genomes of pig breeds across distinct agroecological zones.Nevertheless,the mechanisms by which these signatures contribute to phenotypic diversity and facilitate environmental adaptation remain unclear.Results Here,we leveraged whole-genome sequencing data from 82 individuals from 6 domestic pig breeds originating in tropical,high-altitude,and frigid regions.Population genetic analysis suggested that habitat isolation significantly shaped the genetic diversity and contributed to population stratification in local Chinese pig breeds.Analysis of selection signals revealed regions under selection for adaptation in tropical(55.5 Mb),high-altitude(43.6 Mb),and frigid(17.72 Mb)regions.The potential functions of the selective sweep regions were linked to certain complex traits that might play critical roles in different geographic environments,including fat coverage in frigid environments and blood indicators in tropical and high-altitude environments.Candidate genes under selection were significantly enriched in biological pathways involved in environmental adaptation.These pathways included blood circulation,protein degradation,and inflammation for adaptation to tropical environments;heart and lung development,hypoxia response,and DNA damage repair for high-altitude adaptation;and thermogenesis,cold-induced vasodilation(CIVD),and the cell cycle for adaptation to frigid environments.By examining the chromatin state of the selection signatures,we identified the lung and ileum as two candidate functional tissues for environmental adaptation.Finally,we identified a mutation(chr1:G246,175,129A)in the cis-regulatory region of ABCA1 as a plausible promising variant for adaptation to tropical environments.Conclusions In this study,we conducted a genome-wide exploration of the genetic mechanisms underlying the adaptability of local Chinese pig breeds to tropical,high-altitude,and frigid environments.Our findings shed light on the prominent role of cis-regulatory elements in environmental adaptation in pigs and may serve as a valuable biological model of human plateau-related disorders and cardiovascular diseases. 展开更多
关键词 Environmental adaptation Local chinese breeds PIG Population genetics Selection signals Whole-genome resequencing
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The metabolic profiling of Chinese yam fermented by Saccharomyces boulardii and the biological activities of its ethanol extract in vitro
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作者 Xue Li Yiwen Shao +7 位作者 Limin Hao Qiaozhen Kang Xiaolong Wang Jiaqing Zhu Changcheng Zhao Yanling Shi Jike Lu Juanjuan Yi 《Food Science and Human Wellness》 SCIE CAS CSCD 2024年第5期2718-2726,共9页
Chinese yam(Dioscorea opposita Thunb.),as one of the medicinal and edible homologous plants,is rich in various nutrients and functional factors.In this study,Chinese yam fermented by Saccharomyces boulardii was perfor... Chinese yam(Dioscorea opposita Thunb.),as one of the medicinal and edible homologous plants,is rich in various nutrients and functional factors.In this study,Chinese yam fermented by Saccharomyces boulardii was performed to investigate its bioactive components and metabolic profile.And then,the main bioactive components and biological activities of fermented Chinese yam ethanol extract(FCYE)were evaluated.Results showed that there were 49 up-regulated metabolites and 52 down-regulated metabolites in fermented Chinese yam compared to unfermented Chinese yam.Besides,corresponding metabolic pathways analysis initially revealed that the distribution of bioactive substances was concentrated on alcoholsoluble small molecular substances.Ulteriorly,the total polyphenol content and the total flavonoid content in FCYE were significantly increased,and the corresponding antioxidant and immunomodulatory activities in vitro were also significantly enhanced.Our study provided a new reference for the comprehensive utilization of Chinese yam and laid a theoretical foundation for the development and application of natural probiotic-fermented products. 展开更多
关键词 chinese yam Saccharomyces boulardii METABOLITES ANTIOXIDANT IMMUNOMODULATION
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UV-B irradiation enhances the accumulation of beneficial glucosinolates induced by melatonin in Chinese kale sprout
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作者 Mengyu Wang Jiansheng Wang +6 位作者 Yuhe Yang Zhiqing Li Ghazala Mustafa Yubo Li Lihong Liu Zuofa Zhang Qiaomei Wang 《Horticultural Plant Journal》 SCIE CAS CSCD 2024年第4期995-1006,共12页
Cruciferous sprout is a new form of vegetable product rich in bioactive compounds,especially glucosinolates.Previous studies have focused on increasing the accumulation of glucosinolates in cruciferous sprouts by appl... Cruciferous sprout is a new form of vegetable product rich in bioactive compounds,especially glucosinolates.Previous studies have focused on increasing the accumulation of glucosinolates in cruciferous sprouts by applying different chemical regulators,with a particular focus on their contribution to nutritional quality and health benefits.Nevertheless,the effects of melatonin and UV-B irradiation on glucosinolate biosynthesis remain unclear.In this study,it was found that changes in melatonin concentrations significantly affected the contents of individual as well as total aliphatic and indolic glucosinolates.The 5μmol·L^(-1)melatonin was decided as the optimum concentration that could increase the content of beneficial glucosinolates including glucoraphanin and 4-methoxy glucobrassicin in Chinese kale sprouts.Notably,the enhancement of glucosinolate accumulation by melatonin treatment could be further amplified by UV-B irradiation.Furthermore,our results showed that R2R3-MYB transcription factor BoaMYB28 and BoaMYB51,which are central regulators of aliphatic and indolic glucosinolate biosynthesis respectively,were both involved in the regulation of glucosinolate biosynthesis by melatonin and UV-B irradiation.Additionally,the expression of glucosinolate biosynthetic genes,including BoaCYP79F1,BoaCYP83A1,BoaSUR1,BoaUGT74B1,BoaCYP79B2,BoaCYP79B3,and BoaCYP83B1 participated in the formation of core structures and BoaFMOGS-OX5,BoaAOP2,BoaCYP81F2,and BoaIGMT1 involved in the sidechain modification of aliphatic and indolic glucosinolate,was regulated by melatonin or UV-B irradiation.Taken together,these findings provide a potential strategy for improving the nutritional quality and resistance of Chinese kale sprouts. 展开更多
关键词 MELATONIN chinese kale SPROUTS UV-B GLUCOSINOLATES Nutritional quality Second metabolism
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Model informed precision medicine of Chinese herbal medicines formulas-A multi-scale mechanistic intelligent model
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作者 Yuanyuan Qian Xiting Wang +8 位作者 Lulu Cai Jiangxue Han Zhu Huang Yahui Lou Bingyue Zhang Yanjie Wang Xiaoning Sun Yan Zhang Aisong Zhu 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2024年第4期585-600,共16页
Recent trends suggest that Chinese herbal medicine formulas(CHM formulas)are promising treatments for complex diseases.To characterize the precise syndromes,precise diseases and precise targets of the precise targets ... Recent trends suggest that Chinese herbal medicine formulas(CHM formulas)are promising treatments for complex diseases.To characterize the precise syndromes,precise diseases and precise targets of the precise targets between complex diseases and CHM formulas,we developed an artificial intelligence-based quantitative predictive algorithm(DeepTCM).DeepTCM has gone through multilevel model calibration and validation against a comprehensive set of herb and disease data so that it accurately captures the complex cellular signaling,molecular and theoretical levels of traditional Chinese medicine(TCM).As an example,our model simulated the optimal CHM formulas for the treatment of coronary heart disease(CHD)with depression,and through model sensitivity analysis,we calculated the balanced scoring of the formulas.Furthermore,we constructed a biological knowledge graph representing interactions by associating herb-target and gene-disease interactions.Finally,we experimentally confirmed the therapeutic effect and pharmacological mechanism of a novel model-predicted intervention in humans and mice.This novel multiscale model opened up a new avenue to combine“disease syndrome”and“macro micro”system modeling to facilitate translational research in CHM formulas. 展开更多
关键词 chinese herbal medicine formulas Precision medicine Mathematical modeling Systems biology Coronary heart disease Depression ISCHEMIA-REPERFUSION Inflammation
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Systems Theory-Driven Framework for AI Integration into the Holistic Material Basis Research of Traditional Chinese Medicine
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作者 Jingqi Zeng Xiaobin Jia 《Engineering》 SCIE EI CAS CSCD 2024年第9期28-50,共23页
This paper introduces a systems theory-driven framework to integration artificial intelligence(AI)into traditional Chinese medicine(TCM)research,enhancing the understanding of TCM’s holistic material basis while adhe... This paper introduces a systems theory-driven framework to integration artificial intelligence(AI)into traditional Chinese medicine(TCM)research,enhancing the understanding of TCM’s holistic material basis while adhering to evidence-based principles.Utilizing the System Function Decoding Model(SFDM),the research progresses through define,quantify,infer,and validate phases to systematically explore TCM’s material basis.It employs a dual analytical approach that combines top-down,systems theory-guided perspectives with bottom-up,elements-structure-function methodologies,provides comprehensive insights into TCM’s holistic material basis.Moreover,the research examines AI’s role in quantitative assessment and predictive analysis of TCM’s material components,proposing two specific AIdriven technical applications.This interdisciplinary effort underscores AI’s potential to enhance our understanding of TCM’s holistic material basis and establishes a foundation for future research at the intersection of traditional wisdom and modern technology. 展开更多
关键词 Artificial intelligence Systems theory Traditional chinese medicine Material basis BOTTOM-UP
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Bio-soft matter derived from traditional Chinese medicine:Characterizations of hierarchical structure,assembly mechanism,and beyond
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作者 Guiya Yang Yue Liu +4 位作者 Yuying Hu Yue Yuan Yunan Qin Quan Li Shuangcheng Ma 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2024年第6期823-839,共17页
Structural and functional explorations on bio-soft matter such as micelles,vesicles,nanoparticles,aggregates or polymers derived from traditional Chinese medicine(TCM)has emerged as a new topic in the field of TCM.The... Structural and functional explorations on bio-soft matter such as micelles,vesicles,nanoparticles,aggregates or polymers derived from traditional Chinese medicine(TCM)has emerged as a new topic in the field of TCM.The discovery of such cross-scaled bio-soft matter may provide a unique perspective for unraveling the new effective material basis of TCM as well as developing innovative medicine and biomaterials.Despite the rapid rise of TCM-derived bio-soft matter,their hierarchical structure and assembly mechanism must be unambiguously probed for a further in-depth understanding of their pharmacological activity.In this review,the current emerged TCM-derived bio-soft matter assembled from either small molecules or macromolecules is introduced,and particularly the unambiguous elucidation of their hierarchical structure and assembly mechanism with combined electron microscopic and spectroscopic techniques is depicted.The pros and cons of each technique are also discussed.The future challenges and perspective of TCM-derived bio-soft matter are outlined,particularly the requirement for their precise in situ structural determination is highlighted. 展开更多
关键词 Electron microscopy SPECTROSCOPY Traditional chinese medicine Bio-soft matter Structural characterization
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