Molecular mechanism and research progress of traditional Chinese medicine in the treatment of prostate cancer

Prostate cancer(PCa)is one of the most common malignant tumors in the male genitourinary system,ranking second in incidence worldwide.Traditional Chinese medicine(TCM),as an important component of complementary and alternative medicine,shows unique advantages in cancer treatment.Chinese herbal medicine is usually composed of multiple ingredients and involves multiple signaling pathways,which showed function of inducing apoptosis of cancer cells,arresting the cell cycle,inhibiting invasion and metastasis,reducing drug resistance,and regulating immune function.Physical therapy is also an important treatment of TCM.Currently,Physical therapy such as acupuncture or Tai Chi and Qigong are gaining increased recognition in the management of PCa,particularly in addressing issues like urinary incontinence and bone metastasis-related pain.This article reviews the TCM treatment and therapy of PCa,in order to provide new research avenues and treatment options for the treatment of PCa with TCM and improve the quality of life of patients.

探讨Chinese way术式在关节镜下治疗巨大肩袖损伤的应用价值

目的探讨Chinese way术式在关节镜下治疗巨大肩袖损伤的应用价值,为临床治疗提供参考。方法选取2022年3月至2024年3月于扬州市江都中医院接受治疗的70例巨大肩袖损伤患者的临床资料,进行回顾性分析。根据治疗方式不同分为双排锚钉缝线桥组和Chinese way组,每组35例。双排锚钉缝线桥组患者采用关节镜下双排锚钉缝线桥固定术治疗,Chinese way组患者采用关节镜下Chinese way术式治疗。比较两组患者肩关节活动度、并发症发生情况、Fugl-Meyer评定量表(FMA-UE)评分。结果术后3个月,两组患者前屈、后伸、内旋、外旋的肩关节活动度均增加,且Chinese way组均大于双排锚钉缝线桥组(均P<0.05)。Chinese way组患者并发症总发生率低于双排锚钉缝线桥组(均P<0.05)。术后3个月,两组患者运动功能、感觉功能、平衡功能、关节活动度、疼痛的各项FMA-UE评分均升高,且Chinese way组均高于双排锚钉缝线桥组(均P<0.05)。结论Chinese way术式在关节镜下治疗巨大肩袖损伤的效果较好,可有效提升患者肩关节活动度和上肢运动功能,且安全性较高,值得临床应用。

Research progress on insomnia treated by traditional Chinese medicine and acupuncture based on microbial-gut-brain axis theory

Insomnia,as one of the emotional diseases,has been increasing in recent years,which has a great impact on people's life and work.Therefore,researchers are eager to find a more perfect treatment.The microbiome-gut-brain axis is a new theory that has gradually become popular abroad in recent years and has a profound impact in the field of insomnia.In recent years,traditional Chinese medicine(TCM)has played an increasingly important role in the treatment of insomnia,especially acupuncture and Chinese herbal medicine.It is the main method of TCM in the treatment of insomnia.This paper mainly reviews the combination degree of"microorganism-gut-brain axis"theory with TCM and acupuncture under the system of TCM.To explore the mechanism of TCM and acupuncture in the treatment of insomnia under the guidance of"microorganismgut-brain axis"theory,in order to provide a new idea for the diagnosis and treatment of insomnia.

Advances in Research of Preparation and Application of Pure Functional Yaoqu by Adding Traditional Chinese Medicine

This paper introduces the origin and research status of traditional Yaoqu(Chinese medicinal koji)in China,and advances in the research of preparation and development of pure functional Yaoqu.The study results showed that the quality of the products was significantly improved when pure Yaoqu was used as saccharifying agent in the brewing of sake,soy sauce and other products.Based on the high saccharification performance and special functional components,Yaoqu can be applied to the development of fermented food.

Cohort study on the treatment of BRAF V600E mutant metastatic colorectal cancer with integrated Chinese and western medicine

BACKGROUND Patients with BRAF V600E mutant metastatic colorectal cancer(mCRC)have a low incidence rate,poor biological activity,suboptimal response to conventional treatments,and a poor prognosis.In the previous cohort study on mCRC conducted by our team,it was observed that integrated Chinese and Western medicine treatment could significantly prolong the overall survival(OS)of patients with colorectal cancer.Therefore,we further explored the survival benefits in the population with BRAF V600E mutant mCRC.AIM To evaluate the efficacy of integrated Chinese and Western medicine in the treatment of BRAF V600E mutant metastatic colorectal cancer.METHODS A cohort study was conducted on patients with BRAF V600E mutant metastatic colorectal cancer admitted to Xiyuan Hospital of China Academy of Chinese Medical Sciences and Traditional Chinese Medicine Hospital of Xinjiang Uygur Autonomous Region from January 2016 to December 2022.The patients were divided into two cohorts.RESULTS A total of 34 cases were included,with 23 in Chinese-Western medicine cohort(cohort A)and 11 in Western medicine cohort(cohort B).The median overall survival was 19.9 months in cohort A and 14.2 months in cohort B,with a statistically significant difference(P=0.038,hazard ratio=0.46).The 1-3-year survival rates were 95.65%(22/23),39.13%(9/23),and 26.09%(6/23)in cohort A,and 63.64%(7/11),18.18%(2/11),and 9.09%(1/11)in cohort B,respectively.Subgroup analysis showed statistically significant differences in median OS between the two cohorts in the right colon,liver metastasis,chemotherapy,and first-line treatment subgroups(P<0.05).CONCLUSION Integrated Chinese and Western medicine can prolong the survival and reduce the risk of death in patients with BRAF V600E mutant metastatic colorectal cancer,with more pronounced benefits observed in patients with right colon involvement,liver metastasis,combined chemotherapy,and first-line treatment.

Harnessing multi-omics approaches to elucidate the role of Chinese herbal compounds in chemotherapy-induced gastrointestinal damage

In this editorial,we discuss the findings reported by Wang et al in the latest issue of the World Journal of Gastrointestinal Oncology.Various research methodologies,including microbiome analysis,assert that the Tzu-Chi Cancer-Antagonizing and Life-Protecting II Decoction of Chinese herbal compounds mitigates inflammatory responses by inhibiting the NF-κB signaling pathway.This action helps maintain the dynamic equilibrium of the intestinal microecology and lessens chemotherapy-induced gastrointestinal damage.The efficacy of these compounds is intimately linked to the composition of intestinal microbes.These compounds regulate intestinal microecology by virtue of their specific compatibility and effectiveness,thereby enhancing the overall therapeutic outcomes of cancer chemotherapy.Nonetheless,the exact mechanisms underlying these effects warrant further investigation.Multi-omics technologies offer a systematic approach to elucidate the mechanisms and effectiveness of Chinese herbal compounds in vivo.This manuscript reviews the application of multi-omics technologies to Chinese herbal compounds and explores their potential role in modulating the gastrointestinal microenvironment following cancer chemotherapy,thus providing a theoretical foundation for their continued use in adjunct cancer treatment.

Low-concentration atropine(0.01%)on quantitative contrast sensitivity function in Chinese children with myopia

AIM:To investigate the effect of 0.01%low-concentration atropine(LA)on quantitative contrast sensitivity function(qCSF)in children with myopia.METHODS:This paired case-control study included 90 eyes of 58 children who were sex-,age-,and refractionmatched and equally divided into two groups:the 0.01%LA group had undergone 6mo use of daily 0.01%atropine and control group was naïve to LA.Routine ophthalmic examinations and qCSF test without refractive correction were performed.Two groups were compared in monocular and binocular qCSF parameters,including the area under logCSF,CSF acuity,and contrast sensitivity(CS)at 1.0-18.0 cycle per degree(cpd).RESULTS:In the monocular comparison,the CSF acuity of the LA group was significantly higher than that of the control group(7.58±5.51 vs 6.37±4.22 cpd,P<0.05).The subgroup analysis showed that in the 6-9y group,CSF acuity was significantly higher in the LA group than the control group(8.76±6.19 vs 6.54±4.25 cpd,P<0.05),and in the Female group,low refraction sphere group,and high refraction cylinder group,the CS at high spatial frequencies(12.0 and 18.0 cpd)were significantly higher in the LA group than in the control group(all P<0.05).In the binocular test,CSF acuity and CS at 12.0 cpd were significantly higher in the LA group than in the control group(10.95±7.00 vs 8.65±5.12 cpd;0.17±0.33 vs 0.06±0.16,respectively;both P<0.05).CONCLUSION:Use of LA may result in improved CS in children with early onset myopia.

Mitigating ethyl carbamate production in Chinese rice wine:Role of raspberry extract

This study investigated the use of raspberry extract(RBE) for mitigating ethyl carbamate(EC) accumulation in Chinese rice wine(Huangjiu), a traditional fermented beverage. It focused on the addition of RBE to the fermentation mash and its effects on EC levels. The results showed a significant reduction in EC production that could be attributed to RBE's role in altering urea and citrulline catabolism and inhibiting arginine metabolism, thus preventing EC precursors from reacting with ethanol. Additionally, RBE enhanced the rice wine's flavor profile, as shown by volatile component and amino acid analysis. This study also explored RBE's impact on the metabolism of arginine by Saccharomyces cerevisiae in a simulated fermentation environment, and found increased arginine, reduced urea and citrulline levels, altered enzyme activities, and gene expression changes in the arginine metabolism and transport pathways. In conclusion, the results clearly demonstrated RBE's efficacy in reducing the EC content in Chinese rice wine, offering valuable insights for EC reduction strategies.

The potential of Chinese herbal medicines in treating anxiety disorders

In recent years,there has not been much progress in developing anxiolytic drugs.Amongst the barriers are the lack of clarity on the pathogenesis of anxiety disorders,low product conversion rates for developing drugs targeting the receptors,and species variability.Some scientists have focused on natural medicines,especially herbal medicines in traditional Chinese medicine.New drugs with excellent anxiolytic activity are hoped to be found in herbal medicines with anxiolytic effects.This mini-review summarised three Chinese herbal medicines with anxiolytic effects and anxiolytic herbal formulas used in the traditional Chinese medicine clinic.Several key issues that block the development of new anxiolytic drugs are also discussed.We hope to provide some ideas for researching and developing new anxiolytic drugs and studying anxiolytic components in traditional Chinese medicine.

Traditional Chinese medicine treatment of insomnia based on microbial-gut-brain axis theory

In recent years,insomnia has gradually become a common disease in society,which seriously affects people's quality of life.At present,with the deepening of research on intestinal microbiota-gut-brain axis in Western medicine,many studies suggest that regulating the gastrointestinal tract can treat brain-related diseases.It is found that brain-gut-bacteria axis plays an important role in the prevention and treatment of primary insomnia.At present,although the clinical treatment of insomnia with Western medicine can improve the insomnia symptoms of patients to a certain extent,there are still obvious adverse reactions,such as anxiety and depression,drug addiction,etc.,so long-term oral drug therapy cannot be carried out.Traditional Chinese medicine(TCM)and acu-puncture techniques have certain therapeutic effects on insomnia.TCM believes that the brain and gastrointestinal system are connected through the meridian,and the pathophysiology is closely related.This paper will discuss the theory and feasibility of TCM for the treatment of insomnia from the pathological relation-ship between brain-gut axis,intestinal flora and insomnia.

English Translation of Chinese Natural Ecological Discourse:A Corpus-based Case Study on Xi Jinping:The Governance of China

Amid the increasingly severe global natural eco-environment,it is necessary to build a natural ecological civilization by constructing an ecological civilization discourse.Against this background,this study compiles a corpus of natural ecological discourse in the English translation of Xi Jinping:The Governance of China(short for Xi).By using Wordsmith and AntConc,this study explores the linguistic features of the ecological discourse in English translation of Xi in the following dimensions,including high-frequency words,keywords,word collocations,concordance lines.This study aims to analyze the concepts and attitudes towards natural ecology,so as to provide certain valuable insights for the construction of China’s discourse on natural ecological civilization.The study found that the natural ecology discourse involving in the English translation of Xi turned out to be ecologically beneficial.

From Differential Mode of Association to Tianxia Worldview:A Study on Chinese Entrepreneurial Spirit

China has made significant strides in economic and social development since reform and opening up over the past four decades.This process has been influenced by the exceptional innovation and entrepreneurship of Chinese business leaders,as well as their profound sentiments of compassion for the world and their country.It is of great significance to foster and promote an entrepreneurial spirit with distinctive Chinese characteristics.Not only is such spirit essential to the high-quality development of enterprises and the economy,but it is also a critical impetus for achieving Chinese modernization.Nevertheless,there is still a paucity of adequate theoretical discourse on the cultural origins and entrepreneurial spirit of outstanding Chinese business leaders.This paper employs the classical grounded theory method to conduct a 10-year follow-up research on 11 representative entrepreneurs and their enterprises.The results indicate that these entrepreneurs exhibit an evolving worldview along the paths of“self-cultivation and moral conduct”,“assisting employees to achieve”,“multilateral symbiosis”,and“the oneness of existence”when interacting with themselves,employees,partners,the general public,and all things in nature.Such entrepreneurial spirit is embodied in this paper as the“Tianxia(all-under-heaven)worldview”.Through theoretical construction,this study defines the concept of“Tianxia worldview”and extensively examines the distinctions and connections between the broadminded“Tianxia worldview”and the kinship-centered“differential mode of association”in terms of internal structure,value orientation,and applicable groups.It is posited that the transition from the former to the latter is a continuous process of transcendence and evolution of the individual mindset.This study has theoretical significance in the context of advancing the research on the Chinese entrepreneurial spirit,transcending the constraints of the management approach based on the“differential mode of association”,and enhancing the research on social responsibility from the perspective of“benefit corporations”.It also has practical value in overcoming the trust dilemma and development impediment of family businesses,ensuring that enterprises consciously fulfill their social responsibilities in a broader social context,and achieving common prosperity and progress for both enterprises and society.

Translation Strategies for the Chinese Four-Character Structure Into German:The Case Study of Stories From Xi Jinping Erzählt GeschichtenÜBer Die Kommunistische Partei Chinas

In the context of globalization,cultural exchanges among countries are becoming increasingly intimate.As we embark on a new era,the external promotion of the red culture of Party history has emerged as a crucial avenue for conveying the good voice of China,showcasing Chinese wisdom,and enhancing China’s image.Xi Jinping Erzählt GeschichtenÜber Die Kommunistische Partei Chinas includes over 80 stories narrated by General Secretary Xi Jinping,providing readers worldwide with a deeper understanding of the revolutionary spirit of the Communist Party of China.This paper systematically categorizes and analyzes the four-character phrases found in Xi Jinping Erzählt GeschichtenÜber Die Kommunistische Partei Chinas,employing the theory of cultural translation to explore translation strategies for these phrases in the context of Party history literature.This research aims to promote the global dissemination of China’s red culture and foster a greater understanding of China in the world.

Chinese named entity recognition with multi-network fusion of multi-scale lexical information

Named entity recognition(NER)is an important part in knowledge extraction and one of the main tasks in constructing knowledge graphs.In today’s Chinese named entity recognition(CNER)task,the BERT-BiLSTM-CRF model is widely used and often yields notable results.However,recognizing each entity with high accuracy remains challenging.Many entities do not appear as single words but as part of complex phrases,making it difficult to achieve accurate recognition using word embedding information alone because the intricate lexical structure often impacts the performance.To address this issue,we propose an improved Bidirectional Encoder Representations from Transformers(BERT)character word conditional random field(CRF)(BCWC)model.It incorporates a pre-trained word embedding model using the skip-gram with negative sampling(SGNS)method,alongside traditional BERT embeddings.By comparing datasets with different word segmentation tools,we obtain enhanced word embedding features for segmented data.These features are then processed using the multi-scale convolution and iterated dilated convolutional neural networks(IDCNNs)with varying expansion rates to capture features at multiple scales and extract diverse contextual information.Additionally,a multi-attention mechanism is employed to fuse word and character embeddings.Finally,CRFs are applied to learn sequence constraints and optimize entity label annotations.A series of experiments are conducted on three public datasets,demonstrating that the proposed method outperforms the recent advanced baselines.BCWC is capable to address the challenge of recognizing complex entities by combining character-level and word-level embedding information,thereby improving the accuracy of CNER.Such a model is potential to the applications of more precise knowledge extraction such as knowledge graph construction and information retrieval,particularly in domain-specific natural language processing tasks that require high entity recognition precision.

Discussion on Traditional Chinese Medicine Treatment of Liver-Depression-Spleen-Deficiency Type Insomnia Based on the State-Target Theory and the Regulation of Microbiome-Gut-Brain Axis

Insomnia has become an urgent clinical problem in modern society.Current research has found that the gut flora-gut-brain axis plays an important role in regulating insomnia.The state-target theory is a product of the combination of traditional Chinese medicine and modern molecular biology technology.This paper clarifies the correlation between the state-target theory,the intestinal flora-gut-brain axis,and liver-depression-spleen-deficiency insomnia.The use of traditional Chinese medicine to regulate the structure and abundance of intestinal flora was also explored,aiming to integrate traditional Chinese medicine with Western medicine for the prevention and treatment of liver-depression-spleen-deficiency insomnia.

Analysis of the Clinical Effect of Chinese Medicine Combined with Acupuncture and Moxibustion on Insomnia

Objective:To explore and analyze the clinical efficacy of Chinese medicine combined with acupuncture and moxibustion in the treatment of insomnia.Method:80 patients with primary insomnia were selected as the study sample,with 20 cases randomly selected as the control group and the rest as the observation group.The control group was treated with ordinary western medicine,while the observation group patients were treated with traditional Chinese medicine combined with acupuncture and moxibustion based on this syndrome differentiation.The comparison items were treatment effect,sleep quality,mental health,quality of life,specific sleep indicators,cerebral blood flow and neurotransmitters.Result:The treatment effectiveness showed that the observation group had a higher treatment effectiveness rate than the control group(P<0.05);The results of sleep quality showed that after treatment,the scores of the observation group were lower than those of the control group in seven dimensions:sleep quality,sleep time,sleep onset time,sleep efficiency,sleep disorders,hypnotic drugs,and daytime dysfunc‐tion score(P<0.05);The quality of life results showed that after treatment,the observa‐tion group had higher scores than the control group in eight dimensions:physiological function,physiological function,physical pain,health status,energy,social function,emotional function,and mental health(P<0.05);The results of slow wave sleep time and fast eye movement sleep time showed that after treatment,the HAMA and HAMD scores of the physiological mechanism in the observation group were lower than those in the control group(P<0.05);The results of cerebral blood flow and neurotransmitter indica‐tors show that after treatment,glutamateγ-The peak systolic blood flow velocity of ami‐nobutyric acid,vertebral artery,and basilar artery in the observation group was higher than that in the control group(P<0.05).Conclusion:The clinical treatment of Chinese medicine combined with acupuncture and moxibustion in the treatment of insomnia patients can significantly improve the clinical treatment effect,and improve the cerebral hemorrhage and neurotransmitter status of patients,promote the improvement of their physical and mental status,can more significantly improve the quality of sleep,reduce sleep difficulties,reduce the dosage of sleeping pills,which has important clinical application value.

Research on the Development Strategy of Panxi Sunshine Health and Wellness Homestays and Hotels Based on Traditional Chinese Medicine Health Preservation

This study is the first phase of research results from the student innovation project“Yunqiao Sunshine Health and Wellness Homestay”group at Chengdu Normal University.By analyzing the current state of the Sunshine Health and Wellness Tourism Area economy in the Panxi region of Sichuan,local policies,and the current state of Sunshine Health and Wellness homestays and hotels,this paper proposes the possibility of developing Sunshine Health and Wellness homestays and hotels through traditional Chinese medicine(TCM)health preservation methods.It also proposes development strategies for such hotels through a market survey SWOT analysis.

Oxidation Resistance of Flavonoids in Chinese Jujube Stone

[Objective] The aim was to study on the oxidation resistance of flavonoids in Chinese jujube stone. [Method] The extract of flavonoids from Chinese jujube stone was added to fresh rapeseed oil and lard to explore the oxidation resistance of flavonoids; the removal rates of it to O2-·,DPPH· and ·OH were also studied. [Result] The flavonoids from Chinese jujube stone had good oxidation resistance on rapeseed oil and lard,and the effects showed dose-dependent; citric acid and vitamin C appeared synergistic effects to the flavonoids; in free-radical reaction experiment,the flavonoids from Chinese Jujube stone also showed strong scavenging ability on O2-·,DPPH· and ·OH,in addition,the scavenging ability increased with concentration increasing. [Conclusion] The result of this study had provided theoretical basis for the further development and utilization of Chinese jujube resource.

Effect of Different Irrigation Maximums on Absorption and Utilization of Water in Chinese Kale

[Objective] This study was conducted to investigate the effect of soil moisture on the growth and water utilization of Chinese kale. [Method] The law of water absorption and utilization of Chinese kale was researched under the same irri- gation frequency and different irrigation maximums. [Result] Soil water deficit re- duced water contents in plants in seedling stage and in plants and various organs in maturation stage; water consumption of individual plant was the lowest in 55% treatment of soil A and 45% treatment of soil B, which showed the values of 2.244 and 2.235 L/plant, respectively, and saved water by 23.91% and 21.14% compared with CK; water use efficiencies of soil A with a water content of 55% and soil B with a water content of 35% were the highest, i.e., 6.043 and 5.958 g/L, which were higher than that of CK by 20.09% and 41.72%, respectively; and regulated deficit irrigation also improved irrigation water productivity, and the two kinds of soil both showed in 75% treatments the highest irrigation water productivities, i.e., 40.44 and 40.49 g/L, which were higher than that of CK by 5.64% and 13.39%, respec- tively. [Conclusion[ Controlling irrigation maximum could save water consumed by Chinese kale, improve water use efficiency and improve yield and quality.

Effect of Different Irrigation Maximums on Accumulation and Distribution of Material in Chinese Kale

[Objective] The aim was to explore effects of soil moisture on dry matter accumulation and distribution and growth of kai-lan. [Method] In the context of the same irrigation frequency, the influence of irrigation maximum was researched on growth rate, net assimilation rate, and dry matter distribution of kai-lan. [Result] The results showed that regulation on soil moisture extremely significantly affected accumulation of photosynthate. When soil moisture was insufficient, the growth term from seedling to mature extended and growth rate declined sharply. Besides, the growth term was of extremely significant negative correlation with growth rate. Meanwhile,leaf assimilation rate decreased considerably. For example, when soil moisture was65%, distribution of dry matter in plant organs tended to be rational. [Conclusion]Deficit irrigation would significantly lower growth rate, and improve dry matter distribution in organs and economic yield and quality of kai-lan.