Objective：To observe the therapeutic effect of Chinese herbal medicine for strengthening qi, nourishing yin,and removing stasis on serum osteopontin（OPN） and quality of life（QOL） in patients with primary Sjogren...Objective：To observe the therapeutic effect of Chinese herbal medicine for strengthening qi, nourishing yin,and removing stasis on serum osteopontin（OPN） and quality of life（QOL） in patients with primary Sjogren＇s syndrome（pSS） and to study the correlation between OPN level and the disease.Methods：Sixtyeight pSS patients were randomly assigned to two groups：the treatment group（35 cases） treated by Chinese herbal medicine for strengthening qi,nourishing yin,and removing stasis combined with hydroxychloroquine sulfate tablet（HCQ） and the control group（33 cases） treated by HCQ only.Both were treated for 3 months. Before and after treatment,immunoglobulin G（IgG） level,erythrocyte sedimentation rate（ESR）,and OPN level were measured.The QOL in patients was evaluated using the Short Form-36 Health Survey（SF-36） before and after treatment.Thirty healthy females were taken as the normal control.Results：Before treatment,levels of IgG,ESR,and OPN in patients were higher than those in the normal control.After 3 months of treatment, those in both treatment groups decreased but were lower in the treatment group than those in the control group （P0.05）.The scores of 8 dimensions of SF-36 were lower in the pSS patients than those in the normal control （P0.05） and higher in the treatment group than in the control group after treatment（P0.05）.Furthermore, there was a positive correlation between the levels of OPN and the levels of IgG and ESR,and a negative correlation between OPN levels and the overall score of SF-36（P0.05）.Conclusions：Chinese herbal medicine for strengthening qi,nourishing yin,and removing stasis could alleviate pSS disease and improve the QOL.In addition,the OPN level might be used as an evaluating index for pSS disease.展开更多
OBJECTIVE: To evaluate the efficacy and safety of Traditional Chinese Medicine(TCM) herbs for tonifying Qi and kidney, and replenishing spleen on intermittent asthma in children aged 2 and 5 years.METHODS: A randomize...OBJECTIVE: To evaluate the efficacy and safety of Traditional Chinese Medicine(TCM) herbs for tonifying Qi and kidney, and replenishing spleen on intermittent asthma in children aged 2 and 5 years.METHODS: A randomized, single-blind, placebo controlled trial was conducted. Children with intermittent asthma were enrolled and their baseline conditions were measured using a questionnaire. A total of 60 participants, aged 2 to 5, were randomized into either the treatment group(n = 40) or the placebo group(n = 20). The treatment group was treated with granules of TCM herbs for tonifying Qi and kidney, and replenishing spleen, and the placebo group was given placebo granules for 3 months.The number of asthma attacks was counted and TCM syndrome scores were measured at 1, 2, 3, 6, 9,and 12 months. The airway resistance and levels of eosinophil cationic protein for the two groups were observed before and after 3 months. The results were statistically analyzed.RESULTS: Compared with the placebo group, the number of asthma attacks significantly decreased in the treatment group(P < 0.05). For the treatment group, the TCM syndrome scores decreased after 1 and 2 months; there was also a significant difference in scores between the two groups(P < 0.05).The difference remained after the medicine was stopped for 9 months(P < 0.05). After the 3-month treatment, compared with the placebo group, the airway resistance decreased in the treatment group(P < 0.05). No adverse events were reported in the treatment group.CONCLUSION: The TCM herbs for tonifying Qi and kidney, and replenishing spleen reduced the number of intermittent asthma attacks, decreased the TCM syndrome scores, and reduced the airway resistance in the children aged 2 to 5.展开更多
目的 观察中医不同治法对大鼠骨质疏松症模型骨骼、骨骼肌中钙调神经磷酸酶(Calcineurin, CaN)、T细胞活化核因子(Nuclear Factor of the Activated T cell, NFAT)含量的影响,探讨中医药治疗骨质疏松症的分子机制。方法 将雌性SD大鼠随...目的 观察中医不同治法对大鼠骨质疏松症模型骨骼、骨骼肌中钙调神经磷酸酶(Calcineurin, CaN)、T细胞活化核因子(Nuclear Factor of the Activated T cell, NFAT)含量的影响,探讨中医药治疗骨质疏松症的分子机制。方法 将雌性SD大鼠随机分为正常组、模型对照组、补肾法组、健脾法组、活血法组。采用酶联免疫吸附(ELISA)法进行测定,比较不同组别CaN、NFAT的含量变化。结果 模型对照组与正常组比较,骨骼、骨骼肌的CaN含量有显著降低(P<0.01);补肾法组、健脾法组、活血法组与模型对照组比较,骨骼、骨骼肌的CaN的含量均明显升高(P<0.01),其中补肾法组升高程度比较明显,骨骼的CaN含量其次为活血法组,骨骼肌的CaN含量其次为健脾组。模型对照组与正常组比较,骨骼、骨骼肌的NFAT含量显著降低(P<0.01);补肾法组、健脾法组、活血法组与模型对照组比较,NFAT含量明显升高,其中补肾法组升高程度比较明显,其次为健脾法组。结论 (1)骨骼、骨骼肌中CaN、NFAT的含量变化可能与骨质疏松症的发生有一定的相关性。(2)补肾法和健脾法可明显改善骨质疏松症大鼠骨骼、骨骼肌中CaN、NFAT的含量,预防骨质疏松的发生发展。(3)中医不同治法能够有效改善骨质疏松,补肾法、健脾法是治疗骨质疏松的重要治法。展开更多
文摘Objective：To observe the therapeutic effect of Chinese herbal medicine for strengthening qi, nourishing yin,and removing stasis on serum osteopontin（OPN） and quality of life（QOL） in patients with primary Sjogren＇s syndrome（pSS） and to study the correlation between OPN level and the disease.Methods：Sixtyeight pSS patients were randomly assigned to two groups：the treatment group（35 cases） treated by Chinese herbal medicine for strengthening qi,nourishing yin,and removing stasis combined with hydroxychloroquine sulfate tablet（HCQ） and the control group（33 cases） treated by HCQ only.Both were treated for 3 months. Before and after treatment,immunoglobulin G（IgG） level,erythrocyte sedimentation rate（ESR）,and OPN level were measured.The QOL in patients was evaluated using the Short Form-36 Health Survey（SF-36） before and after treatment.Thirty healthy females were taken as the normal control.Results：Before treatment,levels of IgG,ESR,and OPN in patients were higher than those in the normal control.After 3 months of treatment, those in both treatment groups decreased but were lower in the treatment group than those in the control group （P0.05）.The scores of 8 dimensions of SF-36 were lower in the pSS patients than those in the normal control （P0.05） and higher in the treatment group than in the control group after treatment（P0.05）.Furthermore, there was a positive correlation between the levels of OPN and the levels of IgG and ESR,and a negative correlation between OPN levels and the overall score of SF-36（P0.05）.Conclusions：Chinese herbal medicine for strengthening qi,nourishing yin,and removing stasis could alleviate pSS disease and improve the QOL.In addition,the OPN level might be used as an evaluating index for pSS disease.
基金Supported by the Research Fund of Capital Medical Development(Traditional Chinese Medicine):Function Evaluation on Influence of TCM Herbs for Tonifying Qi and Kidney,and Replenishing Spleen To Children with Intermittent Asthma(No.SF-2007-Ⅲ-16)
文摘OBJECTIVE: To evaluate the efficacy and safety of Traditional Chinese Medicine(TCM) herbs for tonifying Qi and kidney, and replenishing spleen on intermittent asthma in children aged 2 and 5 years.METHODS: A randomized, single-blind, placebo controlled trial was conducted. Children with intermittent asthma were enrolled and their baseline conditions were measured using a questionnaire. A total of 60 participants, aged 2 to 5, were randomized into either the treatment group(n = 40) or the placebo group(n = 20). The treatment group was treated with granules of TCM herbs for tonifying Qi and kidney, and replenishing spleen, and the placebo group was given placebo granules for 3 months.The number of asthma attacks was counted and TCM syndrome scores were measured at 1, 2, 3, 6, 9,and 12 months. The airway resistance and levels of eosinophil cationic protein for the two groups were observed before and after 3 months. The results were statistically analyzed.RESULTS: Compared with the placebo group, the number of asthma attacks significantly decreased in the treatment group(P < 0.05). For the treatment group, the TCM syndrome scores decreased after 1 and 2 months; there was also a significant difference in scores between the two groups(P < 0.05).The difference remained after the medicine was stopped for 9 months(P < 0.05). After the 3-month treatment, compared with the placebo group, the airway resistance decreased in the treatment group(P < 0.05). No adverse events were reported in the treatment group.CONCLUSION: The TCM herbs for tonifying Qi and kidney, and replenishing spleen reduced the number of intermittent asthma attacks, decreased the TCM syndrome scores, and reduced the airway resistance in the children aged 2 to 5.
文摘目的 观察中医不同治法对大鼠骨质疏松症模型骨骼、骨骼肌中钙调神经磷酸酶(Calcineurin, CaN)、T细胞活化核因子(Nuclear Factor of the Activated T cell, NFAT)含量的影响,探讨中医药治疗骨质疏松症的分子机制。方法 将雌性SD大鼠随机分为正常组、模型对照组、补肾法组、健脾法组、活血法组。采用酶联免疫吸附(ELISA)法进行测定,比较不同组别CaN、NFAT的含量变化。结果 模型对照组与正常组比较,骨骼、骨骼肌的CaN含量有显著降低(P<0.01);补肾法组、健脾法组、活血法组与模型对照组比较,骨骼、骨骼肌的CaN的含量均明显升高(P<0.01),其中补肾法组升高程度比较明显,骨骼的CaN含量其次为活血法组,骨骼肌的CaN含量其次为健脾组。模型对照组与正常组比较,骨骼、骨骼肌的NFAT含量显著降低(P<0.01);补肾法组、健脾法组、活血法组与模型对照组比较,NFAT含量明显升高,其中补肾法组升高程度比较明显,其次为健脾法组。结论 (1)骨骼、骨骼肌中CaN、NFAT的含量变化可能与骨质疏松症的发生有一定的相关性。(2)补肾法和健脾法可明显改善骨质疏松症大鼠骨骼、骨骼肌中CaN、NFAT的含量,预防骨质疏松的发生发展。(3)中医不同治法能够有效改善骨质疏松,补肾法、健脾法是治疗骨质疏松的重要治法。
