CLINICAL APPLICATION OF CHINESE HERBS REMEDIES AS IMMUNOMODULATORS IN THE TREATMENT OF CANCER

IMMUNITY AND TUMOR Immune system has closely relation to the growth and development of tumor. One of its immune functions is to constantly recognize and kill malignant cells which develop from normal cells. The occurance of tumor indicates to some extent the failure of this "immune serveillance" function. Many studies have shown that the tumor cells of body have some tumor interrelative antigen that dose not exist in normal tissues. Tests in vitro

China Association of Chinese Medicine Paper notice for seminar on clinical application of TCM classic prescriptions and herbs in the treatment of emotional diseases

Hosted by ChinaAssociation of Chinese Medicine,and organized by World Journal of Integrated traditional and western Medicine,seminar on clinical application of TCM classic prescriptions and herbs in the treatment of emotional diseaseis planned to be held in Yichang,Hubei province from June 22nd to 24th.

CLINICAL OBSERVATION ON COMBINED TREATMENT OF VASCULAR DEMENTIA WITH ACUPUNCTURE, MOXIBUSTION AND CHINESE MEDICINAL HERBS

In the present study, the clinical effect of acupuncture, moxibustion plus Chinese medicinal herbs for treatment of 30 cases of vascular dementia (VD) was observed and their mechanisms were analyzed by determining the activity of SOD, LPO and GSH-Px. Results showed that after 2 months’combined treatment, of the 30 cases, 12 had marked improvement, 15 had improvement and 3 had not any improvement, with an effective rate of 90%; the activity of SOD and GSH-Px increased considerably while the content of LPO lowered strikingly. There were significant differences between pre-and post-treatment in the activity of SOD and GSH-Px and the content of LPO (P<0. 01). It reveals that this method is capable of improving VD patients’ clinical symptoms and signs such as headache, dizziness, hemi-paralysis or hemianesthesia, forced crying and laughing, etc.and also raising the ability of the body in removing oxygen free radical, and suppressing peroxidization of free radical to reduce its products, thereby alleviating the toxic effect of oxygen free radical on the brain tissues.

Treatment of Retinal Vein Obstruction with Acupuncture and Chinese Medicinal Herbs

We have treated thirty-two cases (52 eyes) of retinal vein obstruction by acupuncture and oral administration of Huo Xue Ming Mu Decoction. The total effective rate of 90.38% demonstrated that the treatment was definitely effective.

Application of external treatment of traditional Chinese medicine in the treatment of cancer-related fatigue

External treatment of traditional Chinese medicine(TCM),also known as external treatment of internal diseases,has many advantages,such as simple,easy to operate,cost-effective and so on.Therefore,external treatment of TCM is favored by the majority of medical workers.By consulting the domestic literature reports on the treatment of cancer-related fatigue(CRF),it is found that the external treatment of TCM has a significant effect on the intervention of CRF,and has a good effect on reducing fatigue,improving the quality of life and prolonging the survival time.The purpose of this paper is to summarize the application of several external treatments in this disease,and to provide a variety of references for clinical treatment of CRF.

Analysis of Traditional Chinese Medicine Syndromes and Treatment Laws of Diabetic Kidney Disease and the Action Mechanism of High-Frequency Chinese Herbs in the Treatment of Diabetic Kidney Disease Based on Real-World Study

Objective Our objective was to analyze the traditional Chinese medicine(TCM)syndrome and treatment laws of diabetic kidney disease(DKD)and the action mechanism of high-frequency Chinese herbs in the treatment of DKD based on realworldstudy.MethodsThe data of patients with DKD who had been treated in the First Hospital Affiliated to Henan Universityof ChineseMedicine from January1,2014to December 31,2021 were retrospectively analyzed through the hospital information management system.The contents of the cases were statistically analyzed using IBM SPsS Statistics 25 software,and the laws of DKDtreatment were summarized.Network pharmacology and molecular docking were used to analyze the action mechanism of high-frequency Chinese herbs in the treatment of DKD.ResultsThe data of a total of 1,201 patients with DKD were included,involving 72 kinds of TCM syndromes.Nine disease nature elements and six disease location elements were extracted,involving 405 Chinese herbs.The top five high-frequency Chinese herbs were Baizhu(Atractylodis Macrocephalae Rhizoma),Fuling(Poria),Huangqi(Astragali Radix),Chuanxiong(Chuanxiong Rhizoma),and Danshen(Salviae Miltiorrhizae Radix et Rhizoma).Thirty kinds of Chinese herbs with the frequency of≥100 were mainly deficiency-tonifying herbs and blood-activating and stasis-eliminating herbs.The medicinal properties were mainly warm and mild,and the medicinal flavors were sweet and bitter mostly.For the meridian tropism,the main meridian tropism of these herbs is spleen meridian and lung meridian.The clustering method.

Effects of Integrated Chinese Herbs and Western Medicine on Swine Toxoplasmosis

[ Objective] To evaluate the efficacy of integrated Chinese herbs and western medicine on the treatment of swine toxoplasmosis, in order to increase cure rate and lower recurrence rate. [ Method] Pigs artificially infected by Toxoplasma gondii were treated with compound suffonamide and a self-designed Chinese herbs formula, and the quantities of toxoplasma in ascites were determined. Animal regression experiment was per- formed after mice were inoculated with pathological samples of the pigs infected with toxoplasma. After treatment with integrated Chinese herbs and western medicine, the clinical manifestations of pigs were observed and the level of circulating antigen （CAg） in sera was detected. Curative effect indexes of integrated Chinese herbs and western medicine-treated group were compared with that of Chinese herbs-treated group, western medi- cine-treated group and positive control group. [ Result] All the toxoplasma trophozoites were killed by integrated and westem medicine. Regression expedment results showed that toxoplasma appeared only in one mouse that was inoculated with brain of pig. The treated pigs had nonsignificant clinical symptoms; the peak of serum CAg was lower than that of the positive control group and CAg turned negative faster than that of Chinese herbs-treated group, westem medicine-treated group, and positive control group. [ Conclusion] The integrated Chinese herbs and western medicine has good effect on the treatment of swine toxoplasmosis.

Kinematic improvement after the external-application herbs combine rehabilitation in upper-limb spasticity due to stroke

Background: Spasm is one of the most serious physical impairment after stroke. the external-application herbs have showed some effects on the spasm. This study was conducted to evaluate the comparative effectiveness of the external-application herbs and physical therapy in upper limb spasticity after stroke. Methods: A total of 100 patients with upper limb spasm after stroke (stroke time less than 1 month), have been recruited in Shun-yi Hospital of Beijing Traditional Chinese Medicine Hospital. Patients will be randomly allotted to one of two groups (N = 50, respectively): the TCM external application group, and the usual rehab (conventional physical therapy and medication treatment) group. The two groups will be administered once a month for three months. The primary outcome will be Modified Athworth Scale (MAS) and the simplified scale (Fugl-Meyer assessment, FMA) for upper limb. Results: Muscle tension and motor function were evaluated before and 4 weeks after treatments. There was a significant improvement in muscle tension and motor function in patients with stroke after the external-application herbs and physical therapy (P < 0.05). Conclusion: There was a significant improvement in kinematics in patients with stroke.

Traditional Chinese medicine for prevention and treatment of hepatocarcinoma: From bench to bedside

Traditional Chinese medicine(TCM) has played a positive role in the management of hepatocarcinoma. Hepatocarcinoma patients may present Qi-stagnation, damp-heat, blood stasis, Qi-deficiency, Yin-deficiency and other TCM syndromes(Zheng). Modern treatments such as surgery, transarterial chemoembolization(TACE) and high intensity focus ultrasound treatment would influence the manifestation of TCM syndromes. Herbs with traditional efficacy of tonifying Qi, blood and Yin, soothing liver-Qi stagnation, clearing heat and detoxifying and dissolving stasis, have been demonstrated to be potent to prevent hepatocarcinogenesis. TCM has been widely used in all aspects of integrative therapy in hepatocarcinoma, including surgical resection, liver transplantation, TACE, local ablative therapies and even as monotherapy for middle-advanced stage hepatocarcinoma. Clinical practices have confirmed that TCM is effective to alleviate clinical symptoms, improve quality of life and immune function, prevent recurrence and metastasis, delay tumor progression, and prolong survival time in hepatocarcinoma patients. The effective mechanism of TCM against hepatocarcinoma is related to inducing apoptosis, autophagy, anoikis and cell senescence, arresting cell cycle, regulating immune function, inhibiting metastasis and angiogenesis, reversing drug resistance and enhancing effects of chemotherapy. Along with the progress of research in this field, TCM will contribute more to the prevention and treatment of hepatocarcinoma.

Traditional Chinese Medicinal Syndromes and Treatment in Colorectal Cancer

Colorectal cancer remains the third most common malignancy worldwide. According to the principles of Traditional Chinese Medicine (TCM), colorectal cancer is related to spleen-deficiency, damp-heat, and toxicity accumulation. Traditional Chinese medicine has been confirmed to effectively reduce toxic side effects and enhance curative effects of chemotherapy, palliate clinical syndrome, prevent recurrence and metastasis, improve quality of life and immune function, and prolong survival time in colorectal cancer. However, TCM theoretical and syndrome differentiation study has lagged far behind due to progression of therapy model in colorectal cancer. As a type of drug treatment, there are some common biological basis between chemotherapy, targeted therapy and anti-cancer herb therapy in colorectal cancer, such as apoptosis, cell senescence and autophagy. There are growing needs to explore the effect mechanism and compatibility of anti-cancer herbs, to further enhance the efficacy of TCM treatment in colorectal cancer.

Study on Early Application of Chinese Medicinal Herbs after Total Gastrectomy

Objective: To evaluate the effect of Chinese medicinal herbs on digestive function, nutritional status, immune function and complication rate in patients after total gastrectomy. Methods: Thirty-nine patients performed total gastrectomy were divided into two groups and had their small intestine intubated for administering medicine postoperatively. Twenty-one of them belonged to the treated group and had Chinese medicinal herbs dripped into their small intestine intraluminally during the early postoperative stage, while the 18 cases in the control group were dripped with 0.9% sodium chloride. Results: The digestive function of the treated group recovered rapidly, and the nutritional status and immune function improved markedly as compared with those of the control group (P<0.01-0.05). Conclusion: Early application of Chinese medicinal herbs after total gastrectomy could promote the digestive function to recover to normal, and improve the nutritional status and immune function. And occurrence of complication was reduced.

Clinical Study on Application of Chinese Herbs during the Perioperative Period of Laparoscopic Cholecystectomy

Objective： To explore the effect of Chinese herbs during the perioperative period of laparoscopic cholecystectomy （LC）. Methods： Three hundred and sixty patients of chronic lithic cholecystitis （LOOT） were randomly assigned to two groups by lottery, 180 patients in each group. During the peri-operative period, the control group was treated with conventional Western medicine and placebo. The treated group was given the same conventional Western medicine and Chinese herbal decoctions, with Shitong mixture No. 1 （石通1号） added before LC, and Liujunzi decoction （六君子汤） added after LC for three days. The operation time, body temperature after LC, white blood cell count, wind-breaking time after operation, as well as the changes of tongue coating in the first three post-operative days were recorded. Results： There was no significant difference between the two groups in operation time （P〉0.05）, while the improvement in body temperature recovery, windbreaking time and changes of tongue coating in the treated group were better than those in the control group （P〈0.01）. Conclusion： Applying Chinese herbs during perioperative period of LC could effectively benefit early recovery in such patients.

The clinical application of Governor moxibustion in China

Governor moxibustion is a type of external treatment in traditional Chinese medicine that remains being little understood This article briefly describes the current status, limitations, and future development of the clinical application of Governor moxibustion, to facilitate its use in treatment and health care

新型特色水药罐的设计和应用

目的:研制一种新型特色水药罐,以提高水药罐的操作便利性、密封性、保温性及牢固性。方法:新型特色水药罐材质为树脂类,由双层保温罐体、单向排气阀、调节开关、活塞、风琴软管和弹簧组成。其中双层保温罐体的罐壁为内部中空的双层结构;调节开关的中部设有长方形滑动孔;活塞由活塞杆、尾座和活塞头组成;弹簧位于开关底座旁,上端和调节开关连接,下端和双层保温罐体连接。结果:相较于传统特色水药罐,新型特色水药罐用于拔罐所需时间更短,药液洒漏量更少,拔罐前后药液温差更小。结论:新型特色水药罐临床操作简便、密封性强、保温性能良好、不易破碎,是一种适合临床推广使用的拔罐器具。

Research and Development of New Chinese Materia Medica for Treatment of Refractory Hematopathy by Establishment and Application of Multiple Technique Platforms

Research Objective and Overview It is necessary to find effective Chinese materia medica （CMM） for the treatment of refractory hematopathy as commonly used prednisone, androgen and immune suppression agents of tendemonstrate poor efficacy and serious side effects.

“筋揉骨正”中医特色疗法在股骨粗隆间骨折术后康复中的应用

目的:基于“筋揉骨正”理论观察中医特色康复疗法在股骨粗隆间骨折患者术后康复中的应用效果。方法:回顾性分析天津中医药大学第二附属医院2021年6月至2022年6月收治的股骨粗隆间骨折住院患者84例,按照治疗方法不同分为对照组和观察组,每组42例。对照组采用Intertan或PFNA髓内钉固定手术治疗,观察组在其基础上结合中医特色三期辨证治疗。比较2组疗效、中医证候积分、髋关节功能、骨强度及并发症。结果:观察组治疗总有效率高于对照组,观察组治疗后的各项中医证候积分均低于对照组,差异有统计学意义(P<0.05)。观察组治疗后的Harris髋关节评分和骨密度值高于对照组,差异有统计学意义(P<0.05)。2组感染、下肢深静脉血栓、关节僵硬、压疮等并发症发生率差异无统计学意义(P>0.05)。结论:基于“筋揉骨正”理论采用中医特色康复疗法治疗股骨粗隆间骨折术后康复效果显著,可以提高患者髋关节功能和骨密度,安全性良好。

中医舌诊客观化研究进展

该文对舌诊的发展进行简要介绍,阐述了舌诊图像信息的采集、预处理以及分析技术等舌诊客观化研究及近5年的关于舌诊客观化在呼吸系统、循环系统、消化系统、泌尿系统、内分泌系统等方面临床应用进行综述,旨在为舌诊客观化研究提供参考,为舌诊的深入全面发展提供新思路。

中药制剂在烧伤治疗中的应用进展

中药制剂主要分为中药合剂、方剂及单方等。其中,中药合剂具有抗休克、控制感染、促进创面愈合、控制瘢痕增生及瘙痒等作用,在烧伤治疗中应用广泛;方剂的剂型众多,临床上主要用于保护创面及促进创面修复;单方因其成分较为单一,故其种类繁多,多为民间流传,具有取材方便、用法简单等优点,主要应用于Ⅰ度Ⅱ度的烧伤创面的治疗。文章从中医角度辩证分析中药制剂的效用,并从促进皮肤组织生长、抑制炎症反应、抗休克、调控胶原蛋白代谢等角度阐述其加速创面愈合和抑制瘢痕增生的作用机制。未来,应进一步完善中药制剂作用机制和临床疗效评价体系的研究。

多期组学特征联合应用在经中医药联合微创术综合治疗后肝癌早期复发中的预测价值

目的:探究基于多期CT影像组学特征联合应用在肝癌经中医药联合微创术综合治疗后早期复发的预测价值。方法:选取104例已确诊肝癌病例在接受综合治疗前一个月内的上腹部CT平扫及增强检查图像,用单因素和多因素Logistic分析筛选与肝癌早期复发相关的临床独立预测因素;使用ITK-snap软件对平扫期、动脉期、门静脉期图像进行病灶勾画,利用K最佳、LASSO对提取的组学特征进行筛选,使用LR、SVM、RF模型算法为筛选好的特征构建组学预测模型,通过AUC值、敏感度、特异度及ROC曲线等指标评估模型的预测效能,最后使在最优模型算法基础上具有稳健预测效能及高特异度的组学模型与临床独立预测因素结合构建综合预测模型。结果:通过Logistic分析发现肿瘤直径≥5 cm(P=0.05)、多发肿瘤(P=0.04)、门静脉栓塞(P=0.04)是与肝癌复发相关的临床独立预测因素;此外,在3种模型算法中SVM模型算法预测性能最好,并基于此模型算法构建的三期组学模型预测效能稳健(AUC值为0.96)且特异度最高(97%),使之与临床独立预测因素结合构建的综合模型AUC值为0.94,特异度为98.5%。结论:多期组学特征联合应用并与临床特征变量共同构建的综合模型可高效且准确地预测综合治疗肝癌病例的早期复发情况。

不同施钾处理对甘蓝型油菜菜薹产量和品质的影响

为了探究不同施钾技术对甘蓝型油菜菜薹产量和品质的影响,笔者通过对高钾含量品种(玉油7号)、较高钾含量品种(中双8号)和低钾含量品种(保油10号)进行不同施钾处理,摘取菜薹进行产量和品质指标测定。结果表明,不同施钾处理能提高菜薹产量,玉油7号产量有所增加,但其产量远低于其他2个油菜品种,中双8号在T3处理下菜薹产量最高(20.66 kg·小区^(-1)),保油10号在T8处理下菜薹产量最高(23.30 kg·小区^(-1));中双8号在T1处理下菜薹可溶性糖和可溶性蛋白质含量最高,T3处理下钾含量最高,T4处理下游离氨基酸含量最高,而保油10号在T2处理下综合营养品质最高。高钾含量油菜品种玉油7号不适合作为摘薹品种,中双8号提高施钾量有利于油菜菜薹产量和品质的提高,保油10号在抽薹期追施钾肥有利于菜薹产量的增加,一定范围内提高施钾量也有利于其营养品质的提高。