The response of the upper-ocean temperatures and currents in the tropical Pacific to the spatial distribution of chlorophyll-a and its seasonal cycle is investigated using a coupled atmosphere-ocean model and a stand-...The response of the upper-ocean temperatures and currents in the tropical Pacific to the spatial distribution of chlorophyll-a and its seasonal cycle is investigated using a coupled atmosphere-ocean model and a stand-alone oceanic general circulation model.The spatial distribution of chlorophyll-a significantly influences the mean state of models in the tropical Pacific.The annual mean SST in the eastern equatorial Pacific decreases accompanied by a shallow thermocline and stronger currents because of shallow penetration depth of solar radiation.Equatorial upwelling dominates the heat budget in that region.Atmosphere-ocean interaction processes can further amplify such changes. The seasonal cycle of chlorophyll-a can dramatically change ENSO period in the coupled model.After introducing the seasonal cycle of chlorophyll-a concentration,the peak of the power spectrum becomes broad,and longer periods(3 years) are found.These changes led to ENSO irregularities in the model. The increasing period is mainly due to the slow speed of Rossby waves,which are caused by the shallow mean thermocline in the northeastern Pacific.展开更多
The algorithms of extracting chlorophyll-a (Chl-a) concentration have been established for Chinese moderate resolution imaging spectrometer (CMODIS) mounted on Shenzhou-3 spaceship launched on 25 March 2002. The C...The algorithms of extracting chlorophyll-a (Chl-a) concentration have been established for Chinese moderate resolution imaging spectrometer (CMODIS) mounted on Shenzhou-3 spaceship launched on 25 March 2002. The CMODIS is an ocean color sensor with 30 visible channels and 4 infrared channels, much different from other ocean color satellites and needs new algorithms to process data. Three models of Chl-a concentration were established based on Chl-a data retrieved from sea-viewing wide field-ofview sensor (SeaWiFS), with the average relative errors of 26. 6%, 24%. 0% and 33.5%, respectively. This practical and economic approach can be used for developing the algorithms of Chinese ocean color and temperature sensor (COCTS) on the satellite Haiyang-1 to derive the Chl-a concentration concentration distribution. The applicability of the algorithms was analyzed using some in situ measurements. Suspended sediment is the main factor influencing the accuracy of the spectral ratio algorithms of Chl-a concentration. The algorithms are suitable to using in the regions where suspended sediment concentrations ( SSC ) are less than 5 g/m^3 under the condition of relative error of Chl-a concentration retrieval within 35%. High concentration of suspended sediment leads to the overestimate remote sensing retrieval of concentration of Chl-a, while low-middle SSCs lead to the low Chl-a concentration values using the spectral ratio algorithms. Since the accuracy of Chl-a concentration by the spectral ratio algorithms is limited to waters of Case 2, it is necessary to develop semi-analytical models to improve the performance of satellite ocean color remote sensing in turbid coastal waters.展开更多
In this paper seven of the ten Water Control Zones (WCZs) in Hong Kong's coastal waters with monthly or bi-weekly sampling data of 17 parameters collected at 37 monitoring stations from 1988 to 1999 were selected ...In this paper seven of the ten Water Control Zones (WCZs) in Hong Kong's coastal waters with monthly or bi-weekly sampling data of 17 parameters collected at 37 monitoring stations from 1988 to 1999 were selected to analyze the spatial and temporal variations of chlorophyll-a and its influencing factors. Cluster analysis was employed to group the monitoring stations based on the structure of the data set. Multiple step regression was employed to determine the significant influencing factors of chlorophyll-a level. The results suggest that all the monitoring stations could be grouped into two clusters. Cluster Ⅰ with frequent red tide incidents comprises two WCZs which are semi-enclosed bays. Cluster Ⅱ with less red tide occurrence comprises the other five WCZs in an estuarine environment in the west. For both clusters, the organic contents indicator, BODS, was a common significant influencing factor of the chlorophyll-a level. Nitrogen and light penetration condition related to turbidity, total volatile solids and suspended solids had more influence on the cholophyll-a level in Cluster Ⅰ than in Cluster Ⅱ, while phosphorus and oceanographic conditions associated with salinity, temperature, dissolved oxygen and pH were more important in Cluster Ⅱ than in Cluster Ⅰ. Generally, there was a higher average chlorophyll-a level in winter and autumn in a year. The chlorophyll-a level was much higher in Cluster Ⅰ than in Cluster Ⅱ among all seasons. Although the chlorophyll-a concentration had great variations from place to place in Hong Kong's coastal waters, it seemed to have a common long term fluctuation period of 8-10 years with a high-low-high variation in the period in the whole region, which might be influenced by other factors of global scale.展开更多
The chlorophyll-a concentration is generally overestimated for the southern China coastalwaters if the default algorithm of the SeaDAS is employed. An algorithm is developed for retrieval of chlorophyll-a concentratio...The chlorophyll-a concentration is generally overestimated for the southern China coastalwaters if the default algorithm of the SeaDAS is employed. An algorithm is developed for retrieval of chlorophyll-a concentration in the Zhujiang Estuary, Guangdong Province, China, by using simulated reflectance data. The simulated reflectance is calculated corresponding to the SeaWiFS wavelength bands, via a general model by inputting measured water components, i.e. , the suspended sediment, chlorophyll-a, and yellow substance (DOC) concentration data of 130 samples. Empirical relationships of the chlorophyll-a concentration to 240 different band combinations are investigated based on the simulated reflectance data, and the band combination, R_5R_5/R_3R_4, is found to be the optimum one for the development of an algorithm valid for the Zhujiang Estuary. This algorithm is then employed to determine the chlorophyll-a concentration from SeaWiFS data. The estimated concentrations have a better accuracy than those obtained from the SeaDAS default algorithm when compared with sea truth data. The new algorithm is demonstrated to work well and is used to derive a series of image maps of the chlorophyll-a concentration distribution for the Zhujiang Estuary and adjacent coastal areas.展开更多
Ocean colour remote sensing is one of the conventional methods in satellite oceanography used to study the biological response of the upper ocean to the tropical cyclones. This paper aims to study the impact of the Ve...Ocean colour remote sensing is one of the conventional methods in satellite oceanography used to study the biological response of the upper ocean to the tropical cyclones. This paper aims to study the impact of the Very Severe Cyclonic storm PHAILIN, and its consequence on the surface chlorophyll-aconcentration distribution in the Bay of Bengal using Oceansat-2 Ocean Colour Monitor (OCM). The impact of this cyclone on ocean primary productivity has been studied using MODIS-A data. Sea surface temperature (SST) plays an important role in the generation of primary productivity along with the other oceanographic parameters;SST patterns in the Bay of Bengal during the cyclone period were studied. From the analysis, it is observed that the chlorophyll-aconcentration has increased from 1.08 (before) to 7.06 mg/m3 after the cyclone with an SST drop of ~3°C (29.19°C to 26°C). The primary productivity has increased from 410.0506 to 779.9814 mg/C/m2/day after the cyclone. In addition to the above analysis, an attempt has also been made to study the impact of cyclone intensity on the chlorophyll concentration. The study shows that the comparison between cyclone intensity (CI) and chlorophyll concentration shows a positive relationship.展开更多
Chlorophyll-a (Chl-a) concentration in lakes can tell a lot about a lake’s water quality and ecosystem. It is a measure of the amount of algae growing in a waterbody and can be used to monitor the trophic condition o...Chlorophyll-a (Chl-a) concentration in lakes can tell a lot about a lake’s water quality and ecosystem. It is a measure of the amount of algae growing in a waterbody and can be used to monitor the trophic condition of a waterbody. We studied the pre and post effects of marine ranch construction in Chl-a concentration in Zhelin Bay, Southern China using Normalized Difference Chlorophyll Index (NDCI) and a web-based tool (https://mapcoordinates.info/). We used 8 day composite MODIS image collections of 500 m resolution and randomly selected two stations to extract the chlorophyll-a concentration values through the web-based tool. We recorded the slight increase in NDCI values in all stations after the construction of marine ranch which is a good indicator of the marine organisms’ reproduction and survival.展开更多
AIM:To compare high or low concentration of hyaluronic acid eye drops(HY)for dry eye syndromes(DES).METHODS:Randomized controlled trials(RCTs)comparing various concentrations of HY were searched in PubMed,Embase,Web o...AIM:To compare high or low concentration of hyaluronic acid eye drops(HY)for dry eye syndromes(DES).METHODS:Randomized controlled trials(RCTs)comparing various concentrations of HY were searched in PubMed,Embase,Web of Science,Cochrane,SinoMed,CNKI,Wanfang Database,CQVIP,and Chinese journals databases between inception and July 2023.Pooled standardized mean differences(SMD)or weighted mean difference(WMD)with 95%confidence intervals(CI)from RCTs evaluating Schirmer’s I test(SIT),corneal fluorescein staining score(CFS),tear breakup time(TBUT),DES score(DESS),and Ocular Surface Disease Index(OSDI)were calculated.Sensitivity analysis,Egger’s test and Meta-regression analysis were performed for all indicators.RESULTS:We conducted a Meta-analysis of 10 RCTs that met the inclusion criteria,involving 1796 cases.High-concentrations group significantly improved the outcome of CFS according to random effects modelling(SMD,-3.37;95%CI,-5.25 to-1.48;P=0.0005).The rest of the results were not statistically significant,including indicators such as SIT,TBUT,DESS and OSDI.CONCLUSION:For dry eyes with positive corneal staining,a high concentration of HY is recommended,whereas in other cases,a high concentration of HY does not offer a more pronounced advantage over a low concentration of HY in the treatment of dry eyes.展开更多
The study of non-axisymmetric fuel dispersal and detonation can provide reference for the prevention of industrial cloud explosion accidents and the design of fuel air explosive(FAE).The concentration and detonation f...The study of non-axisymmetric fuel dispersal and detonation can provide reference for the prevention of industrial cloud explosion accidents and the design of fuel air explosive(FAE).The concentration and detonation fields of 85 kg cylindrical and fan-shaped fuel are investigated by experiments and numerical simulations.A dynamic model of the whole process for fuel dispersal and detonation is built.The concentration distribution of fuel is used as the initial condition to calculate the detonation stage,thus solving the initial value problem of detonation field.The phase and component changes of fuel cloud at different locations are compared.The fuel cloud is divided into directions of 0°,90°,135°and 180°.The results show that the maximum cloud radius is 20.94 m in 135°and the minimum is 12.04 m in 0°.The diameter of the detonation fireball is 53.6 m,and the peak temperature is 3455 K.The highest peak overpressure is 3.44 MPa in 0°and the lowest is 2.97 MPa in 135°.The proportion of liquid phase in 0°is22.90%,and the fuel loss is 11.8% and 9% higher than that in 135°and cylindrical charge,respectively.The stable propagation distance of blast wave in 135°is 42.50% longer than 0°and 28.37% longer than cylindrical charge.展开更多
Nitrogen(N), phosphorus(P), and potassium(K) are essential macronutrients that are crucial not only for maize growth and development, but also for crop yield and quality. The genetic basis of macronutrient dynamics an...Nitrogen(N), phosphorus(P), and potassium(K) are essential macronutrients that are crucial not only for maize growth and development, but also for crop yield and quality. The genetic basis of macronutrient dynamics and accumulation during grain filling in maize remains largely unknown. In this study, we evaluated grain N, P, and K concentrations in 206 recombinant inbred lines generated from a cross of DH1M and T877 at six time points after pollination. We then calculated conditional phenotypic values at different time intervals to explore the dynamic characteristics of the N, P, and K concentrations. Abundant phenotypic variations were observed in the concentrations and net changes of these nutrients. Unconditional quantitative trait locus(QTL) mapping revealed 41 non-redundant QTLs, including 17, 16, and 14 for the N, P, and K concentrations, respectively. Conditional QTL mapping uncovered 39 non-redundant QTLs related to net changes in the N, P, and K concentrations. By combining QTL, gene expression, co-expression analysis, and comparative genomic data, we identified 44, 36, and 44 candidate genes for the N, P, and K concentrations, respectively, including GRMZM2G371058 encoding a Doftype zinc finger DNA-binding family protein, which was associated with the N concentration, and GRMZM2G113967encoding a CBL-interacting protein kinase, which was related to the K concentration. The results deepen our understanding of the genetic factors controlling N, P, and K accumulation during maize grain development and provide valuable genes for the genetic improvement of nutrient concentrations in maize.展开更多
BACKGROUND In vitro expansion to increase numbers of hematopoietic stem cells(HSCs)in cord blood could improve clinical efficacy of this vital resource.Nicotinamide(NAM)can promote HSC expansion ex vivo,but its effect...BACKGROUND In vitro expansion to increase numbers of hematopoietic stem cells(HSCs)in cord blood could improve clinical efficacy of this vital resource.Nicotinamide(NAM)can promote HSC expansion ex vivo,but its effect on hematopoietic stem and progenitor cells(HSPCs,CD34^(+)CD38)and functional subtypes of HSCs-shortterm repopulating HSCs(ST-HSCs,CD34^(+)CD38CD45RACD49f^(+))and long-term repopulating HSCs(LT-HSCs,CD34^(+)CD38CD45RACD49f^(+)CD90^(+))is not yet known.As a sirtuin 1(SIRT1)inhibitor,NAM participates in regulating cell adhesion,polarity,migration,proliferation,and differentiation.However,SIRT1 exhibits dual effects by promoting or inhibiting differentiation in different tissues or cells.We propose that the concentration of NAM may influence proliferation,differentiation,and SIRT1 signaling of HSCs.AIM To evaluate the effects and underlying mechanisms of action of different concentrations of NAM on HSC proliferation and differentiation.METHODS CD34^(+)cells were purified from umbilical cord blood using MacsCD34 beads,and cultured for 10-12 d in a serum-free medium supplemented with cytokines,with different concentrations of NAM added according to experimental requirements.Flow cytometry was used to detect phenotype,cell cycle distribution,and apoptosis of the cultured cells.Real-time polymerase chain reaction was used to detect the transcription levels of target genes encoding stemness-related factors,che mokines,components of hypoxia pathways,and antioxidant enzymes.Dichloro-dihydro-fluorescein diacetate probes were used to evaluate intracellular production of reactive oxygen species(ROS).Determination of the effect of different culture conditions on the balance of cytokine by cytometric bead array.RESULTS Compared with the control group,the proportion and expansion folds of HSPCs(CD34^(+)CD38)incubated with 5 mmol/L or 10 mmol/L NAM were significantly increased(all P<0.05).The ST-HSCs ratio and fold expansion of the 5 mmol/L NAM group were significantly higher than those of the control and 10 mmol/L NAM groups(all P<0.001),whereas the LT-HSCs ratio and fold expansion of the 10 mmol/L NAM group were significantly higher than those of the other two groups(all P<0.05).When the NAM concentration was>10 mmol/L,cell viability significantly decreased.In addition,compared with the 5 mmol/L NAM group,the proportion of apoptotic cells in the 10 mmol/L NAM group increased and the proportion of cells in S and G2 phase decreased.Compared with the 5 mmol/L NAM group,the HSCs incubated with 10 mmol/L NAM exhibited significantly inhibited SIRT1 expression,increased intracellular ROS content,and downregulated expression of genes encoding antioxidant enzymes(superoxide dismutase 1,peroxiredoxin 1).CONCLUSION Low concentrations(5 mmol/L)of NAM can better regulate the balance between proliferation and differentiation,thereby promoting expansion of HSCs.These findings allow adjustment of NAM concentrations according to expansion needs.展开更多
Cemented paste backfill(CPB)is a key technology for green mining in metal mines,in which tailings thickening comprises the primary link of CPB technology.However,difficult flocculation and substandard concentrations o...Cemented paste backfill(CPB)is a key technology for green mining in metal mines,in which tailings thickening comprises the primary link of CPB technology.However,difficult flocculation and substandard concentrations of thickened tailings often occur.The rheological properties and concentration evolution in the thickened tailings remain unclear.Moreover,traditional indoor thickening experiments have yet to quantitatively characterize their rheological properties.An experiment of flocculation condition optimization based on the Box-Behnken design(BBD)was performed in the study,and the two response values were investigated:concentration and the mean weighted chord length(MWCL)of flocs.Thus,optimal flocculation conditions were obtained.In addition,the rheological properties and concentration evolution of different flocculant dosages and ultrafine tailing contents under shear,compression,and compression-shear coupling experimental conditions were tested and compared.The results show that the shear yield stress under compression and compression-shear coupling increases with the growth of compressive yield stress,while the shear yield stress increases slightly under shear.The order of shear yield stress from low to high under different thickening conditions is shear,compression,and compression-shear coupling.Under compression and compression-shear coupling,the concentration first rapidly increases with the growth of compressive yield stress and then slowly increases,while concentration increases slightly under shear.The order of concentration from low to high under different thickening conditions is shear,compression,and compression-shear coupling.Finally,the evolution mechanism of the flocs and drainage channels during the thickening of the thickened tailings under different experimental conditions was revealed.展开更多
In this paper,the formation process,morphology,and electrochemical performance of PEO coatings on AM50 magnesium alloy prepared in low concentration phosphate,aluminate,and phosphate-aluminate electrolytes were system...In this paper,the formation process,morphology,and electrochemical performance of PEO coatings on AM50 magnesium alloy prepared in low concentration phosphate,aluminate,and phosphate-aluminate electrolytes were systematically studied.The results show that the coatings prepared from the phosphate electrolytes have a higher thickness and better corrosion resistance properties compared to the other electrolytes.The coatings prepared from low concentration phosphate-aluminate mixed electrolytes have slightly thinner thickness,a similar coating structure and an order of magnitude lower value of electrochemical impedance compared with phosphate electrolyte coatings.The Coatings prepared from low concentration aluminate electrolytes have the lowest thickness and the worst corrosion resistance properties which gets close to corrosion behavior of the bare AM50 under the same test conditions.Considering application,coatings prepared from single low concentration phosphate electrolytes and low concentration phosphate-aluminate electrolytes have greater potential than single low concentration aluminate coatings.However,reducing the electrolyte concentrations of coating forming ions too much has negative influence on the coating growth rate.展开更多
To effectively extract multi-scale information from observation data and improve computational efficiency,a multi-scale second-order autoregressive recursive filter(MSRF)method is designed.The second-order autoregress...To effectively extract multi-scale information from observation data and improve computational efficiency,a multi-scale second-order autoregressive recursive filter(MSRF)method is designed.The second-order autoregressive filter used in this study has been attempted to replace the traditional first-order recursive filter used in spatial multi-scale recursive filter(SMRF)method.The experimental results indicate that the MSRF scheme successfully extracts various scale information resolved by observations.Moreover,compared with the SMRF scheme,the MSRF scheme improves computational accuracy and efficiency to some extent.The MSRF scheme can not only propagate to a longer distance without the attenuation of innovation,but also reduce the mean absolute deviation between the reconstructed sea ice concentration results and observations reduced by about 3.2%compared to the SMRF scheme.On the other hand,compared with traditional first-order recursive filters using in the SMRF scheme that multiple filters are executed,the MSRF scheme only needs to perform two filter processes in one iteration,greatly improving filtering efficiency.In the two-dimensional experiment of sea ice concentration,the calculation time of the MSRF scheme is only 1/7 of that of SMRF scheme.This means that the MSRF scheme can achieve better performance with less computational cost,which is of great significance for further application in real-time ocean or sea ice data assimilation systems in the future.展开更多
BACKGROUND Prior studies have noted great variability in the plasma levels of risperidone(RIS).Plasma concentrations of RIS and its active moiety are highly variable and depend on absorption,metabolism,and other predi...BACKGROUND Prior studies have noted great variability in the plasma levels of risperidone(RIS).Plasma concentrations of RIS and its active moiety are highly variable and depend on absorption,metabolism,and other predictors of metabolic dysregulation;however,these factors are poorly understood and the association between metabolic change and change in psychopathology is uncertain.AIM To ascertain the characteristics of chronic schizophrenic patients treated with RIS,and to assess their relationship with plasma RIS levels.METHODS This was a descriptive cross-sectional study of 50 patients with a diagnosis of schizophrenic psychosis treated with RIS in a psychiatric service.The plasma concentrations of RIS and its metabolite 9-hydroxyrisperidone were determined by high performance liquid chromatography.The patients’demographic and clinical characteristics,and psychopathologies were assessed,and the associations between clinical variables and plasma levels of RIS were explored.RESULTS Male patients received higher doses of RIS than female ones,but plasma concentrations of RIS and risperidone+9-hydroxyrisperidone(active moiety)were higher in female patients.Age and the mean scores of the general psychopathology subscale of the Positive and Negative Syndrome Scale(PANSS)were significantly positively correlated with plasma concentrations of risperidone+9-hydroxyrisperidone adjusted for weight and dose in all 50 subjects.In male subjects,we found a statistically significant positive correlation between the concentrations of risperidone+9-hydroxyrisperidone in plasma/(dose×kg)and age,mean PANSS negative subscale scores,mean PANSS general psychopathology subscale scores,and mean PANSS total scores.CONCLUSION Long-term use of RIS should be closely monitored in older patients and females to minimize the risk of high concentrations which could induce side effects.展开更多
Wide-field-of-view(WFV) imager that observes the earth environment with four solar reflective bands in a spatial resolution of 16 m is equipped on board Gaofen-1(GF-1) satellite. Chlorophyll-a(Chl-a) concentration in ...Wide-field-of-view(WFV) imager that observes the earth environment with four solar reflective bands in a spatial resolution of 16 m is equipped on board Gaofen-1(GF-1) satellite. Chlorophyll-a(Chl-a) concentration in Lake Taihu, China from 2018 to 2019 is collected and collocated with GF-1 satellite data. This study develops a general and reliable estimation of Chl-a concentration from GF-1 WFV data under turbid inland water conditions. The collocated data are classified according to season and used in random forest(RF) regression to train models for retrieving the lake Chl-a concentration. A composite index is developed to select the most important variables in the models. The models trained for each season show a better performance than the model trained by using the whole year data in terms of the coefficient of determination(R^(2)) between retrievals and observations. Specifically, the R2 values in spring, summer, autumn, and winter are 0.88, 0.88, 0.94, and 0.74, respectively;whereas that using the whole year data is only 0.71. The Chl-a concentration in Lake Taihu exhibits an obvious seasonal change with the highest in summer, followed by autumn and spring, and the lowest in winter. The Chl-a concentration also displays an obvious spatial variation with season. A high concentration occurs mainly in the northwest of the lake. The temporal and spatial changes of Chl-a concentration are almost consistent with the changes in the areas and times of cyanobacteria blooms based on Moderate Resolution Imaging Spectroradiometer(MODIS) data. The proposed algorithm can be operated without a priori knowledge on atmospheric conditions and water quality. Our study also demonstrates that GF-1 data are increasingly valuable for monitoring the Chl-a concentration of inland water bodies in China at a high spatial resolution.展开更多
The Luanchuan molybdenum polymetallic mine concentration area is rich in mineral resources and has a long history of mining.The environmental impact of long-term mining activities cannot be ignored.It is of great sign...The Luanchuan molybdenum polymetallic mine concentration area is rich in mineral resources and has a long history of mining.The environmental impact of long-term mining activities cannot be ignored.It is of great significance to study the ecological risk and the accumulation trends of heavy metals in the soil of mining areas for scientific prevention and control of heavy metal pollution.Taking the Taowanbeigou River Basin in the mine concentration area as the research object,the ecological pollution risk and cumulative effect of heavy metals in the soil of the basin were studied by using the comprehensive pollution index method,potential ecological risk assessment method and geoaccumulation index method.On this basis,the cumulative exceeding years of specific heavy metals were predicted by using the early warning model.The comprehensive potential ecological risk of heavy metals in the soil near the Luanchuan mine concentration area is moderate,and the single element Cd is the main ecological risk factor,with a contribution rate of 53.6%.The overall cumulative degrees of Cu and Pb in the soil are“none-moderate”,Zn and Cd are moderate,Mo has reached an extremely strong cumulative level,Hg,As and Cr risks are not obvious,and the overall cumulative risks order is Mo>Cd>Zn>Cu>Pb>Hg.According to the current accumulation rate and taking the risk screening values for soil contamination of agricultural land as the reference standard,the locations over standard rates of Cu,Zn and Cd will exceed 78%in 90years,and the over standard rate of Pb will reach approximately 57%in 200 years.The cumulative exceeding standard periods of As,Cr and Hg are generally long,which basically indicates that these elements do not pose a significant potential threat to the ecological environment.Mining activities will accelerate the accumulation of heavy metals in soil.With the continuous development of mining activities,the potential pollution risk of heavy metals in the soil of mining areas will also increase.展开更多
Delays in sowing have significant effects on the grain yield,yield components,and grain protein concentrations of winter wheat.However,little is known about how delayed sowing affects these characteristics at differen...Delays in sowing have significant effects on the grain yield,yield components,and grain protein concentrations of winter wheat.However,little is known about how delayed sowing affects these characteristics at different positions in the wheat spikes.In this study,the effects of sowing date were investigated in a winter wheat cultivar,Shannong 30,which was sown in 2019 and 2020 on October 8(normal sowing)and October 22(late sowing)under field conditions.Delayed sowing increased the partitioning of ^(13)C-assimilates to spikes,particularly to florets at the apical section of a spike and those occupying distal positions on the same spikelet.Consequently,the increase in grain number was the greatest for the apical sections,followed by the basal and central sections.No significant differences were observed between sowing dates in the superior grain number in the basal and central sections,while the number in apical sections was significantly different.The number of inferior grains in each section also increased substantially in response to delayed sowing.The average grain weights in all sections remained unchanged under delayed sowing because there were parallel increases in grain number and ^(13)C-assimilate partitioning to grains at specific positions in the spikes.Increases in grain number m^(–2) resulted in reduced grain protein concentrations as the limited nitrogen supply was diluted into more grains.Delayed sowing caused the greatest reduction in grain protein concentration in the basal sections,followed by the central and apical sections.No significant differences in the reduction of the grain protein concentration were observed between the inferior and superior grains under delayed sowing.In conclusion,a 2-week delay in sowing improved grain yield through increased grain number per spike,which originated principally from an increased grain number in the apical sections of spikes and in distal positions on the same spikelet.However,grain protein concentrations declined in each section because of the increased grain number and reduced N uptake.展开更多
Old-growth forests play a key-role in reducing atmospheric carbon dioxide(CO_(2)) concentrations by storing large CO_(2)amounts in biomass and soil over time.This quantifies the carbon pool into different forest compa...Old-growth forests play a key-role in reducing atmospheric carbon dioxide(CO_(2)) concentrations by storing large CO_(2)amounts in biomass and soil over time.This quantifies the carbon pool into different forest compartments in three Mediterranean old-growth forests of Southern Italy populated by Pinus laricio,Fagus sylvatica and Abies alba.Ecosystem carbon pools have been assessed per compartment,i.e.,living trees,dead wood,litterfall(foliar and woody),roots and 0-20 cm topsoil,combining the whole old-growth forest mass,(i.e.,using tree allometric relationships,deadwood factor conversions,root-to-shoot ratios,litterfall and soil samplings) by the respective organic carbon concentrations.The results show the considerable capacity of these forest ecosystems in storing CO_(2)in biomass and soil,with carbon pool values ranging from 532.2to 596.5 Mg C ha-1.Living trees and 0-20 cm topsoil had larger carbon pool,contributing 53.0 and 22.1%,respectively.In most cases,organic carbon concentration was higher(more than 60%) than the average carbon conversion rate of 50%,especially in living trees,deadwood,and woody litterfall.This study contributes further scientific evidence of the capacity of old-growth forests in storing CO_(2)in their different compartments,with special evidence on tree biomass,litterfall and mineral soil,thereby highlighting the key role of old-growth forests within the challenge of climate change mitigation.展开更多
AIM:To evaluate effects of endogenous dopamine induced by low concentration atropine eye drops on choroidal neovascularization(CNV)in high myopia mice.METHODS:The C57BL/6J mice were deprived of the right eye for 4wk,a...AIM:To evaluate effects of endogenous dopamine induced by low concentration atropine eye drops on choroidal neovascularization(CNV)in high myopia mice.METHODS:The C57BL/6J mice were deprived of the right eye for 4wk,and the high myopia was diagnosed by optometry,the diopter was less than-6.00 D,and CNV was induced by 532 nm laser.The changes of dopamine D1 receptor(DRD1),dopamine D2 receptor(DRD2),and vascular endothelial growth factor A(VEGFA)were detected by Western blot technology at 0.5,1,2h,and 7d after 0.01%,0.05%,and 0.1%atropine eye drops,respectively,the area of CNV was measured.RESULTS:Significant increases were observed on the expression of DRD2 in mouse high myopia model at 0.5,1,2h,7d with 0.05%and 0.1%atropine eye drops(P<0.05).Significant decreases were observed on the expression of DRD1 and VEGFA in mouse high myopia model at 0.5,1,2h,7d with 0.05%and 0.1%atropine eye drops(P<0.05).The area of CNV induced by laser in the drug-treated group was significantly smaller than that in the control group,and the higher the concentration,the more significant the inhibitory effect(P<0.05).CONCLUSION:The 0.01%,0.05%,0.1%atropine eye drops can decrease the level of VEGFA and inhibit high myopia CNV indirectly by up-regulating the level of DRD2 and down-regulating the level of DRD1,and the effect of 0.05%and 0.1%atropine eye drops is more significant.展开更多
Aqueous foam is broadly applicable to enhanced oil recovery(EOR).The rheology of foam as a function of foam quality,gas and liquid velocities,and surfactant concentration constitute the foundation of its application.T...Aqueous foam is broadly applicable to enhanced oil recovery(EOR).The rheology of foam as a function of foam quality,gas and liquid velocities,and surfactant concentration constitute the foundation of its application.The great variations of the above factors can affect the effectiveness of N2 foam in EOR continuously in complex formations,which is rarely involved in previous relevant studies.This paper presents an experimental study of foam flow in porous media by injecting pre-generated N2 foam into a sand pack under the conditions of considering a wide range of gas and liquid velocities and surfactant concentrations.The results show that in a wide range of gas and liquid velocities,the pressure gradient contours are L-shaped near the coordinate axes,but V-shaped in other regions.And the surfactant concentration is a strong factor influencing the trend of pressure gradient contours.Foam flow resistance is very sensitive to the surfactant concentration in both the high-and low-foam quality regime,especially when the surfactant concentration is less than CMC.The foam quality is an important variable to the flow resistance obtained.There exists a transition point from low-to high-quality regime in a particular flow system,where has the maximum flow resistance,the corresponding foam quality is called transition foam quality,which increases as the surfactant concentration increases.The results can add to our knowledge base of foam rheology in porous media,and can provide a strong basis for the field application of foams.展开更多
基金supported by the National Basic Research Program of China (also called 973 Program,Grant Nos.2010CB428904, 2007CB411806,2006CB403600)the National Natural Science Foundation of China under Grant Nos.40775054, 40906012.
文摘The response of the upper-ocean temperatures and currents in the tropical Pacific to the spatial distribution of chlorophyll-a and its seasonal cycle is investigated using a coupled atmosphere-ocean model and a stand-alone oceanic general circulation model.The spatial distribution of chlorophyll-a significantly influences the mean state of models in the tropical Pacific.The annual mean SST in the eastern equatorial Pacific decreases accompanied by a shallow thermocline and stronger currents because of shallow penetration depth of solar radiation.Equatorial upwelling dominates the heat budget in that region.Atmosphere-ocean interaction processes can further amplify such changes. The seasonal cycle of chlorophyll-a can dramatically change ENSO period in the coupled model.After introducing the seasonal cycle of chlorophyll-a concentration,the peak of the power spectrum becomes broad,and longer periods(3 years) are found.These changes led to ENSO irregularities in the model. The increasing period is mainly due to the slow speed of Rossby waves,which are caused by the shallow mean thermocline in the northeastern Pacific.
基金This study was supported by the National Natural Science Foundation of China under contract Nos 40576080 and 40006011the National"863"Program of China under contract Nos 2002AA639220 and 2007AA12Z182.
文摘The algorithms of extracting chlorophyll-a (Chl-a) concentration have been established for Chinese moderate resolution imaging spectrometer (CMODIS) mounted on Shenzhou-3 spaceship launched on 25 March 2002. The CMODIS is an ocean color sensor with 30 visible channels and 4 infrared channels, much different from other ocean color satellites and needs new algorithms to process data. Three models of Chl-a concentration were established based on Chl-a data retrieved from sea-viewing wide field-ofview sensor (SeaWiFS), with the average relative errors of 26. 6%, 24%. 0% and 33.5%, respectively. This practical and economic approach can be used for developing the algorithms of Chinese ocean color and temperature sensor (COCTS) on the satellite Haiyang-1 to derive the Chl-a concentration concentration distribution. The applicability of the algorithms was analyzed using some in situ measurements. Suspended sediment is the main factor influencing the accuracy of the spectral ratio algorithms of Chl-a concentration. The algorithms are suitable to using in the regions where suspended sediment concentrations ( SSC ) are less than 5 g/m^3 under the condition of relative error of Chl-a concentration retrieval within 35%. High concentration of suspended sediment leads to the overestimate remote sensing retrieval of concentration of Chl-a, while low-middle SSCs lead to the low Chl-a concentration values using the spectral ratio algorithms. Since the accuracy of Chl-a concentration by the spectral ratio algorithms is limited to waters of Case 2, it is necessary to develop semi-analytical models to improve the performance of satellite ocean color remote sensing in turbid coastal waters.
基金National Natural Science Foundation of China, No.47176032
文摘In this paper seven of the ten Water Control Zones (WCZs) in Hong Kong's coastal waters with monthly or bi-weekly sampling data of 17 parameters collected at 37 monitoring stations from 1988 to 1999 were selected to analyze the spatial and temporal variations of chlorophyll-a and its influencing factors. Cluster analysis was employed to group the monitoring stations based on the structure of the data set. Multiple step regression was employed to determine the significant influencing factors of chlorophyll-a level. The results suggest that all the monitoring stations could be grouped into two clusters. Cluster Ⅰ with frequent red tide incidents comprises two WCZs which are semi-enclosed bays. Cluster Ⅱ with less red tide occurrence comprises the other five WCZs in an estuarine environment in the west. For both clusters, the organic contents indicator, BODS, was a common significant influencing factor of the chlorophyll-a level. Nitrogen and light penetration condition related to turbidity, total volatile solids and suspended solids had more influence on the cholophyll-a level in Cluster Ⅰ than in Cluster Ⅱ, while phosphorus and oceanographic conditions associated with salinity, temperature, dissolved oxygen and pH were more important in Cluster Ⅱ than in Cluster Ⅰ. Generally, there was a higher average chlorophyll-a level in winter and autumn in a year. The chlorophyll-a level was much higher in Cluster Ⅰ than in Cluster Ⅱ among all seasons. Although the chlorophyll-a concentration had great variations from place to place in Hong Kong's coastal waters, it seemed to have a common long term fluctuation period of 8-10 years with a high-low-high variation in the period in the whole region, which might be influenced by other factors of global scale.
基金This research was supported by the project of the Chinese Academy of Sciences (CAS) under the contract No. KZCX2 - 202 the International Cooperation Program of Guangdong Province under the contract No. 99M05004Z the Scienc Foundation Program of Guan
文摘The chlorophyll-a concentration is generally overestimated for the southern China coastalwaters if the default algorithm of the SeaDAS is employed. An algorithm is developed for retrieval of chlorophyll-a concentration in the Zhujiang Estuary, Guangdong Province, China, by using simulated reflectance data. The simulated reflectance is calculated corresponding to the SeaWiFS wavelength bands, via a general model by inputting measured water components, i.e. , the suspended sediment, chlorophyll-a, and yellow substance (DOC) concentration data of 130 samples. Empirical relationships of the chlorophyll-a concentration to 240 different band combinations are investigated based on the simulated reflectance data, and the band combination, R_5R_5/R_3R_4, is found to be the optimum one for the development of an algorithm valid for the Zhujiang Estuary. This algorithm is then employed to determine the chlorophyll-a concentration from SeaWiFS data. The estimated concentrations have a better accuracy than those obtained from the SeaDAS default algorithm when compared with sea truth data. The new algorithm is demonstrated to work well and is used to derive a series of image maps of the chlorophyll-a concentration distribution for the Zhujiang Estuary and adjacent coastal areas.
文摘Ocean colour remote sensing is one of the conventional methods in satellite oceanography used to study the biological response of the upper ocean to the tropical cyclones. This paper aims to study the impact of the Very Severe Cyclonic storm PHAILIN, and its consequence on the surface chlorophyll-aconcentration distribution in the Bay of Bengal using Oceansat-2 Ocean Colour Monitor (OCM). The impact of this cyclone on ocean primary productivity has been studied using MODIS-A data. Sea surface temperature (SST) plays an important role in the generation of primary productivity along with the other oceanographic parameters;SST patterns in the Bay of Bengal during the cyclone period were studied. From the analysis, it is observed that the chlorophyll-aconcentration has increased from 1.08 (before) to 7.06 mg/m3 after the cyclone with an SST drop of ~3°C (29.19°C to 26°C). The primary productivity has increased from 410.0506 to 779.9814 mg/C/m2/day after the cyclone. In addition to the above analysis, an attempt has also been made to study the impact of cyclone intensity on the chlorophyll concentration. The study shows that the comparison between cyclone intensity (CI) and chlorophyll concentration shows a positive relationship.
文摘Chlorophyll-a (Chl-a) concentration in lakes can tell a lot about a lake’s water quality and ecosystem. It is a measure of the amount of algae growing in a waterbody and can be used to monitor the trophic condition of a waterbody. We studied the pre and post effects of marine ranch construction in Chl-a concentration in Zhelin Bay, Southern China using Normalized Difference Chlorophyll Index (NDCI) and a web-based tool (https://mapcoordinates.info/). We used 8 day composite MODIS image collections of 500 m resolution and randomly selected two stations to extract the chlorophyll-a concentration values through the web-based tool. We recorded the slight increase in NDCI values in all stations after the construction of marine ranch which is a good indicator of the marine organisms’ reproduction and survival.
文摘AIM:To compare high or low concentration of hyaluronic acid eye drops(HY)for dry eye syndromes(DES).METHODS:Randomized controlled trials(RCTs)comparing various concentrations of HY were searched in PubMed,Embase,Web of Science,Cochrane,SinoMed,CNKI,Wanfang Database,CQVIP,and Chinese journals databases between inception and July 2023.Pooled standardized mean differences(SMD)or weighted mean difference(WMD)with 95%confidence intervals(CI)from RCTs evaluating Schirmer’s I test(SIT),corneal fluorescein staining score(CFS),tear breakup time(TBUT),DES score(DESS),and Ocular Surface Disease Index(OSDI)were calculated.Sensitivity analysis,Egger’s test and Meta-regression analysis were performed for all indicators.RESULTS:We conducted a Meta-analysis of 10 RCTs that met the inclusion criteria,involving 1796 cases.High-concentrations group significantly improved the outcome of CFS according to random effects modelling(SMD,-3.37;95%CI,-5.25 to-1.48;P=0.0005).The rest of the results were not statistically significant,including indicators such as SIT,TBUT,DESS and OSDI.CONCLUSION:For dry eyes with positive corneal staining,a high concentration of HY is recommended,whereas in other cases,a high concentration of HY does not offer a more pronounced advantage over a low concentration of HY in the treatment of dry eyes.
基金supported by the National Key Research and Development Program of China (Grant No.2021YFC3001204)。
文摘The study of non-axisymmetric fuel dispersal and detonation can provide reference for the prevention of industrial cloud explosion accidents and the design of fuel air explosive(FAE).The concentration and detonation fields of 85 kg cylindrical and fan-shaped fuel are investigated by experiments and numerical simulations.A dynamic model of the whole process for fuel dispersal and detonation is built.The concentration distribution of fuel is used as the initial condition to calculate the detonation stage,thus solving the initial value problem of detonation field.The phase and component changes of fuel cloud at different locations are compared.The fuel cloud is divided into directions of 0°,90°,135°and 180°.The results show that the maximum cloud radius is 20.94 m in 135°and the minimum is 12.04 m in 0°.The diameter of the detonation fireball is 53.6 m,and the peak temperature is 3455 K.The highest peak overpressure is 3.44 MPa in 0°and the lowest is 2.97 MPa in 135°.The proportion of liquid phase in 0°is22.90%,and the fuel loss is 11.8% and 9% higher than that in 135°and cylindrical charge,respectively.The stable propagation distance of blast wave in 135°is 42.50% longer than 0°and 28.37% longer than cylindrical charge.
基金supported by the Seed Industry Revitalization Project of Jiangsu Province,China(JBGS[2021]009)the National Natural Science Foundation of China(32061143030 and 31972487)+3 种基金the Jiangsu Province University Basic Science Research Project,China(21KJA210002)the Key Research and Development Program of Jiangsu Province,China(BE2022343)the Innovative Research Team of Universities in Jiangsu Province,China,the High-end Talent Project of Yangzhou University,China,the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD),Chinathe Qing Lan Project of Jiangsu Province,China。
文摘Nitrogen(N), phosphorus(P), and potassium(K) are essential macronutrients that are crucial not only for maize growth and development, but also for crop yield and quality. The genetic basis of macronutrient dynamics and accumulation during grain filling in maize remains largely unknown. In this study, we evaluated grain N, P, and K concentrations in 206 recombinant inbred lines generated from a cross of DH1M and T877 at six time points after pollination. We then calculated conditional phenotypic values at different time intervals to explore the dynamic characteristics of the N, P, and K concentrations. Abundant phenotypic variations were observed in the concentrations and net changes of these nutrients. Unconditional quantitative trait locus(QTL) mapping revealed 41 non-redundant QTLs, including 17, 16, and 14 for the N, P, and K concentrations, respectively. Conditional QTL mapping uncovered 39 non-redundant QTLs related to net changes in the N, P, and K concentrations. By combining QTL, gene expression, co-expression analysis, and comparative genomic data, we identified 44, 36, and 44 candidate genes for the N, P, and K concentrations, respectively, including GRMZM2G371058 encoding a Doftype zinc finger DNA-binding family protein, which was associated with the N concentration, and GRMZM2G113967encoding a CBL-interacting protein kinase, which was related to the K concentration. The results deepen our understanding of the genetic factors controlling N, P, and K accumulation during maize grain development and provide valuable genes for the genetic improvement of nutrient concentrations in maize.
基金the Science and Technology Department of Shanxi Province,No.YDZJSX2021B009Health Commission of Shanxi Province,No.2021XM07Shanxi Provincial Department of Education,No.2023KY380.
文摘BACKGROUND In vitro expansion to increase numbers of hematopoietic stem cells(HSCs)in cord blood could improve clinical efficacy of this vital resource.Nicotinamide(NAM)can promote HSC expansion ex vivo,but its effect on hematopoietic stem and progenitor cells(HSPCs,CD34^(+)CD38)and functional subtypes of HSCs-shortterm repopulating HSCs(ST-HSCs,CD34^(+)CD38CD45RACD49f^(+))and long-term repopulating HSCs(LT-HSCs,CD34^(+)CD38CD45RACD49f^(+)CD90^(+))is not yet known.As a sirtuin 1(SIRT1)inhibitor,NAM participates in regulating cell adhesion,polarity,migration,proliferation,and differentiation.However,SIRT1 exhibits dual effects by promoting or inhibiting differentiation in different tissues or cells.We propose that the concentration of NAM may influence proliferation,differentiation,and SIRT1 signaling of HSCs.AIM To evaluate the effects and underlying mechanisms of action of different concentrations of NAM on HSC proliferation and differentiation.METHODS CD34^(+)cells were purified from umbilical cord blood using MacsCD34 beads,and cultured for 10-12 d in a serum-free medium supplemented with cytokines,with different concentrations of NAM added according to experimental requirements.Flow cytometry was used to detect phenotype,cell cycle distribution,and apoptosis of the cultured cells.Real-time polymerase chain reaction was used to detect the transcription levels of target genes encoding stemness-related factors,che mokines,components of hypoxia pathways,and antioxidant enzymes.Dichloro-dihydro-fluorescein diacetate probes were used to evaluate intracellular production of reactive oxygen species(ROS).Determination of the effect of different culture conditions on the balance of cytokine by cytometric bead array.RESULTS Compared with the control group,the proportion and expansion folds of HSPCs(CD34^(+)CD38)incubated with 5 mmol/L or 10 mmol/L NAM were significantly increased(all P<0.05).The ST-HSCs ratio and fold expansion of the 5 mmol/L NAM group were significantly higher than those of the control and 10 mmol/L NAM groups(all P<0.001),whereas the LT-HSCs ratio and fold expansion of the 10 mmol/L NAM group were significantly higher than those of the other two groups(all P<0.05).When the NAM concentration was>10 mmol/L,cell viability significantly decreased.In addition,compared with the 5 mmol/L NAM group,the proportion of apoptotic cells in the 10 mmol/L NAM group increased and the proportion of cells in S and G2 phase decreased.Compared with the 5 mmol/L NAM group,the HSCs incubated with 10 mmol/L NAM exhibited significantly inhibited SIRT1 expression,increased intracellular ROS content,and downregulated expression of genes encoding antioxidant enzymes(superoxide dismutase 1,peroxiredoxin 1).CONCLUSION Low concentrations(5 mmol/L)of NAM can better regulate the balance between proliferation and differentiation,thereby promoting expansion of HSCs.These findings allow adjustment of NAM concentrations according to expansion needs.
基金financially supported by the National Natural Science Foundation of China(Nos.52130404 and 52304121)the Fundamental Research Funds for the Central Universities(No.FRF-TP-22-112A1)+4 种基金the Guangdong Basic and Applied Basic Research Foundation(No.2021A 1515110161)the ANID(Chile)through Fondecyt project 1210610the Centro de Modelamiento Matemático(BASAL funds for Centers of Excellence FB210005)the CRHIAM project ANID/FONDAP/15130015 and ANID/FONDAP/1523A0001the Anillo project ANID/ACT210030。
文摘Cemented paste backfill(CPB)is a key technology for green mining in metal mines,in which tailings thickening comprises the primary link of CPB technology.However,difficult flocculation and substandard concentrations of thickened tailings often occur.The rheological properties and concentration evolution in the thickened tailings remain unclear.Moreover,traditional indoor thickening experiments have yet to quantitatively characterize their rheological properties.An experiment of flocculation condition optimization based on the Box-Behnken design(BBD)was performed in the study,and the two response values were investigated:concentration and the mean weighted chord length(MWCL)of flocs.Thus,optimal flocculation conditions were obtained.In addition,the rheological properties and concentration evolution of different flocculant dosages and ultrafine tailing contents under shear,compression,and compression-shear coupling experimental conditions were tested and compared.The results show that the shear yield stress under compression and compression-shear coupling increases with the growth of compressive yield stress,while the shear yield stress increases slightly under shear.The order of shear yield stress from low to high under different thickening conditions is shear,compression,and compression-shear coupling.Under compression and compression-shear coupling,the concentration first rapidly increases with the growth of compressive yield stress and then slowly increases,while concentration increases slightly under shear.The order of concentration from low to high under different thickening conditions is shear,compression,and compression-shear coupling.Finally,the evolution mechanism of the flocs and drainage channels during the thickening of the thickened tailings under different experimental conditions was revealed.
基金China Scholarship Council for the award of fellowship and funding(No.202006370022).
文摘In this paper,the formation process,morphology,and electrochemical performance of PEO coatings on AM50 magnesium alloy prepared in low concentration phosphate,aluminate,and phosphate-aluminate electrolytes were systematically studied.The results show that the coatings prepared from the phosphate electrolytes have a higher thickness and better corrosion resistance properties compared to the other electrolytes.The coatings prepared from low concentration phosphate-aluminate mixed electrolytes have slightly thinner thickness,a similar coating structure and an order of magnitude lower value of electrochemical impedance compared with phosphate electrolyte coatings.The Coatings prepared from low concentration aluminate electrolytes have the lowest thickness and the worst corrosion resistance properties which gets close to corrosion behavior of the bare AM50 under the same test conditions.Considering application,coatings prepared from single low concentration phosphate electrolytes and low concentration phosphate-aluminate electrolytes have greater potential than single low concentration aluminate coatings.However,reducing the electrolyte concentrations of coating forming ions too much has negative influence on the coating growth rate.
基金The National Key Research and Development Program of China under contract No.2023YFC3107701the National Natural Science Foundation of China under contract No.42375143.
文摘To effectively extract multi-scale information from observation data and improve computational efficiency,a multi-scale second-order autoregressive recursive filter(MSRF)method is designed.The second-order autoregressive filter used in this study has been attempted to replace the traditional first-order recursive filter used in spatial multi-scale recursive filter(SMRF)method.The experimental results indicate that the MSRF scheme successfully extracts various scale information resolved by observations.Moreover,compared with the SMRF scheme,the MSRF scheme improves computational accuracy and efficiency to some extent.The MSRF scheme can not only propagate to a longer distance without the attenuation of innovation,but also reduce the mean absolute deviation between the reconstructed sea ice concentration results and observations reduced by about 3.2%compared to the SMRF scheme.On the other hand,compared with traditional first-order recursive filters using in the SMRF scheme that multiple filters are executed,the MSRF scheme only needs to perform two filter processes in one iteration,greatly improving filtering efficiency.In the two-dimensional experiment of sea ice concentration,the calculation time of the MSRF scheme is only 1/7 of that of SMRF scheme.This means that the MSRF scheme can achieve better performance with less computational cost,which is of great significance for further application in real-time ocean or sea ice data assimilation systems in the future.
基金Supported by Shanghai Civil Administration Bureau,No.8-2-50.
文摘BACKGROUND Prior studies have noted great variability in the plasma levels of risperidone(RIS).Plasma concentrations of RIS and its active moiety are highly variable and depend on absorption,metabolism,and other predictors of metabolic dysregulation;however,these factors are poorly understood and the association between metabolic change and change in psychopathology is uncertain.AIM To ascertain the characteristics of chronic schizophrenic patients treated with RIS,and to assess their relationship with plasma RIS levels.METHODS This was a descriptive cross-sectional study of 50 patients with a diagnosis of schizophrenic psychosis treated with RIS in a psychiatric service.The plasma concentrations of RIS and its metabolite 9-hydroxyrisperidone were determined by high performance liquid chromatography.The patients’demographic and clinical characteristics,and psychopathologies were assessed,and the associations between clinical variables and plasma levels of RIS were explored.RESULTS Male patients received higher doses of RIS than female ones,but plasma concentrations of RIS and risperidone+9-hydroxyrisperidone(active moiety)were higher in female patients.Age and the mean scores of the general psychopathology subscale of the Positive and Negative Syndrome Scale(PANSS)were significantly positively correlated with plasma concentrations of risperidone+9-hydroxyrisperidone adjusted for weight and dose in all 50 subjects.In male subjects,we found a statistically significant positive correlation between the concentrations of risperidone+9-hydroxyrisperidone in plasma/(dose×kg)and age,mean PANSS negative subscale scores,mean PANSS general psychopathology subscale scores,and mean PANSS total scores.CONCLUSION Long-term use of RIS should be closely monitored in older patients and females to minimize the risk of high concentrations which could induce side effects.
基金Supported by the National Key Research and Development Program of China(2018YFC1506500)Foundation for Key Scientific Research of Jiangsu Meteorological Bureau(KZ202003)。
文摘Wide-field-of-view(WFV) imager that observes the earth environment with four solar reflective bands in a spatial resolution of 16 m is equipped on board Gaofen-1(GF-1) satellite. Chlorophyll-a(Chl-a) concentration in Lake Taihu, China from 2018 to 2019 is collected and collocated with GF-1 satellite data. This study develops a general and reliable estimation of Chl-a concentration from GF-1 WFV data under turbid inland water conditions. The collocated data are classified according to season and used in random forest(RF) regression to train models for retrieving the lake Chl-a concentration. A composite index is developed to select the most important variables in the models. The models trained for each season show a better performance than the model trained by using the whole year data in terms of the coefficient of determination(R^(2)) between retrievals and observations. Specifically, the R2 values in spring, summer, autumn, and winter are 0.88, 0.88, 0.94, and 0.74, respectively;whereas that using the whole year data is only 0.71. The Chl-a concentration in Lake Taihu exhibits an obvious seasonal change with the highest in summer, followed by autumn and spring, and the lowest in winter. The Chl-a concentration also displays an obvious spatial variation with season. A high concentration occurs mainly in the northwest of the lake. The temporal and spatial changes of Chl-a concentration are almost consistent with the changes in the areas and times of cyanobacteria blooms based on Moderate Resolution Imaging Spectroradiometer(MODIS) data. The proposed algorithm can be operated without a priori knowledge on atmospheric conditions and water quality. Our study also demonstrates that GF-1 data are increasingly valuable for monitoring the Chl-a concentration of inland water bodies in China at a high spatial resolution.
基金supported by the Science and Technology Research Project to Henan Provincial Department of Natural Resources(Henan Natural Resources Letter[2019]373–10)。
文摘The Luanchuan molybdenum polymetallic mine concentration area is rich in mineral resources and has a long history of mining.The environmental impact of long-term mining activities cannot be ignored.It is of great significance to study the ecological risk and the accumulation trends of heavy metals in the soil of mining areas for scientific prevention and control of heavy metal pollution.Taking the Taowanbeigou River Basin in the mine concentration area as the research object,the ecological pollution risk and cumulative effect of heavy metals in the soil of the basin were studied by using the comprehensive pollution index method,potential ecological risk assessment method and geoaccumulation index method.On this basis,the cumulative exceeding years of specific heavy metals were predicted by using the early warning model.The comprehensive potential ecological risk of heavy metals in the soil near the Luanchuan mine concentration area is moderate,and the single element Cd is the main ecological risk factor,with a contribution rate of 53.6%.The overall cumulative degrees of Cu and Pb in the soil are“none-moderate”,Zn and Cd are moderate,Mo has reached an extremely strong cumulative level,Hg,As and Cr risks are not obvious,and the overall cumulative risks order is Mo>Cd>Zn>Cu>Pb>Hg.According to the current accumulation rate and taking the risk screening values for soil contamination of agricultural land as the reference standard,the locations over standard rates of Cu,Zn and Cd will exceed 78%in 90years,and the over standard rate of Pb will reach approximately 57%in 200 years.The cumulative exceeding standard periods of As,Cr and Hg are generally long,which basically indicates that these elements do not pose a significant potential threat to the ecological environment.Mining activities will accelerate the accumulation of heavy metals in soil.With the continuous development of mining activities,the potential pollution risk of heavy metals in the soil of mining areas will also increase.
基金Financial support was received from the National Key Research and Development Program of China(2016YFD0300403 and 2017YFD0201705)。
文摘Delays in sowing have significant effects on the grain yield,yield components,and grain protein concentrations of winter wheat.However,little is known about how delayed sowing affects these characteristics at different positions in the wheat spikes.In this study,the effects of sowing date were investigated in a winter wheat cultivar,Shannong 30,which was sown in 2019 and 2020 on October 8(normal sowing)and October 22(late sowing)under field conditions.Delayed sowing increased the partitioning of ^(13)C-assimilates to spikes,particularly to florets at the apical section of a spike and those occupying distal positions on the same spikelet.Consequently,the increase in grain number was the greatest for the apical sections,followed by the basal and central sections.No significant differences were observed between sowing dates in the superior grain number in the basal and central sections,while the number in apical sections was significantly different.The number of inferior grains in each section also increased substantially in response to delayed sowing.The average grain weights in all sections remained unchanged under delayed sowing because there were parallel increases in grain number and ^(13)C-assimilate partitioning to grains at specific positions in the spikes.Increases in grain number m^(–2) resulted in reduced grain protein concentrations as the limited nitrogen supply was diluted into more grains.Delayed sowing caused the greatest reduction in grain protein concentration in the basal sections,followed by the central and apical sections.No significant differences in the reduction of the grain protein concentration were observed between the inferior and superior grains under delayed sowing.In conclusion,a 2-week delay in sowing improved grain yield through increased grain number per spike,which originated principally from an increased grain number in the apical sections of spikes and in distal positions on the same spikelet.However,grain protein concentrations declined in each section because of the increased grain number and reduced N uptake.
基金the project"Determination of carbon pools in old-growth forests located within the Sila National Park—CARBOSIL"funded by the Ministry of the Environment,Land and Sea Protection—Department for Nature Protection under the Directive on Biodiversity。
文摘Old-growth forests play a key-role in reducing atmospheric carbon dioxide(CO_(2)) concentrations by storing large CO_(2)amounts in biomass and soil over time.This quantifies the carbon pool into different forest compartments in three Mediterranean old-growth forests of Southern Italy populated by Pinus laricio,Fagus sylvatica and Abies alba.Ecosystem carbon pools have been assessed per compartment,i.e.,living trees,dead wood,litterfall(foliar and woody),roots and 0-20 cm topsoil,combining the whole old-growth forest mass,(i.e.,using tree allometric relationships,deadwood factor conversions,root-to-shoot ratios,litterfall and soil samplings) by the respective organic carbon concentrations.The results show the considerable capacity of these forest ecosystems in storing CO_(2)in biomass and soil,with carbon pool values ranging from 532.2to 596.5 Mg C ha-1.Living trees and 0-20 cm topsoil had larger carbon pool,contributing 53.0 and 22.1%,respectively.In most cases,organic carbon concentration was higher(more than 60%) than the average carbon conversion rate of 50%,especially in living trees,deadwood,and woody litterfall.This study contributes further scientific evidence of the capacity of old-growth forests in storing CO_(2)in their different compartments,with special evidence on tree biomass,litterfall and mineral soil,thereby highlighting the key role of old-growth forests within the challenge of climate change mitigation.
文摘AIM:To evaluate effects of endogenous dopamine induced by low concentration atropine eye drops on choroidal neovascularization(CNV)in high myopia mice.METHODS:The C57BL/6J mice were deprived of the right eye for 4wk,and the high myopia was diagnosed by optometry,the diopter was less than-6.00 D,and CNV was induced by 532 nm laser.The changes of dopamine D1 receptor(DRD1),dopamine D2 receptor(DRD2),and vascular endothelial growth factor A(VEGFA)were detected by Western blot technology at 0.5,1,2h,and 7d after 0.01%,0.05%,and 0.1%atropine eye drops,respectively,the area of CNV was measured.RESULTS:Significant increases were observed on the expression of DRD2 in mouse high myopia model at 0.5,1,2h,7d with 0.05%and 0.1%atropine eye drops(P<0.05).Significant decreases were observed on the expression of DRD1 and VEGFA in mouse high myopia model at 0.5,1,2h,7d with 0.05%and 0.1%atropine eye drops(P<0.05).The area of CNV induced by laser in the drug-treated group was significantly smaller than that in the control group,and the higher the concentration,the more significant the inhibitory effect(P<0.05).CONCLUSION:The 0.01%,0.05%,0.1%atropine eye drops can decrease the level of VEGFA and inhibit high myopia CNV indirectly by up-regulating the level of DRD2 and down-regulating the level of DRD1,and the effect of 0.05%and 0.1%atropine eye drops is more significant.
基金financially supported by National Natural Science Foundation of China(No.U20B6003).
文摘Aqueous foam is broadly applicable to enhanced oil recovery(EOR).The rheology of foam as a function of foam quality,gas and liquid velocities,and surfactant concentration constitute the foundation of its application.The great variations of the above factors can affect the effectiveness of N2 foam in EOR continuously in complex formations,which is rarely involved in previous relevant studies.This paper presents an experimental study of foam flow in porous media by injecting pre-generated N2 foam into a sand pack under the conditions of considering a wide range of gas and liquid velocities and surfactant concentrations.The results show that in a wide range of gas and liquid velocities,the pressure gradient contours are L-shaped near the coordinate axes,but V-shaped in other regions.And the surfactant concentration is a strong factor influencing the trend of pressure gradient contours.Foam flow resistance is very sensitive to the surfactant concentration in both the high-and low-foam quality regime,especially when the surfactant concentration is less than CMC.The foam quality is an important variable to the flow resistance obtained.There exists a transition point from low-to high-quality regime in a particular flow system,where has the maximum flow resistance,the corresponding foam quality is called transition foam quality,which increases as the surfactant concentration increases.The results can add to our knowledge base of foam rheology in porous media,and can provide a strong basis for the field application of foams.