Background:Choerospondias axillaris(CA)is a traditional Mongolian medicine that has been proven to have a good therapeutic effect on cerebrovascular disease.Cerebral Ischemia(CI)is a severe and life-threatening cerebr...Background:Choerospondias axillaris(CA)is a traditional Mongolian medicine that has been proven to have a good therapeutic effect on cerebrovascular disease.Cerebral Ischemia(CI)is a severe and life-threatening cerebrovascular disease.However,the specific mechanism of action of CA in the treatment of CI is still unclear.Methods:In this study,the related targets and pathways of CA in the treatment of CI were first predicted by system pharmacology and then verified by relevant experiments.Results:The results showed that 12 active ingredients and 208 targets were selected.Further validation through protein-protein interaction(PPI)network analysis and active ingredients-target-pathway(A-T-P)network analysis has confirmed the pivotal roles of the main bioactive constituents,including quercetin,kaempferol,naringin,β-sitosterol,and gallic acid.These components exert their anti-ischemic effects by modulating key targets such as IL6,TNF,MAPK3,and CASP3,thereby regulating the PI3K-Akt,HIF-1,and MAPK signaling pathways,which are integral to processes like inflammation,apoptosis,and oxidative stress.More importantly,through experimental verification,this study confirmed our prediction that CAE significantly reduced neurological function scores,infarct volume,and the percentage of apoptosis neurons.Conclusion:This indicates that CA acts on CI through multi-target synergistic mechanism,and this study provides theoretical basis for the clinical application of CA.展开更多
Changes in acidity of Udic Ferrosols, caused by growth of Choerospondias axillaris (Roxb.) Burtt et Hill, in comparison to wild grass, were investigated for pH distribution in the soil profile, exchangeable acidity, a...Changes in acidity of Udic Ferrosols, caused by growth of Choerospondias axillaris (Roxb.) Burtt et Hill, in comparison to wild grass, were investigated for pH distribution in the soil profile, exchangeable acidity, and cation status in the soil leachate of a simulated leaching experiment. Soils were sampled in profiles at 5 cm intervals to a depth of 100 cm. In the 15-60 cm layer the soils with 10-year old C. axillaris had significantly lower pH (P < 0.05), with the largest difference being 0.41; and in…展开更多
The bark of Choerospondias axillaris is not only an authentic medicine in Guangxi,but also one of the commonly used medicines of many ethnic minorities.This paper intends to study,summarize,and analyze the planting ar...The bark of Choerospondias axillaris is not only an authentic medicine in Guangxi,but also one of the commonly used medicines of many ethnic minorities.This paper intends to study,summarize,and analyze the planting area,harvesting and processing,processing technology,chemical composition,pharmacological action and the establishment and evaluation of quality standard of C.axillaris,in order to provide more reference basis for the development,research and utilization of Zhuang medicine C.axillaris and the establishment of quality standard.展开更多
Objective:To investigate the mechanism of treating chronic wounds in rats by using Zhuang medicine choerospondias axillaris bark.Methods: The whole layer skin defection 40 rats were used and randomly divided into 4 gr...Objective:To investigate the mechanism of treating chronic wounds in rats by using Zhuang medicine choerospondias axillaris bark.Methods: The whole layer skin defection 40 rats were used and randomly divided into 4 groups: normal group, model group, MEBO group, choerospondias group. The normal group and model group were given external deposited normal saline external application. MEBO group used MEBT/MEBO. Choerospondias group was given external deposited choerospondias axillaris bark water decoction external application. Detected cell ultrastructure, PTEN、VEGF mRNA after 12 d.Results: The organelle structure in MEBO group and choerospondias group were restored. In 12 d, PTEN in MEBO group and choerospondias group were lower, VEGF were higher than 1 d (P<0.05). PTEN in MEBO group and choerospondias group were lower, VEGF were higher than model group (P<0.05). MEBO group had no difference with choerospondias group (P>0.05). Conclusion: Choerospondias axillaris bark water decoction could remarkably improve the cell ultrastructure in chronic wounds, regulate the PTEN signal conduction effect, and promote wound healing.展开更多
Choerospondias axillaris is thought to be gaining popularity and economical significance,because of its nutritional and therapeutic values.This is because it contains bioactive compounds,such as polyphenols,which have...Choerospondias axillaris is thought to be gaining popularity and economical significance,because of its nutritional and therapeutic values.This is because it contains bioactive compounds,such as polyphenols,which have a variety of therapeutic uses.Fruits,seeds,and bark are just a few of the parts of C.axillaris that can be used for both therapeutic and everyday needs.It is regarded as an underutilized fruit despite offering significant health,nutritional,and medicinal benefits.Numerous important studies have been conducted to assess the pharmacological and medicinal qualities of C.axillaris in various applications.In this review article,we discussed about the general characteristics of C.axillaris,as well as its nutritional and phytochemical properties,and therapeutic applications.In-depth research on the various potential properties of various parts of C.axillaris is compiled in this review,along with a summary of the key findings.The pharmacological and therapeutic usage of C.axillaris have been studied for a variety of potential biological properties,such as antimicrobial,antitumor,anti-inflammatory,antidiabetic,improved cardiac function,second degree burns treatment,immune boosting,improved haematological parameters,anti-angiogenesis,and antihyperlipidemic.This is the reason applications for the food and pharmaceutical industries can be made.展开更多
ObjectiveTo investigate the effect of total flavones from the leaves of Choerospondias axillaris (TFLCA) on the immune function of normal mice and to provide the experimental basis for the reasonable application of C....ObjectiveTo investigate the effect of total flavones from the leaves of Choerospondias axillaris (TFLCA) on the immune function of normal mice and to provide the experimental basis for the reasonable application of C. axillaris.MethodsThe carbon clearance method, cutaneous delayed hypersensitivity reaction method, serum hemolysin method, and index of immune organs were used to study the effect of TFLCA on the immune function of mice.ResultsTFLCA could enhance the phagocytic function of mononuclear macrophage and the cutaneous delayed hypersensitivity reaction of mice, and increase the content of hemolysin antibody and the thymus index in mice.ConclusionTFLCA could improve the celiac macrophage activity and specific immunity of mice, and TFLCA, consisting with the total flavones of Choerospondiatis Fructus (TFCF), has the effect on the immune function of mice. So both TFLCA and TFCF have the regulatory effects on the immune function of mice.展开更多
采用响应面法超声提取广枣[Choerospondias axillaris(Roxb.)Burtt et Hill]中总黄酮,在单因素试验基础上,利用Design-Expert 8.0、5.0软件设计响应面试验,研究乙醇溶液体积分数、液料比、超声时间和超声温度对总黄酮提取率的影响。结...采用响应面法超声提取广枣[Choerospondias axillaris(Roxb.)Burtt et Hill]中总黄酮,在单因素试验基础上,利用Design-Expert 8.0、5.0软件设计响应面试验,研究乙醇溶液体积分数、液料比、超声时间和超声温度对总黄酮提取率的影响。结果表明,广枣中总黄酮的最佳超声提取工艺参数乙醇溶液体积分数为62%,超声提取时间为55 min,液料比为35.00∶1(V∶m),在此试验条件下广枣总黄酮平均提取率为3.472%。展开更多
Many underutilized fruit plants are still obscure,in spite of possessing high medicinal and nutritional properties.Here,we reviewed one of the underutilized fruits tree(Choerospondias axillaris)and explored its occurr...Many underutilized fruit plants are still obscure,in spite of possessing high medicinal and nutritional properties.Here,we reviewed one of the underutilized fruits tree(Choerospondias axillaris)and explored its occurrence,distribution,nutritional properties,phytochemicals,and medicinal value,along with associated challenges and prospects.Literature mining using scientific and common name of this plant species,yielded 77 articles,indicating limited availability of information.Various parts of the species including fruits,seeds and bark have the potential to be used in different daily needs and therapeutic activities.The core problem to underutilized fruit tree sustainability includes indiscrimination,lesser accessibility and acceptability,insufficient information on their growth and cultivation.The challenges for the production and marketing of C.axillaris fruits along with the opportunities of having a high source of income and health benefits from these plants have been discussed.A scheme for the enhancement of utility of this underutilized fruit plants has been suggested in this review.A collective effort of botanists,food scientists,government and international shareholders are needed for promoting its domestication and commercialization.C.axillaris fruits have been found to be a very promising resource in the areas of food and health industries,and possess great opportunity to flourish in the international market.展开更多
基金supported by the National Natural Science Foundation of China,specifically through grants(No.8227431382074321).
文摘Background:Choerospondias axillaris(CA)is a traditional Mongolian medicine that has been proven to have a good therapeutic effect on cerebrovascular disease.Cerebral Ischemia(CI)is a severe and life-threatening cerebrovascular disease.However,the specific mechanism of action of CA in the treatment of CI is still unclear.Methods:In this study,the related targets and pathways of CA in the treatment of CI were first predicted by system pharmacology and then verified by relevant experiments.Results:The results showed that 12 active ingredients and 208 targets were selected.Further validation through protein-protein interaction(PPI)network analysis and active ingredients-target-pathway(A-T-P)network analysis has confirmed the pivotal roles of the main bioactive constituents,including quercetin,kaempferol,naringin,β-sitosterol,and gallic acid.These components exert their anti-ischemic effects by modulating key targets such as IL6,TNF,MAPK3,and CASP3,thereby regulating the PI3K-Akt,HIF-1,and MAPK signaling pathways,which are integral to processes like inflammation,apoptosis,and oxidative stress.More importantly,through experimental verification,this study confirmed our prediction that CAE significantly reduced neurological function scores,infarct volume,and the percentage of apoptosis neurons.Conclusion:This indicates that CA acts on CI through multi-target synergistic mechanism,and this study provides theoretical basis for the clinical application of CA.
文摘Changes in acidity of Udic Ferrosols, caused by growth of Choerospondias axillaris (Roxb.) Burtt et Hill, in comparison to wild grass, were investigated for pH distribution in the soil profile, exchangeable acidity, and cation status in the soil leachate of a simulated leaching experiment. Soils were sampled in profiles at 5 cm intervals to a depth of 100 cm. In the 15-60 cm layer the soils with 10-year old C. axillaris had significantly lower pH (P < 0.05), with the largest difference being 0.41; and in…
基金Guangxi Key R&D Program(GuiKeAB19110027)Guangxi University High-level Innovation Team and Outstanding Scholars Program:Basic and Clinical Research Innovation Team for Zhuang Medicine(GuiJiaoRen201407)2018 Guangxi First-class Discipline Construction Project in Guangxi University of Chinese Medicine(2018XK056).
文摘The bark of Choerospondias axillaris is not only an authentic medicine in Guangxi,but also one of the commonly used medicines of many ethnic minorities.This paper intends to study,summarize,and analyze the planting area,harvesting and processing,processing technology,chemical composition,pharmacological action and the establishment and evaluation of quality standard of C.axillaris,in order to provide more reference basis for the development,research and utilization of Zhuang medicine C.axillaris and the establishment of quality standard.
文摘Objective:To investigate the mechanism of treating chronic wounds in rats by using Zhuang medicine choerospondias axillaris bark.Methods: The whole layer skin defection 40 rats were used and randomly divided into 4 groups: normal group, model group, MEBO group, choerospondias group. The normal group and model group were given external deposited normal saline external application. MEBO group used MEBT/MEBO. Choerospondias group was given external deposited choerospondias axillaris bark water decoction external application. Detected cell ultrastructure, PTEN、VEGF mRNA after 12 d.Results: The organelle structure in MEBO group and choerospondias group were restored. In 12 d, PTEN in MEBO group and choerospondias group were lower, VEGF were higher than 1 d (P<0.05). PTEN in MEBO group and choerospondias group were lower, VEGF were higher than model group (P<0.05). MEBO group had no difference with choerospondias group (P>0.05). Conclusion: Choerospondias axillaris bark water decoction could remarkably improve the cell ultrastructure in chronic wounds, regulate the PTEN signal conduction effect, and promote wound healing.
文摘Choerospondias axillaris is thought to be gaining popularity and economical significance,because of its nutritional and therapeutic values.This is because it contains bioactive compounds,such as polyphenols,which have a variety of therapeutic uses.Fruits,seeds,and bark are just a few of the parts of C.axillaris that can be used for both therapeutic and everyday needs.It is regarded as an underutilized fruit despite offering significant health,nutritional,and medicinal benefits.Numerous important studies have been conducted to assess the pharmacological and medicinal qualities of C.axillaris in various applications.In this review article,we discussed about the general characteristics of C.axillaris,as well as its nutritional and phytochemical properties,and therapeutic applications.In-depth research on the various potential properties of various parts of C.axillaris is compiled in this review,along with a summary of the key findings.The pharmacological and therapeutic usage of C.axillaris have been studied for a variety of potential biological properties,such as antimicrobial,antitumor,anti-inflammatory,antidiabetic,improved cardiac function,second degree burns treatment,immune boosting,improved haematological parameters,anti-angiogenesis,and antihyperlipidemic.This is the reason applications for the food and pharmaceutical industries can be made.
基金Inner Mongolia Science and Technology Projects(20100825)Health-care Scientific Research Programs of Ministry of Health of Inner Mongolia(2010058)
文摘ObjectiveTo investigate the effect of total flavones from the leaves of Choerospondias axillaris (TFLCA) on the immune function of normal mice and to provide the experimental basis for the reasonable application of C. axillaris.MethodsThe carbon clearance method, cutaneous delayed hypersensitivity reaction method, serum hemolysin method, and index of immune organs were used to study the effect of TFLCA on the immune function of mice.ResultsTFLCA could enhance the phagocytic function of mononuclear macrophage and the cutaneous delayed hypersensitivity reaction of mice, and increase the content of hemolysin antibody and the thymus index in mice.ConclusionTFLCA could improve the celiac macrophage activity and specific immunity of mice, and TFLCA, consisting with the total flavones of Choerospondiatis Fructus (TFCF), has the effect on the immune function of mice. So both TFLCA and TFCF have the regulatory effects on the immune function of mice.
文摘Many underutilized fruit plants are still obscure,in spite of possessing high medicinal and nutritional properties.Here,we reviewed one of the underutilized fruits tree(Choerospondias axillaris)and explored its occurrence,distribution,nutritional properties,phytochemicals,and medicinal value,along with associated challenges and prospects.Literature mining using scientific and common name of this plant species,yielded 77 articles,indicating limited availability of information.Various parts of the species including fruits,seeds and bark have the potential to be used in different daily needs and therapeutic activities.The core problem to underutilized fruit tree sustainability includes indiscrimination,lesser accessibility and acceptability,insufficient information on their growth and cultivation.The challenges for the production and marketing of C.axillaris fruits along with the opportunities of having a high source of income and health benefits from these plants have been discussed.A scheme for the enhancement of utility of this underutilized fruit plants has been suggested in this review.A collective effort of botanists,food scientists,government and international shareholders are needed for promoting its domestication and commercialization.C.axillaris fruits have been found to be a very promising resource in the areas of food and health industries,and possess great opportunity to flourish in the international market.
