Hepatitis E virus(HEV)infection is now endemic worldwide.Most patients with acute infection recover uneventfully.Outbreaks and sporadic cases,particularly in high-risk individuals are emerging increasingly.The patient...Hepatitis E virus(HEV)infection is now endemic worldwide.Most patients with acute infection recover uneventfully.Outbreaks and sporadic cases,particularly in high-risk individuals are emerging increasingly.The patients with risk factors like pregnancy and pre-existing chronic liver disease,present with or progress rapidly to severe disease.Immuno-suppression in post-transplant patients is an additional risk factor.Standardized FDA-approved diagnostic tests are the need of the hour.Further studies are needed to establish guideline-based treatment regimen and outbreak preparedness for HEV to decrease global morbidity,mortality,and healthcare burden.Policies for screening donors and transplant cases are requi-red.展开更多
Hepatitis E is the fifth known form of human viral hepatitis.Although not very common in our clinical practice,the incidence in Western countries is increasing.Infection with the hepatitis E virus(HEV)may be related t...Hepatitis E is the fifth known form of human viral hepatitis.Although not very common in our clinical practice,the incidence in Western countries is increasing.Infection with the hepatitis E virus(HEV)may be related to acute illness,liver failure,chronic hepatitis and cirrhosis.HEV itself is an RNA virus,with eight described genotypes(HEV 1-8),four of which more commonly affect humans and have,thus,been better studied.Besides liver manifestations,genotype 3 is also related to extra-hepatic manifestations,such as neurological,renal and rheumatological.Evolution to chronic disease occurs especially in patients who underwent transplantation,have hematological malignancies requiring chemotherapy,or have infection with the human immunodeficiency virus.The diagnosis may be difficult because of the low availability of tests and due to low sensibility and specificity.The acute form of illness does not have to be treated,but the chronic one does.We present here a literature review of hepatitis E and the relation between chronic hepatitis E and transplantation.展开更多
Chronic hepatitis E virus(HEV)infection is increasingly being reported in immunosuppressed individuals with HIV,patients with haematological malignancy and transplant recipients.The diagnosis of cirrhosis and liver fa...Chronic hepatitis E virus(HEV)infection is increasingly being reported in immunosuppressed individuals with HIV,patients with haematological malignancy and transplant recipients.The diagnosis of cirrhosis and liver failure post chronic HEV is controversial due to lack of standard diagnostic criteria.The treatment benefits of ribavirin in chronic HEV of genotype 1 are not well reported.We report a case of chronic HEV infection of genotype 1 leading to chronic liver disease in a child cured of acute leukaemia.Our report also highlights the successful use of ribavirin for eradicating chronic HEV infection and its subsequent survival benefits.Chronic hepatitis E may be an emerging disease of immunosuppressed patients and should be suspected in the presence of cryptogenic transaminitis.Ribavirin is an effective therapy for controlling HEV.展开更多
文摘Hepatitis E virus(HEV)infection is now endemic worldwide.Most patients with acute infection recover uneventfully.Outbreaks and sporadic cases,particularly in high-risk individuals are emerging increasingly.The patients with risk factors like pregnancy and pre-existing chronic liver disease,present with or progress rapidly to severe disease.Immuno-suppression in post-transplant patients is an additional risk factor.Standardized FDA-approved diagnostic tests are the need of the hour.Further studies are needed to establish guideline-based treatment regimen and outbreak preparedness for HEV to decrease global morbidity,mortality,and healthcare burden.Policies for screening donors and transplant cases are requi-red.
文摘Hepatitis E is the fifth known form of human viral hepatitis.Although not very common in our clinical practice,the incidence in Western countries is increasing.Infection with the hepatitis E virus(HEV)may be related to acute illness,liver failure,chronic hepatitis and cirrhosis.HEV itself is an RNA virus,with eight described genotypes(HEV 1-8),four of which more commonly affect humans and have,thus,been better studied.Besides liver manifestations,genotype 3 is also related to extra-hepatic manifestations,such as neurological,renal and rheumatological.Evolution to chronic disease occurs especially in patients who underwent transplantation,have hematological malignancies requiring chemotherapy,or have infection with the human immunodeficiency virus.The diagnosis may be difficult because of the low availability of tests and due to low sensibility and specificity.The acute form of illness does not have to be treated,but the chronic one does.We present here a literature review of hepatitis E and the relation between chronic hepatitis E and transplantation.
文摘Chronic hepatitis E virus(HEV)infection is increasingly being reported in immunosuppressed individuals with HIV,patients with haematological malignancy and transplant recipients.The diagnosis of cirrhosis and liver failure post chronic HEV is controversial due to lack of standard diagnostic criteria.The treatment benefits of ribavirin in chronic HEV of genotype 1 are not well reported.We report a case of chronic HEV infection of genotype 1 leading to chronic liver disease in a child cured of acute leukaemia.Our report also highlights the successful use of ribavirin for eradicating chronic HEV infection and its subsequent survival benefits.Chronic hepatitis E may be an emerging disease of immunosuppressed patients and should be suspected in the presence of cryptogenic transaminitis.Ribavirin is an effective therapy for controlling HEV.
