Chronic insomnia disorder(CID)is a relatively common clinical sleep disorder,which is es-sentially characterized by dissatisfaction with sleep due to frequent and persistent difficulties in falling asleep or maintaini...Chronic insomnia disorder(CID)is a relatively common clinical sleep disorder,which is es-sentially characterized by dissatisfaction with sleep due to frequent and persistent difficulties in falling asleep or maintaining sleep.The etiology and pathogenesis of CID are not fully understood.In the past decades,medical re-search has explored the interrelationship between cyto-kines(CKs)and sleep disorders,and this paper reviews the correlation between CID and inflammatory factors in the context of domestic and international research on the subject.展开更多
Objective To compare the different efficacy in treating patients with chronic insomnia by pricking,acupuncture and estazolam.Methods Sixty patients were divided into pricking group（group A）,acupuncture group（group ...Objective To compare the different efficacy in treating patients with chronic insomnia by pricking,acupuncture and estazolam.Methods Sixty patients were divided into pricking group（group A）,acupuncture group（group B） and western medicine group（group C） according to the random number table,with 20 cases in each group.In group A,hook-type needles were applied on Shenmai（申脉 BL 62） and Zhaohai（照海 Kl 6） bilaterally by piercing the skin,a small amount of mucus was squeezed and subcutaneous fibers were broken;in group B,disposable acupuncture needles were applied by needling BL 62 and Kl 6 bilaterally at the depth of 0.5 cun;in group C,patients were asked to take 1 mg estazolam once a day at bedtime.The three groups were observed for 28 days,and Epworth scores and improvement of symptoms in daytime dysfunction were recorded.Results The total effective rate of improvement of symptoms in daytime dysfunction of group A（100%,20/20） was superior to that of group B（70%,14/20）,and the differences were statistically significant（P〈0.05）;the total effective rates of group A and group B were superior to that of group C（25%,5/20）,and the differences were statistically significant（P〈0.01,P〈0.05）.In terms of Epworth scores,the efficacy of group A was significantly superior to that of group B（13.35±2.85 vs 11.10±3.88,P〈0.05）,the efficacy of group A was superior to that of group C（13.35±2.85 vs 5.30±3.28,P〈0.01）,and the efficacy of group B was superior to that of group C（11.10±3.88 vs 5.30±3.28,P〈0.01）.Epworth scores significantly decreased in each group after treatment（P〈0.01）.Conclusion The therapy of pricking BL 62 and Kl 6 for patients of chronic insomnia was effective,daytime sleepiness was relieved and daytime dysfunctions were improved,and the therapy was superior to estazolam,and more advantageous than acupuncture.展开更多
Background Due to the quick rhythm of life and work pressure, more and more people suffer from sleep quality problems. In this study, we investigated the effect of electroacupuncture on sleep quality of chronic insomn...Background Due to the quick rhythm of life and work pressure, more and more people suffer from sleep quality problems. In this study, we investigated the effect of electroacupuncture on sleep quality of chronic insomniacs and the safety of electroacupuncture therapy. Methods Four courses of electroacupuncture treatment were applied to 47 patients. With pre-treatment and post-treatment self-control statistical method, Pittsburgh sleep quality index （PSQI） scores were used for evaluating sleep quality. Polysomnogram was used for detecting insomniacs＇ changes in sleep architecture. The safety of electroacupuncture was evaluated by monitoring the self-designed adverse events and side effects during treatment and post-treatment. Results Electroacupuncture considerably improved insomniacs＇ sleep quality and social function during the daytime. Electroacupuncture had certain repairing effect on the disruption in sleep architecture. At the same time, electroacupuncture prolonged slow wave sleep （SWS） time and relatively rapid eye movement sleep （REM sleep） time. There was no hangover, addiction or decrements in vigilance during the daytime （incidence rate was 0）. However, insomnia rebound rate was about 23% within one month. Conclusions These results suggest that electroacupuncture has beneficial effect on sleep quality improvement in the patients with chronic insomnia, which may be associated with repairing sleep architecture, reconstructing sleep continuity as well as prolonging SWS time and REM sleep time. Electroacupuncture treatment for chronic insomnia is safe. Therefore, electroacupuncture therapy could be a promising avenue of treatment for chronic insomnia.展开更多
Background: Sleep is an important lifestyle factor to be addressed in patients having chronic non-communicable diseases. Data revealing prevalence of insomnia in chronic medical illnesses (CMIs) in Indian population a...Background: Sleep is an important lifestyle factor to be addressed in patients having chronic non-communicable diseases. Data revealing prevalence of insomnia in chronic medical illnesses (CMIs) in Indian population are lacking. Yoga has been found effective in improving sleep quality in patients with chronic medical illnesses (CMIs). Aim: To find the prevalence of insomnia in major chronic medical illnesses and to assess the effect of Integrated Approach of Yoga Therapy (IAYT) on them. Methods and Material: From the outpatients and inpatients of our integrative therapy clinics, 200 patients (116 males;84 females) in the age range 49.57 ± 11.71 years, who satisfied the inclusion criteria and were diagnosed by the physician with any of the four major categories of CMIs: cardio-pulmonary, diabetes, musculoskeletal, and psychiatric were screened for insomnia using Insomnia Severity Index (ISI) scale. Those found suffering from clinically significant insomnia (ISI score > 14) were admitted and a residential IAYT intervention was given for a week. Before and after the intervention, ISI and Pittsburg insomnia rating scale (PIRS) were administered to assess extent of insomnia. Data was analyzed before and after the intervention using paired t-test. Results: Taking all patients of CMIs together, we found that 35% suffered from clinical insomnia, out of which, 12.5% had severe and 22.5% had moderate insomnia. We also found that prevalence of clinical insomnia was highest among those suffering from psychiatric illnesses (62.07%) and minimum in those having musculoskeletal disorders (28.05%). Those suffering from diabetes mellitus and cardio-pulmonary disorders reported prevalence of 32.25% and 31.94% respectively. After IAYT intervention of one week, extent of clinical insomnia reduced from 35% at the baseline to 8.5% in all patients of CMIs taken together. Following changes were observed in percentage of patients suffering from clinical insomnia in different CMIs before and after one week of IAYT intervention: 1) In psychiatric patients, the percentage reduced from 62.07% to 24.13%;2) In diabetic patients, the percentage reduced from 32.27% to 3.0%;3) In patients having musculoskeletal disorders, the percentage reduced from 28.05% to 8.53%;and 4) In patients having cardio-pulmonary illnesses, the percentage reduced from 31.94% to 2.7%. Conclusion: Prevalence of insomnia is higher in patients suffering from chronic medical illnesses. IAYT intervention of one week may be helpful in reducing extent of insomnia in this population.展开更多
Excessive distress and insomnia are much too common in the modern world and often lead to a myriad of detrimental effects including loss of cognitive ability and even physical ailments such as cancer. Current pharmace...Excessive distress and insomnia are much too common in the modern world and often lead to a myriad of detrimental effects including loss of cognitive ability and even physical ailments such as cancer. Current pharmaceutical treatments can be addictive, detrimental to health, and in the case of insomnia don’t produce naturalistic sleep. We present a viewpoint on a potential adjunctive treatment of distress and insomnia that harnesses specific mental imagery as a component of mind/body relaxation technique. Via our perspective on the modern nature of stress and insomnia, our theoretical perspective on how specific guided mental imagery can be used to treat these ailments, and our review on the current literature on treatment with mental imagery, we hope to stimulate further research into mental health treatment with mental imagery which has traditionally been neglected. This perspective on the pathology of insomnia and distress is founded in prevailing “dysevolution” and hyper-arousal theories. Hyper-arousal is characterized in part by a vicious cycle of chronic physiological and emotional stimulation/distress. We argue for spatially based mental imagery in the form of nighttime-sky imagery to attenuate such pathology by breaking one away from a vicious cycle of stimulation and distress and discuss neuropsychological bases for its potential treatment mechanisms which include the autonomic nervous system and a phenomenal foundation of conscious cognition.展开更多
目的观察针刺疗法对心脾两虚型慢性失眠症患者的过度觉醒状态、睡眠质量、疲劳状态和心率变异性(HRV)的影响。方法将120例慢性失眠症患者随机分为治疗组和对照组各60例。治疗组针刺百会,双侧心俞、脾俞、神门、照海、申脉、安眠、三阴...目的观察针刺疗法对心脾两虚型慢性失眠症患者的过度觉醒状态、睡眠质量、疲劳状态和心率变异性(HRV)的影响。方法将120例慢性失眠症患者随机分为治疗组和对照组各60例。治疗组针刺百会,双侧心俞、脾俞、神门、照海、申脉、安眠、三阴交、足三里;对照组非经非穴浅刺。2组均隔日针刺1次,共针刺4周,总计治疗14次。记录患者治疗前、治疗4周结束时过度觉醒量表评分(HAS)、匹兹堡睡眠质量指标(PSQI)、疲劳量表评分(FS-14);记录患者24 h 12导动态心电图数据,以Kubios HRV version软件分析心率变异性指标。结果治疗后,2组HAS量表评分均低于治疗前(P<0.01),且治疗组低于对照组(P<0.01)。治疗后,治疗组PSQI各维度分数及总分均低于治疗前(P<0.01),对照组睡眠质量、日间功能障碍及PSQI总分均低于治疗前(P<0.05),治疗组睡眠质量、入睡时间、睡眠时间、日间功能障碍以及PSQI总分均低于对照组(P<0.01);2组FS-14量表评分均低于治疗前(P<0.01,P<0.05),且治疗组低于对照组(P<0.01);治疗组PNN50、RMSSD、HRV三角指数、VLF和LF/HF较治疗前均呈上升趋势(P<0.05),HF、LF较治疗前均呈下降趋势(P<0.05);对照组SDNN、VLF较治疗前呈下降趋势(P<0.05);治疗组PNN50、LF/HF高于对照组(P<0.05),LF低于对照组(P<0.05)。结论针刺可以改善过度觉醒和疲劳状态,提高慢性失眠症患者的睡眠质量,并通过调整心率变异性反映出其下调交感神经兴奋性,上调副交感神经调节的能力,进而平衡自主神经系统,提高人体适应性,其作用与经穴特异性有关。展开更多
文摘Chronic insomnia disorder(CID)is a relatively common clinical sleep disorder,which is es-sentially characterized by dissatisfaction with sleep due to frequent and persistent difficulties in falling asleep or maintaining sleep.The etiology and pathogenesis of CID are not fully understood.In the past decades,medical re-search has explored the interrelationship between cyto-kines(CKs)and sleep disorders,and this paper reviews the correlation between CID and inflammatory factors in the context of domestic and international research on the subject.
基金Supported by Research Fund for Young Teachers from Beijing University of Chinese Medicine
文摘Objective To compare the different efficacy in treating patients with chronic insomnia by pricking,acupuncture and estazolam.Methods Sixty patients were divided into pricking group（group A）,acupuncture group（group B） and western medicine group（group C） according to the random number table,with 20 cases in each group.In group A,hook-type needles were applied on Shenmai（申脉 BL 62） and Zhaohai（照海 Kl 6） bilaterally by piercing the skin,a small amount of mucus was squeezed and subcutaneous fibers were broken;in group B,disposable acupuncture needles were applied by needling BL 62 and Kl 6 bilaterally at the depth of 0.5 cun;in group C,patients were asked to take 1 mg estazolam once a day at bedtime.The three groups were observed for 28 days,and Epworth scores and improvement of symptoms in daytime dysfunction were recorded.Results The total effective rate of improvement of symptoms in daytime dysfunction of group A（100%,20/20） was superior to that of group B（70%,14/20）,and the differences were statistically significant（P〈0.05）;the total effective rates of group A and group B were superior to that of group C（25%,5/20）,and the differences were statistically significant（P〈0.01,P〈0.05）.In terms of Epworth scores,the efficacy of group A was significantly superior to that of group B（13.35±2.85 vs 11.10±3.88,P〈0.05）,the efficacy of group A was superior to that of group C（13.35±2.85 vs 5.30±3.28,P〈0.01）,and the efficacy of group B was superior to that of group C（11.10±3.88 vs 5.30±3.28,P〈0.01）.Epworth scores significantly decreased in each group after treatment（P〈0.01）.Conclusion The therapy of pricking BL 62 and Kl 6 for patients of chronic insomnia was effective,daytime sleepiness was relieved and daytime dysfunctions were improved,and the therapy was superior to estazolam,and more advantageous than acupuncture.
文摘Background Due to the quick rhythm of life and work pressure, more and more people suffer from sleep quality problems. In this study, we investigated the effect of electroacupuncture on sleep quality of chronic insomniacs and the safety of electroacupuncture therapy. Methods Four courses of electroacupuncture treatment were applied to 47 patients. With pre-treatment and post-treatment self-control statistical method, Pittsburgh sleep quality index （PSQI） scores were used for evaluating sleep quality. Polysomnogram was used for detecting insomniacs＇ changes in sleep architecture. The safety of electroacupuncture was evaluated by monitoring the self-designed adverse events and side effects during treatment and post-treatment. Results Electroacupuncture considerably improved insomniacs＇ sleep quality and social function during the daytime. Electroacupuncture had certain repairing effect on the disruption in sleep architecture. At the same time, electroacupuncture prolonged slow wave sleep （SWS） time and relatively rapid eye movement sleep （REM sleep） time. There was no hangover, addiction or decrements in vigilance during the daytime （incidence rate was 0）. However, insomnia rebound rate was about 23% within one month. Conclusions These results suggest that electroacupuncture has beneficial effect on sleep quality improvement in the patients with chronic insomnia, which may be associated with repairing sleep architecture, reconstructing sleep continuity as well as prolonging SWS time and REM sleep time. Electroacupuncture treatment for chronic insomnia is safe. Therefore, electroacupuncture therapy could be a promising avenue of treatment for chronic insomnia.
文摘Background: Sleep is an important lifestyle factor to be addressed in patients having chronic non-communicable diseases. Data revealing prevalence of insomnia in chronic medical illnesses (CMIs) in Indian population are lacking. Yoga has been found effective in improving sleep quality in patients with chronic medical illnesses (CMIs). Aim: To find the prevalence of insomnia in major chronic medical illnesses and to assess the effect of Integrated Approach of Yoga Therapy (IAYT) on them. Methods and Material: From the outpatients and inpatients of our integrative therapy clinics, 200 patients (116 males;84 females) in the age range 49.57 ± 11.71 years, who satisfied the inclusion criteria and were diagnosed by the physician with any of the four major categories of CMIs: cardio-pulmonary, diabetes, musculoskeletal, and psychiatric were screened for insomnia using Insomnia Severity Index (ISI) scale. Those found suffering from clinically significant insomnia (ISI score > 14) were admitted and a residential IAYT intervention was given for a week. Before and after the intervention, ISI and Pittsburg insomnia rating scale (PIRS) were administered to assess extent of insomnia. Data was analyzed before and after the intervention using paired t-test. Results: Taking all patients of CMIs together, we found that 35% suffered from clinical insomnia, out of which, 12.5% had severe and 22.5% had moderate insomnia. We also found that prevalence of clinical insomnia was highest among those suffering from psychiatric illnesses (62.07%) and minimum in those having musculoskeletal disorders (28.05%). Those suffering from diabetes mellitus and cardio-pulmonary disorders reported prevalence of 32.25% and 31.94% respectively. After IAYT intervention of one week, extent of clinical insomnia reduced from 35% at the baseline to 8.5% in all patients of CMIs taken together. Following changes were observed in percentage of patients suffering from clinical insomnia in different CMIs before and after one week of IAYT intervention: 1) In psychiatric patients, the percentage reduced from 62.07% to 24.13%;2) In diabetic patients, the percentage reduced from 32.27% to 3.0%;3) In patients having musculoskeletal disorders, the percentage reduced from 28.05% to 8.53%;and 4) In patients having cardio-pulmonary illnesses, the percentage reduced from 31.94% to 2.7%. Conclusion: Prevalence of insomnia is higher in patients suffering from chronic medical illnesses. IAYT intervention of one week may be helpful in reducing extent of insomnia in this population.
文摘Excessive distress and insomnia are much too common in the modern world and often lead to a myriad of detrimental effects including loss of cognitive ability and even physical ailments such as cancer. Current pharmaceutical treatments can be addictive, detrimental to health, and in the case of insomnia don’t produce naturalistic sleep. We present a viewpoint on a potential adjunctive treatment of distress and insomnia that harnesses specific mental imagery as a component of mind/body relaxation technique. Via our perspective on the modern nature of stress and insomnia, our theoretical perspective on how specific guided mental imagery can be used to treat these ailments, and our review on the current literature on treatment with mental imagery, we hope to stimulate further research into mental health treatment with mental imagery which has traditionally been neglected. This perspective on the pathology of insomnia and distress is founded in prevailing “dysevolution” and hyper-arousal theories. Hyper-arousal is characterized in part by a vicious cycle of chronic physiological and emotional stimulation/distress. We argue for spatially based mental imagery in the form of nighttime-sky imagery to attenuate such pathology by breaking one away from a vicious cycle of stimulation and distress and discuss neuropsychological bases for its potential treatment mechanisms which include the autonomic nervous system and a phenomenal foundation of conscious cognition.
文摘目的观察针刺疗法对心脾两虚型慢性失眠症患者的过度觉醒状态、睡眠质量、疲劳状态和心率变异性(HRV)的影响。方法将120例慢性失眠症患者随机分为治疗组和对照组各60例。治疗组针刺百会,双侧心俞、脾俞、神门、照海、申脉、安眠、三阴交、足三里;对照组非经非穴浅刺。2组均隔日针刺1次,共针刺4周,总计治疗14次。记录患者治疗前、治疗4周结束时过度觉醒量表评分(HAS)、匹兹堡睡眠质量指标(PSQI)、疲劳量表评分(FS-14);记录患者24 h 12导动态心电图数据,以Kubios HRV version软件分析心率变异性指标。结果治疗后,2组HAS量表评分均低于治疗前(P<0.01),且治疗组低于对照组(P<0.01)。治疗后,治疗组PSQI各维度分数及总分均低于治疗前(P<0.01),对照组睡眠质量、日间功能障碍及PSQI总分均低于治疗前(P<0.05),治疗组睡眠质量、入睡时间、睡眠时间、日间功能障碍以及PSQI总分均低于对照组(P<0.01);2组FS-14量表评分均低于治疗前(P<0.01,P<0.05),且治疗组低于对照组(P<0.01);治疗组PNN50、RMSSD、HRV三角指数、VLF和LF/HF较治疗前均呈上升趋势(P<0.05),HF、LF较治疗前均呈下降趋势(P<0.05);对照组SDNN、VLF较治疗前呈下降趋势(P<0.05);治疗组PNN50、LF/HF高于对照组(P<0.05),LF低于对照组(P<0.05)。结论针刺可以改善过度觉醒和疲劳状态,提高慢性失眠症患者的睡眠质量,并通过调整心率变异性反映出其下调交感神经兴奋性,上调副交感神经调节的能力,进而平衡自主神经系统,提高人体适应性,其作用与经穴特异性有关。
