It has been reported that retinol-binding protein 4(RBP4) is associated to adiposity,insulin resistance,and type 2 diabetes.Meanwhile,circulating RBP4 levels are also affected by renal function.The aim of the present ...It has been reported that retinol-binding protein 4(RBP4) is associated to adiposity,insulin resistance,and type 2 diabetes.Meanwhile,circulating RBP4 levels are also affected by renal function.The aim of the present study is to investigate whether serum levels of RBP4 are primarily associated with different stages of chronic kidney disease(CKD) or type 2 diabetes,if there is more potential relevance between RBP4 and renal replacement therapy.The serum levels of RBP4 were assessed by commercial competitive enzyme-linked immunosorbent assay(ELISA)kit in 212 patients with the CKD stages 1—5 and in 24 healthy controls,while its correlation with clinical and metabolic parameters was analyzed.The serum level of RBP4 had a strong correlation with estimated glomerular filtration rate(e GFR)(P < 0.001).Stratified by e GFR and treatment,no more differences in RBP4 serum concentration were detected between type 2 diabetic and non-diabetic subjects [CKD stages 1—5,non-dialysis(ND),hemodialysis(HD) and peritoneal dialysis(PD);P > 0.05 for all].The elevation of RBP4 become higher in HD than in PD and ND in CKD5 patients(P = 0.008 and P = 0.04,respectively),while there was no significant difference between PD and ND groups.Multivariate linear regression analysis demonstrated three independent predictors of e GFR(β =-0.676,P < 0.001),C-reactive protein(CRP)(β =-0.573,P < 0.001) and creatine(β = 0.509,P = 0.024) in the study population.The study results demonstrated that the serum level of RBP4 was negatively related to the e GFR,whether diabetes mellitus(DM) affected the blood concentration of RBP4 or not.And the serum level of RBP4 exhibited significant difference in different renal replacement therapies.展开更多
目的： Meta分析TNF‐α水平与不同分期糖尿病慢性肾脏疾病（CKD）的关系。方法通过计算机检索，收集有关CKD患者血清TNF‐α水平的文献，采用Rev Man 4.2软件进行Meta分析，合并结果以标准化均数差（SMD）表示。结果本研究共纳入15篇...目的： Meta分析TNF‐α水平与不同分期糖尿病慢性肾脏疾病（CKD）的关系。方法通过计算机检索，收集有关CKD患者血清TNF‐α水平的文献，采用Rev Man 4.2软件进行Meta分析，合并结果以标准化均数差（SMD）表示。结果本研究共纳入15篇文献。Meta分析结果显示，早期CKD组血清TNF‐α水平高于正常对照（NC）组[SWD＝9.14，95％ CI（7.57～10.72），P＜0.00001]和单纯糖尿病组[SWD＝5.17，95％ CI （4.27～6.06），P＜0.00001]。临床期CKD组血清TNF‐α水平高于早期CKD组[SWD＝11.09，95％ CI（8.25～13.93），P＜0.00001]。结论现有临床研究证据显示，CKD患者血清TNF‐α水平增高，且血清TNF‐α含量随糖尿病严重程度升高，血清TNF‐α测定对判断CKD的病情有指导意义。展开更多
基金the National Natural Science Foundation of China(Nos.81570603,81270824 and 81670632)the New-100 Talent Plan of Shanghai Jiao Tong University School of Medicine,the Shanghai Talents Development Fund(No.201350)the Shanghai Pujiang Talent Projects(No.15PJ1406700)
文摘It has been reported that retinol-binding protein 4(RBP4) is associated to adiposity,insulin resistance,and type 2 diabetes.Meanwhile,circulating RBP4 levels are also affected by renal function.The aim of the present study is to investigate whether serum levels of RBP4 are primarily associated with different stages of chronic kidney disease(CKD) or type 2 diabetes,if there is more potential relevance between RBP4 and renal replacement therapy.The serum levels of RBP4 were assessed by commercial competitive enzyme-linked immunosorbent assay(ELISA)kit in 212 patients with the CKD stages 1—5 and in 24 healthy controls,while its correlation with clinical and metabolic parameters was analyzed.The serum level of RBP4 had a strong correlation with estimated glomerular filtration rate(e GFR)(P < 0.001).Stratified by e GFR and treatment,no more differences in RBP4 serum concentration were detected between type 2 diabetic and non-diabetic subjects [CKD stages 1—5,non-dialysis(ND),hemodialysis(HD) and peritoneal dialysis(PD);P > 0.05 for all].The elevation of RBP4 become higher in HD than in PD and ND in CKD5 patients(P = 0.008 and P = 0.04,respectively),while there was no significant difference between PD and ND groups.Multivariate linear regression analysis demonstrated three independent predictors of e GFR(β =-0.676,P < 0.001),C-reactive protein(CRP)(β =-0.573,P < 0.001) and creatine(β = 0.509,P = 0.024) in the study population.The study results demonstrated that the serum level of RBP4 was negatively related to the e GFR,whether diabetes mellitus(DM) affected the blood concentration of RBP4 or not.And the serum level of RBP4 exhibited significant difference in different renal replacement therapies.
文摘目的： Meta分析TNF‐α水平与不同分期糖尿病慢性肾脏疾病（CKD）的关系。方法通过计算机检索，收集有关CKD患者血清TNF‐α水平的文献，采用Rev Man 4.2软件进行Meta分析，合并结果以标准化均数差（SMD）表示。结果本研究共纳入15篇文献。Meta分析结果显示，早期CKD组血清TNF‐α水平高于正常对照（NC）组[SWD＝9.14，95％ CI（7.57～10.72），P＜0.00001]和单纯糖尿病组[SWD＝5.17，95％ CI （4.27～6.06），P＜0.00001]。临床期CKD组血清TNF‐α水平高于早期CKD组[SWD＝11.09，95％ CI（8.25～13.93），P＜0.00001]。结论现有临床研究证据显示，CKD患者血清TNF‐α水平增高，且血清TNF‐α含量随糖尿病严重程度升高，血清TNF‐α测定对判断CKD的病情有指导意义。
