Preventive and Therapeutic Role of Vitamin E in Chronic Plumbism

The ability of vitamin E to prevent or treat experimental lead intoxication was investigated in rats.Lead ingestion(10 mg/kg,lead as lead acetate,orally fbr 6 weeks)significantly inhibited the activity of blood δ-aminolevulinic acid dehydratase(ALAD),reduced the brain dopamine (DA)contents,enhanced the blood zinc protoporphyrin,and enhanced the urinary excretion of δ-aminolevulinic acid(ALA).Lead exposure also elevated brain norepinephrine,homovanillic acid,and 5-hydroxyindole acetic acid(5-HIAA)levels and concentration of lead in blood and tissue.Simultaneous supplementation of vitamin E along with lead significantly reduced the inhibition of blood ALAD activity,brain DA and 5-HIAA levels,and elevation of urinary ALA excretion.Blood and liver lead concentrations were also significantly reduced by simultaneous supplementation with vitamin E.Postlead exposure treatment with vitamin E was ineffective in reducing the lead-induced effects,except that the inhibition of blood ALAD activity was slightly reduced.The present results suggest that vitamin E given simultaneously with lead is effective in reducing the severity of lead intoxication.1989 Academic Press.Inc.

The Limits of the Intervention of Public Power in Individual Health Choices——From the Perspective of the Realization of the Right to Health in the Prevention and Control of Chronic Diseases

Noncommunicable chronic diseases have become the most important public health problem in the world today,so the focus of public health services should be shifted from the traditional area of communicable diseases to the prevention and control of chronic diseases.Since bad living habits are the most direct cause of chronic diseases,the most effective measure to prevent and control chronic diseases is to promote healthy lifestyles for the individual citizen.The theories of equal health opportunity,the right to health from the perspective of human rights,and determinants of a healthy society provide justified reasons for the intervention of public power in individual health choices.In the current legal system,the intervention of public power is limited to flexible measures such as health education,which shows respect for individual autonomy.However,it is inconsistent with the needs of current public health practice.We should expand diversified intervention means to encourage individuals to make healthy choices under the guidance of the management model.The“ladder of intervention”outlines a panoramic view of the intervention measures available.However,for the selection of specific measures,it is necessary to consider the public health objectives and the invasion of individual freedom,introduce the“legal reservation principle”and“proportionality principle”as policy analysis tools,and reasonably choose intervention measures at different levels on the ladder to properly handle the tension between public power and private rights.

我国慢性病防治人员素质分析

目的分析我国31个省(自治区、直辖市)慢性病防治人员素质及变化趋势,探讨我国慢性病防治人员素质的区域差异、变化原因及提升建议。方法收集1995—2017年所有涉及我国各省(自治区、直辖市)慢性病防治人力资源的文献,摘录慢性病防治人员素质的相关表述,综合计算慢性病防治人员素质适宜程度,描述2000—2017年我国各省(自治区、直辖市)慢性病防治人员素质的现状及变化趋势。结果从全国来看,2017年我国慢性病防治人员素质适宜程度的平均水平为40.3%,与适宜标准(85.0%)相差52.6%。从各省(自治区、直辖市)来看,东部地区慢性病防治人员的素质较高(适宜程度为42.3%),中西部地区慢性病防治人员素质的适宜程度在36.0%左右。2000—2017年我国各省(自治区、直辖市)慢性病防治人员素质大幅提升,适宜程度的平均水平提升了417.6%。结论我国慢性病防治人员素质存在区域差异。2000年以来防治人员素质稳步提升,但距适宜标准仍有较大差距。建设高素质慢性病防治人才队伍任重道远。

Influence of Probiotic Fermented Fruit and Vegetables on Human Health and the Related Industrial Development Trend

The paper briefly discusses the relationship between chronic diseases and gut health,and points out that an imbalance of intestinal microflora and an inadequate intake of dietary fiber are two important causes of chronic diseases.This paper also summarizes the research status of probiotic fermented fruit and vegetables,and discusses the main achievements of our group in this field and future developments of the related industry.The application of fermentation technology to fruit and vegetable processing and the development of a series of probiotic fermented fruit and vegetable products not only increase the added value of fruit and vegetables,but also organically combine probiotics and their active metabolites with prebiotics(dietary fiber,etc.),thereby promoting intestinal health as well as preventing and relieving chronic diseases.Fermentation technology provides a new approach to the study of the effect of probiotics on human health,and will have a revolutionary influence on probiotic application and on the fruit and vegetable processing industry.Thus,fruit and vegetable fermentation technology has excellent market potential.

国内外慢性病防控从业者循证能力提升方案

目的了解国内外干预项目的内容及成果经验,为以后在我国慢性病防控从业群体中推广循证慢性病防控提供参考。方法检索知网、万方、维普、PubMed、Web of Science和Scopus数据库中1995年1月1日—2019年11月31日发表的与慢性病防控循证能力干预相关的文献,最终纳入45篇文献进行分析。结果国内极为缺乏针对提升公共卫生从业者慢性病防控循证能力的干预项目。发达国家较早实践提升医务人员慢性病能力的干预措施,包括各类面对面课程、研讨会、网络课程、书籍等,但干预课程设置普遍遇到的问题包括慢性病防控机构缺乏数据库权限,未对不同循证认知层次和工作环境的从业者进行有针对性的分类。结论我国应积极借鉴慢性病防控的国外经验,开发各类干预途径并加以推广和应用。

Efficacy of estradiol on preventing chronic kidney allograft rejection

hronic rejection is the main factor to result in the loss of renal allograft In order to look for a potential therapy chronic rejection, we investigated the efficacy of estradiol on preventing renal chronic rejection The kidneys of female F344 rats were orthotopically transplanted into ovatiectomized female Lewis rats and treated for 16 weeks with either estradiol or vehicle Compared with controls treated with vehicle, estradiol treatment reduced urinary protein excretion, glomerular sclerosis, interstitial infiltration and fibrosis, vascular lesions, in parallel to a reduced ICAM 1 and TGF β mRNA expression Our results suggested that estrodiol could significantly decrease the progression of chronic rejection, at least in female recipients, and the reduced adhesion molecule and TGF β gene expression may be involved in the mechanism for estradiol to prevent chronic rejection

Guideline on prevention and treatment of chronic hepatitis B in China (2005)

Chronic hepatitis B is one of the most common epidemic diseases in China and has become a majorhealth issue. To help standardize the prevention, diagnosis, and treatment of chronic hepatitis B, the Guideline on prevention and treatment of chronic hepatitis B （abbr. Guideline） was created by a group of appropriate experts belonging to the Society of Hepatology and the Society of Infectious Disease, the Chinese Medical Association according to the principles of evidence-based medicine using the latest clinical research data. The evidence used to formulate the recommendation has been classified into 3 classes and 5 grades, which are indicated by Roman numerals in brackets.

Reflections on Human Longevity and Chinese Medicine Prevention and Treatment of Chronic Diseases

Life Expectancy Study International geriatric life science community, including medical and scientific communities, currently considers human life expectancy to be about 120 years. This is in congruence with recordings from ＂Hong Fan-Book of Documents （Shang Shu Hong Fan）＂, and is also in general agreement with teachings from ＂Longevity-Yellow Emperor＇s Canon of Internal Medicine （Huang Di Nei Jing ~ Tian Nian）＂ where it is said ＇a man is to die at age of a hundred years＇ meaning ＇passing away after living a hundred years＇. Recently there is a report of people dying at the age of 150 years in England, I am afraid this is misinformed.

Study on Preventive and Therapeutic Actionsof Poria Extracton Acute and Chronic HepaticInjuryinRats

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