目的:探讨高血压患者血压昼夜节律与ST-T异常改变以及心律失常之间的关系,为临床治疗提供可靠依据。方法:对56例高血压病患者同步检测24 h动态血压(ABP)和动态心电图(DCG),分析其血压昼夜节律变化与发生心肌缺血、心律失常之间的关系。...目的:探讨高血压患者血压昼夜节律与ST-T异常改变以及心律失常之间的关系,为临床治疗提供可靠依据。方法:对56例高血压病患者同步检测24 h动态血压(ABP)和动态心电图(DCG),分析其血压昼夜节律变化与发生心肌缺血、心律失常之间的关系。结果:血压昼夜节律下降、消失占83.9%,呈非杓型ABP曲线占76.8%;DCG有ST-T改变分别占28.5%和55.3%;房性、室性心律失常较多见分别占78.5%和39.2%;ST-T改变和房性、室性心律失常与ABP血压昼夜节律异常(白天最低值)及最高值有显著相关性(P<0.05)。结论:24 h ABP和DCG同步监测高血压患者,其血压昼夜节律异常与心肌缺血、心律失常有密切关系,更具有临床指导意义。展开更多
The paraventricular nucleus of the hypothalamus(PVH)acts as a cohesive functional unit that regulates neuroendocrine and autonomic function,complex behavior,and negative emotions after stress.However,how the PVH integ...The paraventricular nucleus of the hypothalamus(PVH)acts as a cohesive functional unit that regulates neuroendocrine and autonomic function,complex behavior,and negative emotions after stress.However,how the PVH integrates arousal with these biological functions has only recently been explored.Clinical reports,combined with neurotoxic lesioning,immunochemistry,neuronal activity recordings,and the polysomnographic analyses of genetically modified animals,have revealed that the PVH is important for the control of wakefulness.Here,we review emerging anatomical and neural mechanisms for sleep–wake regulation in the PVH to support its essential role in the promotion and maintenance of wakefulness.展开更多
文摘目的:探讨高血压患者血压昼夜节律与ST-T异常改变以及心律失常之间的关系,为临床治疗提供可靠依据。方法:对56例高血压病患者同步检测24 h动态血压(ABP)和动态心电图(DCG),分析其血压昼夜节律变化与发生心肌缺血、心律失常之间的关系。结果:血压昼夜节律下降、消失占83.9%,呈非杓型ABP曲线占76.8%;DCG有ST-T改变分别占28.5%和55.3%;房性、室性心律失常较多见分别占78.5%和39.2%;ST-T改变和房性、室性心律失常与ABP血压昼夜节律异常(白天最低值)及最高值有显著相关性(P<0.05)。结论:24 h ABP和DCG同步监测高血压患者,其血压昼夜节律异常与心肌缺血、心律失常有密切关系,更具有临床指导意义。
基金partly supported by the National Major Project of China Science and Technology Innovation 2030 for Brain Science and BrainInspired Technology(Grant No.2021ZD0203400 to Z.-L.H.)the National Natural Science Foundation of China(Grant Nos.82020108014 and 32070984 to Z.-L.H.)+3 种基金the Shanghai Science and Technology Innovation Action Plan Laboratory Animal Research Project(Grant No.201409001800 to Z.-L.H.)Program for Shanghai Outstanding Academic Leaders(to Z.-L.H.)the Shanghai Municipal Science and Technology Major ProjectZJLab(Grant No.2018SHZDZX01 to Z-.L.H.)。
文摘The paraventricular nucleus of the hypothalamus(PVH)acts as a cohesive functional unit that regulates neuroendocrine and autonomic function,complex behavior,and negative emotions after stress.However,how the PVH integrates arousal with these biological functions has only recently been explored.Clinical reports,combined with neurotoxic lesioning,immunochemistry,neuronal activity recordings,and the polysomnographic analyses of genetically modified animals,have revealed that the PVH is important for the control of wakefulness.Here,we review emerging anatomical and neural mechanisms for sleep–wake regulation in the PVH to support its essential role in the promotion and maintenance of wakefulness.
