Pneumoconiosis is a systemic occupational disease that commonly manifests as diffuse fibrosis of the lungs caused by long-term inhalation of silica dust in the production process. The development of pneumoconiosis is ...Pneumoconiosis is a systemic occupational disease that commonly manifests as diffuse fibrosis of the lungs caused by long-term inhalation of silica dust in the production process. The development of pneumoconiosis is a chronic and progressive process;once it occurs, it is irreversible, and gradually develops into lung injury and respiratory failure, and can cause death regardless of exposure to dust. The incidence of pneumoconiosis is the highest in China and the direct and indirect economic loss as a result of pneumoconiosis is approximately 9 billion yuan per year.展开更多
Cell count, LDH, total protein, Clara cell protein (CC16) and lysozyme in bronchoalveolar lavage fluid (BAL) and serum were determined in rats. 30 - 50 ppm sulfur dioxide for 4 h, 12 h and 2 week exposure didn't p...Cell count, LDH, total protein, Clara cell protein (CC16) and lysozyme in bronchoalveolar lavage fluid (BAL) and serum were determined in rats. 30 - 50 ppm sulfur dioxide for 4 h, 12 h and 2 week exposure didn't produce any change of above parameters. 1. 0 ppm, 0. 5 ppm, 0. 38 ppm, 0. 25 ppm and 0. 20 ppm ozone for 7 h exposure tests were performed. CC16, total protein and LDH in BAL had significantly changes in BAL in ozone groups. Only serum CC16 showed significant increase among ozone groups. Both BAL and serum CC16 were of the best exposure-response relationship with ozone concentration.The change of BAL fluid reached high peak 18-24 h after ozone exposure.Serum CC16 seemed to be a valid marker of the distal airway damages caused by air pollutants.展开更多
基金supported by Nanjing Medical Technology Development Funds [YKK15188]Nanjing Medical Science and technique Development Foundation [QRX17197]
文摘Pneumoconiosis is a systemic occupational disease that commonly manifests as diffuse fibrosis of the lungs caused by long-term inhalation of silica dust in the production process. The development of pneumoconiosis is a chronic and progressive process;once it occurs, it is irreversible, and gradually develops into lung injury and respiratory failure, and can cause death regardless of exposure to dust. The incidence of pneumoconiosis is the highest in China and the direct and indirect economic loss as a result of pneumoconiosis is approximately 9 billion yuan per year.
文摘Cell count, LDH, total protein, Clara cell protein (CC16) and lysozyme in bronchoalveolar lavage fluid (BAL) and serum were determined in rats. 30 - 50 ppm sulfur dioxide for 4 h, 12 h and 2 week exposure didn't produce any change of above parameters. 1. 0 ppm, 0. 5 ppm, 0. 38 ppm, 0. 25 ppm and 0. 20 ppm ozone for 7 h exposure tests were performed. CC16, total protein and LDH in BAL had significantly changes in BAL in ozone groups. Only serum CC16 showed significant increase among ozone groups. Both BAL and serum CC16 were of the best exposure-response relationship with ozone concentration.The change of BAL fluid reached high peak 18-24 h after ozone exposure.Serum CC16 seemed to be a valid marker of the distal airway damages caused by air pollutants.
