Human serum albumin(HSA)injectable product is a severely afflicted area on drug safety due to its high price and restricted supply.Raman spectroscopy performances high specificity on HSA detection and it is even possi...Human serum albumin(HSA)injectable product is a severely afflicted area on drug safety due to its high price and restricted supply.Raman spectroscopy performances high specificity on HSA detection and it is even possible to determine HSA injectable products noninvasively.In this study,we developed a noninvasive rapid screening method for of HSA injectable products by using portable Raman spectrometer.Qualitative models were established by using principal component analysis combined with classical least squares(PCA-CLS)algorithm,while quanti-tative model was established by using partial least squares(PLS)algorithm.Model transfer in different instruments of both the same and different apparatus modules was further discussed in this paper.A total of 34 HSA injectable samples collected from markets were used for verification.The identification results showed 100%accuracy and the predicted concentrations of those identified as true HSA were consistent with their labeled concentrations.The quantitative results also indicated that model transfer was excellent in the same apparatus modules of Raman spectrometer at all concentration levels,and still good enough in the different apparatus modules although the relative standard deviation(RSD)value showed a little increasing trend at low HSA concentration level.In conclusion,the method was proved to be feasible and efficient for screening HSA injections,especially on its screening speed and the consideration of glass containers.Moreover,with inspiring results on the model transfer,the method could be used as a universal screening mean to different Raman instruments.展开更多
The nonlinear least square adjustment is a head object studied in technology fields. The paper studies on the non derivative solution to the nonlinear dynamic least square adjustment and puts forward a new algorithm m...The nonlinear least square adjustment is a head object studied in technology fields. The paper studies on the non derivative solution to the nonlinear dynamic least square adjustment and puts forward a new algorithm model and its solution model. The method has little calculation load and is simple. This opens up a theoretical method to solve the linear dynamic least square adjustment.展开更多
Approximate linear methods and nonlinear methods were adopted usually for solving models of nonlinear surveying and mapping parameters adjustment. But, these iterative algorithms need to compare harsh initial value. A...Approximate linear methods and nonlinear methods were adopted usually for solving models of nonlinear surveying and mapping parameters adjustment. But, these iterative algorithms need to compare harsh initial value. A kind of new algorithm-adaptive algorithm based on analyzing the general methods was put forward. The new algorithm has quick rate of convergence and low dependence for initial value, so it can avoid calculating complex second derivative of the target function. The results indicate that its performance is better than those of the others.展开更多
The LAMBDA method that was proposed by Teunissen is introduced. Then, on the basis of both the back-sequential conditional LS technique and the upper-triangular Cholesky decomposition, another form for LAMBDA method i...The LAMBDA method that was proposed by Teunissen is introduced. Then, on the basis of both the back-sequential conditional LS technique and the upper-triangular Cholesky decomposition, another form for LAMBDA method is proposed. This new form for LAMBDA method has the same principle and calculation speed as the traditional LAMBDA method.展开更多
基金Youth Develop-ment Research Foundation(No.2015C03)of Na-tional Institutes of Food and Drug Control,P.R.China.
文摘Human serum albumin(HSA)injectable product is a severely afflicted area on drug safety due to its high price and restricted supply.Raman spectroscopy performances high specificity on HSA detection and it is even possible to determine HSA injectable products noninvasively.In this study,we developed a noninvasive rapid screening method for of HSA injectable products by using portable Raman spectrometer.Qualitative models were established by using principal component analysis combined with classical least squares(PCA-CLS)algorithm,while quanti-tative model was established by using partial least squares(PLS)algorithm.Model transfer in different instruments of both the same and different apparatus modules was further discussed in this paper.A total of 34 HSA injectable samples collected from markets were used for verification.The identification results showed 100%accuracy and the predicted concentrations of those identified as true HSA were consistent with their labeled concentrations.The quantitative results also indicated that model transfer was excellent in the same apparatus modules of Raman spectrometer at all concentration levels,and still good enough in the different apparatus modules although the relative standard deviation(RSD)value showed a little increasing trend at low HSA concentration level.In conclusion,the method was proved to be feasible and efficient for screening HSA injections,especially on its screening speed and the consideration of glass containers.Moreover,with inspiring results on the model transfer,the method could be used as a universal screening mean to different Raman instruments.
文摘The nonlinear least square adjustment is a head object studied in technology fields. The paper studies on the non derivative solution to the nonlinear dynamic least square adjustment and puts forward a new algorithm model and its solution model. The method has little calculation load and is simple. This opens up a theoretical method to solve the linear dynamic least square adjustment.
基金Project (40174003) supported by the National Natural Science Foundation of China
文摘Approximate linear methods and nonlinear methods were adopted usually for solving models of nonlinear surveying and mapping parameters adjustment. But, these iterative algorithms need to compare harsh initial value. A kind of new algorithm-adaptive algorithm based on analyzing the general methods was put forward. The new algorithm has quick rate of convergence and low dependence for initial value, so it can avoid calculating complex second derivative of the target function. The results indicate that its performance is better than those of the others.
文摘The LAMBDA method that was proposed by Teunissen is introduced. Then, on the basis of both the back-sequential conditional LS technique and the upper-triangular Cholesky decomposition, another form for LAMBDA method is proposed. This new form for LAMBDA method has the same principle and calculation speed as the traditional LAMBDA method.
文摘基于TDOA的超声波测距模型认为距离为声波的速度与时间差之积,忽略了温度等因素对速度的影响,此外,系统计时的误差影响了时间差测量,导致测距精度不高.分析了基于TDOA原理的超声波测距系统误差的主要来源,建立模型,通过实验对温度、距离衰减及时间差测量进行补偿,利用超声波反射特性对障碍物进行测距,并利用多探头在一定程度上削弱了方向性带来的影响.实验结果表明:系统性能稳定,测距精度高,环境适应性更强.在超声波测距范围内,最大误差不超过4 cm.
