BACKGROUND Depression is a common and serious psychological condition,which seriously affects individual well-being and functional ability.Traditional treatment methods include drug therapy and psychological counselin...BACKGROUND Depression is a common and serious psychological condition,which seriously affects individual well-being and functional ability.Traditional treatment methods include drug therapy and psychological counseling;however,these methods have different degrees of side effects and limitations.In recent years,nonconvulsive electrotherapy(NET)has attracted increasing attention as a noninvasive treatment method.However,the clinical efficacy and potential mechanism of NET on depression are still unclear.We hypothesized that NET has a positive clinical effect in the treatment of depression,and may have a regulatory effect on serum inflammatory factors during treatment.AIM To assess the effects of NET on depression and analyze changes in serum inflammatory factors.METHODS This retrospective study enrolled 140 patients undergoing treatment for depression between May 2017 and June 2022,the observation group that received a combination of mindfulness-based stress reduction(MBSR)and NET treatment(n=70)and the control group that only received MBSR therapy(n=70).The clinical effectiveness of the treatment was evaluated by assessing various factors,including the Hamilton Depression Scale(HAMD)-17,self-rating idea of suicide scale(SSIOS),Pittsburgh Sleep Quality Index(PSQI),and levels of serum inflammatory factors before and after 8 wk of treatment.The quality of life scores between the two groups were compared.Comparisons were made using t and χ^(2) tests.RESULTS After 8 wk of treatment,the observation group exhibited a 91.43%overall effectiveness rate which was higher than that of the control group which was 74.29%(64 vs 52,χ^(2)=7.241;P<0.05).The HAMD,SSIOS,and PSQI scores showed a significant decrease in both groups.Moreover,the observation group had lower scores than the control group(10.37±2.04 vs 14.02±2.16,t=10.280;1.67±0.28 vs 0.87±0.12,t=21.970;5.29±1.33 vs 7.94±1.35,t=11.700;P both<0.001).Additionally,there was a notable decrease in the IL-2,IL-1β,and IL-6 in both groups after treatment.Furthermore,the observation group exhibited superior serum inflammatory factors compared to the control group(70.12±10.32 vs 102.24±20.21,t=11.840;19.35±2.46 vs 22.27±2.13,t=7.508;32.25±4.6 vs 39.42±4.23,t=9.565;P both<0.001).Moreover,the observation group exhibited significantly improved quality of life scores compared to the control group(Social function:19.25±2.76 vs 16.23±2.34;Emotions:18.54±2.83 vs 12.28±2.16;Environment:18.49±2.48 vs 16.56±3.44;Physical health:19.53±2.39 vs 16.62±3.46;P both<0.001)after treatment.CONCLUSION MBSR combined with NET effectively alleviates depression,lowers inflammation(IL-2,IL-1β,and IL-6),reduces suicidal thoughts,enhances sleep,and improves the quality of life of individuals with depression.展开更多
Fracture systems have strong influence on the overall mechanical behavior of fractured rock masses dueto their relatively lower stiffness and shear strength than those of the rock matrix. Understanding theeffects of f...Fracture systems have strong influence on the overall mechanical behavior of fractured rock masses dueto their relatively lower stiffness and shear strength than those of the rock matrix. Understanding theeffects of fracture geometrical distribution, such as length, spacing, persistence and orientation, isimportant for quantifying the mechanical behavior of fractured rock masses. The relation betweenfracture geometry and the mechanical characteristics of the fractured rock mass is complicated due tothe fact that the fracture geometry and mechanical behaviors of fractured rock mass are stronglydependent on the length scale. In this paper, a comprehensive study was conducted to determine theeffects of fracture distribution on the equivalent continuum elastic compliance of fractured rock massesover a wide range of fracture lengths. To account for the stochastic nature of fracture distributions, threedifferent simulation techniques involving Oda＇s elastic compliance tensor, Monte Carlo simulation （MCS）,and suitable probability density functions （PDFs） were employed to represent the elastic compliance offractured rock masses. To yield geologically realistic results, parameters for defining fracture distributionswere obtained from different geological fields. The influence of the key fracture parameters andtheir relations to the overall elastic behavior of the fractured rock mass were studied and discussed. Adetailed study was also carried out to investigate the validity of the use of a representative elementvolume （REV） in the equivalent continuum representation of fractured rock masses. A criterion was alsoproposed to determine the appropriate REV given the fracture distribution of the rock mass.展开更多
BACKGROUND Many studies have focused on the femoral tunnel technique and fixation method,but few studies have involved the tibial tunnel technique and fixation method.The all-inside technique is one of the new techniq...BACKGROUND Many studies have focused on the femoral tunnel technique and fixation method,but few studies have involved the tibial tunnel technique and fixation method.The all-inside technique is one of the new techniques that has been described in recent years.All-inside anterior cruciate ligament(ACL)reconstruction is based on a tibial socket instead of a full tunnel.This method has many potential advantages.AIM To compare clinical outcomes of knee ACL autograft reconstruction using allinside quadrupled semitendinosus(AIST)and traditional hamstring tendon(TBT)techniques.METHODS From January 2017 to October 2019,the clinical data of 80 patients with ACL reconstruction were retrospectively analyzed,including 67 males and 13 females.The patients had an average age of 24.3±3.1 years(age range:18-33 years).The AIST technique was used in 42 patients and the TBT technique was used in 38 patients.The time between operation and injury,operative duration,postoperative visual analogue scale(VAS)score and knee functional recovery were recorded and compared between the two groups.The International Knee Documentation Committee(IKDC)and Lysholm scoring system were used to comprehensively evaluate clinical efficacy.RESULTS Eighty patients were followed for 24-36 mo,with an average follow-up duration of 27.5±1.8 mo.There were no significant differences in the time between surgery and injury,operative duration,IKDC and Lysholm scores of the affected knee at the last follow-up evaluation between the two groups.There were significant differences in VAS scores 1 d,3 d,7 d,2 wk and 1 mo after surgery(P<0.05).There was no significant difference in VAS score at 3 mo,6 mo and 1 year after operation.CONCLUSION The efficacy of the AIST ACL reconstruction technique was comparable to the TBT technique,but the postoperative pain was less with the AIST technique.Thus,the AIST technique is an ideal treatment choice for ACL reconstruction.展开更多
Objectives: Femoral neck fractures are becoming more common within nowadays. This research is to explore the clinical effect of primary total hip replacement (THA) via direct anterior approach (DAA) and posterolateral...Objectives: Femoral neck fractures are becoming more common within nowadays. This research is to explore the clinical effect of primary total hip replacement (THA) via direct anterior approach (DAA) and posterolateral approach (PLA) in the treatment of femoral neck fracture. Methods: Retrospective analysis of 100 cases of elderly patients with femoral neck fracture who underwent total hip arthroplasty admitted to Tianyou Hospital affiliated to Wuhan University of Science and Technology from January 2019 to January 2022. 50 patients treated with DAA approach were included in the observation group, and 50 patients treated with PLA approach were included in the control group. The operation indexes, postoperative acetabular abduction angle and anteversion angle, hip joint function, Harris score and complications were compared between the two groups. Result: The length of incision in the observation group was shorter than that in the control group, and the amount of intraoperative bleeding and postoperative hospital stay were shorter than those in the control group (P < 0.05);There was a statistically significant difference between the two groups in the ratio of acetabular abduction angle and its safe zone, and the length difference of both lower limbs (P < 0.05), while there was no statistically significant difference between the two groups in the ratio of acetabular anteversion angle and its safe zone, eccentricity, and its recovery rate (P > 0.05);Harris score of hip joint: 6 months after operation, the anterior approach group was significantly higher than the posterolateral approach group (P < 0.05), and there was no statistical difference between the two groups 12 months after operation (P > 0.05);The total incidence of complications in the observation group was lower than that in the control group, with a statistically significant difference (P Conclusion: DAA and PLA approaches for total hip replacement can restore the hip joint structure of patients with femoral neck fractures and achieve good results, but DAA approach has greater advantages in early postoperative recovery, improvement of hip joint function, small surgical injury, high application value, so it is recommended.展开更多
目的探究不同液体复苏方法治疗严重骨盆骨折失血性休克的效果及预后分析。方法前瞻性选取2021年6月—2023年6月笔者医院收治的严重骨盆骨折失血性休克患者96例为研究对象,其中男性56例,女性40例;年龄18~55岁,平均38.6岁;道路交通伤51例...目的探究不同液体复苏方法治疗严重骨盆骨折失血性休克的效果及预后分析。方法前瞻性选取2021年6月—2023年6月笔者医院收治的严重骨盆骨折失血性休克患者96例为研究对象,其中男性56例,女性40例;年龄18~55岁,平均38.6岁;道路交通伤51例,高处坠落伤24例,挤压伤21例。患者入院后均完成止血、骨折外固定等外科急救处理,常规监测生命体征、建立静脉通道、完善血常规等术前检查。随机数字表法分为研究组48例与对照组48例。对照组患者进行常规快速液体复苏,及时补充足量的平衡液、胶体液、悬浮红细胞、血浆等,研究组予以限制性液体复苏,前期适当输入高渗氯化钠溶液,而后输入平衡液等。比较两组入院时、复苏后3 d生命体征指标,凝血指标与急性生理与慢性健康II(APACHEⅡ)评分,电解质水平以及入院时、复苏后30 min、1 h炎症因子水平,观察两组预后指标差异。结果两组复苏后3 d全心舒张末期容量指数(GEDVI)、心脏指数(CI)、心排血量(CO)、氧合指数(PaO_(2)/FiO_(2))、MAP、中心静脉压(CVP)与入院时比较均升高,血乳酸(LAC)、HR与入院时比较均降低(P<0.05);且研究组复苏后3 d上述生命体征指标改变幅度优于对照组(P<0.05)。两组复苏后3 d TT、PT、APTT与入院时比较均升高,APACHEⅡ评分与入院时比较均降低(P<0.05);且研究组复苏后3 d TT、PT、APTT、APACHEⅡ评分均低于对照组(P<0.05)。两组复苏后3 d Na+与入院时比较均升高,K+与入院时比较均降低(P<0.05);但两组复苏后3 d Cl^(-)、Mg^(2+)、Na^(+)、K^(+)比较差异无统计学意义(P>0.05)。重复测量方差分析结果显示,两组y干扰素(y-IFN)、IL-4、IL-6、TNF-α的时点、组间、交互效应比较差异有统计学意义(P<0.05),两组复苏后30 min、1 h的y-IFN、IL-4、IL-6、TNF-α与入院时相比均显著升高,且复苏后1 h的y-IFN、IL-4、IL-6、TNF-α高于复苏后30 min(P<0.05),但研究组复苏后30 min、1 h的y-IFN、IL-4、IL-6、TNF-α均低于对照组(P<0.05)。两组急性呼吸窘迫综合征、弥散性血管内凝血、多器官功能障碍综合征、急性肾衰竭、肺部感染、腹腔感染发生率比较差异无统计学意义(P>0.05),但研究组并发症总发生率与病死率均低于对照组(8.3%vs.37.5%,2.1%vs.16.7%,P<0.05)。结论限制性急诊液体复苏方法治疗严重骨盆骨折失血性休克具有较好应用效果,可有效改善患者生命体征,纠正凝血功能紊乱状态,减轻炎症反应,降低并发症发生风险,改善预后。展开更多
基金Supported by Guangdong Provincial Medical Scientific Research Fund Project,No.B2016109.
文摘BACKGROUND Depression is a common and serious psychological condition,which seriously affects individual well-being and functional ability.Traditional treatment methods include drug therapy and psychological counseling;however,these methods have different degrees of side effects and limitations.In recent years,nonconvulsive electrotherapy(NET)has attracted increasing attention as a noninvasive treatment method.However,the clinical efficacy and potential mechanism of NET on depression are still unclear.We hypothesized that NET has a positive clinical effect in the treatment of depression,and may have a regulatory effect on serum inflammatory factors during treatment.AIM To assess the effects of NET on depression and analyze changes in serum inflammatory factors.METHODS This retrospective study enrolled 140 patients undergoing treatment for depression between May 2017 and June 2022,the observation group that received a combination of mindfulness-based stress reduction(MBSR)and NET treatment(n=70)and the control group that only received MBSR therapy(n=70).The clinical effectiveness of the treatment was evaluated by assessing various factors,including the Hamilton Depression Scale(HAMD)-17,self-rating idea of suicide scale(SSIOS),Pittsburgh Sleep Quality Index(PSQI),and levels of serum inflammatory factors before and after 8 wk of treatment.The quality of life scores between the two groups were compared.Comparisons were made using t and χ^(2) tests.RESULTS After 8 wk of treatment,the observation group exhibited a 91.43%overall effectiveness rate which was higher than that of the control group which was 74.29%(64 vs 52,χ^(2)=7.241;P<0.05).The HAMD,SSIOS,and PSQI scores showed a significant decrease in both groups.Moreover,the observation group had lower scores than the control group(10.37±2.04 vs 14.02±2.16,t=10.280;1.67±0.28 vs 0.87±0.12,t=21.970;5.29±1.33 vs 7.94±1.35,t=11.700;P both<0.001).Additionally,there was a notable decrease in the IL-2,IL-1β,and IL-6 in both groups after treatment.Furthermore,the observation group exhibited superior serum inflammatory factors compared to the control group(70.12±10.32 vs 102.24±20.21,t=11.840;19.35±2.46 vs 22.27±2.13,t=7.508;32.25±4.6 vs 39.42±4.23,t=9.565;P both<0.001).Moreover,the observation group exhibited significantly improved quality of life scores compared to the control group(Social function:19.25±2.76 vs 16.23±2.34;Emotions:18.54±2.83 vs 12.28±2.16;Environment:18.49±2.48 vs 16.56±3.44;Physical health:19.53±2.39 vs 16.62±3.46;P both<0.001)after treatment.CONCLUSION MBSR combined with NET effectively alleviates depression,lowers inflammation(IL-2,IL-1β,and IL-6),reduces suicidal thoughts,enhances sleep,and improves the quality of life of individuals with depression.
基金supported as part of the project funded by the U.S.Department of Energy under Grant No.DE-FE0002058
文摘Fracture systems have strong influence on the overall mechanical behavior of fractured rock masses dueto their relatively lower stiffness and shear strength than those of the rock matrix. Understanding theeffects of fracture geometrical distribution, such as length, spacing, persistence and orientation, isimportant for quantifying the mechanical behavior of fractured rock masses. The relation betweenfracture geometry and the mechanical characteristics of the fractured rock mass is complicated due tothe fact that the fracture geometry and mechanical behaviors of fractured rock mass are stronglydependent on the length scale. In this paper, a comprehensive study was conducted to determine theeffects of fracture distribution on the equivalent continuum elastic compliance of fractured rock massesover a wide range of fracture lengths. To account for the stochastic nature of fracture distributions, threedifferent simulation techniques involving Oda＇s elastic compliance tensor, Monte Carlo simulation （MCS）,and suitable probability density functions （PDFs） were employed to represent the elastic compliance offractured rock masses. To yield geologically realistic results, parameters for defining fracture distributionswere obtained from different geological fields. The influence of the key fracture parameters andtheir relations to the overall elastic behavior of the fractured rock mass were studied and discussed. Adetailed study was also carried out to investigate the validity of the use of a representative elementvolume （REV） in the equivalent continuum representation of fractured rock masses. A criterion was alsoproposed to determine the appropriate REV given the fracture distribution of the rock mass.
文摘BACKGROUND Many studies have focused on the femoral tunnel technique and fixation method,but few studies have involved the tibial tunnel technique and fixation method.The all-inside technique is one of the new techniques that has been described in recent years.All-inside anterior cruciate ligament(ACL)reconstruction is based on a tibial socket instead of a full tunnel.This method has many potential advantages.AIM To compare clinical outcomes of knee ACL autograft reconstruction using allinside quadrupled semitendinosus(AIST)and traditional hamstring tendon(TBT)techniques.METHODS From January 2017 to October 2019,the clinical data of 80 patients with ACL reconstruction were retrospectively analyzed,including 67 males and 13 females.The patients had an average age of 24.3±3.1 years(age range:18-33 years).The AIST technique was used in 42 patients and the TBT technique was used in 38 patients.The time between operation and injury,operative duration,postoperative visual analogue scale(VAS)score and knee functional recovery were recorded and compared between the two groups.The International Knee Documentation Committee(IKDC)and Lysholm scoring system were used to comprehensively evaluate clinical efficacy.RESULTS Eighty patients were followed for 24-36 mo,with an average follow-up duration of 27.5±1.8 mo.There were no significant differences in the time between surgery and injury,operative duration,IKDC and Lysholm scores of the affected knee at the last follow-up evaluation between the two groups.There were significant differences in VAS scores 1 d,3 d,7 d,2 wk and 1 mo after surgery(P<0.05).There was no significant difference in VAS score at 3 mo,6 mo and 1 year after operation.CONCLUSION The efficacy of the AIST ACL reconstruction technique was comparable to the TBT technique,but the postoperative pain was less with the AIST technique.Thus,the AIST technique is an ideal treatment choice for ACL reconstruction.
文摘Objectives: Femoral neck fractures are becoming more common within nowadays. This research is to explore the clinical effect of primary total hip replacement (THA) via direct anterior approach (DAA) and posterolateral approach (PLA) in the treatment of femoral neck fracture. Methods: Retrospective analysis of 100 cases of elderly patients with femoral neck fracture who underwent total hip arthroplasty admitted to Tianyou Hospital affiliated to Wuhan University of Science and Technology from January 2019 to January 2022. 50 patients treated with DAA approach were included in the observation group, and 50 patients treated with PLA approach were included in the control group. The operation indexes, postoperative acetabular abduction angle and anteversion angle, hip joint function, Harris score and complications were compared between the two groups. Result: The length of incision in the observation group was shorter than that in the control group, and the amount of intraoperative bleeding and postoperative hospital stay were shorter than those in the control group (P < 0.05);There was a statistically significant difference between the two groups in the ratio of acetabular abduction angle and its safe zone, and the length difference of both lower limbs (P < 0.05), while there was no statistically significant difference between the two groups in the ratio of acetabular anteversion angle and its safe zone, eccentricity, and its recovery rate (P > 0.05);Harris score of hip joint: 6 months after operation, the anterior approach group was significantly higher than the posterolateral approach group (P < 0.05), and there was no statistical difference between the two groups 12 months after operation (P > 0.05);The total incidence of complications in the observation group was lower than that in the control group, with a statistically significant difference (P Conclusion: DAA and PLA approaches for total hip replacement can restore the hip joint structure of patients with femoral neck fractures and achieve good results, but DAA approach has greater advantages in early postoperative recovery, improvement of hip joint function, small surgical injury, high application value, so it is recommended.
文摘目的探究不同液体复苏方法治疗严重骨盆骨折失血性休克的效果及预后分析。方法前瞻性选取2021年6月—2023年6月笔者医院收治的严重骨盆骨折失血性休克患者96例为研究对象,其中男性56例,女性40例;年龄18~55岁,平均38.6岁;道路交通伤51例,高处坠落伤24例,挤压伤21例。患者入院后均完成止血、骨折外固定等外科急救处理,常规监测生命体征、建立静脉通道、完善血常规等术前检查。随机数字表法分为研究组48例与对照组48例。对照组患者进行常规快速液体复苏,及时补充足量的平衡液、胶体液、悬浮红细胞、血浆等,研究组予以限制性液体复苏,前期适当输入高渗氯化钠溶液,而后输入平衡液等。比较两组入院时、复苏后3 d生命体征指标,凝血指标与急性生理与慢性健康II(APACHEⅡ)评分,电解质水平以及入院时、复苏后30 min、1 h炎症因子水平,观察两组预后指标差异。结果两组复苏后3 d全心舒张末期容量指数(GEDVI)、心脏指数(CI)、心排血量(CO)、氧合指数(PaO_(2)/FiO_(2))、MAP、中心静脉压(CVP)与入院时比较均升高,血乳酸(LAC)、HR与入院时比较均降低(P<0.05);且研究组复苏后3 d上述生命体征指标改变幅度优于对照组(P<0.05)。两组复苏后3 d TT、PT、APTT与入院时比较均升高,APACHEⅡ评分与入院时比较均降低(P<0.05);且研究组复苏后3 d TT、PT、APTT、APACHEⅡ评分均低于对照组(P<0.05)。两组复苏后3 d Na+与入院时比较均升高,K+与入院时比较均降低(P<0.05);但两组复苏后3 d Cl^(-)、Mg^(2+)、Na^(+)、K^(+)比较差异无统计学意义(P>0.05)。重复测量方差分析结果显示,两组y干扰素(y-IFN)、IL-4、IL-6、TNF-α的时点、组间、交互效应比较差异有统计学意义(P<0.05),两组复苏后30 min、1 h的y-IFN、IL-4、IL-6、TNF-α与入院时相比均显著升高,且复苏后1 h的y-IFN、IL-4、IL-6、TNF-α高于复苏后30 min(P<0.05),但研究组复苏后30 min、1 h的y-IFN、IL-4、IL-6、TNF-α均低于对照组(P<0.05)。两组急性呼吸窘迫综合征、弥散性血管内凝血、多器官功能障碍综合征、急性肾衰竭、肺部感染、腹腔感染发生率比较差异无统计学意义(P>0.05),但研究组并发症总发生率与病死率均低于对照组(8.3%vs.37.5%,2.1%vs.16.7%,P<0.05)。结论限制性急诊液体复苏方法治疗严重骨盆骨折失血性休克具有较好应用效果,可有效改善患者生命体征,纠正凝血功能紊乱状态,减轻炎症反应,降低并发症发生风险,改善预后。
