Clostridium peringens, also called clostridium westergren, mainly causes diseases in ruminants, such as gas gangrene, enterotoxaemia, hemorrhagic enteritis of cattle and sheep. The bacteria are divided into five subty...Clostridium peringens, also called clostridium westergren, mainly causes diseases in ruminants, such as gas gangrene, enterotoxaemia, hemorrhagic enteritis of cattle and sheep. The bacteria are divided into five subtypes including A, B, C, D and E subtype, which can secrete more than 10 kinds of exotoxin,In these toxins, a, β, ε and ζ play a key pathogenic role. At present, the disease is prevented mainly by univalent vaccine, combined vaccine and muhivalent inactivated vaccine. And the genetic engineering subunit vaccine and nucleic acid vaccine has wide develop- ment prospects. In order to provide some reference for comprehensive prevention and deep research of C. pe^ringens, the etiological characteristics of C. perfrin- germ, pathogenic mechanism of exotoxin and research progress of related vaccines were reviewed, and the genetic engineering subunit vaccine and nucleic acid vac- cine development prospects were also discussed in this paper.展开更多
基金Supported by Monitoring and Control Program of Animal Diseases of the Ministry of Agriculture
文摘Clostridium peringens, also called clostridium westergren, mainly causes diseases in ruminants, such as gas gangrene, enterotoxaemia, hemorrhagic enteritis of cattle and sheep. The bacteria are divided into five subtypes including A, B, C, D and E subtype, which can secrete more than 10 kinds of exotoxin,In these toxins, a, β, ε and ζ play a key pathogenic role. At present, the disease is prevented mainly by univalent vaccine, combined vaccine and muhivalent inactivated vaccine. And the genetic engineering subunit vaccine and nucleic acid vaccine has wide develop- ment prospects. In order to provide some reference for comprehensive prevention and deep research of C. pe^ringens, the etiological characteristics of C. perfrin- germ, pathogenic mechanism of exotoxin and research progress of related vaccines were reviewed, and the genetic engineering subunit vaccine and nucleic acid vac- cine development prospects were also discussed in this paper.
