The 8^th International Workshop on Human Leucocyte Differentiation Antigens （chaired by HZ and managed by BS） was run over a 4-year period and culminated in a conference in December 2004. Here we review the achievem...The 8^th International Workshop on Human Leucocyte Differentiation Antigens （chaired by HZ and managed by BS） was run over a 4-year period and culminated in a conference in December 2004. Here we review the achievements of the HLDA Workshops and provide links to information on CD molecules and antibodies against them, including the 93 new CDs assigned in the 8^th Workshop. We consider what remains to be achieved （including an estimate of the number of leucocyte surface molecules still to be discovered）, and how the field can best move forward.展开更多
目的:研究血复生对再生障碍性贫血(aplastic anemia,AA)患者骨髓T细胞表面分化决定簇28(cluster of differentiation 28,CD28)和(或)细胞毒T细胞相关抗原4(cytotoxic T cell antigen 4,CTLA4)表达的影响,探讨血复生治疗AA的作用机制。方...目的:研究血复生对再生障碍性贫血(aplastic anemia,AA)患者骨髓T细胞表面分化决定簇28(cluster of differentiation 28,CD28)和(或)细胞毒T细胞相关抗原4(cytotoxic T cell antigen 4,CTLA4)表达的影响,探讨血复生治疗AA的作用机制。方法:将2006年6月至2008年6月江苏省中医院血液科门诊及住院的30例重型AA患者随机分为两组,治疗组使用血复生加环孢菌素治疗,对照组单用环孢菌素治疗。10名自愿者骨髓为正常对照组。观察时间为3个月,双色免疫荧光法测定治疗组及对照组治疗前后及正常对照组骨髓T细胞表面CD28、CTLA4表达的变化。结果:AA患者治疗前CD28的水平较正常人显著升高,差异有显著性(P<0.05),CTLA4水平有所上升,但差异无显著性(P>0.05)。治疗组及对照组CD28水平较用药前显著下降(P<0.05),治疗组较对照组下降更显著(P<0.05)。结论:血复生可增强环孢菌素的免疫调节作用,对AA的治疗起到增效作用。展开更多
文摘The 8^th International Workshop on Human Leucocyte Differentiation Antigens （chaired by HZ and managed by BS） was run over a 4-year period and culminated in a conference in December 2004. Here we review the achievements of the HLDA Workshops and provide links to information on CD molecules and antibodies against them, including the 93 new CDs assigned in the 8^th Workshop. We consider what remains to be achieved （including an estimate of the number of leucocyte surface molecules still to be discovered）, and how the field can best move forward.
文摘目的:研究血复生对再生障碍性贫血(aplastic anemia,AA)患者骨髓T细胞表面分化决定簇28(cluster of differentiation 28,CD28)和(或)细胞毒T细胞相关抗原4(cytotoxic T cell antigen 4,CTLA4)表达的影响,探讨血复生治疗AA的作用机制。方法:将2006年6月至2008年6月江苏省中医院血液科门诊及住院的30例重型AA患者随机分为两组,治疗组使用血复生加环孢菌素治疗,对照组单用环孢菌素治疗。10名自愿者骨髓为正常对照组。观察时间为3个月,双色免疫荧光法测定治疗组及对照组治疗前后及正常对照组骨髓T细胞表面CD28、CTLA4表达的变化。结果:AA患者治疗前CD28的水平较正常人显著升高,差异有显著性(P<0.05),CTLA4水平有所上升,但差异无显著性(P>0.05)。治疗组及对照组CD28水平较用药前显著下降(P<0.05),治疗组较对照组下降更显著(P<0.05)。结论:血复生可增强环孢菌素的免疫调节作用,对AA的治疗起到增效作用。
