An approach based on combinations of various water compatible Lewis acids and lipophilic group containing amphiphilic prolinamide co-catalysts has been evaluated for the direct asymmetric Aldol reaction. From the broa...An approach based on combinations of various water compatible Lewis acids and lipophilic group containing amphiphilic prolinamide co-catalysts has been evaluated for the direct asymmetric Aldol reaction. From the broad screening of chloride salts from alkali metal to transition metal, LiC1, ZnCI2 and SnCI2 lead to the highest stereoselectivities. The optimized catalytic conditions （10 mol% prolinamide with 10 mol% MC12 or 20 mol% LiC1 at room temperature on water） gave anti-products with improved enantioselectivities （up to 99% ee） compared to the moderately stereoselective procedure based on prolinamide activation only.展开更多
文摘An approach based on combinations of various water compatible Lewis acids and lipophilic group containing amphiphilic prolinamide co-catalysts has been evaluated for the direct asymmetric Aldol reaction. From the broad screening of chloride salts from alkali metal to transition metal, LiC1, ZnCI2 and SnCI2 lead to the highest stereoselectivities. The optimized catalytic conditions （10 mol% prolinamide with 10 mol% MC12 or 20 mol% LiC1 at room temperature on water） gave anti-products with improved enantioselectivities （up to 99% ee） compared to the moderately stereoselective procedure based on prolinamide activation only.
