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Coupled DEM-FDM analyses of the effects of falling rock’s shape and impact angle on response of granular cushion and rock shed
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作者 Jingyu Xue Chen Cao +2 位作者 Jianhua Yan Yaopeng Ji Jianping Chen 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第8期3353-3364,共12页
Rock shed is an effective protection measure against rockfall.To investigate the influences of falling rock’s shape and impact angle on the impact effect of the cushioned rock shed,a modeling approach for a rock shed... Rock shed is an effective protection measure against rockfall.To investigate the influences of falling rock’s shape and impact angle on the impact effect of the cushioned rock shed,a modeling approach for a rock shed with a cushion layer using PFC-FLAC.The granular cushion is modeled as an aggregate of discrete non-cohesion particles,while the concrete plate and the beam are modeled as zones.The falling rock with different sphericities and impact angles is modeled as a rigid assembly.The numerical model is validated by comparing the simulation results with experimental and numerical results from previous literature.This model is applied to analyze the effects of rock shape and impact angle on the dynamic interaction effects between falling rock and cushioned rock shed,including the impact force,transmitted bottom force,penetration depth,and plate deflection.The numerical results show that the variation in the falling rock’s shape has different effects on the falling rock with different impact angles.These findings could support rock shed design by revealing the limitations of the assumptions in the past research,which may result in unsafe rock sheds for some rockfall cases. 展开更多
关键词 Rockfall Coupled DEM-FDM analysis Rock’s shape Impact angle Granular cushion Rock shed
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A Procedure for Trisecting an Acute Angle (Method 2)
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作者 Lyndon O. Barton 《Advances in Pure Mathematics》 2024年第4期204-213,共10页
This paper presents an alternate graphical procedure (Method 2), to that presented in earlier publications entitled, “A Procedure for Trisecting an Acute Angle” and “A Key to Solving the Angle Trisection Problem”.... This paper presents an alternate graphical procedure (Method 2), to that presented in earlier publications entitled, “A Procedure for Trisecting an Acute Angle” and “A Key to Solving the Angle Trisection Problem”. The procedure, when applied to the 30˚ and 60˚ angles that have been “proven” to be nottrisectable and the 45˚ benchmark angle that is known to be trisectable, in each case produced a construction having an identical angular relationship with Archimedes’ Construction, as in Section 2 on THEORY of this paper, where the required trisection angle was found to be one-third of its respective angle (i.e. DE’MA = 1/3 DE’CG). For example, the trisection angle for the 30˚, 45˚ and 60˚ angles were 10.00000˚, 15.00000˚, and 20.00000˚, respectively, and Section 5 on PROOF in this paper. Therefore, based on this identical angular relationship and the numerical results (i.e. to five decimal places), which represent the highest degree of accuracy and precision attainable by The Geometer’s Sketch Pad software, one can only conclude that not only the geometric requirements for arriving at an exact trisection of the 30˚ and 60˚ angle (which have been “proven” to be not-trisectable) have been met, but also, the construction is valid for any arbitrary acute angle, despite theoretical proofs to the contrary by Wantzel, Dudley, and others. 展开更多
关键词 Archimedes Construction College Geometry College Mathematics angle Trisection Famous Problems in Mathematics Mechanism Analysis Geometer’s sketch Pad
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后凸Cobb's角、BMD、P1NP对骨质疏松性椎体压缩性骨折患者PKP术后再发骨折风险的预测价值分析
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作者 张弛 吴海龙 +2 位作者 张帅 田振峰 张斌 《疑难病杂志》 CAS 2024年第4期457-461,共5页
目的探讨后凸Cobb's角、骨密度(BMD)、Ⅰ型前胶原氨基端前肽(P1NP)对骨质疏松性椎体压缩性骨折(OVCF)患者球囊扩张椎体后凸成形术(PKP)术后再发骨折风险的预测价值。方法选取2018年12月—2020年6月石家庄市人民医院骨科收治的行PKP... 目的探讨后凸Cobb's角、骨密度(BMD)、Ⅰ型前胶原氨基端前肽(P1NP)对骨质疏松性椎体压缩性骨折(OVCF)患者球囊扩张椎体后凸成形术(PKP)术后再发骨折风险的预测价值。方法选取2018年12月—2020年6月石家庄市人民医院骨科收治的行PKP术的OVCF患者110例作为研究对象,进行2年随访,根据随访过程中是否出现新发骨折分为再发骨折组28例和未再发骨折组82例。比较2组患者一般资料及术后指标,Cox分析影响PKP术后再发骨折的危险因素,绘制ROC曲线分析后凸Cobb's角、BMD、P1NP对OVCF患者PKP术后再发骨折的预测价值。结果随访期间骨折再发生率为25.45%(28/110)。再发骨折组后凸Cobb's角、P1NP高于未再发骨折组,BMD低于未再发骨折组,差异具有统计学意义(t/P=4.678/<0.001,4.591/<0.001,4.784/<0.001);Cox分析结果显示,后凸Cobb's角增大、BMD降低、P1NP升高均是影响PKP术后再发骨折的危险因素[OR(95%CI)=1.394(1.135~1.712)、1.910(1.127~3.236)、2.140(1.084~4.225),P<0.05];ROC曲线分析显示,后凸Cobb's角≥5.87°、BMD≤-3.38 SD、P1NP≤50.67μg/L为截断值,后凸Cobb's角、BMD、P1NP预测OVCF患者PKP术后再发骨折的AUC分别为0.725、0.846、0.836,3项联合AUC为0.899,高于单项检测(Z/P=8.129/<0.001,7.195/<0.001,7.695/<0.001)。结论定期监测后凸Cobb's角、BMD、P1NP水平可在早期预测OVCF患者PKP术后再发骨折风险以便及时给予干预措施。 展开更多
关键词 椎体压缩性骨折 骨质疏松性 球囊扩张椎体后凸成形术 再发骨折风险 后凸cobb's 骨密度 Ⅰ型前胶原氨基端前肽 预测价值
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A Simplified Graphical Procedure for Constructing a 10˚or 20˚Angle
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作者 Lyndon O. Barton 《Advances in Pure Mathematics》 2023年第7期442-448,共7页
This paper presents a simplified graphical procedure for constructing, using an unmarked straightedge and a compass only, a 10˚ to 20˚ angle, which is in other words, trisecting a 30˚ or 60˚ angle. The procedure, when... This paper presents a simplified graphical procedure for constructing, using an unmarked straightedge and a compass only, a 10˚ to 20˚ angle, which is in other words, trisecting a 30˚ or 60˚ angle. The procedure, when applied to the 30˚ and 60˚ angles that have been “proven” to be not trisectable, produced a construction having the identical angular relationship with Archimedes’ Construction, in which the required trisection angles were found to be 10.00000˚ and 20.00000˚ respectively (i.e. exactly one-third of the given angle or ∠E’MA = 1/3∠E’CG). Based on this identical angular relationship as well as the numerical results obtained, one can only conclude that the geometric requirements for arriving at an exact trisection of the 30˚ or 60˚ angle, and therefore the construction of a 10˚ or 20˚ angle, have been met, notwithstanding the theoretical proofs of Wantzel, Dudley, and others. Thus, the solution to the age-old trisection problem, with respect to these two angles, has been accomplished. 展开更多
关键词 Archimedes Construction College Geometry angle Trisection Trisection of an angle Famous Problems in Mathematics. Geometer’s sketch Pad Mechanisms Mechanism Analysis Kinematics Trisector
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A Key to Solving the Angle Trisection Problem
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作者 Lyndon O. Barton 《Advances in Pure Mathematics》 2023年第9期625-634,共10页
This paper describes the methodology (or approach) that was key to the solution of the angle trisection problem published earlier in article entitled, “A Procedure For Trisecting An Acute Angle.” It was an approach ... This paper describes the methodology (or approach) that was key to the solution of the angle trisection problem published earlier in article entitled, “A Procedure For Trisecting An Acute Angle.” It was an approach that required first, designing a working model of a trisector mechanism, second, studying the motion of key elements of the mechanism and third, applying the fundamental principles of kinematics to arrive at the desired results. In presenting these results, since there was no requirement to provide a detailed analysis of the final construction, this information was not included. However, now that the publication is out, it is considered appropriate as well as instructive to explain more fully the mechanism analysis of the trisector in graphical detail, as covered in Section 3 of this paper, that formed the basis of the long sought solution to the age-old Angle Trisection Problem. 展开更多
关键词 Archimedes Construction College Geometry College Mathematics angle Trisection Trisector Famous Problems in Mathematics History of Mathematics Mechanism Analysis Kinematics Geometer’s sketch Pad
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Reliability of a Novel Cobb Protractor for Measuring the Cobb Angle of Radiograph in Scoliosis 被引量:2
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作者 Gui Wu Hai Wang +3 位作者 Ran Ding Xu-hong Xue Zhi-hong Wu Gui-xing Qiu 《Chinese Medical Sciences Journal》 CAS CSCD 2015年第1期18-22,共5页
Objective To introduce a novel Cobb protractor and assess its reliability and rapidity for measuring Cobb angle in scoliosis patients. Methods The novel Cobb protractor had two endplate markers. A measurement was perf... Objective To introduce a novel Cobb protractor and assess its reliability and rapidity for measuring Cobb angle in scoliosis patients. Methods The novel Cobb protractor had two endplate markers. A measurement was performed just to align the two markers to each endplate of the curve. The Cobb angle on the posteroanterior radiographs of 24 patients clinically diagnosed with adolescent idiopathic scoliosis was measured by three orthopedic surgeons with both standard Cobb method and the new technique, and the time of measurement was recorded. Intraclass correlation coefficients(ICCs) were calculated to assess the reliability of the new method. Results The time for a measurement with the new tool was approximately 10 seconds less than the time that used to finish a measurement with the standard method(P<0.05). The overall mean Cobb angle for the major curve of the 24 patients was 47.8°. The mean overall intraobserver and interobserver ICC was 0.971 and 0.971 for the Cobb method group, while the overall intraobserver ICC and the interobserver was 0.985 and 0.979 for the new tool group. Conclusions The novel Cobb protractor could perform quick measurement and measure almost all forms of radiographs. The Cobb protractor might be an ideal instrument to measure the Cobb angle. 展开更多
关键词 速度测量 量角器 可靠性 X光片 脊柱 侧弯 标准方法 观察者
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骨性Angle′s Ⅲ类错患者正畸手术前后下颌角矢量点位置的变化及意义 被引量:1
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作者 王晨星 高振杰 陈刚 《山东医药》 CAS 北大核心 2011年第22期98-99,共2页
目的观察骨性Angle′sⅢ类错患者下颌角矢量点(Gov点)位置变化,并探讨其临床意义。方法取天津地区健康人29例为对照组,接受正手术治疗的骨性Angle′sⅢ类错畸形患者15例为观察组。均拍摄头颅侧位X线片,测量Gov点的座标。结果观察... 目的观察骨性Angle′sⅢ类错患者下颌角矢量点(Gov点)位置变化,并探讨其临床意义。方法取天津地区健康人29例为对照组,接受正手术治疗的骨性Angle′sⅢ类错畸形患者15例为观察组。均拍摄头颅侧位X线片,测量Gov点的座标。结果观察组术前、术后及对照组Gov点横坐标分别为(-4.54±0.51)、(-5.10±0.69)、(-5.02±0.35)cm,纵坐标分别为(-7.76±0.40)、(-7.65±0.57)、(-7.50±0.43)cm,观察组术前Gov点横、纵坐标与术后及对照组比较P均<0.05,观察组术后与对照组Gov点横、纵坐标比较P均>0.05。对照组下颌神经孔与Gov点间距为(1.35±0.16)cm,观察组术前为(1.27±0.19)cm,两组相比P>0.05。结论骨性Angle′sⅢ类错患者Gov点位置向前下移位,正手术后得以纠正。Gov点位置可能与下颌功能状态存在内在联系,可以作为正手术术前制定手术计划及术后评估矫治效果的指标。 展开更多
关键词 骨性anglesⅢ类错 下颌角矢量点 二维X线头影测量
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基于伤椎高度、Cobb角评估棘突与椎板外缘定位椎弓根技术治疗胸腰椎骨折的疗效
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作者 李忠 尹祖昌 +3 位作者 闫菁辉 王铁铸 孟宪卿 王清河 《生物医学工程与临床》 CAS 2024年第2期198-204,共7页
目的通过伤椎高度、Cobb角评估棘突与椎板外缘定位椎弓根技术研究治疗胸腰椎骨折的疗效。方法选择2017年9月至2020年9月在衡水市第四人民医院收治的胸腰椎骨折患者116例,其中男性61例,女性55例;年龄38~71岁,平均年龄48.59岁;骨折节段,L... 目的通过伤椎高度、Cobb角评估棘突与椎板外缘定位椎弓根技术研究治疗胸腰椎骨折的疗效。方法选择2017年9月至2020年9月在衡水市第四人民医院收治的胸腰椎骨折患者116例,其中男性61例,女性55例;年龄38~71岁,平均年龄48.59岁;骨折节段,L137例,L223例,L1121例,L1235例。按照数字表法将患者分为观察组58例和对照组58例,两组患者均行椎弓根技术治疗。对照组患者给予上关节突外缘垂直线与横突平分线交点(Magerl法)定位椎弓根钉。观察组患者给予棘突与椎板外缘定位椎弓根钉。对比两组患者的Oswestry功能障碍指数(ODI)、伤椎矢状面Cobb角及伤椎前缘高度压缩率、骨代谢、骨愈合、炎症反应、肿胀及疼痛程度。结果两组患者术前、术后1周、术后1年的ODI比较,差异无统计学意义(P>0.05)。术前、术后1周两组患者的伤椎矢状面Cobb角比较,差异无统计学意义(P>0.05)。术后1年观察组伤椎矢状面Cobb角低于对照组[(9.8±2.9)°vs(13.5±3.0)°。P<0.05]。术前、术后1周两组患者的伤椎前缘高度压缩率比较,差异无统计学意义(P>0.05)。术后1年对照组伤椎前缘高度压缩率高于观察组[(14.2±3.4)%vs(8.6±2.2)%。P<0.05]。观察组患者的血清碱性磷酸酶(ALP)、Ⅰ型前胶原羧基端前肽(PICP)及骨钙素(BGP)指标均高于对照组[(219.23±6.34)μg/L vs(182.54±5.17)μg/L、(112.72±2.18)μg/L vs(93.67±2.69)μg/L、(7.52±0.36)μg/L vs(4.21±0.14)μg/L。P<0.05]。观察组可溶性细胞间黏附分子-1(sLCAM-1)、胰岛素样生长因子-1(IGF-1)指标均高于对照组[(107.58±4.25)μg/L vs(92.12±4.19)μg/L、(296.57±8.04)μg/L vs(237.28±7.82)μg/L。P<0.05]。观察组患者肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)及白细胞介素-1(IL-1)指标均低于对照组[(1.20±0.27)μg/L vs(1.52±0.51)μg/L、(1.06±0.14)μg/L vs(1.35±0.28)μg/L、(0.98±0.27)μg/L vs(1.19±0.42)μg/L。P<0.05]。第1天、第5天、第10天、第15天、第20天两组患者的肿胀程度及疼痛评分均逐渐降低,除第1天观察组肿胀程度高于对照组外[(3.88±0.54)分vs(3.31±0.43)分。P<0.05],其他不同时间对照组疼痛评分及肿胀程度高于观察组(P<0.05)。结论棘突与椎板外缘定位椎弓根技术治疗胸腰椎骨折可降低患者的伤椎高度、Cobb角,提高骨代谢,降低炎症反应、肿胀及疼痛程度,促进骨愈合,临床疗效显著。 展开更多
关键词 伤椎高度 骨代谢 cobb 棘突与椎板外缘定位 椎弓根技术 胸腰椎骨折
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Osteonectin促进骨髓来源间充质干细胞成骨分化的机制及其与青少年特发性脊柱侧凸的相关性研究
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作者 赵志蓉 陈涛 陈焕雄 《转化医学杂志》 2024年第2期177-182,共6页
目的 探究Osteonectin在促进骨髓间充质干细胞(BMSCs)成骨分化的分子机制,以及Osteonectin在青少年特发性脊柱侧凸(AIS)中的作用。方法 将2020年5月—2022年5月就诊的20例AIS及健康体检20例分别作为AIS组和健康组。使用qRT-PCR技术测定2... 目的 探究Osteonectin在促进骨髓间充质干细胞(BMSCs)成骨分化的分子机制,以及Osteonectin在青少年特发性脊柱侧凸(AIS)中的作用。方法 将2020年5月—2022年5月就诊的20例AIS及健康体检20例分别作为AIS组和健康组。使用qRT-PCR技术测定2组BMSCs中Osteonectin、BMP2以及Wnt/β-catenin信号通路相关基因(Tcf7、Lef1)和成骨分化相关基因(Runx2、Osteocalcin)的表达水平。通过X线检测AIS患者的Cobb角度,并分析上述基因表达水平与Cobb角度的相关性。在BMSCs中,加入Osteonectin和BMP2抑制剂Noggin,并分为对照组、Osteonectin组和Osteonectin+Noggin组。通过qRT-PCR检测BMSCs中BMP2、Tcf7、Lef1、Runx2和Osteocalcin mRNA表达水平。采用ChIP-qPCR检测β-catenin在Runx2和Osteocalcin基因转录起始位(TSS)的富集水平。结果 与健康组比较,AIS组BMSCs中Osteonectin、BMP2、Tcf7、Lef1、Runx2和Osteocalcin mRNA表达水平均降低(P<0.05);Osteonectin、BMP2、Tcf7、Lef1、Runx2和Osteocalcin mRNA表达水平与AIS患者Cobb角度呈负相关(r=-0.466 3、-0.369 1、-0.272 7、-0.543 4、-0.606 5、-0.343 3,P<0.05,P<0.01)。与对照组比较,Osteonectin组BMSCs中BMP2、Tcf7、Lef1、Runx2和Osteocalcin mRNA表达水平升高,且β-catenin在Runx2和Osteocalcin mRNA TSS富集水平增加(P<0.05)。相比Osteonectin组,Osteonectin+Noggin组BMSCs中Tcf7、Lef1、Runx2和Osteocalcin mRNA表达水平降低,β-catenin在Runx2和Osteocalcin mRNA TSS富集水平降低(P<0.05)。结论 在AIS患者中,BMSCs中Osteonectin、BMP2-Wnt/β-catenin的表达以及成骨分化水平与AIS疾病的发展呈负相关。Osteonectin通过激活BMP2-Wnt/β-catenin信号通路,促使β-catenin转录激活成骨分化相关基因,从而促进BMSCs的成骨分化。 展开更多
关键词 青少年特发性脊柱侧凸 骨结合素 骨粘连蛋白 骨髓来源间充质干细胞 染色质免疫共沉淀 成骨分化 cobb BMP2-Wnt/β-catenin信号通路
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青少年特发性脊柱侧凸主胸弯悬吊位和矫形术后Cobb角分布差异分析
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作者 刘延 刘青山 +4 位作者 王梦真 韩良丽 杨长伟 侯藏龙 张秋林 《海军军医大学学报》 CAS CSCD 北大核心 2024年第6期688-692,共5页
目的分析Lenke 1型青少年特发性脊柱侧凸(AIS)患者主胸弯Cobb角分布特征,以及不同节段间悬吊牵引法测得的柔韧性、矫正率、矫正指数的差异。方法纳入2015年1月至2018年12月于海军军医大学(第二军医大学)第一附属医院行一期脊柱侧凸后路... 目的分析Lenke 1型青少年特发性脊柱侧凸(AIS)患者主胸弯Cobb角分布特征,以及不同节段间悬吊牵引法测得的柔韧性、矫正率、矫正指数的差异。方法纳入2015年1月至2018年12月于海军军医大学(第二军医大学)第一附属医院行一期脊柱侧凸后路三维矫形融合内固定术的48例Lenke 1型AIS患者。将主胸弯分为近段(T_(5)~T_(7)或T_(6)~T_(8))、中段(T_(7)~T_(9)或T_(8)~T_(10))、远段(T_(9)~T_(11)或T_(10)~T_(12)),并测量各段的Cobb角。计算不同节段的侧弯柔韧性、矫正率和矫正指数(术后矫正率/术前侧弯柔韧性)。采用随机区组的方差分析进行统计学分析。结果患者术前平均年龄为(14.31±2.24)岁,总Cobb角为(51.25±11.86)°,平均Risser分级为2.88±1.93;术后平均随访时间为(38.75±8.82)个月。术前近段Cobb角与远段Cobb角相似[(13.31±5.10)°vs(13.94±5.67)°,P=0.757],中段Cobb角[(24.00±5.61)°]大于近段及远段Cobb角(均P<0.001)。术前近段、中段、远段Cobb角占总Cobb角的比例分别为(25.72±7.97)%、(47.08±5.22)%、(27.20±8.00)%。术前远段侧弯柔韧性高于近段和中段[(64.01±24.18)%vs(35.00±18.02)%、(41.49±17.65)%,均P<0.001]。术后1周,近段、中段、远段矫正率分别为(74.61±15.80)%、(65.66±16.36)%和(73.76±19.41)%,差异无统计学意义(P=0.280);矫正指数分别为2.41±1.20、2.03±1.45和1.49±1.31,近段矫正指数高于远段(P=0.040)。末次随访时,近段、中段、远段矫正率分别为(71.10±14.07)%、(62.39±13.47)%和(69.75±17.53)%,差异无统计学意义(P=0.226);矫正指数分别为2.24±1.10、1.92±1.30和1.39±1.10,近段的矫正指数高于远段(P=0.026)。结论在Lenke 1型AIS患者中,近段、中段和远段Cobb角分别占主胸弯的25.72%、47.08%、27.20%。悬吊牵引法对远段柔韧性的评估能力最强,即悬吊位下远端节段最灵活,而各节段术后矫正率无明显差异。 展开更多
关键词 青少年特发性脊柱侧凸 柔韧性 悬吊牵引法 cobb 矫正率
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融合多尺度注意力的脊柱侧弯Cobb角自动估计算法
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作者 韩广萍 张魁星 +2 位作者 王苹苹 李翔 魏本征 《北京生物医学工程》 2024年第4期383-390,共8页
目的 青少年特发性脊柱侧弯(adolescent idiopathic scoliosis,AIS)是危害青少年健康的常见疾病之一。临床上,X线图像Cobb角测量法是评估患者脊柱侧凸严重程度的“金标准”。由于X线图像中肋骨和骨盆阴影重叠以及椎骨形态差异等因素影响... 目的 青少年特发性脊柱侧弯(adolescent idiopathic scoliosis,AIS)是危害青少年健康的常见疾病之一。临床上,X线图像Cobb角测量法是评估患者脊柱侧凸严重程度的“金标准”。由于X线图像中肋骨和骨盆阴影重叠以及椎骨形态差异等因素影响,人工测量在寻找关键点时步骤复杂且耗时长,快速且准确的Cobb角自动测量方法具有重要临床应用价值。现有深度学习方法中基于分割的方法易受图像质量影响;基于关键点检测方法过于关注局部特征提取导致定位不准确等问题。为此,本文提出了一种以椎骨为中心的标志点检测方法,来实现脊柱侧弯Cobb角自动估计算法。方法 构建一种基于融合多尺度和注意力机制M型椎骨检测网络(multi-scale attention M-shaped network,MSAM-Net)。首先,使用多尺度金字塔拆分注意力(multi-scale pyramids squeeze attention,MPSA)模块和注意力特征融合(attentional feature fusion,AFF)模块提取椎骨特征和上下文信息,然后,根据椎体中心和角偏移量定位4个角标志点,以在脊柱侧弯评估任务中提高椎骨标志点检测的性能,进而实现近胸段、主胸段和胸腰段曲线的Cobb角估计。结果 为了评估Cobb角估计与真实侧弯角度之间的偏差程度,本研究算法基于AASCE MICCAI 2019挑战赛数据集,使用4种指标对Cobb角精度进行评估,分别是对称平均绝对百分比误差(symmetric mean absolute percentage error,SMAPE)、欧氏距离(Euclidean distance,ED)、曼哈顿距离(Manhattan distance,MD)和切比雪夫距离(Chebyshev distance,CD)。测试得到SMAPE为9.39%,ED为4.18;MD为5.92;CD为5.34。与基于分割和检测的5种深度学习方法进行对比,实现更好的Cobb角测量结果。结论 本研究可以准确识别和定位X线图像中椎骨,帮助医生测量AIS患者的Cobb角,为临床AIS诊断、手术计划和脊柱健康分析提供决策支持。 展开更多
关键词 青少年特发性脊柱侧弯 椎骨检测 cobb 深度学习 注意力机制
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Modified viscocanalostomy in the Chinese population with open angle glaucoma: a 10-year follow-up results 被引量:3
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作者 Ya Liang Hong Sun +4 位作者 Jie Shuai Kai Xu Fang-Fang Ji Sucijanti Zhi-Lan Yuan 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2019年第3期429-435,共7页
AIM: To study the long-term efficacy and safety of modified viscocanalostomy in Chinese people with open angle glaucoma(OAG).METHODS: This retrospective study included a total of 100 eyes from 100 Chinese patients wit... AIM: To study the long-term efficacy and safety of modified viscocanalostomy in Chinese people with open angle glaucoma(OAG).METHODS: This retrospective study included a total of 100 eyes from 100 Chinese patients with medically uncontrolled OAG. All the patients underwent modified viscocanalostomy with injection of viscoelastic material in the surgically created ostia of Schlemm's canal(SC). The modifications included peeling of the inner wall of SC and the juxtacanalicular meshwork, use of mitomycin C, and loosely suturing the superficial scleral flap. Intraocular pressure(IOP), visual acuity, number of medications, laser goniopuncture data and complications were recorded. The definition of complete(qualified) success was an IOP equal to or lower than 21, 18, 16 mm Hg without(with or without) anti-glaucoma medications. RESULTS: The mean IOP was 33.5±9.9 mm Hg before surgery, 15.2±3.6 mm Hg(mean IOP reduction of 51%) at 5 y after surgery, and 15.6±2.8 mm Hg(mean IOP reduction of 49.9%) at 10 y after surgery(P<0.001). The number of anti-glaucoma medications dropped from 2.39±0.5 preoperatively to 0.47±0.8 at 5 y and 0.67±0.8 at 10 y postoperatively(P<0.001). The follow-up period was 104.5±37.0 mo. The qualified success rate for an IOP of 21, 18 or 16 mm Hg or less was 84% [95% confidence interval(CI): 0.80-0.88], 73%(95%CI: 0.68-0.78), and 59%(95%CI: 0.52-0.66) after 5 y, and 80%(95%CI: 0.76-0.84), 69%(95%CI: 0.64-0.74), 51%(95%CI: 0.44-0.58) after 10 y, respectively. There was a relationship between age, preoperative IOP and success rate(P<0.01, P<0.05). A total of 31 eyes(31.3%)in 31 patients underwent laser goniopuncture, decreasing the IOP from 22.9±4.3 mm Hg to 16.3±2.5 mm Hg(P<0.01). Neither blebitis nor endophthalmitis occurred.CONCLUSION: Modified viscocanalostomy could be performed to lower IOP, decrease multiple anti-glaucoma drops use as well. It's a safe procedure with less complications over 10 y in Chinese individuals with OAG. 展开更多
关键词 non-penetrating GLAUCOMA sURGERY VIsCOCANALOsTOMY schlemm’s CANAL open angle GLAUCOMA laser goniopuncture
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Elevated urine formaldehyde in elderly patients with primary open angle glaucoma 被引量:3
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作者 Ying Cui Tao Su +6 位作者 Shao-Dan Zhang Ping Huang Ying-Ge He Ying Liu Chun Zhang Robert Ritch Rong-Qiao He 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2016年第3期411-416,共6页
AIM:To investigate the risk factor of primary open angle glaucoma(POAG),which is the leading cause of irreversible blindness worldwide.An abnormally high level of endogenous formaldehyde(FA) has recently been fou... AIM:To investigate the risk factor of primary open angle glaucoma(POAG),which is the leading cause of irreversible blindness worldwide.An abnormally high level of endogenous formaldehyde(FA) has recently been found correlated with cell death and neurodegenerative disease,raising the possibility of a putative correlation of abnormal endogenous FA with POAG.· METHODS:Thirty-four elderly patients with POAG and sixteen healthy controls were enrolled.Glaucomatous visual defects were present at both the functional(visual field) and structural[retinal nerve fiber layer(RNFL)thickness]levels.Morning urine samples were obtained and were analyzed by high-performance liquid chromatography(HPLC) to detect the endogenous FA level in a double blind manner.· RESULTS:Patients with POAG(P 〈0.05) had significantly higher urine FA levels.The urine FA level of patients with severe visual field defects[mean deviation(MD)≥12 dB]was significantly(P〈0.001) greater than that of patients with mild to moderate defects(MD〈12 dB).By optical coherence tomography(OCT),the superior and inferior RNFL thickness of POAG group was significantly(P〈0.001) thinner than in controls.Furthermore,the superior and inferior thinning of the RNFL was correlated with the elevation of urine FA concentration.CONCLUSION:Endogenous FA level is positively correlated with the neuronal defects of POAG. 展开更多
关键词 primary open angle glaucoma urineformaldehyde Alzheimer's disease
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雷诺数和侧风对S型垂直轴风力机气动特性的影响
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作者 朱洋 左行 +1 位作者 朱建勇 赵秀勇 《风机技术》 2024年第1期69-76,共8页
相较于工作在郊外良好风场的大型风力机,小型风力机易受城市风环境如低风速、高湍流度以及时变风速风向的影响。采用数值模拟手段研究了雷诺数和来流倾角对小型S型垂直轴风力机气动性能的影响。研究结果表明:S型风力机的气动性能对雷诺... 相较于工作在郊外良好风场的大型风力机,小型风力机易受城市风环境如低风速、高湍流度以及时变风速风向的影响。采用数值模拟手段研究了雷诺数和来流倾角对小型S型垂直轴风力机气动性能的影响。研究结果表明:S型风力机的气动性能对雷诺数不敏感,功率系数几乎不随雷诺数变化;侧风导致S型风力机的气动性能变差,静扭矩系数和功率系数降低,并且随着侧风来流倾角的增大,气动性能越差,侧风影响的流动机理一方面是来流倾角降低了水平速度分量,另一个方面是竖直速度分量减小了前进叶片的压力差,增加回转叶片的压力差,进一步加剧了气动性能的恶化。 展开更多
关键词 风能 s型垂直轴风力机 雷诺数 来流倾角 数值模拟
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Clinical significance of Baumann's angle in the percutaneous pinning fixation for supracondylar fractures of the humerus in children
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作者 孔建中 《外科研究与新技术》 2005年第3期174-174,共1页
To evaluate the clinical significance of Baumann’s angle in the closed reduction and percutaneous pinning fixation for supracondylar fractures of the humerus in children.Methods There were 97 children (male 59,female... To evaluate the clinical significance of Baumann’s angle in the closed reduction and percutaneous pinning fixation for supracondylar fractures of the humerus in children.Methods There were 97 children (male 59,female 38,mean age of 6.8 years) with displaced supracondylar fracrtures of the humerus were treated in this hospital.Under fluoroscopy guidance,three-dimensional displacement of fractures was corrected by closed reduction.The percutaneous Kirschner wire pinning was applied only if the radiographs demonstrated that Baumann’s angle was less than 4 degree compared to that on the normal side.All of them were followed up for 34.5 months (range,12 to 48 months).Results There was one case with ulnar nerve palsy associated with the pinning.There were no Volkmann’s contracture in this group.X-ray examinations revealed an average 73.7 degrees of Baumann angle on the injured and 72.8 on uninjured side.An average 7.6 degrees of the carrying angle on the injured and 9.7 on uninjured side were also demonstrated by radiography.Five patients developed slight cubitus varus deformity.The result according to Flynn criteria were excellent in 85 patients (87.6%),good in 12 patients (12.4%).Conclusion The satisfactory results can be gained in children with displaced supracondylar fractures of the humerus by restoration of the normal Baumann angle and percutaneous pinning fixation.18 refs,2 figs. 展开更多
关键词 Clinical significance of Baumann’s angle in the percutaneous pinning fixation for supracondylar fractures of the humerus in children
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PACS工作站上Cobb角测量的可靠性研究 被引量:19
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作者 何家维 严志汉 +4 位作者 虞志康 池永龙 倪文飞 麻元兴 万梦楠 《中国脊柱脊髓杂志》 CAS CSCD 2006年第10期732-734,共3页
目的:研究在图像存贮及传输系统(picturearchivingandcommunicationsystem,PACS)工作站上进行Cobb角测量的可靠性。方法:由A、B两位医师分别采用传统的标尺和角度测量仪在30例特发性脊柱侧凸患者脊柱X线胶片上测量Cobb角(简称传统法),... 目的:研究在图像存贮及传输系统(picturearchivingandcommunicationsystem,PACS)工作站上进行Cobb角测量的可靠性。方法:由A、B两位医师分别采用传统的标尺和角度测量仪在30例特发性脊柱侧凸患者脊柱X线胶片上测量Cobb角(简称传统法),同时在PACS工作站上行Cobb角测量(简称PACS法),间隔3周后,采用同样方法重复测量一次。另外在一定条件下(确定测量的主弯及上、下端椎),由8位医师对同一患者进行重复测量。测量的结果均进行配对t检验。结果:应用传统法和PACS法测量的最小差值分别是1°和0,最大差值分别是24°和20°,平均为(6.73±4.56)°和(5.70±3.83)°。同一观测者采用传统法或PACS法重复测量时结果均存在统计学差异(P<0.05)。同一测量方法不同观测者间比较亦存在统计学差异(P<0.05)。在设定条件下,对同一患者测量,传统法和PACS法均无统计学差异(P>0.05)。结论:与传统法一样,PACS法重复测量结果的可信度受诸多因素影响,但测量过程更简单,误差减小,在一定条件下重复测量可无统计学差异,PACS法仍值得临床应用。 展开更多
关键词 脊柱侧凸 放射摄影术 测量 PACs cobb 可靠性
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经皮微创椎弓根螺钉内固定与开放手术治疗胸腰椎骨折:Cobb’s角与椎体前缘高度恢复的比较 被引量:98
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作者 聂锋锋 张英华 +2 位作者 黄寿国 鞠亮 陈波 《中国组织工程研究》 CAS CSCD 2014年第44期7094-7099,共6页
背景:切开复位内固定创伤大,并发症多,随着微创观念深入临床,经皮椎弓根螺钉内固定逐步显示出其显著的优越性。目的:对比观察微创经皮椎弓根螺钉内固定与开放手术修复胸腰椎骨折的效果差异。方法:回顾性分析自2012年10月至2014年1月收... 背景:切开复位内固定创伤大,并发症多,随着微创观念深入临床,经皮椎弓根螺钉内固定逐步显示出其显著的优越性。目的:对比观察微创经皮椎弓根螺钉内固定与开放手术修复胸腰椎骨折的效果差异。方法:回顾性分析自2012年10月至2014年1月收治的胸腰椎骨折患者50例,其中微创经皮椎弓根螺钉内固定组25例、开放手术组25例。分别比较手术切口长度、手术出血量、手术时间及治疗后住院时间、手术切口目测类比评分;于治疗前、治疗后24,48 h检测外周血肌酸激酶活性及C-反应蛋白水平;治疗前后通过影像学结果观察椎体前缘高度、后凸Cobb’s角变化。结果与结论:与开放组相比,微创组手术切口长度小、术中出血少、手术时间短,治疗后卧床时间及住院时间短,术后伤口疼痛程度轻。两组血清C-反应蛋白水平及肌酸激酶活性在治疗前比差异无显著性意义,治疗后24,48 h两组均较治疗前明显升高,但开放组治疗后24,48 h的血清C-反应蛋白水平及肌酸激酶活性均明显高于微创组。两组治疗后Cobb’s角及椎体前缘高度与同组治疗前比较,差异均有非常显著性意义(P<0.01)。两组治疗后Cobb’s角与椎体前缘高度差异均无显著性意义(P>0.05)。提示微创经皮椎弓根螺钉内固定与开放手术修复胸腰椎骨折效果相近,但微创经皮椎弓根螺钉内固定后对患者全身创伤反应的影响程度较开放手术明显降低,更具有微创性。 展开更多
关键词 植入物 脊柱植入物 微创 经皮 内固定 开放手术 胸腰椎骨折 肌酸激酶 C-反应蛋白 cobbs 椎体前缘高度
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Surgimap软件测量青少年特发性脊柱侧凸Cobb角的可行性研究 被引量:14
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作者 蒋戚 李博 +4 位作者 陈锴 周潇逸 翟骁 陈自强 李明 《第二军医大学学报》 CAS CSCD 北大核心 2019年第4期372-376,共5页
目的探讨使用Surgimap软件测量青少年特发性脊柱侧凸(AIS)Cobb角的可行性与可重复性。方法 4名医师(1名副主任医师、3名住院医师)分别使用Surgimap软件和传统测量法对67例AIS患者术前标准站立位脊柱全长正侧位X线片的冠状位主弯Cobb角... 目的探讨使用Surgimap软件测量青少年特发性脊柱侧凸(AIS)Cobb角的可行性与可重复性。方法 4名医师(1名副主任医师、3名住院医师)分别使用Surgimap软件和传统测量法对67例AIS患者术前标准站立位脊柱全长正侧位X线片的冠状位主弯Cobb角及矢状位胸椎后凸角(TK)、胸腰后凸角(TLK)、腰椎前凸角(LL)进行测量,记录并比较两种方法的测量时间。对4名医师使用Surgimap软件测量的结果进行一致性检验(可信度分析),对3名住院医师两次测量结果进行观察者内一致性检验(可重复性分析)。结果使用Surgimap软件和传统测量法测量的主弯Cobb角分别为49.4°±8.2°和41.4°±15.6°,两种方法测量结果的绝对平均差值为8.29°±4.36°;测量时间分别为(5.2±0.7)min、(8.8±1.5)min,测量时间差为(3.6±0.9)min,差异有统计学意义(t=2.57,P<0.01)。可信度分析显示,4名医师使用Surgimap软件测量冠状位主弯Cobb角和矢状位TK、TLK、LL均有极佳或好的一致性(组内相关系数分别为0.972、0.924、0.875、0.962)。可重复性分析显示,3名住院医师前后2次使用Surgimap软件测量冠状位主弯Cobb角和矢状位TK、TLK、LL均有极佳或好的一致性(组内相关系数为0.875~0.984)。结论 Surgimap软件测量Cobb角优于传统测量法,具有效率高、学习曲线短、数据可统一导出等优势。 展开更多
关键词 青少年 特发性脊柱侧凸 cobb surgimap软件 传统测量
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经肌间隙入路短节段椎弓根钉置入修复胸腰椎骨折:损伤节段Cobb’s角变化 被引量:17
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作者 王诗成 黄必留 +2 位作者 潘磊 薛厚军 刘青华 《中国组织工程研究》 北大核心 2015年第13期2045-2050,共6页
背景:短节段椎弓根钉技术修复胸腰椎骨折在临床应用广泛,研究表明经肌间隙入路出血少,创伤小,恢复快,采用后正中线旁双皮肤切口经肌间隙椎弓根螺钉置入内固定的优越性需进一步研究。目的:探讨后正中线旁双皮肤切口经椎旁肌间隙入路短节... 背景:短节段椎弓根钉技术修复胸腰椎骨折在临床应用广泛,研究表明经肌间隙入路出血少,创伤小,恢复快,采用后正中线旁双皮肤切口经肌间隙椎弓根螺钉置入内固定的优越性需进一步研究。目的:探讨后正中线旁双皮肤切口经椎旁肌间隙入路短节段椎弓根钉置入内固定修复胸腰椎骨折的临床疗效及Cobb’s角变化。方法:回顾性分析2010年9月至2012年6月收治的56例胸腰椎骨折患者的病历资料,男42例,女14例;年龄18-59岁,平均45岁。根据修复入路分为两组,传统后正中入路组25例,经椎旁肌间隙入路组31例。比较两组患者手术时间、术中出血量、内固定后引流量、内固定后开始下地时间、内固定后7 d、1个月、6个月的腰背部目测类比评分、内固定前后和末次随访时损伤节段的后凸角。结果与结论:所有患者内固定后获得随访,经椎旁肌间隙入路组在手术时间、术中出血量、内固定后引流量、内固定后开始下地时间、内固定后7 d、1个月腰背部目测类比评分等方面均有显著优势(P<0.05)。两组内固定后Cobb’s角与同组治疗前比较,差异均有显著性意义(P<0.05);两组间内固定后Cobb’s角比较差异无显著性意义(P>0.05)。提示后正中线旁双皮肤切口经肌间隙入路短节段椎弓根钉置入修复胸腰椎骨折,具有创伤小、出血少和恢复快等优点,操作简单,与开放手术修复胸腰椎骨折效果相近,能有效恢复椎体的解剖形态及重建脊柱稳定性,与宿主的生物相容性好。 展开更多
关键词 植入物 脊柱植入物 胸椎 腰椎 骨折 外科手术 椎旁肌间隙入路 目测类比评分 cobbs
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Cobb’s综合征的临床诊断与治疗 被引量:4
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作者 王建生 王志潮 +1 位作者 柳江 张鸿祺 《北京医学》 CAS 2012年第10期884-886,共3页
目的总结Cobb’s综合征临床诊断和治疗的经验体会。方法采用磁共振成像与脊髓血管造影确定诊断后,采用血管内栓塞与手术切除相结合的方法消除病变对脊髓的损害,恢复脊髓功能。手术后连续随访确定患者的治疗效果和预后。结果 4例临床治... 目的总结Cobb’s综合征临床诊断和治疗的经验体会。方法采用磁共振成像与脊髓血管造影确定诊断后,采用血管内栓塞与手术切除相结合的方法消除病变对脊髓的损害,恢复脊髓功能。手术后连续随访确定患者的治疗效果和预后。结果 4例临床治愈,1例在手术实施血管畸形近全切除5年后再出血,经过再次栓塞后恢复。结论成功的治疗要依靠先栓塞治疗后手术切除的完整结合,任何一项治疗的不彻底都不能完全消除病变,易复发。 展开更多
关键词 cobbs综合征 脊柱血管疾病 诊断 治疗
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