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Coupled DEM-FDM analyses of the effects of falling rock’s shape and impact angle on response of granular cushion and rock shed
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作者 Jingyu Xue Chen Cao +2 位作者 Jianhua Yan Yaopeng Ji Jianping Chen 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第8期3353-3364,共12页
Rock shed is an effective protection measure against rockfall.To investigate the influences of falling rock’s shape and impact angle on the impact effect of the cushioned rock shed,a modeling approach for a rock shed... Rock shed is an effective protection measure against rockfall.To investigate the influences of falling rock’s shape and impact angle on the impact effect of the cushioned rock shed,a modeling approach for a rock shed with a cushion layer using PFC-FLAC.The granular cushion is modeled as an aggregate of discrete non-cohesion particles,while the concrete plate and the beam are modeled as zones.The falling rock with different sphericities and impact angles is modeled as a rigid assembly.The numerical model is validated by comparing the simulation results with experimental and numerical results from previous literature.This model is applied to analyze the effects of rock shape and impact angle on the dynamic interaction effects between falling rock and cushioned rock shed,including the impact force,transmitted bottom force,penetration depth,and plate deflection.The numerical results show that the variation in the falling rock’s shape has different effects on the falling rock with different impact angles.These findings could support rock shed design by revealing the limitations of the assumptions in the past research,which may result in unsafe rock sheds for some rockfall cases. 展开更多
关键词 Rockfall Coupled DEM-FDM analysis Rock’s shape Impact angle Granular cushion Rock shed
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A Procedure for Trisecting an Acute Angle (Method 2)
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作者 Lyndon O. Barton 《Advances in Pure Mathematics》 2024年第4期204-213,共10页
This paper presents an alternate graphical procedure (Method 2), to that presented in earlier publications entitled, “A Procedure for Trisecting an Acute Angle” and “A Key to Solving the Angle Trisection Problem”.... This paper presents an alternate graphical procedure (Method 2), to that presented in earlier publications entitled, “A Procedure for Trisecting an Acute Angle” and “A Key to Solving the Angle Trisection Problem”. The procedure, when applied to the 30˚ and 60˚ angles that have been “proven” to be nottrisectable and the 45˚ benchmark angle that is known to be trisectable, in each case produced a construction having an identical angular relationship with Archimedes’ Construction, as in Section 2 on THEORY of this paper, where the required trisection angle was found to be one-third of its respective angle (i.e. DE’MA = 1/3 DE’CG). For example, the trisection angle for the 30˚, 45˚ and 60˚ angles were 10.00000˚, 15.00000˚, and 20.00000˚, respectively, and Section 5 on PROOF in this paper. Therefore, based on this identical angular relationship and the numerical results (i.e. to five decimal places), which represent the highest degree of accuracy and precision attainable by The Geometer’s Sketch Pad software, one can only conclude that not only the geometric requirements for arriving at an exact trisection of the 30˚ and 60˚ angle (which have been “proven” to be not-trisectable) have been met, but also, the construction is valid for any arbitrary acute angle, despite theoretical proofs to the contrary by Wantzel, Dudley, and others. 展开更多
关键词 Archimedes Construction College Geometry College Mathematics angle Trisection Famous Problems in Mathematics Mechanism Analysis Geometer’s sketch Pad
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无神经症状胸腰椎骨折行Wiltse入路经伤椎置钉短节段内固定术后Cobb角增加的风险因素分析及预测模型构建
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作者 戴栋栋 张波 +2 位作者 汤卜赫 纪岳 吴苏东 《颈腰痛杂志》 2024年第4期668-672,677,共6页
目的分析无神经症状胸腰椎骨折行Wiltse入路经伤椎置钉短节段内固定术后Cobb角增加的风险因素,并构建预测模型。方法选取2018年6月~2021年12月淮南东方医院集团总院接受经Wiltse入路经伤椎置钉短节段内固定术的无神经症状胸腰椎骨折患者... 目的分析无神经症状胸腰椎骨折行Wiltse入路经伤椎置钉短节段内固定术后Cobb角增加的风险因素,并构建预测模型。方法选取2018年6月~2021年12月淮南东方医院集团总院接受经Wiltse入路经伤椎置钉短节段内固定术的无神经症状胸腰椎骨折患者110例为研究对象,依据术后Cobb角度增加情况分为Cobb角增加组、对照组,对比两组临床资料、手术相关指标、术后随访资料,经多因素Logistic回归法分析术后Cobb角增加的风险因素并构建预测模型。结果术后随访17~36个月,失访5例。73例术后Cobb角度增加值≤3°(记为对照组)、32例≥4°(记为Cobb角增加组);两组在年龄和术前、术后1周、末次随访时椎体Cobb角及Cobb角增加值、术前椎体压缩率、术前伤椎前缘高度比、椎间隙高度改变、伤椎椎体复位程度、术后功能锻炼方面比较,差异有统计学意义(P<0.05);多因素Logistic回归分析显示,术前椎体Cobb角大、术前椎体压缩率>50%、术后功能锻炼不合理为术后Cobb角增加的独立危险因素,伤椎椎体复位程度高是保护因素(P<0.05);构建风险预测模型:Log(P)=1.205×术前椎体Cobb角+1.859×术前椎体压缩率-0.064×伤椎椎体复位程度+3.765×术后功能锻炼不合理-72.909;术前椎体Cobb角、伤椎椎体复位程度预测Cobb角增加的ROC曲线下面积分别为0.792、0.714。该模型的Hosmer-Lemeshow检验差异无统计学意义(χ^(2)=1.489,P=0.356),有较好的符合程度。结论术前椎体Cobb角、术前椎体压缩率、术后功能锻炼,为无神经症状胸腰椎骨折行Wiltse入路经伤椎置钉短节段内固定术后Cobb角增加的风险因素,伤椎椎体复位程度高是保护因素,可采取相应改进措施提高疗效。 展开更多
关键词 Wiltse肌间隙入路 伤椎置钉 内固定 胸腰椎骨折 cobb
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后凸Cobb's角、BMD、P1NP对骨质疏松性椎体压缩性骨折患者PKP术后再发骨折风险的预测价值分析
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作者 张弛 吴海龙 +2 位作者 张帅 田振峰 张斌 《疑难病杂志》 CAS 2024年第4期457-461,共5页
目的探讨后凸Cobb's角、骨密度(BMD)、Ⅰ型前胶原氨基端前肽(P1NP)对骨质疏松性椎体压缩性骨折(OVCF)患者球囊扩张椎体后凸成形术(PKP)术后再发骨折风险的预测价值。方法选取2018年12月—2020年6月石家庄市人民医院骨科收治的行PKP... 目的探讨后凸Cobb's角、骨密度(BMD)、Ⅰ型前胶原氨基端前肽(P1NP)对骨质疏松性椎体压缩性骨折(OVCF)患者球囊扩张椎体后凸成形术(PKP)术后再发骨折风险的预测价值。方法选取2018年12月—2020年6月石家庄市人民医院骨科收治的行PKP术的OVCF患者110例作为研究对象,进行2年随访,根据随访过程中是否出现新发骨折分为再发骨折组28例和未再发骨折组82例。比较2组患者一般资料及术后指标,Cox分析影响PKP术后再发骨折的危险因素,绘制ROC曲线分析后凸Cobb's角、BMD、P1NP对OVCF患者PKP术后再发骨折的预测价值。结果随访期间骨折再发生率为25.45%(28/110)。再发骨折组后凸Cobb's角、P1NP高于未再发骨折组,BMD低于未再发骨折组,差异具有统计学意义(t/P=4.678/<0.001,4.591/<0.001,4.784/<0.001);Cox分析结果显示,后凸Cobb's角增大、BMD降低、P1NP升高均是影响PKP术后再发骨折的危险因素[OR(95%CI)=1.394(1.135~1.712)、1.910(1.127~3.236)、2.140(1.084~4.225),P<0.05];ROC曲线分析显示,后凸Cobb's角≥5.87°、BMD≤-3.38 SD、P1NP≤50.67μg/L为截断值,后凸Cobb's角、BMD、P1NP预测OVCF患者PKP术后再发骨折的AUC分别为0.725、0.846、0.836,3项联合AUC为0.899,高于单项检测(Z/P=8.129/<0.001,7.195/<0.001,7.695/<0.001)。结论定期监测后凸Cobb's角、BMD、P1NP水平可在早期预测OVCF患者PKP术后再发骨折风险以便及时给予干预措施。 展开更多
关键词 椎体压缩性骨折 骨质疏松性 球囊扩张椎体后凸成形术 再发骨折风险 后凸cobb's 骨密度 Ⅰ型前胶原氨基端前肽 预测价值
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A Simplified Graphical Procedure for Constructing a 10˚or 20˚Angle
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作者 Lyndon O. Barton 《Advances in Pure Mathematics》 2023年第7期442-448,共7页
This paper presents a simplified graphical procedure for constructing, using an unmarked straightedge and a compass only, a 10˚ to 20˚ angle, which is in other words, trisecting a 30˚ or 60˚ angle. The procedure, when... This paper presents a simplified graphical procedure for constructing, using an unmarked straightedge and a compass only, a 10˚ to 20˚ angle, which is in other words, trisecting a 30˚ or 60˚ angle. The procedure, when applied to the 30˚ and 60˚ angles that have been “proven” to be not trisectable, produced a construction having the identical angular relationship with Archimedes’ Construction, in which the required trisection angles were found to be 10.00000˚ and 20.00000˚ respectively (i.e. exactly one-third of the given angle or ∠E’MA = 1/3∠E’CG). Based on this identical angular relationship as well as the numerical results obtained, one can only conclude that the geometric requirements for arriving at an exact trisection of the 30˚ or 60˚ angle, and therefore the construction of a 10˚ or 20˚ angle, have been met, notwithstanding the theoretical proofs of Wantzel, Dudley, and others. Thus, the solution to the age-old trisection problem, with respect to these two angles, has been accomplished. 展开更多
关键词 Archimedes Construction College Geometry angle Trisection Trisection of an angle Famous Problems in Mathematics. Geometer’s sketch Pad Mechanisms Mechanism Analysis Kinematics Trisector
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A Key to Solving the Angle Trisection Problem
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作者 Lyndon O. Barton 《Advances in Pure Mathematics》 2023年第9期625-634,共10页
This paper describes the methodology (or approach) that was key to the solution of the angle trisection problem published earlier in article entitled, “A Procedure For Trisecting An Acute Angle.” It was an approach ... This paper describes the methodology (or approach) that was key to the solution of the angle trisection problem published earlier in article entitled, “A Procedure For Trisecting An Acute Angle.” It was an approach that required first, designing a working model of a trisector mechanism, second, studying the motion of key elements of the mechanism and third, applying the fundamental principles of kinematics to arrive at the desired results. In presenting these results, since there was no requirement to provide a detailed analysis of the final construction, this information was not included. However, now that the publication is out, it is considered appropriate as well as instructive to explain more fully the mechanism analysis of the trisector in graphical detail, as covered in Section 3 of this paper, that formed the basis of the long sought solution to the age-old Angle Trisection Problem. 展开更多
关键词 Archimedes Construction College Geometry College Mathematics angle Trisection Trisector Famous Problems in Mathematics History of Mathematics Mechanism Analysis Kinematics Geometer’s sketch Pad
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Reliability of a Novel Cobb Protractor for Measuring the Cobb Angle of Radiograph in Scoliosis 被引量:2
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作者 Gui Wu Hai Wang +3 位作者 Ran Ding Xu-hong Xue Zhi-hong Wu Gui-xing Qiu 《Chinese Medical Sciences Journal》 CAS CSCD 2015年第1期18-22,共5页
Objective To introduce a novel Cobb protractor and assess its reliability and rapidity for measuring Cobb angle in scoliosis patients. Methods The novel Cobb protractor had two endplate markers. A measurement was perf... Objective To introduce a novel Cobb protractor and assess its reliability and rapidity for measuring Cobb angle in scoliosis patients. Methods The novel Cobb protractor had two endplate markers. A measurement was performed just to align the two markers to each endplate of the curve. The Cobb angle on the posteroanterior radiographs of 24 patients clinically diagnosed with adolescent idiopathic scoliosis was measured by three orthopedic surgeons with both standard Cobb method and the new technique, and the time of measurement was recorded. Intraclass correlation coefficients(ICCs) were calculated to assess the reliability of the new method. Results The time for a measurement with the new tool was approximately 10 seconds less than the time that used to finish a measurement with the standard method(P<0.05). The overall mean Cobb angle for the major curve of the 24 patients was 47.8°. The mean overall intraobserver and interobserver ICC was 0.971 and 0.971 for the Cobb method group, while the overall intraobserver ICC and the interobserver was 0.985 and 0.979 for the new tool group. Conclusions The novel Cobb protractor could perform quick measurement and measure almost all forms of radiographs. The Cobb protractor might be an ideal instrument to measure the Cobb angle. 展开更多
关键词 cobb protractor RELIABILITY measurement sCOLIOsIs cobb angle
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骨性Angle′s Ⅲ类错患者正畸手术前后下颌角矢量点位置的变化及意义 被引量:1
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作者 王晨星 高振杰 陈刚 《山东医药》 CAS 北大核心 2011年第22期98-99,共2页
目的观察骨性Angle′sⅢ类错患者下颌角矢量点(Gov点)位置变化,并探讨其临床意义。方法取天津地区健康人29例为对照组,接受正手术治疗的骨性Angle′sⅢ类错畸形患者15例为观察组。均拍摄头颅侧位X线片,测量Gov点的座标。结果观察... 目的观察骨性Angle′sⅢ类错患者下颌角矢量点(Gov点)位置变化,并探讨其临床意义。方法取天津地区健康人29例为对照组,接受正手术治疗的骨性Angle′sⅢ类错畸形患者15例为观察组。均拍摄头颅侧位X线片,测量Gov点的座标。结果观察组术前、术后及对照组Gov点横坐标分别为(-4.54±0.51)、(-5.10±0.69)、(-5.02±0.35)cm,纵坐标分别为(-7.76±0.40)、(-7.65±0.57)、(-7.50±0.43)cm,观察组术前Gov点横、纵坐标与术后及对照组比较P均<0.05,观察组术后与对照组Gov点横、纵坐标比较P均>0.05。对照组下颌神经孔与Gov点间距为(1.35±0.16)cm,观察组术前为(1.27±0.19)cm,两组相比P>0.05。结论骨性Angle′sⅢ类错患者Gov点位置向前下移位,正手术后得以纠正。Gov点位置可能与下颌功能状态存在内在联系,可以作为正手术术前制定手术计划及术后评估矫治效果的指标。 展开更多
关键词 骨性anglesⅢ类错 下颌角矢量点 二维X线头影测量
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基于伤椎高度、Cobb角评估棘突与椎板外缘定位椎弓根技术治疗胸腰椎骨折的疗效
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作者 李忠 尹祖昌 +3 位作者 闫菁辉 王铁铸 孟宪卿 王清河 《生物医学工程与临床》 CAS 2024年第2期198-204,共7页
目的通过伤椎高度、Cobb角评估棘突与椎板外缘定位椎弓根技术研究治疗胸腰椎骨折的疗效。方法选择2017年9月至2020年9月在衡水市第四人民医院收治的胸腰椎骨折患者116例,其中男性61例,女性55例;年龄38~71岁,平均年龄48.59岁;骨折节段,L... 目的通过伤椎高度、Cobb角评估棘突与椎板外缘定位椎弓根技术研究治疗胸腰椎骨折的疗效。方法选择2017年9月至2020年9月在衡水市第四人民医院收治的胸腰椎骨折患者116例,其中男性61例,女性55例;年龄38~71岁,平均年龄48.59岁;骨折节段,L137例,L223例,L1121例,L1235例。按照数字表法将患者分为观察组58例和对照组58例,两组患者均行椎弓根技术治疗。对照组患者给予上关节突外缘垂直线与横突平分线交点(Magerl法)定位椎弓根钉。观察组患者给予棘突与椎板外缘定位椎弓根钉。对比两组患者的Oswestry功能障碍指数(ODI)、伤椎矢状面Cobb角及伤椎前缘高度压缩率、骨代谢、骨愈合、炎症反应、肿胀及疼痛程度。结果两组患者术前、术后1周、术后1年的ODI比较,差异无统计学意义(P>0.05)。术前、术后1周两组患者的伤椎矢状面Cobb角比较,差异无统计学意义(P>0.05)。术后1年观察组伤椎矢状面Cobb角低于对照组[(9.8±2.9)°vs(13.5±3.0)°。P<0.05]。术前、术后1周两组患者的伤椎前缘高度压缩率比较,差异无统计学意义(P>0.05)。术后1年对照组伤椎前缘高度压缩率高于观察组[(14.2±3.4)%vs(8.6±2.2)%。P<0.05]。观察组患者的血清碱性磷酸酶(ALP)、Ⅰ型前胶原羧基端前肽(PICP)及骨钙素(BGP)指标均高于对照组[(219.23±6.34)μg/L vs(182.54±5.17)μg/L、(112.72±2.18)μg/L vs(93.67±2.69)μg/L、(7.52±0.36)μg/L vs(4.21±0.14)μg/L。P<0.05]。观察组可溶性细胞间黏附分子-1(sLCAM-1)、胰岛素样生长因子-1(IGF-1)指标均高于对照组[(107.58±4.25)μg/L vs(92.12±4.19)μg/L、(296.57±8.04)μg/L vs(237.28±7.82)μg/L。P<0.05]。观察组患者肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)及白细胞介素-1(IL-1)指标均低于对照组[(1.20±0.27)μg/L vs(1.52±0.51)μg/L、(1.06±0.14)μg/L vs(1.35±0.28)μg/L、(0.98±0.27)μg/L vs(1.19±0.42)μg/L。P<0.05]。第1天、第5天、第10天、第15天、第20天两组患者的肿胀程度及疼痛评分均逐渐降低,除第1天观察组肿胀程度高于对照组外[(3.88±0.54)分vs(3.31±0.43)分。P<0.05],其他不同时间对照组疼痛评分及肿胀程度高于观察组(P<0.05)。结论棘突与椎板外缘定位椎弓根技术治疗胸腰椎骨折可降低患者的伤椎高度、Cobb角,提高骨代谢,降低炎症反应、肿胀及疼痛程度,促进骨愈合,临床疗效显著。 展开更多
关键词 伤椎高度 骨代谢 cobb 棘突与椎板外缘定位 椎弓根技术 胸腰椎骨折
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Osteonectin促进骨髓来源间充质干细胞成骨分化的机制及其与青少年特发性脊柱侧凸的相关性研究
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作者 赵志蓉 陈涛 陈焕雄 《转化医学杂志》 2024年第2期177-182,共6页
目的 探究Osteonectin在促进骨髓间充质干细胞(BMSCs)成骨分化的分子机制,以及Osteonectin在青少年特发性脊柱侧凸(AIS)中的作用。方法 将2020年5月—2022年5月就诊的20例AIS及健康体检20例分别作为AIS组和健康组。使用qRT-PCR技术测定2... 目的 探究Osteonectin在促进骨髓间充质干细胞(BMSCs)成骨分化的分子机制,以及Osteonectin在青少年特发性脊柱侧凸(AIS)中的作用。方法 将2020年5月—2022年5月就诊的20例AIS及健康体检20例分别作为AIS组和健康组。使用qRT-PCR技术测定2组BMSCs中Osteonectin、BMP2以及Wnt/β-catenin信号通路相关基因(Tcf7、Lef1)和成骨分化相关基因(Runx2、Osteocalcin)的表达水平。通过X线检测AIS患者的Cobb角度,并分析上述基因表达水平与Cobb角度的相关性。在BMSCs中,加入Osteonectin和BMP2抑制剂Noggin,并分为对照组、Osteonectin组和Osteonectin+Noggin组。通过qRT-PCR检测BMSCs中BMP2、Tcf7、Lef1、Runx2和Osteocalcin mRNA表达水平。采用ChIP-qPCR检测β-catenin在Runx2和Osteocalcin基因转录起始位(TSS)的富集水平。结果 与健康组比较,AIS组BMSCs中Osteonectin、BMP2、Tcf7、Lef1、Runx2和Osteocalcin mRNA表达水平均降低(P<0.05);Osteonectin、BMP2、Tcf7、Lef1、Runx2和Osteocalcin mRNA表达水平与AIS患者Cobb角度呈负相关(r=-0.466 3、-0.369 1、-0.272 7、-0.543 4、-0.606 5、-0.343 3,P<0.05,P<0.01)。与对照组比较,Osteonectin组BMSCs中BMP2、Tcf7、Lef1、Runx2和Osteocalcin mRNA表达水平升高,且β-catenin在Runx2和Osteocalcin mRNA TSS富集水平增加(P<0.05)。相比Osteonectin组,Osteonectin+Noggin组BMSCs中Tcf7、Lef1、Runx2和Osteocalcin mRNA表达水平降低,β-catenin在Runx2和Osteocalcin mRNA TSS富集水平降低(P<0.05)。结论 在AIS患者中,BMSCs中Osteonectin、BMP2-Wnt/β-catenin的表达以及成骨分化水平与AIS疾病的发展呈负相关。Osteonectin通过激活BMP2-Wnt/β-catenin信号通路,促使β-catenin转录激活成骨分化相关基因,从而促进BMSCs的成骨分化。 展开更多
关键词 青少年特发性脊柱侧凸 骨结合素 骨粘连蛋白 骨髓来源间充质干细胞 染色质免疫共沉淀 成骨分化 cobb BMP2-Wnt/β-catenin信号通路
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青少年特发性脊柱侧凸主胸弯悬吊位和矫形术后Cobb角分布差异分析 被引量:1
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作者 刘延 刘青山 +4 位作者 王梦真 韩良丽 杨长伟 侯藏龙 张秋林 《海军军医大学学报》 CAS CSCD 北大核心 2024年第6期688-692,共5页
目的分析Lenke 1型青少年特发性脊柱侧凸(AIS)患者主胸弯Cobb角分布特征,以及不同节段间悬吊牵引法测得的柔韧性、矫正率、矫正指数的差异。方法纳入2015年1月至2018年12月于海军军医大学(第二军医大学)第一附属医院行一期脊柱侧凸后路... 目的分析Lenke 1型青少年特发性脊柱侧凸(AIS)患者主胸弯Cobb角分布特征,以及不同节段间悬吊牵引法测得的柔韧性、矫正率、矫正指数的差异。方法纳入2015年1月至2018年12月于海军军医大学(第二军医大学)第一附属医院行一期脊柱侧凸后路三维矫形融合内固定术的48例Lenke 1型AIS患者。将主胸弯分为近段(T_(5)~T_(7)或T_(6)~T_(8))、中段(T_(7)~T_(9)或T_(8)~T_(10))、远段(T_(9)~T_(11)或T_(10)~T_(12)),并测量各段的Cobb角。计算不同节段的侧弯柔韧性、矫正率和矫正指数(术后矫正率/术前侧弯柔韧性)。采用随机区组的方差分析进行统计学分析。结果患者术前平均年龄为(14.31±2.24)岁,总Cobb角为(51.25±11.86)°,平均Risser分级为2.88±1.93;术后平均随访时间为(38.75±8.82)个月。术前近段Cobb角与远段Cobb角相似[(13.31±5.10)°vs(13.94±5.67)°,P=0.757],中段Cobb角[(24.00±5.61)°]大于近段及远段Cobb角(均P<0.001)。术前近段、中段、远段Cobb角占总Cobb角的比例分别为(25.72±7.97)%、(47.08±5.22)%、(27.20±8.00)%。术前远段侧弯柔韧性高于近段和中段[(64.01±24.18)%vs(35.00±18.02)%、(41.49±17.65)%,均P<0.001]。术后1周,近段、中段、远段矫正率分别为(74.61±15.80)%、(65.66±16.36)%和(73.76±19.41)%,差异无统计学意义(P=0.280);矫正指数分别为2.41±1.20、2.03±1.45和1.49±1.31,近段矫正指数高于远段(P=0.040)。末次随访时,近段、中段、远段矫正率分别为(71.10±14.07)%、(62.39±13.47)%和(69.75±17.53)%,差异无统计学意义(P=0.226);矫正指数分别为2.24±1.10、1.92±1.30和1.39±1.10,近段的矫正指数高于远段(P=0.026)。结论在Lenke 1型AIS患者中,近段、中段和远段Cobb角分别占主胸弯的25.72%、47.08%、27.20%。悬吊牵引法对远段柔韧性的评估能力最强,即悬吊位下远端节段最灵活,而各节段术后矫正率无明显差异。 展开更多
关键词 青少年特发性脊柱侧凸 柔韧性 悬吊牵引法 cobb 矫正率
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融合多尺度注意力的脊柱侧弯Cobb角自动估计算法
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作者 韩广萍 张魁星 +2 位作者 王苹苹 李翔 魏本征 《北京生物医学工程》 2024年第4期383-390,共8页
目的 青少年特发性脊柱侧弯(adolescent idiopathic scoliosis,AIS)是危害青少年健康的常见疾病之一。临床上,X线图像Cobb角测量法是评估患者脊柱侧凸严重程度的“金标准”。由于X线图像中肋骨和骨盆阴影重叠以及椎骨形态差异等因素影响... 目的 青少年特发性脊柱侧弯(adolescent idiopathic scoliosis,AIS)是危害青少年健康的常见疾病之一。临床上,X线图像Cobb角测量法是评估患者脊柱侧凸严重程度的“金标准”。由于X线图像中肋骨和骨盆阴影重叠以及椎骨形态差异等因素影响,人工测量在寻找关键点时步骤复杂且耗时长,快速且准确的Cobb角自动测量方法具有重要临床应用价值。现有深度学习方法中基于分割的方法易受图像质量影响;基于关键点检测方法过于关注局部特征提取导致定位不准确等问题。为此,本文提出了一种以椎骨为中心的标志点检测方法,来实现脊柱侧弯Cobb角自动估计算法。方法 构建一种基于融合多尺度和注意力机制M型椎骨检测网络(multi-scale attention M-shaped network,MSAM-Net)。首先,使用多尺度金字塔拆分注意力(multi-scale pyramids squeeze attention,MPSA)模块和注意力特征融合(attentional feature fusion,AFF)模块提取椎骨特征和上下文信息,然后,根据椎体中心和角偏移量定位4个角标志点,以在脊柱侧弯评估任务中提高椎骨标志点检测的性能,进而实现近胸段、主胸段和胸腰段曲线的Cobb角估计。结果 为了评估Cobb角估计与真实侧弯角度之间的偏差程度,本研究算法基于AASCE MICCAI 2019挑战赛数据集,使用4种指标对Cobb角精度进行评估,分别是对称平均绝对百分比误差(symmetric mean absolute percentage error,SMAPE)、欧氏距离(Euclidean distance,ED)、曼哈顿距离(Manhattan distance,MD)和切比雪夫距离(Chebyshev distance,CD)。测试得到SMAPE为9.39%,ED为4.18;MD为5.92;CD为5.34。与基于分割和检测的5种深度学习方法进行对比,实现更好的Cobb角测量结果。结论 本研究可以准确识别和定位X线图像中椎骨,帮助医生测量AIS患者的Cobb角,为临床AIS诊断、手术计划和脊柱健康分析提供决策支持。 展开更多
关键词 青少年特发性脊柱侧弯 椎骨检测 cobb 深度学习 注意力机制
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Modified viscocanalostomy in the Chinese population with open angle glaucoma: a 10-year follow-up results 被引量:3
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作者 Ya Liang Hong Sun +4 位作者 Jie Shuai Kai Xu Fang-Fang Ji Sucijanti Zhi-Lan Yuan 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2019年第3期429-435,共7页
AIM: To study the long-term efficacy and safety of modified viscocanalostomy in Chinese people with open angle glaucoma(OAG).METHODS: This retrospective study included a total of 100 eyes from 100 Chinese patients wit... AIM: To study the long-term efficacy and safety of modified viscocanalostomy in Chinese people with open angle glaucoma(OAG).METHODS: This retrospective study included a total of 100 eyes from 100 Chinese patients with medically uncontrolled OAG. All the patients underwent modified viscocanalostomy with injection of viscoelastic material in the surgically created ostia of Schlemm's canal(SC). The modifications included peeling of the inner wall of SC and the juxtacanalicular meshwork, use of mitomycin C, and loosely suturing the superficial scleral flap. Intraocular pressure(IOP), visual acuity, number of medications, laser goniopuncture data and complications were recorded. The definition of complete(qualified) success was an IOP equal to or lower than 21, 18, 16 mm Hg without(with or without) anti-glaucoma medications. RESULTS: The mean IOP was 33.5±9.9 mm Hg before surgery, 15.2±3.6 mm Hg(mean IOP reduction of 51%) at 5 y after surgery, and 15.6±2.8 mm Hg(mean IOP reduction of 49.9%) at 10 y after surgery(P<0.001). The number of anti-glaucoma medications dropped from 2.39±0.5 preoperatively to 0.47±0.8 at 5 y and 0.67±0.8 at 10 y postoperatively(P<0.001). The follow-up period was 104.5±37.0 mo. The qualified success rate for an IOP of 21, 18 or 16 mm Hg or less was 84% [95% confidence interval(CI): 0.80-0.88], 73%(95%CI: 0.68-0.78), and 59%(95%CI: 0.52-0.66) after 5 y, and 80%(95%CI: 0.76-0.84), 69%(95%CI: 0.64-0.74), 51%(95%CI: 0.44-0.58) after 10 y, respectively. There was a relationship between age, preoperative IOP and success rate(P<0.01, P<0.05). A total of 31 eyes(31.3%)in 31 patients underwent laser goniopuncture, decreasing the IOP from 22.9±4.3 mm Hg to 16.3±2.5 mm Hg(P<0.01). Neither blebitis nor endophthalmitis occurred.CONCLUSION: Modified viscocanalostomy could be performed to lower IOP, decrease multiple anti-glaucoma drops use as well. It's a safe procedure with less complications over 10 y in Chinese individuals with OAG. 展开更多
关键词 non-penetrating GLAUCOMA surgery VIsCOCANALOsTOMY schlemm’s CANAL open angle GLAUCOMA laser goniopuncture
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Elevated urine formaldehyde in elderly patients with primary open angle glaucoma 被引量:3
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作者 Ying Cui Tao Su +6 位作者 Shao-Dan Zhang Ping Huang Ying-Ge He Ying Liu Chun Zhang Robert Ritch Rong-Qiao He 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2016年第3期411-416,共6页
AIM:To investigate the risk factor of primary open angle glaucoma(POAG),which is the leading cause of irreversible blindness worldwide.An abnormally high level of endogenous formaldehyde(FA) has recently been fou... AIM:To investigate the risk factor of primary open angle glaucoma(POAG),which is the leading cause of irreversible blindness worldwide.An abnormally high level of endogenous formaldehyde(FA) has recently been found correlated with cell death and neurodegenerative disease,raising the possibility of a putative correlation of abnormal endogenous FA with POAG.· METHODS:Thirty-four elderly patients with POAG and sixteen healthy controls were enrolled.Glaucomatous visual defects were present at both the functional(visual field) and structural[retinal nerve fiber layer(RNFL)thickness]levels.Morning urine samples were obtained and were analyzed by high-performance liquid chromatography(HPLC) to detect the endogenous FA level in a double blind manner.· RESULTS:Patients with POAG(P 〈0.05) had significantly higher urine FA levels.The urine FA level of patients with severe visual field defects[mean deviation(MD)≥12 dB]was significantly(P〈0.001) greater than that of patients with mild to moderate defects(MD〈12 dB).By optical coherence tomography(OCT),the superior and inferior RNFL thickness of POAG group was significantly(P〈0.001) thinner than in controls.Furthermore,the superior and inferior thinning of the RNFL was correlated with the elevation of urine FA concentration.CONCLUSION:Endogenous FA level is positively correlated with the neuronal defects of POAG. 展开更多
关键词 primary open angle glaucoma urineformaldehyde Alzheimer's disease
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S弯收扩喷管过膨胀状态下流动分离特性研究
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作者 王明新 周莉 +2 位作者 史经纬 张诣 王占学 《推进技术》 EI CAS CSCD 北大核心 2024年第9期71-82,共12页
为了研究S弯收扩喷管过膨胀状态下的流动分离特性,数值模拟了不同落压比(NPR)下S弯收扩喷管内的流动特征。结果表明:在落压比为2.0时,喷管内发生非对称分离,出现非对称的双“λ”激波结构,喷流整体向上偏转,上侧出现限制性流动分离RSS,... 为了研究S弯收扩喷管过膨胀状态下的流动分离特性,数值模拟了不同落压比(NPR)下S弯收扩喷管内的流动特征。结果表明:在落压比为2.0时,喷管内发生非对称分离,出现非对称的双“λ”激波结构,喷流整体向上偏转,上侧出现限制性流动分离RSS,下侧出现自由性流动分离FSS,并产生三维分离涡,喷流出现明显的三维效应。随着落压比从高度过膨胀状态下开始增加,喷管下侧保持FSS不变,喷管上侧RSS逐渐向后移动,直至与外界大气相连,转变为FSS,之后随着落压比增加,上下侧分离结构逐渐对称。推力矢量角随着落压比的增加先增加,后在极小的落压比变化范围内快速降低,直至变为0°,之后保持0°不变。 展开更多
关键词 s弯收扩喷管 过膨胀状态 流动分离 落压比 推力矢量角
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Astronomic background of global huge earthquakes at beginning of 21st century
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作者 Hu Hui Su You-Jin 《Applied Geophysics》 SCIE CSCD 2024年第3期423-432,616,共11页
Since the beginning of the 21st century,major earthquakes have frequently occurred worldwide.To explore the impact of astronomical factors on earthquakes,in this study,the statistical analysis method of correlation is... Since the beginning of the 21st century,major earthquakes have frequently occurred worldwide.To explore the impact of astronomical factors on earthquakes,in this study,the statistical analysis method of correlation is used to systematically analyze the effects of astronomical factors,such as solar activity,Earth’s rotation,lunar declination angle,celestial tidal force,and other phenomena on M≥8 global earthquakes at the beginning of the 21st century.With regard to solar activity,this study focuses on the analysis of the 11-year and century cycles of solar activity.The causal relationship of the Earth’s rotation is not obvious in this work and previous works;in contrast,the valley period of the solar activity century cycle may be an important astronomical factor leading to the frequent occurrence of global earthquakes at the beginning of the 21st century.This topic warrants further study. 展开更多
关键词 M≥8.0 earthquake astronomical factors solar activity Earth’s rotation lunar declination angle tidal force phenomena
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电针联合Schroth疗法治疗轻度青少年特发性脊柱侧凸的临床研究
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作者 张莞岚 冯达庆 +2 位作者 魏宗敏 李捷 闵水平 《世界复合医学》 2024年第5期10-13,34,共5页
目的 探讨电针联合Schroth疗法对轻度青少年特发性脊柱侧凸(adolescent idiopathic scoliosis,AIS)的疗效。方法 选取2023年2—8月深圳市龙岗区骨科医院就诊的60例轻度AIS患者为研究对象,按照治疗方法的不同分为两组,每组30例。两组均... 目的 探讨电针联合Schroth疗法对轻度青少年特发性脊柱侧凸(adolescent idiopathic scoliosis,AIS)的疗效。方法 选取2023年2—8月深圳市龙岗区骨科医院就诊的60例轻度AIS患者为研究对象,按照治疗方法的不同分为两组,每组30例。两组均接受常规健康宣教,在此基础上对照组进行Schroth练习,联合组予以电针联合Schroth练习治疗。比较两组主弯Cobb角、躯干旋转角度(angle of trunk rotation,ATR)、中文版脊柱侧凸研究学会-22量表(Scoliosis Research Society-22,SRS-22)和简体中文版脊柱外观问卷(Spinal Appearance Questionnaire,SAQ)评分,并进行疗效评定。结果治疗后,两组主弯Cobb角、ATR均较治疗前显著降低,且联合组ATR显著低于对照组,差异有统计学意义(P均<0.05)。治疗后,联合组SRS-22和SAQ得分均显著高于对照组,差异有统计学意义(P均<0.05)。联合组治疗总有效率为96.67%(29/30),明显高于对照组的76.67%(23/30),差异有统计学意义(χ^(2)=5.192,P<0.05)。结论 电针联合Schroth疗法对轻度AIS具有明显的疗效,能有效改善脊柱侧凸的程度,提高患者的生活质量和外观满意度。 展开更多
关键词 电针 schroth疗法 青少年特发性脊柱侧凸 疗效 主弯cobb
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On China's Economy: A Tentative Research from a Dual Visual Angle
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作者 Guibin Suo Zhiyong Shi 《Chinese Business Review》 2005年第4期80-81,共2页
Most economists approach the economy of China from a single visual angle considering it as a special economic modality of transition economy. Based on the analysis from the single visual angle, the paper puts forward ... Most economists approach the economy of China from a single visual angle considering it as a special economic modality of transition economy. Based on the analysis from the single visual angle, the paper puts forward a dual visual angle treating China's economy as one of both transition and transformation features, and attempts to research it from this dual visual angle. 展开更多
关键词 China's economy transition and transformation dual visual angle
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The Possibility of Angle Trisection (A Compass-Straightedge Construction) Kimuya M Alex
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作者 Kimuya M Alex 《Journal of Mathematics and System Science》 2017年第1期25-42,共18页
The objective of this paper is to provide a provable solution of the ancient Greek problem of trisecting an arbitrary angle employing only compass and straightedge (ruler). (Pierre Laurent Wantzel, 1837) obscurely... The objective of this paper is to provide a provable solution of the ancient Greek problem of trisecting an arbitrary angle employing only compass and straightedge (ruler). (Pierre Laurent Wantzel, 1837) obscurely presented a proof based on ideas from Galois field showing that, the solution of angle trisection corresponds to solution of the cubic equation; x3 - 3x - 1 = 0, which is geometrically irreducible [1]. The focus of this work is to show the possibility to solve the trisection of an angle by correcting some flawed methods meant for general construction of angles, and exemplify why the stated trisection impossible proof is not geometrically valid. The revealed proof is based on a concept from the Archimedes proposition of straightedge construction [2, 3]. 展开更多
关键词 angle trisection COMPAss Ruler straightedge) Classical Construction GeoGebra software Greek's geometry Cubic equation Plane geometry solid geometry
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雷诺数和侧风对S型垂直轴风力机气动特性的影响
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作者 朱洋 左行 +1 位作者 朱建勇 赵秀勇 《风机技术》 2024年第1期69-76,共8页
相较于工作在郊外良好风场的大型风力机,小型风力机易受城市风环境如低风速、高湍流度以及时变风速风向的影响。采用数值模拟手段研究了雷诺数和来流倾角对小型S型垂直轴风力机气动性能的影响。研究结果表明:S型风力机的气动性能对雷诺... 相较于工作在郊外良好风场的大型风力机,小型风力机易受城市风环境如低风速、高湍流度以及时变风速风向的影响。采用数值模拟手段研究了雷诺数和来流倾角对小型S型垂直轴风力机气动性能的影响。研究结果表明:S型风力机的气动性能对雷诺数不敏感,功率系数几乎不随雷诺数变化;侧风导致S型风力机的气动性能变差,静扭矩系数和功率系数降低,并且随着侧风来流倾角的增大,气动性能越差,侧风影响的流动机理一方面是来流倾角降低了水平速度分量,另一个方面是竖直速度分量减小了前进叶片的压力差,增加回转叶片的压力差,进一步加剧了气动性能的恶化。 展开更多
关键词 风能 s型垂直轴风力机 雷诺数 来流倾角 数值模拟
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