OBJETTIVE: To observe the effects of Yinxingdamo Injection combined with oxiracetam capsule on cognitive function and neurological deficit in patients with acute cerebral infarction. METHODS: A total of 76 patients wi...OBJETTIVE: To observe the effects of Yinxingdamo Injection combined with oxiracetam capsule on cognitive function and neurological deficit in patients with acute cerebral infarction. METHODS: A total of 76 patients with acute cerebral infarction were randomly divided into observation group and control group, with 38 patients in each group. Patients in the control group were treated with conventional western medicine and oxiracetam capsules while patients in the observation group were given Yinxingdamo injection intravenous drip treatment on the basis of the same treatment. After 4 weeks of treatment, the cognitive function of the two groups before and after treatment was observed [Simple Intelligence Scale(MMSE Score), Montreal Cognitive Assessment Scale(MoCA Score)], Neurological Deficit [Chinese Stroke Scale(CSS Score), Daily Life Activity ability(ADL score)], free radical biochemical indicators [malondialdehyde(MDA), oxide dismutase(SOD)] changes, and statistical effects of two groups. RESULTS: After treatment, the total effective rate of the observation group was 92.1%, which was significantly higher than 73.7% of the control group(P < 0.05). The MMSE score and MoCA score of the two groups were significantly increased after treatment(P < 0.05), and the MMSE score and MoCA score inobservation group were significantly increased after treatment than the control group(P < 0.05). The CSS scores of the two groups were significantly decreased after treatment(P < 0.05), and the ADL scores were significantly increased(P < 0.05). The improvement of CSS score and ADL score in the observation group were significantly better than those in the control group(P < 0.05), and serum MDA levels were significantly decreased in both groups after treatment(P < 0.05), and SOD levels were significantly increased(P < 0.05), and the improvement of MDA and SOD levels in the observation group was significantly better than that in the control group group(P < 0.05). CONCLUSION: Yinxingdamo injection combined with oxiracetam capsule can effectively inhibit the oxygen free radical reaction injury in patients with acute cerebral infarction, and significantly improve the symptoms of cognitive dysfunction and neurological deficit in patients. Its curative effect is exact and worthy of clinical application.展开更多
Objective：To observe the event related potential 300 （P300） after scalp acupuncture treatment in patients with cognitive disorder due to cerebral infarction,and evaluate its therapeutic effect.Methods：Sixty-six pa...Objective：To observe the event related potential 300 （P300） after scalp acupuncture treatment in patients with cognitive disorder due to cerebral infarction,and evaluate its therapeutic effect.Methods：Sixty-six patients aged below 70 years old with cognitive disorder after initial onset of cerebral infarction were randomized into a treatment group and a control group.Conventional neurological drugs and physical trainings were prescribed to both groups.In addition,the treatment group received scalp acupuncture.The two groups were compared by evaluating the latency and amplitude of P300 before and after the 3-month treatment.Results：After treatment,the latency of P300 was shortened by 39.1 ms in the treatment group,versus 16.7 ms in the control group,and the difference was statistically significant （P0.05）.Conclusion：P300 can objectively evaluate the therapeutic effect of scalp acupuncture in treating the patients with cognitive disorder due to cerebral infarction.Scalp acupuncture has positive effect in treating this group of patients.展开更多
文摘OBJETTIVE: To observe the effects of Yinxingdamo Injection combined with oxiracetam capsule on cognitive function and neurological deficit in patients with acute cerebral infarction. METHODS: A total of 76 patients with acute cerebral infarction were randomly divided into observation group and control group, with 38 patients in each group. Patients in the control group were treated with conventional western medicine and oxiracetam capsules while patients in the observation group were given Yinxingdamo injection intravenous drip treatment on the basis of the same treatment. After 4 weeks of treatment, the cognitive function of the two groups before and after treatment was observed [Simple Intelligence Scale(MMSE Score), Montreal Cognitive Assessment Scale(MoCA Score)], Neurological Deficit [Chinese Stroke Scale(CSS Score), Daily Life Activity ability(ADL score)], free radical biochemical indicators [malondialdehyde(MDA), oxide dismutase(SOD)] changes, and statistical effects of two groups. RESULTS: After treatment, the total effective rate of the observation group was 92.1%, which was significantly higher than 73.7% of the control group(P < 0.05). The MMSE score and MoCA score of the two groups were significantly increased after treatment(P < 0.05), and the MMSE score and MoCA score inobservation group were significantly increased after treatment than the control group(P < 0.05). The CSS scores of the two groups were significantly decreased after treatment(P < 0.05), and the ADL scores were significantly increased(P < 0.05). The improvement of CSS score and ADL score in the observation group were significantly better than those in the control group(P < 0.05), and serum MDA levels were significantly decreased in both groups after treatment(P < 0.05), and SOD levels were significantly increased(P < 0.05), and the improvement of MDA and SOD levels in the observation group was significantly better than that in the control group group(P < 0.05). CONCLUSION: Yinxingdamo injection combined with oxiracetam capsule can effectively inhibit the oxygen free radical reaction injury in patients with acute cerebral infarction, and significantly improve the symptoms of cognitive dysfunction and neurological deficit in patients. Its curative effect is exact and worthy of clinical application.
基金supported by Scientific Research Project of Administration of Traditional Chinese Medicine of Guangdong Province (2008221)
文摘Objective：To observe the event related potential 300 （P300） after scalp acupuncture treatment in patients with cognitive disorder due to cerebral infarction,and evaluate its therapeutic effect.Methods：Sixty-six patients aged below 70 years old with cognitive disorder after initial onset of cerebral infarction were randomized into a treatment group and a control group.Conventional neurological drugs and physical trainings were prescribed to both groups.In addition,the treatment group received scalp acupuncture.The two groups were compared by evaluating the latency and amplitude of P300 before and after the 3-month treatment.Results：After treatment,the latency of P300 was shortened by 39.1 ms in the treatment group,versus 16.7 ms in the control group,and the difference was statistically significant （P0.05）.Conclusion：P300 can objectively evaluate the therapeutic effect of scalp acupuncture in treating the patients with cognitive disorder due to cerebral infarction.Scalp acupuncture has positive effect in treating this group of patients.
