Background:Coronavirus disease 2019 is still spreading all over the world and without any specific medicine.Traditional Chinese medicine has played an important role in the control of epidemics in China and accumulate...Background:Coronavirus disease 2019 is still spreading all over the world and without any specific medicine.Traditional Chinese medicine has played an important role in the control of epidemics in China and accumulated many experiences.The aim of this study is to summarize the law of traditional Chinese medicine and provide reference for coronavirus disease 2019 traditional Chinese medicine treatment.Methods:We collected the treatment plans of traditional Chinese medicine for coronavirus disease 2019 in 24 provinces of China to evaluate the basic Chinese medicine formulas,and the efficacy types,frequency,“Four Characters”,“Five Tastes”,“Channel Tropism”of herbal medicines.Combination rules between medicines were calculated by Apriori algorithm and Clementine12.0.Results:The formulas for“Relieving Exterior Syndrome”,“Expelling Dampness”,“Clearing Heat”and“Supplementing”have highest proportion.In prevention period and medical observation period,the medicines mainly have effect for“Clearing Heat”,“Relieving Exterior Syndrome”and“Supplementing”.In treatment period,medicines for“Clearing Heat”,“Relieving Superficies”and“Relieving Dampness”had higher frequency.The“Four Characters”of Chinese medicines in all treatment plans were mainly“Cold”and“Warm”.Medicines in the treatment plans always belong to“Pungent Taste”,“Bitter Taste”and“Sweet Taste”.For“Channel Tropism”,most medicines turned over to the“Lung”,“Stoma”and“Spleen”.The common medicine combinations in the recommended formulas during the prevention period and medical observation period were medicines for“Qi-Supplementing”and“Relieving Superficies”.In treatment period(mild,moderate,severe/critical),medicines for“Dampness Expelling”,“Relieving Superficies”and“Qi-Supplementing”were combined in a high frequency.In recovery period,the medicines for“Dispelling Dampness”combined the medicines for“Promoting Blood Circulation”with highest frequency.Conclusions:We found the characteristics of medicine and prescription rules of traditional Chinese medicine for the treatment of coronavirus disease 2019 and provided scientificity and effectiveness of it.More importantly,it provides reference for the development of new clinical prescriptions for coronavirus disease 2019.展开更多
目的挖掘国内关于中医药治疗糖尿病下肢血管病变的文献,探索糖尿病下肢血管病变的中药组方用药规律及特点。方法通过检索维普、万方和CNKI等数据库,筛选纳入中医药治疗糖尿病下肢血管病变的文献,运用中医传承辅助系统(Traditional Chine...目的挖掘国内关于中医药治疗糖尿病下肢血管病变的文献,探索糖尿病下肢血管病变的中药组方用药规律及特点。方法通过检索维普、万方和CNKI等数据库,筛选纳入中医药治疗糖尿病下肢血管病变的文献,运用中医传承辅助系统(Traditional Chinese Medicine Inheritance Support System,TCMISS)2.5软件建立数据库并进行数据分析。结果共筛选出54个中药复方用于治疗糖尿病下肢血管病变,其中出现频次超过20次的药物分别为黄芪、川芎、当归、丹参、桂枝、水蛭、牛膝和地龙,进一步挖掘出44个高频药对,提炼核心组合12个,形成新处方5个。结论借助TCMISS软件定量分析药物之间的关联性,分析各医家治疗糖尿病下肢血管病变的用药经验和方药规律,凝练出糖尿病下肢血管病变的治疗新处方。展开更多
The outbreak of COVID-19 has brought great health threat to human beings all over the world,it also brings great challenges to the development of medicine.Several traditional Chinese medicines have good effects on tre...The outbreak of COVID-19 has brought great health threat to human beings all over the world,it also brings great challenges to the development of medicine.Several traditional Chinese medicines have good effects on treating pneumonia patients in COVID-19.In this article,the active composition,pharmacological mechanism and clinical practice of these traditional Chinese medicines were reviewed.This will be of positive significance to the further research and clinical application of traditional Chinese medicine for treating COVID-19 pneumonia.展开更多
Yinqiao powder comes from the book"Wenbing Tiaobian"(Detailed Analysis of Epidemic Warm Diseases)written by Wu Jutong in the Qing Dynasty(1636-1912),in which it is mentioned that"pungent-cool diaphoreti...Yinqiao powder comes from the book"Wenbing Tiaobian"(Detailed Analysis of Epidemic Warm Diseases)written by Wu Jutong in the Qing Dynasty(1636-1912),in which it is mentioned that"pungent-cool diaphoretic agent Yinqiao power is used to treat patients with fever,not aversion to cold but thirsty"Yinqiao powder is often used to treat Wind-warm syndrome,warm-heat syndrome and miscellaneous diseases caused by some pathogenic factors in Wei-fen syndrome(Wei-fen syndrome is the syndrome name of the disease and is often used to indicate the initial stage of exogenous febrile disease,which is the syndrome of the body's guard surface.)and upper energizer.With the further research and application of Yinqiao powder,it is more and more widely used in clinic.This article summarizes the clinical application of Yinqiao powder through the analysis of the prescription meaning,compatible prescriptions,decoction methods and other aspects of Yinqiao powder in order to provide more evidence for clinical treatment of febrile disease.At the same time,through the prescription thinking of Yinqiao powder,we can learn Wu Jutong's treatment principle and academic thought of"Shangjiao(Shangjiao is one of the three and is the upper part of the Sanjiao.Generally refers to the chest above the diaphragm,including the heart,lungs and throat.)is like a feather,not lightly".Wu Jutong's flexible use of Chinese medicine and the thought of syndrome differentiation and treatment are also worthy of our study and reference.展开更多
目的:通过数据挖掘总结稳定型心绞痛的证候分布特点及组方用药规律。方法:搜索国家知识基础设施数据库(CNKI)、中国学术期刊数据库(CSPD)、中文科技期刊数据库(CCD)、PubMed、Web of Science数据库从建库至2022年2月收录的有关中医药治...目的:通过数据挖掘总结稳定型心绞痛的证候分布特点及组方用药规律。方法:搜索国家知识基础设施数据库(CNKI)、中国学术期刊数据库(CSPD)、中文科技期刊数据库(CCD)、PubMed、Web of Science数据库从建库至2022年2月收录的有关中医药治疗稳定型心绞痛的相关文献,建立方药数据库,并对高频药物进行关联规则及系统聚类分析。结果:共纳入文献105篇,处方111首,涉及患者9 786例,涵盖中医证型21种,频次最高证型为气虚血瘀,共提取出7个病性证素和2个病位证素。涉及中药123味,共计使用频次1 162次,使用频次前5位的中药分别是丹参70次、川芎69次、甘草54次、黄芪53次、当归50次。前30味高频药物关联规则分析显示,支持度最高的前3位药对为川芎-当归、川芎-赤芍、川芎-红花,聚类分析得到4个药物核心组合。结论:稳定型心绞痛常见气虚血瘀、痰瘀互结、气滞血瘀证;病性证素以实性居多,常见血瘀、痰浊,虚性证素主要为气虚;用药主要以活血化瘀、理气通滞、化痰降浊、益气通脉为法,是现代中医治疗稳定型心绞痛的主导思想。展开更多
基金This study was funded by the National Natural Science Foundation of China(No.81403040)Key Programs in Sichuan Department of Science and Technology(20ZDYF2376)Achievement Transformation Project of Chengdu Medical College(CYCG18-06).
文摘Background:Coronavirus disease 2019 is still spreading all over the world and without any specific medicine.Traditional Chinese medicine has played an important role in the control of epidemics in China and accumulated many experiences.The aim of this study is to summarize the law of traditional Chinese medicine and provide reference for coronavirus disease 2019 traditional Chinese medicine treatment.Methods:We collected the treatment plans of traditional Chinese medicine for coronavirus disease 2019 in 24 provinces of China to evaluate the basic Chinese medicine formulas,and the efficacy types,frequency,“Four Characters”,“Five Tastes”,“Channel Tropism”of herbal medicines.Combination rules between medicines were calculated by Apriori algorithm and Clementine12.0.Results:The formulas for“Relieving Exterior Syndrome”,“Expelling Dampness”,“Clearing Heat”and“Supplementing”have highest proportion.In prevention period and medical observation period,the medicines mainly have effect for“Clearing Heat”,“Relieving Exterior Syndrome”and“Supplementing”.In treatment period,medicines for“Clearing Heat”,“Relieving Superficies”and“Relieving Dampness”had higher frequency.The“Four Characters”of Chinese medicines in all treatment plans were mainly“Cold”and“Warm”.Medicines in the treatment plans always belong to“Pungent Taste”,“Bitter Taste”and“Sweet Taste”.For“Channel Tropism”,most medicines turned over to the“Lung”,“Stoma”and“Spleen”.The common medicine combinations in the recommended formulas during the prevention period and medical observation period were medicines for“Qi-Supplementing”and“Relieving Superficies”.In treatment period(mild,moderate,severe/critical),medicines for“Dampness Expelling”,“Relieving Superficies”and“Qi-Supplementing”were combined in a high frequency.In recovery period,the medicines for“Dispelling Dampness”combined the medicines for“Promoting Blood Circulation”with highest frequency.Conclusions:We found the characteristics of medicine and prescription rules of traditional Chinese medicine for the treatment of coronavirus disease 2019 and provided scientificity and effectiveness of it.More importantly,it provides reference for the development of new clinical prescriptions for coronavirus disease 2019.
文摘目的挖掘国内关于中医药治疗糖尿病下肢血管病变的文献,探索糖尿病下肢血管病变的中药组方用药规律及特点。方法通过检索维普、万方和CNKI等数据库,筛选纳入中医药治疗糖尿病下肢血管病变的文献,运用中医传承辅助系统(Traditional Chinese Medicine Inheritance Support System,TCMISS)2.5软件建立数据库并进行数据分析。结果共筛选出54个中药复方用于治疗糖尿病下肢血管病变,其中出现频次超过20次的药物分别为黄芪、川芎、当归、丹参、桂枝、水蛭、牛膝和地龙,进一步挖掘出44个高频药对,提炼核心组合12个,形成新处方5个。结论借助TCMISS软件定量分析药物之间的关联性,分析各医家治疗糖尿病下肢血管病变的用药经验和方药规律,凝练出糖尿病下肢血管病变的治疗新处方。
文摘The outbreak of COVID-19 has brought great health threat to human beings all over the world,it also brings great challenges to the development of medicine.Several traditional Chinese medicines have good effects on treating pneumonia patients in COVID-19.In this article,the active composition,pharmacological mechanism and clinical practice of these traditional Chinese medicines were reviewed.This will be of positive significance to the further research and clinical application of traditional Chinese medicine for treating COVID-19 pneumonia.
文摘Yinqiao powder comes from the book"Wenbing Tiaobian"(Detailed Analysis of Epidemic Warm Diseases)written by Wu Jutong in the Qing Dynasty(1636-1912),in which it is mentioned that"pungent-cool diaphoretic agent Yinqiao power is used to treat patients with fever,not aversion to cold but thirsty"Yinqiao powder is often used to treat Wind-warm syndrome,warm-heat syndrome and miscellaneous diseases caused by some pathogenic factors in Wei-fen syndrome(Wei-fen syndrome is the syndrome name of the disease and is often used to indicate the initial stage of exogenous febrile disease,which is the syndrome of the body's guard surface.)and upper energizer.With the further research and application of Yinqiao powder,it is more and more widely used in clinic.This article summarizes the clinical application of Yinqiao powder through the analysis of the prescription meaning,compatible prescriptions,decoction methods and other aspects of Yinqiao powder in order to provide more evidence for clinical treatment of febrile disease.At the same time,through the prescription thinking of Yinqiao powder,we can learn Wu Jutong's treatment principle and academic thought of"Shangjiao(Shangjiao is one of the three and is the upper part of the Sanjiao.Generally refers to the chest above the diaphragm,including the heart,lungs and throat.)is like a feather,not lightly".Wu Jutong's flexible use of Chinese medicine and the thought of syndrome differentiation and treatment are also worthy of our study and reference.
文摘目的:通过数据挖掘总结稳定型心绞痛的证候分布特点及组方用药规律。方法:搜索国家知识基础设施数据库(CNKI)、中国学术期刊数据库(CSPD)、中文科技期刊数据库(CCD)、PubMed、Web of Science数据库从建库至2022年2月收录的有关中医药治疗稳定型心绞痛的相关文献,建立方药数据库,并对高频药物进行关联规则及系统聚类分析。结果:共纳入文献105篇,处方111首,涉及患者9 786例,涵盖中医证型21种,频次最高证型为气虚血瘀,共提取出7个病性证素和2个病位证素。涉及中药123味,共计使用频次1 162次,使用频次前5位的中药分别是丹参70次、川芎69次、甘草54次、黄芪53次、当归50次。前30味高频药物关联规则分析显示,支持度最高的前3位药对为川芎-当归、川芎-赤芍、川芎-红花,聚类分析得到4个药物核心组合。结论:稳定型心绞痛常见气虚血瘀、痰瘀互结、气滞血瘀证;病性证素以实性居多,常见血瘀、痰浊,虚性证素主要为气虚;用药主要以活血化瘀、理气通滞、化痰降浊、益气通脉为法,是现代中医治疗稳定型心绞痛的主导思想。
