Relay node selection and combination ratio for amplify-and-forward OFDM-UWB communication

Due to its large bandwidth and the complexity of indoor environment, the ultra-wideband （UWB） channel is frequency selective, which affects the data rate and reliability of UWB communication. This paper investigates amplify-and-forward （AF） relay scheme to mitigate this reliability problem for orthogonal frequency division multiplexing （OFDM）-UWB communication. The relay can be used to acquire capacity gain and diversity gain just like multiple-input and multiple-output （MIMO） system. The first investigation focuses on the relay-node selection criterion and combination ratio for capacity gain. Capacity gain depends on the correlation of frequency responses between direct link and relay link in addition to signal-to-noise ratio （SNR） of relay link. Increased similarity of the two frequency responses increases capacity gain. Capacity gain＇s best relay and combination ratio are found by taking the derivative of the capacity equation. Solution of the quadratic derivative equation of ratio finds the optimal ratios for every potential relay node. The second investigation focuses on relay-node selection criterion and combination ratio for diversity gain. Higher diversity gain corresponds to less deep-faded sub-channels of combined signal. Reduced computation divides the problem into two steps： the first step selects the relay node according to the criterion that is dependent on the expectation value and variance of S（f）--the function of SNR of Jq the second step solves the optimization problem for optimal combination ratio. Numerical simulation shows that our scheme is effective in pursuit of capacity gain and of diversity gain.

Glycated haemoglobin reduction and fixed ratio combinations of analogue basal insulin and glucagon-like peptide-1 receptor agonists:A systematic review

BACKGROUND Fixed ratio combinations(FRCs)of analogue basal insulin and glucagon-like peptide-1 receptor agonists are a newer addition to the therapeutic armamentarium for the management of type 2 diabetes mellitus.They reduce treatment complexity by combining two injectables in a single daily injectable,thus potentially improving adherence and persistence.Clinicians wanting to use FRCs would need to choose between members of the class.AIM To describe and contrast the glycated haemoglobin reduction of two FRCs of analogue basal insulin and glucagon like peptide-1 receptor agonist in adults with type 2 diabetes mellitus.METHODS The following Population,Intervention,Comparison,Outcome question was used for the primary analysis:Among adult patients with type 2 diabetes mellitus[P],what is the effect of iGlarLixi[I]compared to IDegLira[C]for bringing about glycaemic control(as measured by reduction in glycosylated haemoglobin)[O]?The Prisma Statement was used as a guideline for framing this systematic review.We searched PubMed,EMBASE and Cochrane library databases and Clinicaltrials.gov using various keywords and medical search headings related to type 2 diabetes mellitus,iGlarlixi,IDegLira and glycated haemoglobin A1c.RESULTS All 14 studies identified by the systematic search met the primary efficacy endpoint of reduction in glycated haemoglobin.There were no head-to-head studies between the FRCs of iGlarlixi and IDegLira,and we therefore did an indirect comparison based on a common comparator of insulin glargine U100.Both iGlarLixi and IDegLira effectively reduce glycated haemoglobin when compared to insulin glargine U100.However,using indirect comparisons,IDegLira had a greater haemoglobin A1c reducing ability(0.6%vs 0.3%).The indirect comparison is limited by the differences between the studies;the fasting blood glucose targets were slightly higher for iGlarLixi studies when compared to the IDegLira studies(4.0-5.0 mmol/L and 4.4-5.6 mmol/L),and the IDegLira study used a greater average dose of insulin glargine when compared to the iGlarLixi studies(66 U/d vs 40 U/d).CONCLUSION Both iGlarLixi and IDegLira effectively reduce glycated haemoglobin.Indirect comparisons,using insulin glargine as the common comparator,suggest that IDegLira reduces glycated haemoglobin to a greater extent than iGlarLixi.However,given the limitations of indirect comparisons,robust head to head studies and real-world data would better inform clinician choice and clinical practice guidelines.

An Evaluation of Genotoxicity and Cytotoxicity of Melamine in Combination with Cyanuric Acid at Three Mass Ratios

Melamine in combination with cyanuric acid has been considered to be more toxic than either melamine or cyanuric acid alone. The objective of this study was designed to evaluate the combined genotoxicity and cytotoxicity of melamine （M） and cyanuric acid （C） at three mass ratios （1：1, 1：2, 2：1）. MC （1：1）, MC （1：2）, and MC （2：1） were evaluated for their potential genotoxic risk, at gene level by Ames test, and at chromosomal level by micronucleus test. In order to evaluate cytotoxicity in HEK-293 cells, the MTT assay was included. Western blot was also employed to investigate the renal injury molecule-1 （Kim-1） expression in HEK-293 cells exposed to MC. Neither genotoxicity at gene level nor at chromosomal level was observed for MC （1：1）, MC （1：2）, and MC （2：1）. Based on MTT assay, three ratios of MC at 82.5 and 165 μg/mL slightly inhibited viability of HEK-293 cells （P〈0.05）. MC （1：1） at 41.25 and 82.50 IJg/mL could elevate the Kim-1 expression in HEK-293 cells.

Inclusion Complex of Paclitaxel in Hydroxypropyl-β-cyclodextrin

Introduction Paclitaxel （as Taxol） is a kind of diterpenoid natural product extracted from Chinese yew. It has been reported to have high anti-tumor effects, such as the activity against oophorama, mammary cancer, encephaloma, cervical carcinoma, and non- small-cell lung carcinoma. One of the major problems of paclitaxel applied to therapy is its extremely low solubility in water. In addition, paclitaxel is administered as a slow infusion in a vehicle consisting of Cremophor EL （ polyoxyethylated castor oil ）. However, Cremophor has been observed to cause severe, occasionally fatal hypersensitivity reactions in animals and humans. Therefore, paclitaxel therapy includes a prophylactic regimen of antihistamines and corticosteroids , along with a prolonged infusion time to reduce the severity and incidence of hypersensitivity reactions. Because of the reasons mentioned above, currently its preparation needs to be improved further.

On the System Performance of Mobile Edge Computing in an Uplink NOMA WSN With a Multiantenna Access Point Over Nakagami-m Fading

In this paper,we study the system performance of mobile edge computing(MEC)wireless sensor networks(WSNs)using a multiantenna access point(AP)and two sensor clusters based on uplink nonorthogonal multiple access(NOMA).Due to limited computation and energy resources,the cluster heads(CHs)offload their tasks to a multiantenna AP over Nakagami-m fading.We proposed a combination protocol for NOMA-MEC-WSNs in which the AP selects either selection combining(SC)or maximal ratio combining(MRC)and each cluster selects a CH to participate in the communication process by employing the sensor node(SN)selection.We derive the closed-form exact expressions of the successful computation probability(SCP)to evaluate the system performance with the latency and energy consumption constraints of the considered WSN.Numerical results are provided to gain insight into the system performance in terms of the SCP based on system parameters such as the number of AP antennas,number of SNs in each cluster,task length,working frequency,offloading ratio,and transmit power allocation.Furthermore,to determine the optimal resource parameters,i.e.,the offloading ratio,power allocation of the two CHs,and MEC AP resources,we proposed two algorithms to achieve the best system performance.Our approach reveals that the optimal parameters with different schemes significantly improve SCP compared to other similar studies.We use Monte Carlo simulations to confirm the validity of our analysis.

A Survey on Low Complexity Detectors for OTFS Systems

The newly emerging orthogonal time frequency space(OTFS)modulation can ob⁃tain delay-Doppler diversity gain to significantly improve the system performance in high mobility wireless communication scenarios such as vehicle-to-everything(V2X),high-speed railway and unmanned aerial vehicles(UAV),by employing inverse symplectic finite Fouri⁃er transform(ISFFT)and symplectic finite Fourier transform(SFFT).However,OTFS modu⁃lation will dramatically increase system complexity,especially at the receiver side.Thus,de⁃signing low complexity OTFS receiver is a key issue for OTFS modulation to be adopted by new-generation wireless communication systems.In this paper,we review low complexity OTFS detectors and provide some insights on future researches.We firstly present the OTFS system model and basic principles,followed by an overview of OTFS detector structures,classifications and comparative discussion.We also survey the principles of OTFS detection algorithms.Furthermore,we discuss the design of hybrid OTFS and orthogonal frequency di⁃vision multiplexing(OFDM)detectors in single user and multi-user multi-waveform commu⁃nication systems.Finally,we address the main challenges in designing low complexity OT⁃FS detectors and identify some future research directions.

Cooperative Communication Protocols for Performance Improvement in Mobile Satellite Systems

A mobile satellite indoor signal is proposed to model perfor mance of cooperative communication protocols and maximal ra tio combining.Cooperative diversity can improve the reliability of satellite system and increase data speed or expand cell radi us by lessening the effects of fading.Performance is determined by measured bit error rates（BERs）in different types of coopera tive protocols and indoor systems（e.g.GSM and WCDMA net works）.The effect of performance on cooperative terminals lo cated at different distances from an indoor cellular system is al so discussed.The proposed schemes provide higher signal-tonoise ratio（SNR）-around 1.6 dB and 2.6 dB gap at BER 10-2for amplify-and-forward（AF）and decode-and-forward（DF）cooperative protocols,respectively,when the cooperative termi nal is located 10 m from the WCDMA indoor system.Coopera tive protocols improve effective power utilization and,hence,improve performance and cell coverage of the mobile satellite network.

Modified Cooperative Subchannel Allocation Algorithms and PSO Based Power Allocation for an Alamouti Decode and Forward Relaying Protocol in Multiuser OFDMA Systems

The present work is a discussion on the performance analysis of Modified Cooperative Subchannel Allocation (CSA) Algorithms which is used in Alamouti Decoded and Forward (Alamouti DF) Relaying Protocol for wireless multi-user Orthogonal Frequency Division Multiplexing Access (OFDMA) systems. In addition, the performance of approximate Symbol Error Rate (SER) for the Alamouti DF Relaying Protocol with the Cooperative Maximum Ratio Combining Technique (C-MRC) is analyzed and compared with SER upper bound. The approximate SER is asymptotically tight bound at higher Signal-to-Noise Ratio (SNR). From the asymptotic tight bound approximate SER, Particle Swarm Optimization (PSO) based Power Allocation (PA) is determined for the Alamouti DF Relaying Protocol. The simulation results suggested that the Modified Throughput based Subchannel Allocation Algorithm achieved an improved throughput of 6% to 33% compared to that of existing cooperative diversity protocol. Further, the Modified Fairness based Subchannel Allocation Algorithm rendered fairness of 7.2% to 17% among the multiuser against the existing cooperative diversity protocol.

The performance of a combined nitritation–anammox reactor treating anaerobic digestion supernatant under various C/N ratios

A combined nitritation–anammox reactor was developed to treat the digestion supernatant under various C/N ratios. Due to the difficulties for heterotroph to utilize the refractory organics, the reactor presented relatively stable performance with increasing supernatant addition. Nevertheless, the adverse effects of supernatant would accumulate during the long-term operation and thus weakened the activity and shock resistance of microbes,which further led to the gradual decrease of reactor performance after 92 days＇ operation.Under this circumstance, supernatant with volatile fatty acids（VFAs） residuals was further introduced into the reactor to investigate the performance of combined nitritation–anammox process with VFA addition. With the appearance of VFAs, the nitrogen removal performance gradually restored and the reactor finally achieved stable and efficient performance with C/N ratio of 0.35. The VFA residuals within 150 mg/L in the supernatant served as the extra electron donors and stimulated the heterotrophic denitrification process, which was vital for the enhancement of reactor. The nitrogen removal rate and total nitrogen removal efficiency reached 0.49 kg N/（m^3·day） and 88.8% after 140 days＇ operation, respectively. The combined nitritation–anammox reactor was proved suitable to treat digestion supernatant.

Virtualization of Wireless Communication Systems and Its Maximal Ratio Combining Macrodiversity To Extend CDMA Capacity

The concept of virtualization of wireless communication systems is based on the open and scalable hardware platform of software radios in the personal communication network. The base station is divided into four components according to their functions: antenna, IF, baseband, and control, which are connected by the ATM network. Virtualization provides great benefits such as fast handoff and easy realization of different macrodiversity algorithms. Macrodiversity can not be easily realized in conventional cellular systems. An exact analysis is presented for the performance of maximal ratio combining (MRC) macrodiversity in virtualized wireless communication systems. The results show that compared with soft handoff in CDMA systems, MRC can greatly increase the reverse link capacity.