In underground engineering with complex conditions,the bolt(cable)anchorage support system is in an environment where static and dynamic stresses coexist,under the action of geological conditions such as high stresses...In underground engineering with complex conditions,the bolt(cable)anchorage support system is in an environment where static and dynamic stresses coexist,under the action of geological conditions such as high stresses and strong disturbances and construction conditions such as the application of high prestress.It is essential to study the support components performance under dynamic-static coupling conditions.Based on this,a multi-functional anchorage support dynamic-static coupling performance test system(MAC system)is developed,which can achieve 7 types of testing functions,including single component performance,anchored net performance,anchored rock performance and so on.The bolt and cable mechanical tests are conducted by MAC system under different prestress levels.The results showed that compared to the non-prestress condition,the impact resistance performance of prestressed bolts(cables)is significantly reduced.In the prestress range of 50–160 k N,the maximum reduction rate of impact energy resisted by different types of bolts is 53.9%–61.5%compared to non-prestress condition.In the prestress range of 150–300 k N,the impact energy resisted by high-strength cable is reduced by76.8%–84.6%compared to non-prestress condition.The MAC system achieves dynamic-static coupling performance test,which provide an effective means for the design of anchorage support system.展开更多
The development of deepwater oil fields has reached a new stage with the dramatic increase in water depth and the recent increasing demands of the economic development in the filed. The use of a Tension Leg Platform ...The development of deepwater oil fields has reached a new stage with the dramatic increase in water depth and the recent increasing demands of the economic development in the filed. The use of a Tension Leg Platform (TIP) combined with other systems, such as Floating Production Storage and Offloading (FPSO) system, Floating Production Unit (FPU) system, Tender Assisted Drilling (TAD) system, etc., has drawn the industry attention and increased significantly in the past few years. For the areas lacking of pipeline system, the use of TIP(s) combined with FPSO has been chosen to efficiently develop the deepwater fields. The TIP with a Tender Assisted Drilling system significantly reduces the payload of the platform and reduces the investment in the TIP system substantially. This opens the door for many new deepwater field developments to use the tension leg platform. The advantage of the TIP combined with a TAD system is more significant when several TIPs are used for the continuous development of the field. One of the applications for the TIP with a tender assisted drilling system can be in the development of an offshore marginal field. Owing to the increase of water depth, the conventional fixed platform model for the exploration of those fields becomes uneconomical. It also would be too expensive to use a large TIP structure for those marginal fields due to the large amount of initial investment. The TIP system with tender assisted drilling can be used to develop those fields economically. There are many marginal fields in China offshore, especially in shelf areas. The application of this field developing model, combined with the existing field developing experience in China, will open the door for many marginal field developments. This paper will review the application of the combined TIP system through some examples of completed/ongoing projects, and major technical issues encountered in those practices. The potential application of this technology in China deepwater development will be discussed in the end.展开更多
With the continuous development of deep oil and gas,minerals,geothermal resources,and other resources,there are increasingly more stringent requirements for equipment.In particular,the ultra-highpressure dynamic seals...With the continuous development of deep oil and gas,minerals,geothermal resources,and other resources,there are increasingly more stringent requirements for equipment.In particular,the ultra-highpressure dynamic seals of deep mining device need to be developed.Therefore,considering the use of dynamic seals in unique deep mining environments,an ultra-high-pressure rotating combined dynamic seal was designed and developed and its sealing performance was experimentally measured and analyzed.The results show that the experimental device can operate stably under a pressure of up to150 MPa and a rotating speed of 76 r/min,and can also operate normally under a rotating speed of up to 140 r/min and a sealing pressure of 120 MPa.During the operation of the ultra-high-pressure rotating combined dynamic seal,the sealing ring does not show obvious damage,which vouches for its sealing performance.No leakage of flow and pressure was detected in the all seal structures within the sealing pressure range of 0-150 MPa.Therefore,the dynamic sealing performance of the device is intact under ultra-high-pressure conditions and can be applied in deep mining environments at a certain depth.The research and development of this device can aid future deep energy exploration and exploitation.展开更多
To achieve the goals of carbon peaking and carbon neutrality under the backgrounds of poor resource endowments, weak theoretical basis and other factors, the development of the coalbed methane industry of China faces ...To achieve the goals of carbon peaking and carbon neutrality under the backgrounds of poor resource endowments, weak theoretical basis and other factors, the development of the coalbed methane industry of China faces many bottlenecks and challenges. This paper systematically analyzes the coalbed methane resources, key technologies and progress, exploration effect and production performance in China and abroad. The main problems are summarized as low exploration degree, low technical adaptability, low return on investment and small development scale. This study suggests that the coalbed methane industry in China should follow the “two-step”(short-term and long-term) development strategy. The short-term action before 2030, can be divided into two stages:(1) From the present to 2025, to achieve new breakthroughs in theory and technology, and accomplish the target of annual production of 10 billion cubic meters;(2) From 2025 to 2030, to form the technologies suitable for most geological conditions, further expand the industry scale, and achieve an annual output of 30 billion cubic meters, improving the proportion of coalbed methane in the total natural gas production. The long-term action after 2030 is to gradually realize an annual production of 100 billion cubic meters. The strategic countermeasure to achieve the above goals is to adhere to “technology+management dual wheel drive”, realize the synchronous progress of technology and management, and promote the high-quality development of the coalbed methane industry. Technically, the efforts will focus on fine and effective development of coalbed methane in the medium to shallow layers of mature fields, effective development of coalbed methane in new fields, extensive and beneficial development of deep coalbed methane, three-dimensional comingled development of coalbed methane, applying new technologies such as coalbed methane displacement by carbon dioxide, microwave heating and stimulation technology, ultrasonic stimulation, high-temperature heat injection stimulation, rock breaking by high-energy laser. In terms of management, the efforts will focus on coordinative innovation of resource, technology, talent, policy and investment, with technological innovation as the core, to realize an all-round and integrated management and promote the development of coalbed methane industry at a high level.展开更多
Purpose: Endometriosis can be managed effectively by medication, surgery, or a combination of both. Numerous studies have been conducted on surgical and medication treatment options, but their results are still under ...Purpose: Endometriosis can be managed effectively by medication, surgery, or a combination of both. Numerous studies have been conducted on surgical and medication treatment options, but their results are still under discussion. Therefore, we performed a study to develop a combinational treatment for various stages of endometriosis. Methods: Over a 3-year period, 218 documented endometriosis patients were classified in 4 stages. After first laparoscopy (with electrocoagulation and adhesion removal for stages I to III), the patients were treated with GnRH analogs (Gonadotropin Releasing Hormone Agonist-375 mg of Decapeptyl) for 3, 6 & 6 months, respectively. The second and third laparoscopy procedures were performed after 3 and 6 months, with add-back therapy. The treatment was evaluated by direct observation based on laparoscopic view and the pain relief was measured by the VAS (Visual Analogue Scale) after the first step of medication for patients of stages I-III. Results: After 3 months, 70/76 patients (91.9%) with stage-I endometriosis showed complete recovery (six cases after 6 months) while 65/72 and 32/43 cases with stage-II and -III (90.3 and 74.4%), respectively, showed complete recovery after 6 months of treatment. The remaining patients had GnRH treatment for another 3 months, and all showed a complete recovery after 9 months. Furthermore, 12 of the patients with stage-IV symptoms were candidates for laparoscopy or laparotomy, and their treatment response rate was 55.6%. The pain relief was significant after the combinational treatment in patients with stages I-III (P = 0.0001). Conclusion: Our study showed efficacy of the developed protocol for the endometriosis management.展开更多
Land use suitability analysis plays an important role in sustainable land use and solving environmental problems caused by rapid urban development.A land use suitability mapping approach for town development planning ...Land use suitability analysis plays an important role in sustainable land use and solving environmental problems caused by rapid urban development.A land use suitability mapping approach for town development planning in hilly areas was constructed based on two multi-criteria evaluation methods:Weighted Linear Combination(WLC)and Ordered Weighted Averaging(OWA),to comparatively evaluate and map land use suitability of Tangshan new town in Nanjing,China.Fourteen evaluation factors related to topographic,environmental,socio-economics and historical sites data were used as suitability criteria.The analytic hierarchy process(AHP)method and GIS techniques were integrated into the evaluation models to create the land use suitability map for town development planning.The results of WLC approach showed that 11.4%of the total area is highly suitable while the 48.6%is unsuitable.The results of WLC and OWA approach showed the distribution of degree of land use suitability is almost the same.The areas located at the southern and eastern flat regions are highly suitable for land use,whereas the areas close to the mountain forests,steep slopes,waters,and hot springs,have lower suitability for land use.Sensitivity analysis indicated that the suitability results of the two proposed methods are robust.Indirect validation was achieved by mutual comparison of suitability maps derived from the WLC and OWA methods.It demonstrated that the overall agreement is 90.81%and kappa coefficient is 0.81,indicating that both methods provide very similar spatial suitability distributions.By overlaying the resultant map with the previous master plan map of Tangshan new town,the overlay map once again indicated a satisfactory ecological fit between the two maps.At last,several recommendations are proposed aiming at improving the long-term town development plan for Tangshan new town.展开更多
The clustered regularly interspaced short palindromic repeats(CRISPR)–CRISPR-associated protein(Cas) system has been widely used for genome editing. In this system, the cytosine base editor(CBE) and adenine base edit...The clustered regularly interspaced short palindromic repeats(CRISPR)–CRISPR-associated protein(Cas) system has been widely used for genome editing. In this system, the cytosine base editor(CBE) and adenine base editor(ABE) allow generating precise and irreversible base mutations in a programmable manner and have been used in many different types of cells and organisms. However, their applications are limited by low editing efficiency at certain genomic target sites or at specific target cytosine(C) or adenine(A) residues. Using a strategy of combining optimized synergistic core components, we developed a new multiplex super-assembled ABE(sABE) in rice that showed higher base-editing efficiency than previously developed ABEs. We also designed a new type of nuclear localization signal(NLS) comprising a FLAG epitope tag with four copies of a codon-optimized NLS(F4NLS^(r2)) to generate another ABE named F4NLS-sABE. This new NLS increased editing efficiency or edited additional A at several target sites. A new multiplex super-assembled CBE(sCBE) and F4NLS^(r2) involved F4NLS-sCBE were also created using the same strategy. F4NLS-sCBE was proven to be much more efficient than sCBE in rice. These optimized base editors will serve as powerful genome-editing tools for basic research or molecular breeding in rice and will provide a reference for the development of superior editing tools for other plants or animals.展开更多
With the rapid development of audio-visual language, production of traditional hand-painted animation has failed to keep pace with the times. This paper discussed the current foreign and domestic researches on animati...With the rapid development of audio-visual language, production of traditional hand-painted animation has failed to keep pace with the times. This paper discussed the current foreign and domestic researches on animation, and found that the researches still focused on application of technology or theories of animation arts. The study tried to integrate traditional hand painting with computer technology, produce hand-painted pastel animation, enrich the artistic forms of hand-painted pastel animation short fi lm, improve the effi ciency of handpainted pastel production, so as to form a complete artistic realization theory system of hand-painted pastel animation short fi lm, and provide a technological and theoretical support for the development of traditional hand-painted animation.展开更多
Objective:To explore the nursing effects of medical treatment combination on patients at high risk of developing pressure ulcers at rural homes.Methods:From January 2018 to December 2018,86 patients at high risk of de...Objective:To explore the nursing effects of medical treatment combination on patients at high risk of developing pressure ulcers at rural homes.Methods:From January 2018 to December 2018,86 patients at high risk of developing pressure ulcers at rural homes who were in Wenjiang Hospital were randomly divided into a control group and an observed group.The control group received the routine publicity and education and visiting,while the observed group adopted the cooperative nursing model of medical treatment combination.Then compare the healing status and nursing satisfaction of the two groups.Results:Of the 43 patients with pressure ulcers in the observed group,18 had been in the second stage of pressure ulcers and 16 had been healed;14 had been in the third stage of pressure ulcers and 8 had been healed;11 had been in the fourth stage of pressure ulcers and 5 had been healed.The nursing satisfaction of the patients in the observed group was 95.35%.Conclusion:Conducting medical treatment combination on patients at high risk of developing pressure ulcers at rural homes can effectively improve the patients’and their families’awareness of pressure ulcer nursing,standardize their nursing behaviour,help recover the patients themselves and promote the patients’satisfaction.展开更多
基金supported by the National Natural Science Foundation of China(Nos.51927807,52074164,42277174,42077267 and 42177130)the Natural Science Foundation of Shandong Province,China(No.ZR2020JQ23)China University of Mining and Technology(Beijing)Top Innovative Talent Cultivation Fund for Doctoral Students(No.BBJ2023048)。
文摘In underground engineering with complex conditions,the bolt(cable)anchorage support system is in an environment where static and dynamic stresses coexist,under the action of geological conditions such as high stresses and strong disturbances and construction conditions such as the application of high prestress.It is essential to study the support components performance under dynamic-static coupling conditions.Based on this,a multi-functional anchorage support dynamic-static coupling performance test system(MAC system)is developed,which can achieve 7 types of testing functions,including single component performance,anchored net performance,anchored rock performance and so on.The bolt and cable mechanical tests are conducted by MAC system under different prestress levels.The results showed that compared to the non-prestress condition,the impact resistance performance of prestressed bolts(cables)is significantly reduced.In the prestress range of 50–160 k N,the maximum reduction rate of impact energy resisted by different types of bolts is 53.9%–61.5%compared to non-prestress condition.In the prestress range of 150–300 k N,the impact energy resisted by high-strength cable is reduced by76.8%–84.6%compared to non-prestress condition.The MAC system achieves dynamic-static coupling performance test,which provide an effective means for the design of anchorage support system.
文摘The development of deepwater oil fields has reached a new stage with the dramatic increase in water depth and the recent increasing demands of the economic development in the filed. The use of a Tension Leg Platform (TIP) combined with other systems, such as Floating Production Storage and Offloading (FPSO) system, Floating Production Unit (FPU) system, Tender Assisted Drilling (TAD) system, etc., has drawn the industry attention and increased significantly in the past few years. For the areas lacking of pipeline system, the use of TIP(s) combined with FPSO has been chosen to efficiently develop the deepwater fields. The TIP with a Tender Assisted Drilling system significantly reduces the payload of the platform and reduces the investment in the TIP system substantially. This opens the door for many new deepwater field developments to use the tension leg platform. The advantage of the TIP combined with a TAD system is more significant when several TIPs are used for the continuous development of the field. One of the applications for the TIP with a tender assisted drilling system can be in the development of an offshore marginal field. Owing to the increase of water depth, the conventional fixed platform model for the exploration of those fields becomes uneconomical. It also would be too expensive to use a large TIP structure for those marginal fields due to the large amount of initial investment. The TIP system with tender assisted drilling can be used to develop those fields economically. There are many marginal fields in China offshore, especially in shelf areas. The application of this field developing model, combined with the existing field developing experience in China, will open the door for many marginal field developments. This paper will review the application of the combined TIP system through some examples of completed/ongoing projects, and major technical issues encountered in those practices. The potential application of this technology in China deepwater development will be discussed in the end.
基金supported by the Program for Guangdong Introducing Innovative and Enterpreneurial Teams(Grant No.2019ZT08G315)the National Natural Science Foundation of China(Grant No.51827901)
文摘With the continuous development of deep oil and gas,minerals,geothermal resources,and other resources,there are increasingly more stringent requirements for equipment.In particular,the ultra-highpressure dynamic seals of deep mining device need to be developed.Therefore,considering the use of dynamic seals in unique deep mining environments,an ultra-high-pressure rotating combined dynamic seal was designed and developed and its sealing performance was experimentally measured and analyzed.The results show that the experimental device can operate stably under a pressure of up to150 MPa and a rotating speed of 76 r/min,and can also operate normally under a rotating speed of up to 140 r/min and a sealing pressure of 120 MPa.During the operation of the ultra-high-pressure rotating combined dynamic seal,the sealing ring does not show obvious damage,which vouches for its sealing performance.No leakage of flow and pressure was detected in the all seal structures within the sealing pressure range of 0-150 MPa.Therefore,the dynamic sealing performance of the device is intact under ultra-high-pressure conditions and can be applied in deep mining environments at a certain depth.The research and development of this device can aid future deep energy exploration and exploitation.
基金Supported by the China National Science and Technology Major Project (2016ZX05042)。
文摘To achieve the goals of carbon peaking and carbon neutrality under the backgrounds of poor resource endowments, weak theoretical basis and other factors, the development of the coalbed methane industry of China faces many bottlenecks and challenges. This paper systematically analyzes the coalbed methane resources, key technologies and progress, exploration effect and production performance in China and abroad. The main problems are summarized as low exploration degree, low technical adaptability, low return on investment and small development scale. This study suggests that the coalbed methane industry in China should follow the “two-step”(short-term and long-term) development strategy. The short-term action before 2030, can be divided into two stages:(1) From the present to 2025, to achieve new breakthroughs in theory and technology, and accomplish the target of annual production of 10 billion cubic meters;(2) From 2025 to 2030, to form the technologies suitable for most geological conditions, further expand the industry scale, and achieve an annual output of 30 billion cubic meters, improving the proportion of coalbed methane in the total natural gas production. The long-term action after 2030 is to gradually realize an annual production of 100 billion cubic meters. The strategic countermeasure to achieve the above goals is to adhere to “technology+management dual wheel drive”, realize the synchronous progress of technology and management, and promote the high-quality development of the coalbed methane industry. Technically, the efforts will focus on fine and effective development of coalbed methane in the medium to shallow layers of mature fields, effective development of coalbed methane in new fields, extensive and beneficial development of deep coalbed methane, three-dimensional comingled development of coalbed methane, applying new technologies such as coalbed methane displacement by carbon dioxide, microwave heating and stimulation technology, ultrasonic stimulation, high-temperature heat injection stimulation, rock breaking by high-energy laser. In terms of management, the efforts will focus on coordinative innovation of resource, technology, talent, policy and investment, with technological innovation as the core, to realize an all-round and integrated management and promote the development of coalbed methane industry at a high level.
文摘Purpose: Endometriosis can be managed effectively by medication, surgery, or a combination of both. Numerous studies have been conducted on surgical and medication treatment options, but their results are still under discussion. Therefore, we performed a study to develop a combinational treatment for various stages of endometriosis. Methods: Over a 3-year period, 218 documented endometriosis patients were classified in 4 stages. After first laparoscopy (with electrocoagulation and adhesion removal for stages I to III), the patients were treated with GnRH analogs (Gonadotropin Releasing Hormone Agonist-375 mg of Decapeptyl) for 3, 6 & 6 months, respectively. The second and third laparoscopy procedures were performed after 3 and 6 months, with add-back therapy. The treatment was evaluated by direct observation based on laparoscopic view and the pain relief was measured by the VAS (Visual Analogue Scale) after the first step of medication for patients of stages I-III. Results: After 3 months, 70/76 patients (91.9%) with stage-I endometriosis showed complete recovery (six cases after 6 months) while 65/72 and 32/43 cases with stage-II and -III (90.3 and 74.4%), respectively, showed complete recovery after 6 months of treatment. The remaining patients had GnRH treatment for another 3 months, and all showed a complete recovery after 9 months. Furthermore, 12 of the patients with stage-IV symptoms were candidates for laparoscopy or laparotomy, and their treatment response rate was 55.6%. The pain relief was significant after the combinational treatment in patients with stages I-III (P = 0.0001). Conclusion: Our study showed efficacy of the developed protocol for the endometriosis management.
基金funded by the National Natural Science Foundation of China(No.31270746)the Scientific Research Innovation Program for Graduate Students in Jiangsu Province(SJKY19_0870)。
文摘Land use suitability analysis plays an important role in sustainable land use and solving environmental problems caused by rapid urban development.A land use suitability mapping approach for town development planning in hilly areas was constructed based on two multi-criteria evaluation methods:Weighted Linear Combination(WLC)and Ordered Weighted Averaging(OWA),to comparatively evaluate and map land use suitability of Tangshan new town in Nanjing,China.Fourteen evaluation factors related to topographic,environmental,socio-economics and historical sites data were used as suitability criteria.The analytic hierarchy process(AHP)method and GIS techniques were integrated into the evaluation models to create the land use suitability map for town development planning.The results of WLC approach showed that 11.4%of the total area is highly suitable while the 48.6%is unsuitable.The results of WLC and OWA approach showed the distribution of degree of land use suitability is almost the same.The areas located at the southern and eastern flat regions are highly suitable for land use,whereas the areas close to the mountain forests,steep slopes,waters,and hot springs,have lower suitability for land use.Sensitivity analysis indicated that the suitability results of the two proposed methods are robust.Indirect validation was achieved by mutual comparison of suitability maps derived from the WLC and OWA methods.It demonstrated that the overall agreement is 90.81%and kappa coefficient is 0.81,indicating that both methods provide very similar spatial suitability distributions.By overlaying the resultant map with the previous master plan map of Tangshan new town,the overlay map once again indicated a satisfactory ecological fit between the two maps.At last,several recommendations are proposed aiming at improving the long-term town development plan for Tangshan new town.
基金supported by the Beijing Scholars Program[BSP041]。
文摘The clustered regularly interspaced short palindromic repeats(CRISPR)–CRISPR-associated protein(Cas) system has been widely used for genome editing. In this system, the cytosine base editor(CBE) and adenine base editor(ABE) allow generating precise and irreversible base mutations in a programmable manner and have been used in many different types of cells and organisms. However, their applications are limited by low editing efficiency at certain genomic target sites or at specific target cytosine(C) or adenine(A) residues. Using a strategy of combining optimized synergistic core components, we developed a new multiplex super-assembled ABE(sABE) in rice that showed higher base-editing efficiency than previously developed ABEs. We also designed a new type of nuclear localization signal(NLS) comprising a FLAG epitope tag with four copies of a codon-optimized NLS(F4NLS^(r2)) to generate another ABE named F4NLS-sABE. This new NLS increased editing efficiency or edited additional A at several target sites. A new multiplex super-assembled CBE(sCBE) and F4NLS^(r2) involved F4NLS-sCBE were also created using the same strategy. F4NLS-sCBE was proven to be much more efficient than sCBE in rice. These optimized base editors will serve as powerful genome-editing tools for basic research or molecular breeding in rice and will provide a reference for the development of superior editing tools for other plants or animals.
文摘With the rapid development of audio-visual language, production of traditional hand-painted animation has failed to keep pace with the times. This paper discussed the current foreign and domestic researches on animation, and found that the researches still focused on application of technology or theories of animation arts. The study tried to integrate traditional hand painting with computer technology, produce hand-painted pastel animation, enrich the artistic forms of hand-painted pastel animation short fi lm, improve the effi ciency of handpainted pastel production, so as to form a complete artistic realization theory system of hand-painted pastel animation short fi lm, and provide a technological and theoretical support for the development of traditional hand-painted animation.
基金To explore the integrated use of nursing resources under the medical treatment combination(Program Number:2017P27)。
文摘Objective:To explore the nursing effects of medical treatment combination on patients at high risk of developing pressure ulcers at rural homes.Methods:From January 2018 to December 2018,86 patients at high risk of developing pressure ulcers at rural homes who were in Wenjiang Hospital were randomly divided into a control group and an observed group.The control group received the routine publicity and education and visiting,while the observed group adopted the cooperative nursing model of medical treatment combination.Then compare the healing status and nursing satisfaction of the two groups.Results:Of the 43 patients with pressure ulcers in the observed group,18 had been in the second stage of pressure ulcers and 16 had been healed;14 had been in the third stage of pressure ulcers and 8 had been healed;11 had been in the fourth stage of pressure ulcers and 5 had been healed.The nursing satisfaction of the patients in the observed group was 95.35%.Conclusion:Conducting medical treatment combination on patients at high risk of developing pressure ulcers at rural homes can effectively improve the patients’and their families’awareness of pressure ulcer nursing,standardize their nursing behaviour,help recover the patients themselves and promote the patients’satisfaction.