Terminalia Linn,a genus of mostly medium or large trees in the family Combretaceae with about 250 species in the world,is distributed mainly in southern Asia,Himalayas,Madagascar,Australia,and the tropical and subtrop...Terminalia Linn,a genus of mostly medium or large trees in the family Combretaceae with about 250 species in the world,is distributed mainly in southern Asia,Himalayas,Madagascar,Australia,and the tropical and subtropical regions of Africa.Many species are used widely in many traditional medicinal systems,e.g.,traditional Chinese medicine,Tibetan medicine,and Indian Ayurvedic medicine practices.So far,about 39 species have been phytochemically studied,which led to the identification of 368 compounds,including terpenoids,tannins,flavonoids,phenylpropanoids,simple phenolics and so on.Some of the isolates showed various bioactivities,in vitro or in vivo,such as antitumor,anti HIV-1,antifungal,antimicrobial,antimalarial,antioxidant,diarrhea and analgesic.This review covers research articles from 1934 to 2018,retrieved from SciFinder,Wikipedia,Google Scholar,Chinese Knowledge Network and Baidu Scholar by using“Terminalia”as the search term(“all fields”)with no specific time frame setting for the search.Thirty-nine important medicinal and edible Terminalia species were selected and summarized on their geographical distribution,traditional uses,phytochemistry and related pharmacological activities.展开更多
AIM To evaluate the anti-inflammatory intestinal effect of the ethanolic extract(EtO HE) and hexane phase(HexP) obtained from the leaves of Combretum duarteanum(Cd).METHODS Inflammatory bowel disease was induced using...AIM To evaluate the anti-inflammatory intestinal effect of the ethanolic extract(EtO HE) and hexane phase(HexP) obtained from the leaves of Combretum duarteanum(Cd).METHODS Inflammatory bowel disease was induced using trinitrobenzenesulfonic acid in acute and relapsed ulcerative colitis in rat models. Damage scores, and biochemical, histological and immunohistochemical parameters were evaluated. RESULTS Both Cd-Et OHE and Cd-Hex P caused significant reductions in macroscopic lesion scores and ulcerative l e sionareas. The vegetable samples inhibited myeloperoxidase increase, as well as pro-inflammatory cytokines TNF-α and IL-1β. Anti-inflammatory cytokine IL-10 also increased in animals treated with the tested plant samples. The anti-inflammatory intestinal effect is related to decreased expression of cyclooxygenase-2, proliferating cell nuclear antigen, and an increase in superoxide dismutase. CONCLUSION The data indicate anti-inflammatory intestinal activity. The effects may also involve participation of the antioxidant system and principal cytokines relating to inflammatory bowel disease.展开更多
Objective: To evaluate the structural and chemical composition of plant and the antioxidant and antimicrobial activities promoted by hexanic, ethanolic and ethyl acetate fractions obtained from leaves of Conocarpus er...Objective: To evaluate the structural and chemical composition of plant and the antioxidant and antimicrobial activities promoted by hexanic, ethanolic and ethyl acetate fractions obtained from leaves of Conocarpus erectus.Methods: Organic fractions were characterized through UPLC-MS and GC-MS.Antioxidant potential was performed through DPPH and molybdenum phosphate techniques.Antibacterial and antifungal assays were performed in accordance with Clinical and Laboratory Standards Institute protocols.Results: The obtained biomass of Conocarpus erectus leaves showed the high presence of glucose(0.45 g/L), cellulose(28.69%), Na(55.126 μg/L) and K(31.163 μg/L).We identified seven compounds in the hexanic and ethyl acetate fractions, and eight compounds in ethanolic fraction.Moreover, phenolic compounds are prevalent in all organic fractions with values of(10.04 ± 0.24),(221.26 ± 1.84),(340.53 ± 0.84) mg/g GAE to hexanic, ethyl acetate and ethanolic fraction, respectively.Antioxidant results showed a high potential in ethyl acetate fraction(71.82 ± 6.87)% and(10.89 ± 0.05)% in DPPH and molybdenum phosphate techniques, respectively.The ethanolic fraction showed moderate bacteriostatic and bactericidal activity against Staphylococcus aureus and presented a high fungistatic potential for all Candida species tested.Conclusions: Organic fractions obtained from leaves of Conocarpus erectus present antimicrobial and antioxidant properties, and these findings contribute to scientific information for the effectiveness on use of this plant in the development of a phytotherapic compound.展开更多
Cytological studies involving root-tip chromosomes of ten Combretum species belonging to the family Combretaceae from Nigeriawere carried out. The result showed that C. platypterum, C. racemosum, C. constrictum, C. br...Cytological studies involving root-tip chromosomes of ten Combretum species belonging to the family Combretaceae from Nigeriawere carried out. The result showed that C. platypterum, C. racemosum, C. constrictum, C. bracteatum and a yet to be identified Combretum sp.2 have a chromosome number of 2n = 26. Also, C. racemosum, C. zenkeri and Combretum sp.3 (yet to be identified) have a chromosome number of 2n = 39. A basic chromosome number of x = 13 for the genus is therefore proposed.展开更多
基金This work was supported by the Key Projects of Yunnan Science and TechnologyYunnan Key Laboratory of Natural Medicinal Chemistry(S2017-ZZ14).
文摘Terminalia Linn,a genus of mostly medium or large trees in the family Combretaceae with about 250 species in the world,is distributed mainly in southern Asia,Himalayas,Madagascar,Australia,and the tropical and subtropical regions of Africa.Many species are used widely in many traditional medicinal systems,e.g.,traditional Chinese medicine,Tibetan medicine,and Indian Ayurvedic medicine practices.So far,about 39 species have been phytochemically studied,which led to the identification of 368 compounds,including terpenoids,tannins,flavonoids,phenylpropanoids,simple phenolics and so on.Some of the isolates showed various bioactivities,in vitro or in vivo,such as antitumor,anti HIV-1,antifungal,antimicrobial,antimalarial,antioxidant,diarrhea and analgesic.This review covers research articles from 1934 to 2018,retrieved from SciFinder,Wikipedia,Google Scholar,Chinese Knowledge Network and Baidu Scholar by using“Terminalia”as the search term(“all fields”)with no specific time frame setting for the search.Thirty-nine important medicinal and edible Terminalia species were selected and summarized on their geographical distribution,traditional uses,phytochemistry and related pharmacological activities.
文摘AIM To evaluate the anti-inflammatory intestinal effect of the ethanolic extract(EtO HE) and hexane phase(HexP) obtained from the leaves of Combretum duarteanum(Cd).METHODS Inflammatory bowel disease was induced using trinitrobenzenesulfonic acid in acute and relapsed ulcerative colitis in rat models. Damage scores, and biochemical, histological and immunohistochemical parameters were evaluated. RESULTS Both Cd-Et OHE and Cd-Hex P caused significant reductions in macroscopic lesion scores and ulcerative l e sionareas. The vegetable samples inhibited myeloperoxidase increase, as well as pro-inflammatory cytokines TNF-α and IL-1β. Anti-inflammatory cytokine IL-10 also increased in animals treated with the tested plant samples. The anti-inflammatory intestinal effect is related to decreased expression of cyclooxygenase-2, proliferating cell nuclear antigen, and an increase in superoxide dismutase. CONCLUSION The data indicate anti-inflammatory intestinal activity. The effects may also involve participation of the antioxidant system and principal cytokines relating to inflammatory bowel disease.
基金CAPES (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior) for the grant of a master’s degree scholarship during the entire research period
文摘Objective: To evaluate the structural and chemical composition of plant and the antioxidant and antimicrobial activities promoted by hexanic, ethanolic and ethyl acetate fractions obtained from leaves of Conocarpus erectus.Methods: Organic fractions were characterized through UPLC-MS and GC-MS.Antioxidant potential was performed through DPPH and molybdenum phosphate techniques.Antibacterial and antifungal assays were performed in accordance with Clinical and Laboratory Standards Institute protocols.Results: The obtained biomass of Conocarpus erectus leaves showed the high presence of glucose(0.45 g/L), cellulose(28.69%), Na(55.126 μg/L) and K(31.163 μg/L).We identified seven compounds in the hexanic and ethyl acetate fractions, and eight compounds in ethanolic fraction.Moreover, phenolic compounds are prevalent in all organic fractions with values of(10.04 ± 0.24),(221.26 ± 1.84),(340.53 ± 0.84) mg/g GAE to hexanic, ethyl acetate and ethanolic fraction, respectively.Antioxidant results showed a high potential in ethyl acetate fraction(71.82 ± 6.87)% and(10.89 ± 0.05)% in DPPH and molybdenum phosphate techniques, respectively.The ethanolic fraction showed moderate bacteriostatic and bactericidal activity against Staphylococcus aureus and presented a high fungistatic potential for all Candida species tested.Conclusions: Organic fractions obtained from leaves of Conocarpus erectus present antimicrobial and antioxidant properties, and these findings contribute to scientific information for the effectiveness on use of this plant in the development of a phytotherapic compound.
文摘Cytological studies involving root-tip chromosomes of ten Combretum species belonging to the family Combretaceae from Nigeriawere carried out. The result showed that C. platypterum, C. racemosum, C. constrictum, C. bracteatum and a yet to be identified Combretum sp.2 have a chromosome number of 2n = 26. Also, C. racemosum, C. zenkeri and Combretum sp.3 (yet to be identified) have a chromosome number of 2n = 39. A basic chromosome number of x = 13 for the genus is therefore proposed.
