Developing biomarkers for neurodegenerative diseases using genetically-modified common marmoset models

Mouse and non-human primate models of neurodegenerative disease：The prevalence of age-related neurodegenerative diseases continues to increase with ever increasing aging population over the age of 60.Although the difficulties associated with neurodegenerative diseases present an urgent global issue,there is no effective treatment for these conditions.

Evaluating Common Land Model Energy Fluxes Using FLUXNET Data

Given the crucial role of land surface processes in global and regional climates, there is a pressing need to test and verify the performance of land surface models via comparisons to observations. In this study, the eddy covariance measurements from 20 FLUXNET sites spanning more than 100 site-years were utilized to evaluate the performance of the Common Land Model （CoLM） over different vegetation types in various climate zones. A decomposition method was employed to separate both the observed and simulated energy fluxes, i.e., the sensible heat flux, latent heat flux, net radiation, and ground heat flux, at three timescales ranging from stepwise （30 rain） to monthly. A comparison between the simulations and observations indicated that CoLM produced satisfactory simulations of all four energy fluxes, although the different indexes did not exhibit consistent results among the different fluxes, A strong agreement between the simulations and observations was found for the seasonal cycles at the 20 sites, whereas CoLM underestimated the latent heat flux at the sites with distinct dry and wet seasons, which might be associated with its weakness in simulating soil water during the dry season. CoLM cannot explicitly simulate the midday depression of leaf gas exchange, which may explain why CoLM also has a maximum diurnal bias at noon in the summer. Of the eight selected vegetation types analyzed, CoLM performs best for evergreen broadleaf forests and worst for croplands and wetlands.

Land Response to Atmosphere at Different Resolutions in the Common Land Model over East Asia

Towards a better understanding of hydrological interactions between the land surface and atmosphere, land surface mod- els are routinely used to simulate hydro-meteorological fluxes. However, there is a lack of observations available for model forcing, to estimate the hydro-meteorological fluxes in East Asia. In this study, Common Land Model （CLM） was used in offline-mode during the summer monsoon period of 2006 in East Asia, with different forcings from Asiaflux, Korea Land Data Assimilation System （KLDAS）, and Global Land Data Assimilation System （GLDAS）, at point and regional scales, separately. The CLM results were compared with observations from Asiaflux sites. The estimated net radiation showed good agreement, with r = 0.99 for the point scale and 0.85 for the regional scale. The estimated sensible and latent heat fluxes using Asiaflux and KLDAS data indicated reasonable agreement, with r = 0.70. The estimated soil moisture and soil temperature showed similar patterns to observations, although the estimated water fluxes using KLDAS showed larger discrepancies than those of Asiaflux because of scale mismatch. The spatial distribution of hydro-meteorological fluxes according to KLDAS for East Asia were compared to the CLM results with GLDAS, and the GLDAS provided online. The spatial distributions of CLM with KLDAS were analogous to CLM with GLDAS, and the standalone GLDAS data. The results indicate that KLDAS is a good potential source of high spatial resolution forcing data. Therefore, the KLDAS is a promising alternative product, capable of compensating for the lack of observations and low resolution grid data for East Asia.

Common Management Process Model of New TQM Based on the Situation Analysis

In the previous study, we suggested the concept of new TQM based on the consideration of basic concept of Quality Control. Also, in the previous study, we suggested the target domains and entities of product and process based on the TQM Matrix and view point of Three Dimensional Unification Value Models for managing quality of organization systems. Furthermore, in the previous study, we suggest the Common Management Process of organizations. Based on the above suggestion, in this paper, we would like to propose the Common Management Process Model of Total Quality Management based on the consideration of situation analysis and more precise definition of TQM Matrix and Three Dimensional Unification Value Model of “Product and Process”. Improvement of quality and efficiency of organization management can be expected by the integration of conventional different management such as quality assurance, quality improvement, risk management, investment individually from the view point of common management process.

中国天气雷达基数据模型与CDM集成研究

现有标准格式雷达基数据解析工具在设计上存在通用性和抽象性不足的问题,不便于雷达数据的解析和处理。为了解决这个问题,本文基于Unidata的CDM(Common Data Model),设计和构建了中国天气雷达基数据模型,在数据模型层面实现了对天气雷达标准格式基数据的访问,并以Unidata开源的NetCDF Java库和IDV(Integrated Data Viewer)可视化软件为基础,形成了一套基于CDM的天气雷达标准格式基数据内容提取和可视化分析工具。本研究以广州雷达新旧两种格式基本反射率数据对比为例,展示了研究成果在多普勒天气雷达标准格式基数据评估中的应用。结果表明:本研究成果方便了雷达标准格式基数据的使用,对雷达标准格式基数据的业务应用起到了促进作用。本研究成果亦可应用于雷达基数据处理与分析相关的实际业务和科研工作中,为雷达资料的应用提供基础支持。

Improving the CoLM in Taklimakan Desert Hinterland with Accurate Key Parameters and an Appropriate Parameterization Scheme

Improving and validating land surface models based on integrated observations in deserts is one of the challenges in land modeling. Particularly, key parameters and parameterization schemes in desert regions need to be evaluated in-situ to improve the models. In this study, we calibrated the land-surface key parameters and evaluated several formulations or schemes for thermal roughness length （z 0h ） in the common land model （CoLM）. Our parameter calibration and scheme evaluation were based on the observed data during a torrid summer （29 July to 11 September 2009） over the Taklimakan Desert hinterland. First, the importance of the key parameters in the experiment was evaluated based on their physics principles and the significance of these key parameters were further validated using sensitivity test. Second, difference schemes （or physics-based formulas） of z 0h were adopted to simulate the variations of energy-related variables （e.g., sensible heat flux and surface skin temperature） and the simulated variations were then compared with the observed data. Third, the z 0h scheme that performed best （i.e., Y07） was then selected to replace the defaulted one （i.e., Z98）; the revised scheme and the superiority of Y07 over Z98 was further demonstrated by comparing the simulated results with the observed data. Admittedly, the revised model did a relatively poor job of simulating the diurnal variations of surface soil heat flux, and nighttime soil temperature was also underestimated, calling for further improvement of the model for desert regions.

XML-based integration data model and schema mappingin multidatabase systems

Multidatabase systems are designed to achieve schema integration and data interoperation among distributed and heterogeneous database systems. But data model heterogeneity and schema heterogeneity make this a challenging task. A multidatabase common data model is firstly introduced based on XML, named XML-based Integration Data Model (XIDM), which is suitable for integrating different types of schemas. Then an approach of schema mappings based on XIDM in multidatabase systems has been presented. The mappings include global mappings, dealing with horizontal and vertical partitioning between global schemas and export schemas, and local mappings, processing the transformation between export schemas and local schemas. Finally, the illustration and implementation of schema mappings in a multidatabase prototype - Panorama system are also discussed. The implementation results demonstrate that the XIDM is an efficient model for managing multiple heterogeneous data sources and the approaches of schema mapping based on XIDM behave very well when integrating relational, object-oriented database systems and other file systems.

Is right lobe liver graft without main right hepatic vein suitable for living donor liver transplantation?

BACKGROUND Since the first living donor liver transplantation(LDLT)was performed by Raia and colleagues in December 1988,LDLT has become the gold standard treatment in countries where cadaveric organ donation is not sufficient.Adequate hepatic venous outflow reconstruction in LDLT is essential to prevent graft congestion and its complications including graft loss.However,this can be complex and technically demanding especially in the presence of complex variations and congenital anomalies in the graft hepatic veins.CASE SUMMARY Herein,we aimed to present two cases who underwent successful right lobe LDLT using a right lobe liver graft with rudimentary or congenital absence of the right hepatic vein and describe the utility of a common large opening drainage model in such complex cases.CONCLUSION Thanks to this venous reconstruction model,none of the patients developed postoperative complications related to venous drainage.Our experience with venous drainage reconstruction models shows that congenital variations in the hepatic venous structure of living liver donors are not absolute contraindications for LDLT.

An Approach for Establishing a Common Grid Model for Flow-based Market Mechanism Simulations

The discussions on the development of an electricity market model for accommodating cross-border cooperation remains active in Europe.The main interest is the establishment of market couplings without curtailing the fair use of the scarce transmission capacity.However,it is difficult to gain mutual consensus on this subject because of the absence of convincing simulation results for the entire region.To achieve that,researchers need a common grid model(CGM)which is a simplified representation of the detailed transmission model which comprises aggregated buses and transmission lines.A CGM should sufficiently represent the inter-area power flow characteristics.Generally,it is difficult to establish a standard CGM that represents the actual transmission network with a suf-ficient degree of exactness because it requires knowledge on the details of the transmission network,which are undisclosed.This paper addresses the issue and reviews the existing approaches in transmission network approximation,and their shortcomings.Then,it proposes a new approach called the adaptive CGM approximation(ACA)for serving the purpose.The ACA is a datadriven approach,developed based on the direct current power flow theory.It is able to construct a CGM based on the published power flow data between the inter-connected market areas.This is done by solving the issue as a non-linear model fitting problem.The method is validated using three case studies.

A Common Reasoning Model and Its Application in Knowledge-Based System

To use reasoning knowledge accurately and efficiently,many reasoning methods have been proposed. However,the differences in form among the methods may obstruct the systematical analysis and harmonious integration of them.In this paper,a common reasoning model JUM(Judgement Model)is introduced. According to JUM,a common knowledge representation form is abstracted from different reasoning methods and its limitation is reduced.We also propose an algorithm for transforming one type of JUMs into another.In some cases,the algorithm can be used to resolve the key problem of integrating different types of JUM in one system.It is possible that a new architecture of knowledge-based system can be realized under JUM.

Estimation of Net Surface Shortwave Radiation from Land Surface Temperature in Regional Scale

The method to estimate NSSR （net surface shortwave radiation） from LST （land surface temperature） in regional scale is discussed. First, an elliptical model between the time series of normalized LST and NSSR was developed using the daily evolution of LST and NSSR. Second, time series of LST and NSSR were simulated by common land model （CoLM） and were proved to be of high accuracy. On the basis of these, a non-linear least square ellipse fitting using the genetic algorithm method was used to fit the normalized LST and NSSR. Finally, LST was inverted using MODIS （moderate resolution imaging spectroradiometer） data with the split-window algorithm, and the regional NSSR was then estimated with LST and an elliptical model. The validation result shows that the derived average NSSR of 50×50 pixels of MODIS data was quite close to the observed data, and the distribution was reasonable, which indicates that the proposed method was capable of estimating NSSR on a regional scale.

A Review on TSO-DSO Data Exchange,CIM Extensions and Interoperability Aspects

The exchange of information between transmission system operators(TSOs)and distribution system operators(DSOs)is a common practice.However,the evolution of the regulatory frameworks in Europe has increased the need for enhancing TSO-DSO data exchange and interoperability.This paper provides an overview of the TSO-DSO data exchanges and demonstrates the best practices using International Electrotechnical Commission(IEC)common information model(CIM),including the implementation of IEC common grid model exchange standard(CGMES),and discussion of the corresponding advantages,disadvantages,and challenges.Furthermore,this paper evaluates and reports the activities already carried out within European projects,with particular focus on TSO-DSO interoperability.Finally,this paper concludes the need for TSOs and DSOs to rely on standard-based solutions when performing TSO-DSO data exchange,which enables the efficient operation and development of the future power systems.

Design and Implementation of an Interoperable Object Platform for Multi-Databases

In this paper, the authors present the design and implementation of an Interoperable Object Platform for Multi-Databases (IOPMD). The aim of the system is to provide a uniform object view and a set of tools for object manipu lation and query based on heterogeneous multiple data sources under client/server environment. The common object model is compatible with ODMG2.0 and OMG'sCORBA, which provides main OO features such as OID, attribute, method, inheri tance, reference, etc. Three types of interfaCes, namely Vface, IOQL and C++ API, are given to provide the database programmer with tools and functionalities for application development. Nested transactions and compensating technology are adopted in transaction manager. In discussing some key 'implementation techlliques, translation and mapping approaches from various schemata to a common object schemaare proposed. Buffer management provides the data caching policy and consistency maintenance of cached data. Version managemellt presellts some operations based on the definitions in semantic version model, and introduces the implemelltation of the semantic version graph.

Electromagnetic Radiation Mechanism Analysis and Field Strength Prediction of an Elementary Digital Inverter with Cables

In this paper,common mode(CM)and differential mode(DM)far-field radiation models of a typical digital inverter with cables are built up to predict electromagnetic field strength and analyze field characteristics.The CM current model and its analyses are based on the imbalance difference method.It is found out that the voltage between the drain and the source electrodes of upper transistor is the key equivalent source of electromagnetic interference(EMI).Far-field radiation strength of the digital inverter in free space is predicted by using the asymmetrical antenna radiation method and current loop radiation method.The accuracy of these methods is verified by the CST electromagnetic simulation results in the frequency range from 1 MHz to 400 MHz.Furthermore,the radiation models are improved by using the mirror method,which enables to include the reflection effect of the metal ground plane at the electromagnetic compatibility(EMC)test site.Both the results of measurements in a semi-anechoic chamber and the simulation results confirm the proposed electromagnetic radiation prediction method.

Nacelle intake flow separation reduction at cruise condition using active flow control

Turbofan engine intakes are designed to provide separation-free flow at the fan faceover a wide range of operating conditions. But at some off-design conditions, like at high flightspeeds and high angles of attack (AoA), the aero engine intake may encounter flow separation.This boundary layer separation inside the nacelle inlet of an aircraft engine can lead to a largenumber of undesirable outcomes like reduction in fan efficiency, engine stall and high levels ofstress on the fan blades. Active flow control is a promising solution to reduce inlet boundarylayer separation and the associated fan-face flow distortion at such off-design conditions. Byblowing pressurized air into the intake near the separation point, the boundary layer is ener-gized and separation can be controlled. This study investigates the applicability of lip blowing,an active flow control technique, to control intake separation and flow distortion at the fan-face.First, intake separation was triggered in a 3D CFD model based on the NASA CommonResearch Model (CRM) using high AoA cases at cruise condition (Mach number 0.85, Massflow capture ratio w0.7) and the features of separated flow were analyzed. Thereafter, activeflow control was introduce to the intake in the form of two types of lip blowing, direct andpitched blowing. The efficacy of lip blowing at achieving separation control in an ultra highbypass ratio turbofan engine intake has been established through this study. The present paperalso examines the significance of blowing parameters like the type of blowing, blowing pres-sure ratio, and blowing slot dimension, at different angles of attack to identify the critical con-trol parameters. Our research successfully establishes proof of concept by demonstrating the feasibility of using lip blowing for separation control in aero-intakes, via numerical modelling.Furthermore, this study also provides crucial insights regarding the important variables to beconsidered for future experimental studies, and also for detailed studies covering a wider rangeof operating and blowing conditions.