Long-term application of levodopa （L-3, 4-dihydroxyphenylalanine, L-DOPA） for Parkinson＇s disease can lead to adverse effects and reduce the amount of dopamine transporter （DAT） in the corpus striatum. The presen...Long-term application of levodopa （L-3, 4-dihydroxyphenylalanine, L-DOPA） for Parkinson＇s disease can lead to adverse effects and reduce the amount of dopamine transporter （DAT） in the corpus striatum. The present study attempted to vedfy whether increasing the amount of DAT can reduce the adverse effects of L-DOPA. The specific radioactive uptake value of DAT in the corpus striatum of the lesioned hemisphere was significantly decreased, but was significantly increased following administration of compound rehmannia formula [Radix rehmanniae preparata （prepared rehmannia root）, Concha margantifera usta （nacre）, Radix paeoniae alba （white peony alba）, Radix salviae miltiotThizae （Danshen root）, Scorpio （scorpion）, green tea] for 4 weeks. The changes in DAT 1251-beta-carbomethoxy-3 beta-（4-iodophenyl） tropane autoradiography were consistent with those in radioactivity. The results revealed that the compound rehmannia formula can reduce the adverse effects of L-DOPA in treating Parkinson＇s disease, possibly by increasing the amount of DAT.展开更多
目的探讨恩他卡朋联合复方左旋多巴治疗帕金森病的临床疗效及安全性。方法将116例帕金森病患者随机分为对照组和观察组,各58例。对照组患者常规服用复方左旋多巴,观察组患者加用恩他卡朋。分别于治疗前和治疗8周时行Hoehn and Yahr病程...目的探讨恩他卡朋联合复方左旋多巴治疗帕金森病的临床疗效及安全性。方法将116例帕金森病患者随机分为对照组和观察组,各58例。对照组患者常规服用复方左旋多巴,观察组患者加用恩他卡朋。分别于治疗前和治疗8周时行Hoehn and Yahr病程分级评分、统一帕金森病评分量表(UPDRS)第Ⅱ和Ⅲ部分评分、日常生活能力量表(ADL)评分、非运动症状筛查量表(NMSS)评分,观察药品不良反应。结果治疗后,对照组药物起效时间,开、关期时间及异动时间与试验前相比差异不明显(P>0.05);与试验前相比,观察组患者试验后药物起效时间差异不明显(P>0.05),但开期时间明显延长,关期时间及异动时间明显缩短(P<0.05)。两组患者试验前后Hochn and Yahr病程分级评分均无显著性差异(P>0.05);对照组UPDRS第Ⅱ和Ⅲ部分评分、ADL评分、NMSS评分也无明显改善(P>0.05),观察组患者上述指标则较试验前明显下降(P<0.05)。两组不良反应发生率相当(P>0.05)。结论恩他卡朋联合复方左旋多巴治疗帕金森病疗效确切、稳定,使用过程安全,值得临床推广。展开更多
基金the National Natural Science Foundation of China,No.30672684, 30973722the Third Intention Key Disciplinary Areas of Shanghai,No.S30302
文摘Long-term application of levodopa （L-3, 4-dihydroxyphenylalanine, L-DOPA） for Parkinson＇s disease can lead to adverse effects and reduce the amount of dopamine transporter （DAT） in the corpus striatum. The present study attempted to vedfy whether increasing the amount of DAT can reduce the adverse effects of L-DOPA. The specific radioactive uptake value of DAT in the corpus striatum of the lesioned hemisphere was significantly decreased, but was significantly increased following administration of compound rehmannia formula [Radix rehmanniae preparata （prepared rehmannia root）, Concha margantifera usta （nacre）, Radix paeoniae alba （white peony alba）, Radix salviae miltiotThizae （Danshen root）, Scorpio （scorpion）, green tea] for 4 weeks. The changes in DAT 1251-beta-carbomethoxy-3 beta-（4-iodophenyl） tropane autoradiography were consistent with those in radioactivity. The results revealed that the compound rehmannia formula can reduce the adverse effects of L-DOPA in treating Parkinson＇s disease, possibly by increasing the amount of DAT.
文摘目的探讨恩他卡朋联合复方左旋多巴治疗帕金森病的临床疗效及安全性。方法将116例帕金森病患者随机分为对照组和观察组,各58例。对照组患者常规服用复方左旋多巴,观察组患者加用恩他卡朋。分别于治疗前和治疗8周时行Hoehn and Yahr病程分级评分、统一帕金森病评分量表(UPDRS)第Ⅱ和Ⅲ部分评分、日常生活能力量表(ADL)评分、非运动症状筛查量表(NMSS)评分,观察药品不良反应。结果治疗后,对照组药物起效时间,开、关期时间及异动时间与试验前相比差异不明显(P>0.05);与试验前相比,观察组患者试验后药物起效时间差异不明显(P>0.05),但开期时间明显延长,关期时间及异动时间明显缩短(P<0.05)。两组患者试验前后Hochn and Yahr病程分级评分均无显著性差异(P>0.05);对照组UPDRS第Ⅱ和Ⅲ部分评分、ADL评分、NMSS评分也无明显改善(P>0.05),观察组患者上述指标则较试验前明显下降(P<0.05)。两组不良反应发生率相当(P>0.05)。结论恩他卡朋联合复方左旋多巴治疗帕金森病疗效确切、稳定,使用过程安全,值得临床推广。
