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AIDD与CADD提升药物成功率的思考
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作者 陈柏宇 吕泸楠 +3 位作者 徐小迪 张滎 李炜 付伟 《中国药科大学学报》 CAS CSCD 北大核心 2024年第3期284-294,共11页
随着人工智能(AI)和计算科学的迅速发展,特别是人工智能药物设计(AIDD)与计算机辅助药物设计(CADD)技术的引入,自然语言处理、图像识别、深度学习和机器学习等多种技术为新药开发提供了革命性的新途径,大幅提升了研发流程的效率和成功... 随着人工智能(AI)和计算科学的迅速发展,特别是人工智能药物设计(AIDD)与计算机辅助药物设计(CADD)技术的引入,自然语言处理、图像识别、深度学习和机器学习等多种技术为新药开发提供了革命性的新途径,大幅提升了研发流程的效率和成功率。在药物发现过程中,AI技术加速了药物靶点的识别、候选药物的筛选、药理评估及质量检验,有效降低了研发风险和成本。本文深入探讨AIDD和CADD技术在药物研发中的应用,分析它们在提升药物设计成功率和药物研发效率方面的思考与探索,并探讨这些技术的未来发展趋势及可能面临的挑战。 展开更多
关键词 人工智能药物设计 计算机辅助药物设计 药效团 分子生成 基于片段的药物设计
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Development of a Decision Aid for Family Surrogate Decision Makers of Critically Ill Patients Requiring Renal Replacement Therapy in ICU:A User-Centered Design for Rapid Prototyping
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作者 Miao Zheng Yong-Hui Zhang +2 位作者 Ying Cao Chang-Lin Yin Li-Hua Wang 《Chinese Medical Sciences Journal》 CAS CSCD 2024年第2期91-101,共11页
Objectives Renal replacement therapy(RRT)is increasingly adopted for critically ill patients diagnosed with acute kidney injury,but the optimal time for initiation remains unclear and prognosis is uncertain,leading to... Objectives Renal replacement therapy(RRT)is increasingly adopted for critically ill patients diagnosed with acute kidney injury,but the optimal time for initiation remains unclear and prognosis is uncertain,leading to medical complexity,ethical conflicts,and decision dilemmas in intensive care unit(ICU)settings.This study aimed to develop a decision aid(DA)for the family surrogate of critically ill patients to support their engagement in shared decision-making process with clinicians.Methods Development of DA employed a systematic process with user-centered design(UCD)principle,which included:(i)competitive analysis:searched,screened,and assessed the existing DAs to gather insights for design strategies,developmental techniques,and functionalities;(ii)user needs assessment:interviewed family surrogates in our hospital to explore target user group's decision-making experience and identify their unmet needs;(iii)evidence syntheses:integrate latest clinical evidence and pertinent information to inform the content development of DA.Results The competitive analysis included 16 relevant DAs,from which we derived valuable insights using existing resources.User decision needs were explored among a cohort of 15 family surrogates,revealing four thematic issues in decision-making,including stuck into dilemmas,sense of uncertainty,limited capacity,and delayed decision confirmation.A total of 27 articles were included for evidence syntheses.Relevant decision making knowledge on disease and treatment,as delineated in the literature sourced from decision support system or clinical guidelines,were formatted as the foundational knowledge base.Twenty-one items of evidence were extracted and integrated into the content panels of benefits and risks of RRT,possible outcomes,and reasons to choose.The DA was drafted into a web-based phototype using the elements of UCD.This platform could guide users in their preparation of decision-making through a sequential four-step process:identifying treatment options,weighing the benefits and risks,clarifying personal preferences and values,and formulating a schedule for formal shared decision-making with clinicians.Conclusions We developed a rapid prototype of DA tailored for family surrogate decision makers of critically ill patients in need of RRT in ICU setting.Future studies are needed to evaluate its usability,feasibility,and clinical effects of this intervention. 展开更多
关键词 decision aids renal replacement therapy intensive care units shared decision-making user-centered design surrogate
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Research on Computer Aided Design (CAD) Technique and Novel Pattern for Electronic Architectural Drawing and Perspective
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作者 Tian XiJiang 《International Journal of Technology Management》 2015年第8期95-97,共3页
With the progress of computer technology, CAD technique is urgent needed. In this paper, we conduct numerical and theoretical analysis and research on computer aided design technique and novel pattern for electronic a... With the progress of computer technology, CAD technique is urgent needed. In this paper, we conduct numerical and theoretical analysis and research on computer aided design technique and novel pattern for electronic architectural drawing and perspective. AUTOCAD drawing soRware because of its versatility and easy entry, in engineering has broad user base, but also because of the basis of general drawing software, often cannot directly use of the existing order efficiently complete professional drawing. We modify the current pattern and introduce our proposed pattern for advancement. The experiment proves the effectiveness of the pattern. In addition, we will conduct more insightful research in the future to nolish the current anoroach. 展开更多
关键词 Computer aided design (cad) ELECTRONIC ARCHITECTURAL DRAWING NOVEL Pattern.Computer aided design (cad) ELECTRONIC ARCHITECTURAL DRAWING NOVEL Pattern.
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Design of Aided Decision-Making Program for Prioritizing Construction Projects in Urban Road Network Planning
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作者 任刚 王炜 顾志康 《Journal of Southeast University(English Edition)》 EI CAS 2002年第3期249-253,共5页
The importance and complexity of prioritizing construction projects (PCP) in urban road network planning lead to the necessity to develop an aided decision making program (ADMP). Cost benefit ratio model and stage rol... The importance and complexity of prioritizing construction projects (PCP) in urban road network planning lead to the necessity to develop an aided decision making program (ADMP). Cost benefit ratio model and stage rolled method are chosen as the theoretical foundations of the program, and then benefit model is improved to accord with the actuality of urban traffic in China. Consequently, program flows, module functions and data structures are designed, and particularly an original data structure of road ... 展开更多
关键词 prioritizing construction projects program design urban road network planning aided decision making
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嵌于CAD系统的有限元建模方法及其应用
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作者 吴巧云 刘梓良 +1 位作者 陈旭勇 许峙峰 《铁道工程学报》 EI CSCD 北大核心 2024年第5期79-86,共8页
研究目的:当下,多数有限元分析应用的建模功能较为薄弱,导致复杂结构体系的有限元分析既琐碎又麻烦。另一方面,虽然计算机辅助设计(CAD)应用在建模方面十分强大,由CAD应用建立的模型通常无法用作有限元分析。为此,本文提出一种嵌于CAD... 研究目的:当下,多数有限元分析应用的建模功能较为薄弱,导致复杂结构体系的有限元分析既琐碎又麻烦。另一方面,虽然计算机辅助设计(CAD)应用在建模方面十分强大,由CAD应用建立的模型通常无法用作有限元分析。为此,本文提出一种嵌于CAD系统的有限元建模方法,为说明其有效性及实用性,进一步研发了一款名为DirectMesh的Rhinoceros插件并将其应用于武汉站有限元分析中。研究结论:(1)利用CAD系统所提供的交互性环境及各种建模工具可大幅提高有限元建模的效率;(2)本文所提独立网格生成单元可生成代表单个对象的网格;(3)本文所提综合网格生成单元可生成含多个对象的综合网格系统;(4)本文所提有限元模型生成器可通过网格有效生成复杂结构系统的有限元模型;(5)本文所提方法可大幅提高有限元建模的易用性及效率,有助于提高机械工程、土木工程及岩土工程中仿真模拟工作的智能化程度。 展开更多
关键词 计算机辅助设计 建模 有限元 网格 复杂结构体系
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PSCAD的发电机准同期并列综合实验设计
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作者 司马莉萍 丁涛 尹航 《实验室研究与探索》 CAS 北大核心 2024年第4期164-168,共5页
针对电力系统自动化实验教学中存在的不足,设计了同步发电机准同期并列综合实验。实验模型采用PSCAD/EMTDC,建立了包含发电机及并网系统、原动机及其调速器、励磁系统、准同期并列控制单元、电压向量的动态显示等关键部件。依托实验模... 针对电力系统自动化实验教学中存在的不足,设计了同步发电机准同期并列综合实验。实验模型采用PSCAD/EMTDC,建立了包含发电机及并网系统、原动机及其调速器、励磁系统、准同期并列控制单元、电压向量的动态显示等关键部件。依托实验模型设计了循序渐进的教学实验项目,主要有机组启动与并网的验证性实验、不同并列条件影响的分析性实验、频率差和电压差调节的设计性实验。该实验将电路、电机学、自动控制理论、电力系统分析等多门专业核心课程贯穿起来,提升了学生综合运用知识解决复杂工程问题的能力。 展开更多
关键词 准同期并列 电力系统计算机辅助设计 同步发电机 综合实验
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基于CAD/CAE的异形凸模冲头工装设计与优化研究
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作者 申鹏 《模具技术》 2024年第1期65-70,共6页
异形凸模冲头是汽车锁头连接件模具的重要配件,其材料为冷作模具钢DC53,对汽车锁孔冲压有重要作用。传统加工中,加工质量无法保证,生产效率低。设计了专用工装,结合CAD/CAE软件,优化并改进工装结构设计。实际加工对比表明,该工装的设计... 异形凸模冲头是汽车锁头连接件模具的重要配件,其材料为冷作模具钢DC53,对汽车锁孔冲压有重要作用。传统加工中,加工质量无法保证,生产效率低。设计了专用工装,结合CAD/CAE软件,优化并改进工装结构设计。实际加工对比表明,该工装的设计与优化方案合理,改进工装后,凸模冲头零件生产效率和加工质量均显著提高。该研究对同类异型模具工装设计也具有参考价值。 展开更多
关键词 cad/CAE 凸模冲头 DC53 工装设计
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基于工匠训练营的协同育人模式在机械制图与CAD课程的设计与实践
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作者 程国飞 余杨 +1 位作者 张堃 陈梦龙 《时代汽车》 2024年第11期46-48,共3页
结合机械制造及自动化制图员岗赛证的要求,以工匠训练营融入机械课程与CAD教学中,通过确定思政目标、优化教学内容、推进教学策略、落实考核评价等落实教学过程,实践证明具有良好的成效。
关键词 机械制图与cad 工匠训练营 课程思政 课程设计 教学策略
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基于CATIA的钢结构CAD与CAE一体化实现方法 被引量:1
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作者 徐思豪 戴宇晨 +1 位作者 汤霄扬 王德禹 《船舶工程》 CSCD 北大核心 2024年第3期48-54,共7页
为了应对钢结构在实现计算机辅助设计(CAD)与计算机辅助工程(CAE)一体化时的特殊性所带来的挑战,分析和归纳CAD与CAE一体化中数据转换,与几何理想化等关键问题,在此基础上,提出一种基于CATIA V6软件实现钢结构CAD与CAE一体化的方法,并... 为了应对钢结构在实现计算机辅助设计(CAD)与计算机辅助工程(CAE)一体化时的特殊性所带来的挑战,分析和归纳CAD与CAE一体化中数据转换,与几何理想化等关键问题,在此基础上,提出一种基于CATIA V6软件实现钢结构CAD与CAE一体化的方法,并通过一个绑扎桥钢结构的设计案例验证了该方法的有效性。通过所提方法分别实现了CAE几何理想化的自动切换与整合载荷数据至CAD模型的技术目标,从而避免了基于传统方法所带来的数据分离问题,减少了人工介入的低效工作。 展开更多
关键词 CATIA V6 计算机辅助设计 计算机辅助工程 一体化 几何理想化 载荷传递
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Computer Aided Design Technology for Convex Faceted Gem Cuts Based on the Half-Edge Data Structure 被引量:1
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作者 Linhong Xu Xiangnan Li +3 位作者 Jianhua Rao Yuan Han Zhipeng Li Jichun Li 《Journal of Beijing Institute of Technology》 EI CAS 2019年第3期585-597,共13页
Aiming to increase the efficiency of gem design and manufacturing, a new method in computer-aided-design (CAD) of convex faceted gem cuts (CFGC) based on Half-edge data structure (HDS), including the algorithms for th... Aiming to increase the efficiency of gem design and manufacturing, a new method in computer-aided-design (CAD) of convex faceted gem cuts (CFGC) based on Half-edge data structure (HDS), including the algorithms for the implementation is presented in this work. By using object-oriented methods, geometrical elements of CFGC are classified and responding geometrical feature classes are established. Each class is implemented and embedded based on the gem process. Matrix arithmetic and analytical geometry are used to derive the affine transformation and the cutting algorithm. Based on the demand for a diversity of gem cuts, CAD functions both for free-style faceted cuts and parametric designs of typical cuts and visualization and human-computer interactions of the CAD system including two-dimensional and three-dimensional interactions have been realized which enhances the flexibility and universality of the CAD system. Furthermore, data in this CAD system can also be used directly by the gem CAM module, which will promote the gem CAD/CAM integration. 展开更多
关键词 Half-edge data structure CONVEX faceted GEM CUTS (CFGC) COMPUTER aided design (cad)
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A Computer-aided Design System for Framed-mould in Autoclave Processing 被引量:1
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作者 Tian-Guo Jin Feng-Yang Bi 《International Journal of Automation and computing》 EI 2010年第3期261-270,共10页
The general computer-aided design (CAD) software cannot meet the mould design requirement of the autoclave process for composites, because many parameters such as temperature and pressure should be considered in the... The general computer-aided design (CAD) software cannot meet the mould design requirement of the autoclave process for composites, because many parameters such as temperature and pressure should be considered in the mould design process, in addition to the material and geometry of the part. A framed-mould computer-aided design system (FMCAD) used in the autoclave moulding process is proposed in this paper. A function model of the software is presented, in which influence factors such as part structure, mould structure, and process parameters are considered; a design model of the software is established using object oriented (O-O) technology to integrate the stiffness calculation, temperature field calculation, and deformation field calculation of mould in the design, and in the design model, a hybrid model of mould based on calculation feature and form feature is presented to support those calculations. A prototype system is developed, in which a mould design process wizard is built to integrate the input information, calculation, analysis, data storage, display, and design results of mould design. Finally, three design examples are used to verify the prototype. 展开更多
关键词 Framed-mould autoclave processing computer-aided design (cad temperature field analyzing hybrid model.
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CAD/CAM在口腔修复中的应用现状
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作者 黄浩 李雪林 +3 位作者 韩泽华 舒文 朱鹏飞 向盈盈 《昆明医科大学学报》 CAS 2024年第8期161-165,共5页
近年来计算机辅助设计和制造(CAD/CAM)不断推动口腔领域的发展和改革。口腔修复是口腔医学的重要组成部分,CAD/CAM越来越多地运用于口腔修复,促使口腔修复飞速发展。通过总结多篇国内外文献,概述CAD/CAM在口腔修复中的应用进展。
关键词 计算机辅助设计 计算机辅助制造 口腔修复
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Application of computer-aided engineering optimum design method in aluminum profile extrusion mould 被引量:8
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作者 帅词俊 肖刚 +1 位作者 倪正顺 钟掘 《Journal of Central South University of Technology》 2003年第1期64-68,共5页
The finite element analysis and the optimum design of aluminum profile extrusion mould were investigated using the ANSYS software and its parameterized modeling method. The optimum dimensions of the mould were obtaine... The finite element analysis and the optimum design of aluminum profile extrusion mould were investigated using the ANSYS software and its parameterized modeling method. The optimum dimensions of the mould were obtained. It is found that the stress distribution is very uneven, and the stress convergence is rather severe in the bridge of the aluminum profile extrusion mould. The optimum height of the mould is 70.527 mm, and the optimum radius of dividing holes are 70.182 mm and 80.663 mm. Increasing the height of the mould in the range of 61.282 mm to 70.422 mm can prolong its longevity, but when the height is over 70.422 mm, its longevity reduces. 展开更多
关键词 EXTRUSION MOULD COMPUTER-aided ENGINEERING OPTIMUM design ANSYS
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工程学科常用CAD软件及功能分析
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作者 姜艳霞 金晔 《智能物联技术》 2024年第1期14-18,共5页
计算机辅助设计(Computer Aided Design,CAD)已经成为机械、电子、航天、化工及建筑等产业中不可或缺的工具之一。概述CAD软件行业的最新发展趋势和我国在该领域的进展,分析CAD软件的技术创新、产业布局以及国内企业在底层技术研发方面... 计算机辅助设计(Computer Aided Design,CAD)已经成为机械、电子、航天、化工及建筑等产业中不可或缺的工具之一。概述CAD软件行业的最新发展趋势和我国在该领域的进展,分析CAD软件的技术创新、产业布局以及国内企业在底层技术研发方面的进展。通过调研国际知名CAD软件公司的最新产品和策略以及国内企业的研发成果,分析CAD软件行业的技术动向。结果显示,CAD软件正朝着云端化、集成化、一体化以及智能化的方向发展,国内外企业都在不断探索新技术与CAD软件的结合,以提高设计效率和产品质量。我国CAD软件行业在政策支持和市场需求增长下将迎来更大发展空间,应加强自主研发和创新力度,以推出更多具有自主知识产权和核心竞争力的CAD产品。 展开更多
关键词 计算机辅助设计(cad) 内核 一体化 智能化 云端化
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Computer Aided Composition Design of Prehardened-Mould Steel for Plastic 被引量:4
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作者 YanlinHE LinLI +1 位作者 XiaochunWU PatrickWOLLANTS 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2004年第1期71-74,共4页
The improvement of machining behavior of prehardened-mould steel for plastic is realized by using computer-aided composition design in this work. The results showed that the matrix composition of large sectional preha... The improvement of machining behavior of prehardened-mould steel for plastic is realized by using computer-aided composition design in this work. The results showed that the matrix composition of large sectional prehardened mould steel for plastic markedly influences the precipitation of non-metallic inclusion and the control of composition aided by Thermo-Calc software package minimizes the amount of detrimental oxide inclusion. In addition the modification of calcium is optimized in the light of composition design. 展开更多
关键词 Prehardened-mould steel for plastic PRECIPITATION Computer-aided composition design Thermo-Calc software
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Computer-aided Design and Custom-made Guide in Corrective Osteotomy for Complex Femoral Deformity 被引量:4
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作者 柴伟 许猛 +4 位作者 张国强 张立海 苟文隆 倪明 陈继营 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 2013年第3期398-405,共8页
Summary: Preoperative planning of corrective osteotomy with traditional radiography has limitations in regards to determining the ideal osteotomy location and orientation in three-dimensional femoral de- formities. T... Summary: Preoperative planning of corrective osteotomy with traditional radiography has limitations in regards to determining the ideal osteotomy location and orientation in three-dimensional femoral de- formities. Though a successful operation can be planned preoperatively, intraoperative contingencies might adhere to the procedural plan in the performance of operation. To efficiently perform a planned procedure, proposed is a design to implement three-dimensional reconstruction photography, based on computer-tomography (CT) scan. A custom-made guide was designed to navigate the osteotomy as planned, and additionally, a personalized intramedullary nail was used for fixation after osteotomy. Three-dimensional (3D) photography of deformed femur was established based on the CT dataset and transferred into 3D photography processing software for further planning. Osteotomy planes were de- signed and adjusted at deformity sites to correct the 3D deformities. The methodology of a custom-made osteotomy guide was introduced in femoral corrective osteotomy, for the first time, to navigate the op- eration as planned. After the virtual osteotomy and reduction of bone segments, the parameters of a custom-made intramedullary nail were measured for manufacturing. Findings Virtual operation in computer shows complete correction of the 3D deformity. The osteotomy guide, obtained by rapid-prototyping techniques, navigates mimicking surgery on rapid-prototyping model of the involved femur as planned. Internal fixation was achieved using the custom-made intramedullary nail. Interpreta- tion three-dimensional visualization introduces an advantage in preoperative planning for corrective os- teotomy of 3D femoral deformity, and the custom-made osteotomy guide is crucial to realize such a de- liberate plan during the actual procedures. The internal fixator, such as an intramedullary nail, can be modified or personalized for fixation in unique cases. 展开更多
关键词 compater-aided design femoral deformity corrective osteotomy custom-made guide in- tramedullary nail
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Computer-Aided Rapid Variant Design System for Hydraulic Support
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作者 赵继云 李炳文 +1 位作者 苗运江 顾力强 《International Journal of Mining Science and Technology》 SCIE EI 1998年第2期153-156,共4页
The paper gives a detail analysis on the necessity of rapid hydraulic support design, and presents a computer-aided rapid variant design system for hydraulic support. The system integrates the type selection and embod... The paper gives a detail analysis on the necessity of rapid hydraulic support design, and presents a computer-aided rapid variant design system for hydraulic support. The system integrates the type selection and embodiment design of hydraulic support. Case-based reasoning and rule-based reasoning are the main reasoning methods. Several crucial problems are discussed. 展开更多
关键词 HYDRAULIC support cad VARIANT design case-based REASONING RULE-BASED REASONING
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DESIGN OBJECT MODEL AND DESIGN PROCESS MODEL OF COMPUTER AIDED AIRCRAFT CONCEPTUAL DESIGN SYSTEM
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作者 Shen Zhang(Aircraft CAD Research Center, Beijing University of Aeronautics andAstronautics, Beijing, China, 100083) 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 1995年第3期198-204,共7页
DESIGNOBJECTMODELANDDESIGNPROCESSMODELOFCOMPUTERAIDEDAIRCRAFTCONCEPTUALDESIGNSYSTEMShenZhang(AircraftCADRese... DESIGNOBJECTMODELANDDESIGNPROCESSMODELOFCOMPUTERAIDEDAIRCRAFTCONCEPTUALDESIGNSYSTEMShenZhang(AircraftCADResearchCenter,Beijin... 展开更多
关键词 computer aided design aircraft design models
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A NEW SYSTEM FOR COMPUTER AIDED PATTERN DESIGN——CAPDS
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作者 张伯钧 邵世煌 《Journal of China Textile University(English Edition)》 EI CAS 1990年第4期37-44,共8页
This paper proposes a new computer aided pattern design system(CAPDS)in which a uniformmathematical expression is used to construct different objects. In the geometric model, 3 B-splineis adopted as a line model. The ... This paper proposes a new computer aided pattern design system(CAPDS)in which a uniformmathematical expression is used to construct different objects. In the geometric model, 3 B-splineis adopted as a line model. The new system with uniform mathematical expression has the distin-guishing features: curve smoothness and fidelity, convenience to process graphic data in thedatabase and etc.. This paper presents the data structure, the program structure and also the implementation. 展开更多
关键词 COMPUTER aided design data recording design proposals PATTERN design geometric model data structure
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Computer-aided designing and manufacturing of advanced steels 被引量:1
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作者 LI Lin HE Yanlin +3 位作者 B.C. De Cooman P. Wollants S. G. Huang J. Vleugels 《Rare Metals》 SCIE EI CAS CSCD 2006年第5期407-411,共5页
Suitable optimization and simulation were performed using a powerful software package with a mature database as well as modem measurement facilities, which led to the successful designing and manufacturing of advanced... Suitable optimization and simulation were performed using a powerful software package with a mature database as well as modem measurement facilities, which led to the successful designing and manufacturing of advanced steels. In the course of designing, the composition of a large section of prehardened mold steel for plastics was estimated so as to lower the quantities of oxide inclusions to change the type of carbides and to raise the machinability. The composition and process were adjusted to obtain satisfactory surface quality for the prevailing galvanization in transformation-induced plasticity (TRIP) steel. The refuting process of low-carbon steel was simulated in the light of both Thermo-Calc and Factsage. Thermodynamic and kinetic analyses were always conducted during the test and the procedure. 展开更多
关键词 material science advanced steel computer-aided design REFINING THERMODYNAMICS KINETICS
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