Computer-assisted three-dimensional individualized extreme liver resection for hepatoblastoma in proximity to the major liver vasculature

BACKGROUND The management of hepatoblastoma(HB)becomes challenging when the tumor remains in close proximity to the major liver vasculature(PMV)even after a full course of neoadjuvant chemotherapy(NAC).In such cases,extreme liver resection can be considered a potential option.AIM To explore whether computer-assisted three-dimensional individualized extreme liver resection is safe and feasible for children with HB who still have PMV after a full course of NAC.METHODS We retrospectively collected data from children with HB who underwent surgical resection at our center from June 2013 to June 2023.We then analyzed the detailed clinical and three-dimensional characteristics of children with HB who still had PMV after a full course of NAC.RESULTS Sixty-seven children diagnosed with HB underwent surgical resection.The age at diagnosis was 21.4±18.8 months,and 40 boys and 27 girls were included.Fifty-nine(88.1%)patients had a single tumor,39(58.2%)of which was located in the right lobe of the liver.A total of 47 patients(70.1%)had PRE-TEXT III or IV.Thirty-nine patients(58.2%)underwent delayed resection.After a full course of NAC,16 patients still had close PMV(within 1 cm in two patients,touching in 11 patients,compressing in four patients,and showing tumor thrombus in three patients).There were 6 patients of tumors in the middle lobe of the liver,and four of those patients exhibited liver anatomy variations.These 16 children underwent extreme liver resection after comprehensive preoperative evaluation.Intraoperative procedures were performed according to the preoperative plan,and the operations were successfully performed.Currently,the 3-year event-free survival of 67 children with HB is 88%.Among the 16 children who underwent extreme liver resection,three experienced recurrence,and one died due to multiple metastases.CONCLUSION Extreme liver resection for HB that is still in close PMV after a full course of NAC is both safe and feasible.This approach not only reduces the necessity for liver transplantation but also results in a favorable prognosis.Individualized three-dimensional surgical planning is beneficial for accurate and complete resection of HB,particularly for assessing vascular involvement,remnant liver volume and anatomical variations.

Diagnostic efficacy of virtual organ computer-assisted analysis in measuring the volume ratio of subchorionic hematoma with serum progesterone

BACKGROUND Subchorionic hematoma(SCH)is a common complication in early pregnancy characterized by the accumulation of blood between the uterine wall and the chorionic membrane.SCH can lead to adverse pregnancy outcomes such as miscarriage,preterm birth,and other complications.Early detection and accurate assessment of SCH are crucial for appropriate management and improved pregnancy outcomes.AIM To evaluate the diagnostic efficacy of virtual organ computer-assisted analysis(VOCAL)in measuring the volume ratio of SCH to gestational sac(GS)combined with serum progesterone on early pregnancy outcomes in patients with SCH.METHODS A total of 153 patients with SCH in their first-trimester pregnancies between 6 and 11 wk were enrolled.All patients were followed up until a gestational age of 20 wk.The parameters of transvaginal two-dimensional ultrasound,including the circumference of SCH(Cs),surface area of SCH(Ss),circumference of GS(Cg),and surface area of GS(Sg),and the parameters of VOCAL with transvaginal three-dimensional ultrasound,including the three-dimensional volume of SCH(3DVs)and GS(3DVg),were recorded.The size of the SCH and its ratio to the GS size(Cs/Cg,Ss/Sg,3DVs/3DVg)were recorded and compared.RESULTS Compared with those in the normal pregnancy group,the adverse pregnancy group had higher Cs/Cg,Ss/Sg,and 3DVs/3DVg ratios(P<0.05).When 3DVs/3DVg was 0.220,the highest predictive performance predicted adverse pregnancy outcomes,resulting in an AUC of 0.767,and the sensitivity,specificity were 70.2%,75%respectively.VOCAL measuring 3DVs/3DVg combined with serum progesterone gave a diagnostic AUC of 0.824 for early pregnancy outcome in SCH patients,with a high sensitivity of 82.1%and a specificity of 72.1%,which showed a significant difference between AUC.CONCLUSION VOCAL-measured 3DVs/3DVg effectively quantifies the severity of SCH,while combined serum progesterone better predicts adverse pregnancy outcomes.

A study on the feasibility of CET oral test based on automatic essay marking

This paper discusses the approach to the CET （college English test） oral test based on automatic essay marking （AEM）. The reliability and validity arouses a dispute on Internet-based CET （iB-CET） oral test in China, leading to the penetration into oral test contents in dialogue, description or comment, and question answering. Then, a probe into transformation from a spoken document into a textual document is touched on a conversion ratio of 72% adopted at the present time, AEM to be carried forward being a necessary hypothesis for Afterwards, this paper focuses on the pipeline in AEM with the content features and the language itself, which is established in two different models in marking for extraction and detection. Through experiments, this paper reveals the fact that an iB-CET oral test can be performed perfectly in the pipeline of spoken documents transformed into textual documents which can be automatically marked. Hence the design of the iB-CET oral test reaches its reliability and validity.

应用Beach marking方法检测钢结构疲劳裂纹扩展

掌握裂纹扩展规律是钢结构疲劳性能研究的一个基本问题。本文介绍了一种检测钢结构疲劳裂纹扩展的新型方法,即Beach marking方法。论文首先简述了这种方法测试疲劳裂纹扩展的基本原理,然后通过一个试验案例,展示了这种方法的具体应用和要点试验表明这种方法简单实用,通过运用合适的疲劳荷载序列,可在疲劳断口留下疲劳弧线,从而间接有效地记录了疲劳裂纹的扩展全过程。

Computer-assisted Surgery for Scaphoid Fracture

The computer-assisted surgery (CAS)has significantly improved the accuracy, reliability and outcomes of traumatic,spinal,nerve surgery and many other operations with a less invasive way.The application of CAS for scaphoid fractures remains experimental.The related studies are scanty and most of them are cadaver researches.Some intrinsic defects from the registration procedure,scan and immobilization of limbs may inevitably result in deviations. Some deviations become more obvious with operations of small bones (such as scaphoid)although they are acceptable for spine and other orthopedic surgeries.We reviewed the current literatures on the applications of CAS for scaphoid operation and summarized technical principles,scan and registration methods,immobilization of limbs and their outcomes.On the basis of the data,we analyzed the limitations of this technique and envisioned its future development.

Establishment and validation of a computer-assisted colonic polyp localization system based on deep learning

BACKGROUND Artificial intelligence in colonoscopy is an emerging field,and its application may help colonoscopists improve inspection quality and reduce the rate of missed polyps and adenomas.Several deep learning-based computer-assisted detection(CADe)techniques were established from small single-center datasets,and unrepresentative learning materials might confine their application and generalization in wide practice.Although CADes have been reported to identify polyps in colonoscopic images and videos in real time,their diagnostic performance deserves to be further validated in clinical practice.AIM To train and test a CADe based on multicenter high-quality images of polyps and preliminarily validate it in clinical colonoscopies.METHODS With high-quality screening and labeling from 55 qualified colonoscopists,a dataset consisting of over 71000 images from 20 centers was used to train and test a deep learning-based CADe.In addition,the real-time diagnostic performance of CADe was tested frame by frame in 47 unaltered full-ranged videos that contained 86 histologically confirmed polyps.Finally,we conducted a selfcontrolled observational study to validate the diagnostic performance of CADe in real-world colonoscopy with the main outcome measure of polyps per colonoscopy in Changhai Hospital.RESULTS The CADe was able to identify polyps in the test dataset with 95.0%sensitivity and 99.1%specificity.For colonoscopy videos,all 86 polyps were detected with 92.2%sensitivity and 93.6%specificity in frame-by-frame analysis.In the prospective validation,the sensitivity of CAD in identifying polyps was 98.4%(185/188).Folds,reflections of light and fecal fluid were the main causes of false positives in both the test dataset and clinical colonoscopies.Colonoscopists can detect more polyps(0.90 vs 0.82,P<0.001)and adenomas(0.32 vs 0.30,P=0.045)with the aid of CADe,particularly polyps<5 mm and flat polyps(0.65 vs 0.57,P<0.001;0.74 vs 0.67,P=0.001,respectively).However,high efficacy is not realized in colonoscopies with inadequate bowel preparation and withdrawal time(P=0.32;P=0.16,respectively).CONCLUSION CADe is feasible in the clinical setting and might help endoscopists detect more polyps and adenomas,and further confirmation is warranted.

A comparison of conventional and computer-assisted semen analysis.（CRISMAS software） using samples from 166 young Danish men

The aim of the present study was to compare assessments of sperm concentration and sperm motility analysed by conventional semen analysis with those obtained by computer-assisted semen analysis （CASA） （Copenhagen Rigshospitalet Image House Sperm Motility Analysis System （CRISMAS） 4.6 software） using semen samples from 166 young Danish men. The CRISMAS software identifies sperm concentration and classifies spermatozoa into three motility categories. To enable comparison of the two methods, the four motility stages obtained by conventional semen analysis were, based on their velocity classifications, divided into three stages, comparable to the three CRISMAS motility categories： rapidly progressive （A）, slowly progressive （B） and non-progressive （C＋ D）. Differences between the two methods were large for all investigated parameters （P〈0.001）. CRISMAS overestimated sperm concentration and the proportion of rapidly progressive spermatozoa and, consequently, underestimated the percentages of slowly progressive and non-progressive spermatozoa, compared to the conventional method. To investigate whether results drifted according to time of semen analysis, results were pooled into quarters according to date of semen analysis. CRISMAS motility results appeared more stable over time compared to the conventional analysis; however, neither method showed any trends. Apparently, CRISMAS CASA results and results from the conventional method were not comparable with respect to sperm concentration and motility analysis. This needs to be accounted for in clinics using this software and in studies of determinants of these semen characteristics.

Glutathione Peroxidase Revisited—Simulation of the Catalytic Cycle by Computer-Assisted Molecular Modelling

Glutathione peroxidase, the first example of selenoproteins identified in mammals, was subjected to force field calculations and molecular dynamics in order to enable a clearer comprehension of enzymatic selenium catalysis. Starting from the established X-ray structure of bovine GPX, all kinetically defined intermediates and enzyme substrate complexes were modelled. The models thus obtained support the hypothesis that the essential steps of the catalysis are three distinct redox changes of the active site selenium which, in the ground state, presents itself at the surface of selenoperoxidases as the center of a characteristic triad built by selenocysteine, glutarnine and tryptophan. In GPX, four arginine residues and a lysine residue provide an electrostatic architecture which, in each reductive step, directs the donor substrate GSH towards the catalytic center in such a way that 1ts sulfhydryl group must react with the selenium moiety. To this end, different equally efficient modes of substrate binding appear possible. The models are consistent with substrate specificity data, kinetic pattern and other functional characteristics of the enzyme. Comparison of molecular models of GPX with those of other members of the GPX superfamily reveals that the cosubstrate binding mechanisrns are unique for the classical type of cytosolic glutathione peroxidases but cannot operate e. g. in plasma GPX and phospholipid hydroperoxide GPX. The structural differences between the selenoperoxidases, shown to be relevant to their specificities, are discussed in terms of functional diversification within the GPX superfamily

The Marking Technology in Motion Capture for the Complex Locomotor Behavior of Flexible Small Animals(Gekko gecko)

Animals have evolved a variety of behavior patterns to adapt to the environment. Motion-capture technology is utilized to quantify and characterize locomotor behaviors to reveal the mechanisms of animal motion. In the capture of flexible, small animals with complex locomotor behaviors, the markers interfere with each other easily, and the motion forms(bending, twisting) of the moving parts are obviously different;thus, it is a great challenge to realize accurate quantitative characterization of complex locomotor behaviors. The correlation between the marker properties, including the size and space length, and the precision of the system are revealed in this paper, and the effects of diverse marker shapes on the capturing accuracy of the captured objects in different motion forms were tested. Results showed that the precision of system is significantly improved when the ratio of the space length to the diameter of the markers is larger than four;for the capture of the spatial twisting motion of the flexible object, the hexagon markers had the lowest spatial lost-marker rate relative to the circle, triangle, and square. Customized markers were used to capture the locomotor behavior of the gecko-inspired robot(rigid connection) and the gecko(flexible connection). The results showed that this marking technology can achieve high accuracy of motion capture for geckos(the average deviation was approximately 0.32 mm, and the average deviation’s variation rate was approximately 0.96%). In this paper, the marking technology for the motion capture of flexible, small animals with complex motion is proposed;it can effectively improve the system precision as well as the capture accuracy, and realize the quantitative characterization of the complex motion of flexible, small objects. It provides a reliable technical means to deeply study the evolution of the motion function of small animals and advance systematic research of motion-capture technology.

A Novel Packet Marking Algorithm in Context-aware Autonomic QoS Framework

Autonomic networking is one of the hot research topics in the research area of future network architectures.In this paper, we introduce context-aware and autonomic attributes into DiffServ QoS framework, and propose a novel autonomic packet marking(APM) algorithm.In the proposed autonomic QoS framework, APM is capable of collecting various QoS related contexts, and adaptively adjusting its behavior to provide better QoS guarantee according to users' requirements and network conditions.Simulation results show that APM provides better performance than traditional packet marker, and significantly improves user's quality of experience.

A Lane-Level Road Marking Map Using a Monocular Camera

The essential requirement for precise localization of a self-driving car is a lane-level map which includes road markings(RMs).Obviously,we can build the lane-level map by running a mobile mapping system(MMS)which is equipped with a high-end 3D LiDAR and a number of high-cost sensors.This approach,however,is highly expensive and ineffective since a single high-end MMS must visit every place for mapping.In this paper,a lane-level RM mapping system using a monocular camera is developed.The developed system can be considered as an alternative to expensive high-end MMS.The developed RM map includes the information of road lanes(RLs)and symbolic road markings(SRMs).First,to build a lane-level RM map,the RMs are segmented at pixel level through the deep learning network.The network is named RMNet.The segmented RMs are then gathered to build a lane-level RM map.Second,the lane-level map is improved through loop-closure detection and graph optimization.To train the RMNet and build a lane-level RM map,a new dataset named SeRM set is developed.The set is a large dataset for lane-level RM mapping and it includes a total of 25157 pixel-wise annotated images and 21000 position labeled images.Finally,the proposed lane-level map building method is applied to SeRM set and its validity is demonstrated through experimentation.

沉默MARK4通过NF-κB信号通路抑制溃疡性结肠炎细胞焦亡和炎症因子表达

目的探讨MARK4(microtubule-affinity regulating kinase 4,MARK4)在脂多糖(lipopolysaccharide,LPS)诱导的FHC细胞溃疡性结肠炎(ulcerative colitis,UC)模型中对FHC细胞焦亡、炎症因子释放和肠道屏障相关蛋白表达的影响及其可能分子机制。方法采用Western blot检测UC患者、健康人群结肠组织和LPS诱导的FHC细胞炎症模型中MARK4和细胞焦亡相关的因子Caspase-1、NLRP3和GSDMD的表达水平;通过质粒转染shRNA沉默FHC细胞中MARK4,在正常对照组、LPS组和沉默MARK4+LPS组中采用Western blot分别检测Caspase-1、NLRP3、GSDMD、肠道屏障相关蛋白和NF-κB信号通路相关蛋白的表达水平;ELISA和RT-qPCR检测炎症因子IL-1β、IL-6和TNF-α表达水平;流式细胞术检测细胞凋亡情况。结果在UC患者结肠组织和LPS诱导FHC细胞体外UC炎症模型中MARK4和焦亡相关蛋白包括NLRP3、Caspase-1和GSDMD的表达水平显著升高。沉默MARK4能够抑制LPS诱导FHC细胞中焦亡相关蛋白NLRP3、Caspase-1、GSDMD表达水平,下调炎症相关细胞因子IL-1β、IL-6和TNF-α的表达水平,抑制FHC细胞凋亡,上调肠道屏障相关蛋白ZO-1、Occludin表达和上调Claudin2的表达水平。GSEA富集分析显示,MARK4与NF-κB信号通路呈正相关。沉默MARK4能够抑制NF-κB信号通路中p-P65、p-IKKα的表达水平。结论MARK4在UC组织和细胞中显著高表达,沉默MARK4能够通过阻滞NF-κB信号通路激活,进而抑制UC细胞焦亡和炎症因子表达。MARK4可能成为UC患者治疗的一个潜在靶点。

Application of a novel computer-assisted surgery system in percutaneous nephrolithotomy:A controlled study

BACKGROUND Most complex renal stones are managed primarily with percutaneous nephrolithotomy(PCNL).However,PCNL is still a great challenge for surgeons because of poor comprehension on complex adjacent structures.Novel techniques are required to assist in planning and navigation.AIM To apply and evaluate the Hisense computer-assisted surgery(CAS)system in PCNL.METHODS A total of 60 patients with complex renal stones were included.Thirty patients in the CAS group had three-dimensional(3 D)virtual models constructed with the CAS system.The model assisted in planning and navigating in the CAS system.Thirty patients in the control group planned and navigated as standard PCNL,without the application of the CAS system.Success rate of one attempt,operation time,initial stone-free rate,decrease in hemoglobin,and complications were collected and analyzed.RESULTS There were no statistically significant differences in the baseline characteristics or planning characteristics.The success rate of one puncturing attempt(90%vs 67%,P=0.028)and the initial stone-free rate(87%vs 63%,P=0.037)were significantly higher in the CAS group.However,there were no statistically significant differences in the operation time(89.20±29.60 min vs 92.33±33.08 min,P=0.859)or in the decrease in hemoglobin(11.07±8.32 g/L vs 9.03±11.72 g/L,P=0.300)between the CAS group and the control group.No statistically significant differences in the incidence of complications(Clavien-Dindo grade≥2)were found.CONCLUSION Compared with standard PCNL,CAS-assisted PCNL had advantages in terms of the puncturing success rate and stone-free rate.The Hisense CAS System was recommended to assist in preoperative planning and intraoperative navigation for an intuitive,precise and convenient PCNL.

Simple Fabrication of Hierarchical Micro/Nanostructure Superhydrophobic Surface with Stable and Superior Anticorrosion Silicon Steel via Laser Marking Treatment

To improve the weak corrosion resistance of silicon steel to acid solution and alkaline solution with high temperature,a stable hierarchical micro/nanostructure superhydrophobic surface with myriad irregular micro-scale hump and sheet-like nanostructure was successfully prepared on silicon steel by a simple,efficient and facile operation in large-area laser marking treatment.The morphology,composition,wettability of the as-prepared surface were studied.The superhydrophobic performance of the surface was investigated as well.Additionally,the corrosion resistance of the superhydrophobic surface to acidic solutions at room temperature and alkaline solutions at high temperature (80 ℃) was carefully explored.The corrosion resistance mechanism was clarified.Moreover,considering the practical application of the surface in the future,the hardness of the hierarchical micro/nanostructure superhydrophobic surface was studied.The experimental results indicate that the hierarchical micro/nanostructure surface with texture spacing of 100 μm treated at laser scanning speed of 100 mms/ presents superior superhydrophobicity after decreasing surface energy.The contact angle can be as high as 156.6°.Additionally,the superhydrophobic surface provide superior and stable anticorrosive protection for silicon steel in various corrosive environments.More importantly,the prepared structure of the surface shows high hardness,which ensures that the surface of the superhydrophobic surface cannot be destroyed easily.The surface is able to maintain great superhydrophobic performance when it suffers from slight impacting and abrasion.

Evidence of return of chum salmon released from Tangwang River by strontium marking method

In order to assess the effect of enhancement release of chum salmon(Oncorhynchus keta),otolith strontium(Sr)marking method was used to tag chum salmon released in Tangwang River in 2016.The homing chum salmon were detected and the samples were collected in Tangwang River,Ussuri River and Suifen River in the autumn of2018.The samples were analyzed by examining Sr and calcium(Ca)fingerprints in the otolith using electron probe microanalysis.The results suggested that two samples collected in Tangwang River had the marking ring near the core of otolith where the Sr concentration and Sr/Ca ratio were significantly higher than comparative samples.Proving that the two fish belonged to the released population in Tangwang River in 2016.This article indicated the success of the enhancement release of chum salmon from the Tangwang River for the first time and also confirmed the validity of Sr marking in enhancement release of fishes.

Fragile Watermarking of 3D Models Using Genetic Algorithms

This paper describes a novel algorithm for fragile watermarking of 3D models. Fragile watermarking requires detection of even minute intentional changes to the 3D model along with the location of the change. This poses a challenge since inserting random amount of watermark in all the vertices of the model would generally introduce perceptible distortion. The proposed algorithm overcomes this challenge by using genetic algorithm to modify every vertex location in the model so that there is no perceptible distortion. Various experimental results are used to justify the choice of the genetic algorithm design parameters. Experimental results also indicate that the proposed algorithm can accurately detect location of any mesh modification.

Reasons and countermeasures for “marking problem” during the production of double-walled copper-brazed steel tubes

This study explores the reasons underlying the frequent appearance of ＂marking problem＂ during the production of double-walled copper-brazed steel tubes. To this end, we compared two types of copper-coated steel strips, of which one has almost no problem during production, whereas the other has higher number of incidences of ＂marking problem＂. We analyzed the chemical composition,mechanical properties,the cross-sectional metallographs, and surface quality of the trimmed edge in both types of specimen. After the roll forming process, the bonding condition between the steel layers of the tubes before and after brazing process has also been examined. Results indicate that the chemical composition and mechanical properties of the two kinds of strips are similar; however, the edge quality of the trimmed strips is significantly different. It is believed that the irregular shape of the edge portions in the strips will be more pronounced during the bevel treatment. Consequently, smooth and tight seams cannot be guaranteed by such uneven beveled edges,which lead to higher number of incidences of ＂marking problem＂ during production.

基于三圆轨迹规划的MARKⅢ型LNG薄膜舱波纹板机器人焊接

MARKⅢ型LNG薄膜舱波纹板的焊接质量是LNG船建造成功与否的关键之一。为了实现MARKⅢ型LNG薄膜舱1.2mm厚304L不锈钢波纹板的机器人焊接,研究了基于“三圆”连接构思的波纹板机器人焊接的轨迹规划模型,通过模型计算了沿波纹板轨迹焊接过程中的焊枪位置和焊枪姿态坐标,并对模型和计算的结果进行了仿真验证;在此基础上,进行了不锈钢波纹板机器人搭接焊的脉冲等离子弧焊的工艺优化研究。结果表明:本文建立的波纹板机器人焊接的“三圆”轨迹规划模型以及基于该模型计算的焊枪位姿坐标准确;基于模型和计算,结合优化后的脉冲等离子弧焊工艺参数,实现了焊缝成形良好的MARKⅢ型LNG薄膜舱1.2mm厚304L不锈钢波纹板搭接的机器人焊接,焊缝成形达到了法国GTT公司标准文件中提供的成形尺寸标准。

Glass Marking with CO₂Laser: Experimental Study of the Interaction Laser - Material

Laser marking is a laser processing technology used in many fields of industry like automotive [1], aerospace [2], microelectronic [3] and medecine [4]. CO2 laser is an appropriate source for marking glasses [5]. Compared to the other techniques of marking, the principal advantages of the use of the laser are: made inalterable, high degree of accuracy and the smoothness of the features, the possibility of marking at difficult to reach places, and the fact of being able to mark fragile materials like ceramic and glass [6]. In this experimental work, the influence of marking parameters like interaction time laser-glass, laser power, shooting time etc. on the micromarking precision are reported. A “melt” depth prediction model has been established.

Application of computer-assisted navigation in treating congenital maxillomandibular syngnathia:A case report

BACKGROUND Congenital maxillomandibular syngnathia is an extremely rare disorder characterized by craniofacial malformations and inability to open the mouth adequately, which leads to problems with feeding, swallowing, and breathing as well as temporomandibular joint ankylosis. The main goal of the surgery is to release the ankylosis, establish functioning mandible, and prevent re-fusion.However, surgical procedures for this disease are rarely reported.CASE SUMMARY Here, we report a 7-mo-old girl with bilateral maxillomandibular syngnathia. The patient presented with difficulty in feeding, breathing, sounding, and swallowing and had developmental dysplasia. For treatment, we performed bone isolation by computer-assisted navigation and used silicone to fix the wound surface to prevent refusion of bone. To our knowledge, this is the only syngnathia case in the literature treated using computer-assisted navigation. With the guidance of precise navigation, we were able to minimize operation time by at least one hour,the patient's blood vessels, nerves, and tooth germs were well protected, and excessive bleeding was avoided. After six weeks, the patient showed improvement in mouth opening and no major issues of feeding.CONCLUSION Application of computer-assisted navigation can significantly improve accuracy,effectiveness, and surgical safety in correcting congenital maxillomandibular syngnathia.