The concept of intraductal papillary neoplasm of the bile duct(IPNB)has gained recognition as a discrete entity[1,2],possessing many features including multiplicity[3,4],mucin production[3],slow progression[3,5],vario...The concept of intraductal papillary neoplasm of the bile duct(IPNB)has gained recognition as a discrete entity[1,2],possessing many features including multiplicity[3,4],mucin production[3],slow progression[3,5],various morphology[6,7],easy sloughing and seeding[8],and having unique risk factors[2,9-11].We have previously proposed a morphologic classification[6]and a progression model of IPNB[12].展开更多
The theoretical research of cable-driven mechanisms is developed with its broad applications. The first prototype of cable-driven mechanisms is RoboCrane, which was developed by the National Institute of Standards and...The theoretical research of cable-driven mechanisms is developed with its broad applications. The first prototype of cable-driven mechanisms is RoboCrane, which was developed by the National Institute of Standards and Technology (NIST). Then many excellent properties were developed and they have a variety of applications such as aerospace, aircraft and automobile industries [1]. Example application for RoboCrane in the field of aircraft mainte- nance is equipped with a quick-change mechanism to remove the robot arm remotely.展开更多
Coffee is one of the world's favorite and most popular beverages,the third most popular beverage after water and tea.For many people,it is an indispensable habit before going to work and a socialization tool for t...Coffee is one of the world's favorite and most popular beverages,the third most popular beverage after water and tea.For many people,it is an indispensable habit before going to work and a socialization tool for the rest of the day.In general,the average consum ption varies from 2 to6 cups per day.What are the health implications?Given this consum ption,the benefits are actually greater than the risks.This is the conclusion of a careful study published in the New England Journal of Medicine(van Dam et al.,2020).展开更多
Only when the foundation is strong will the state be safe and stable.THE concept that"the people are the foundation of a state"is the best expression of the people-centered philosophy of ancient China.Past C...Only when the foundation is strong will the state be safe and stable.THE concept that"the people are the foundation of a state"is the best expression of the people-centered philosophy of ancient China.Past Chinese sages and philosophers reached this conclusion in their study of state governance amid the rise and fall of dynasties over thousands of years.Based on the belief that the people's support of state power is vital for its success,this precept has inspired policies and practices aimed at nurturing,benefiting and enriching the people throughout Chinese history.展开更多
There are errors in Figure 1D1 on page 94.Specifically,RAB22A-induced autophagosomes were inadvertently marked in Figure 1D.We have revised Figure 1 to correct the errors.Of note,the errors do not impact the conclusio...There are errors in Figure 1D1 on page 94.Specifically,RAB22A-induced autophagosomes were inadvertently marked in Figure 1D.We have revised Figure 1 to correct the errors.Of note,the errors do not impact the conclusion of this article.We apologize for the errors and for any resulting confusion.展开更多
The authors examined the original data of their work and noticed misuse of images in fig.1 and fig.3(as shown below on the upper panels,red box).The correct images are shown on the lower panels(red box).The authors si...The authors examined the original data of their work and noticed misuse of images in fig.1 and fig.3(as shown below on the upper panels,red box).The correct images are shown on the lower panels(red box).The authors sincerely apologize for the mistake and confirm the change does not affect the scientific conclusion of the published work.展开更多
Abnormal subchondral bone remodeling leading to sclerosis is a main feature of osteoarthritis(OA), and osteomodulin(OMD), a proteoglycan involved in extracellular matrix mineralization, is associated with the scleroti...Abnormal subchondral bone remodeling leading to sclerosis is a main feature of osteoarthritis(OA), and osteomodulin(OMD), a proteoglycan involved in extracellular matrix mineralization, is associated with the sclerotic phenotype. However, the functions of OMD remain poorly understood, specifically in vivo. We used Omd knockout and overexpressing male mice and mutant zebrafish to study its roles in bone and cartilage metabolism and in the development of OA. The expression of Omd is deeply correlated with bone and cartilage microarchitectures affecting the bone volume and the onset of subchondral bone sclerosis and spontaneous cartilage lesions. Mechanistically, OMD binds to RANKL and inhibits osteoclastogenesis, thus controlling the balance of bone remodeling. In conclusion, OMD is a key factor in subchondral bone sclerosis associated with OA. It participates in bone and cartilage homeostasis by acting on the regulation of osteoclastogenesis. Targeting OMD may be a promising new and personalized approach for OA.展开更多
In the original version of this article,we published a figure showing a gap in the confidence intervals for body and tail due to data paucity for mid stages of moult progress.Here,we amended this problem adding data f...In the original version of this article,we published a figure showing a gap in the confidence intervals for body and tail due to data paucity for mid stages of moult progress.Here,we amended this problem adding data from the 2023 moulting season,during which we obtained 139 moult records from 98 individuals.The final sample size used for plotting these results are shown in the caption below.This amendment corroborates the conclusion already stated:body moult does not seem to be under physiological constraints,although primary moult appears to be tightly controlled to reduce aerodynamic losses.展开更多
Gravitational waves propagating at nanohertz frequencies?Do they exist?Yes.Four observational networks,from China,Australia,Europe-India,and USA,respectively,simultaneously answered on June 29,releasing results from t...Gravitational waves propagating at nanohertz frequencies?Do they exist?Yes.Four observational networks,from China,Australia,Europe-India,and USA,respectively,simultaneously answered on June 29,releasing results from their independent observations in the extremely low waveband of nanohertz.Consistent with each other,the results arrive at a common conclusion:our planet is immersed in a wavy spacetime ruffled by overlapping low-tone ripples.FAST,the Five-hundred-meter Aperture Spherical radio Telescope of China,is among the many giant telescopes that have played a key role in the search for this low-pitch voice.They are not the real detectors,though.展开更多
The special issue deals with the Cretaceous-Tertiary deserts in southwestern China and relevant sedimentological problems about deserts. The study area is located between 101°10'- 107°00'E and 28°00'...The special issue deals with the Cretaceous-Tertiary deserts in southwestern China and relevant sedimentological problems about deserts. The study area is located between 101°10'- 107°00'E and 28°00'-30°40′ N. The ancient desert study is so little in China that there has not been a systematic report about it up to now. Based on the study in many ways on Cretaceous-Tertiary deserts in southwestern China, plentiful data have been obtained. Though it is still a bit rough, the study is a good beginning of the ancient desert study in China. The main ideas and conclusions are summarized as follows.展开更多
Most recently,Liu and Chen[Chin.Phys.Lett.30(2013)079901]used the tool of information theory to analyze the security of our two improved versions of the MX protocol[Chin.Phys.Lett.30(2013)040305],and they found out th...Most recently,Liu and Chen[Chin.Phys.Lett.30(2013)079901]used the tool of information theory to analyze the security of our two improved versions of the MX protocol[Chin.Phys.Lett.30(2013)040305],and they found out that our two improved versions still have the information leakage problem.After revisiting them with the tool of information theory again,with respect to the security,we draw the same conclusion as Liu and Chen.In addition,we point out that how to use a single quantum state as the sole quantum resource to design a bidirectional quantum secure direct communication protocol without information leakage is still a big challenge that needs to be solved.展开更多
Looking through any exercise science journals today,in fact any science journals including many top Science Citation Index(SCI) journals,one can easily find examples of the wide-spread "p【0.05/significance"...Looking through any exercise science journals today,in fact any science journals including many top Science Citation Index(SCI) journals,one can easily find examples of the wide-spread "p【0.05/significance" abuse phenomenon,i.e., if the p value from a statistical/hypothesis test is less than 0.05(or 0.01 sometimes),a conclusion that "the results/ findings are significant" is then drawn.The abuse is so severe that it is already seriously threatening the integrity of scientific inquiry.展开更多
The linear instability analysis of the present paper shows that the thermocapillary convection in a half floating zone of larger Prandtl number has a steady instability mode ωi = 0 and m = 1 for a fat liquid bridge V...The linear instability analysis of the present paper shows that the thermocapillary convection in a half floating zone of larger Prandtl number has a steady instability mode ωi = 0 and m = 1 for a fat liquid bridge V = 1.2 with small geometrical aspect ratio A = 0.6. This conclusion is different from the usual idea of hydrothermal instability, and implies that the instability of the system may excite a steady and axial asymmetric state before the onset of oscillation in the case of large Prandtl number.展开更多
The authors regret that Fig.7b in our original article was incorrectly published,which is the same as Fig.6b due to an unintentional and random error.The correct Fig.7b is shown as follows(Reusability of the immobiliz...The authors regret that Fig.7b in our original article was incorrectly published,which is the same as Fig.6b due to an unintentional and random error.The correct Fig.7b is shown as follows(Reusability of the immobilized laccase).The change does not affect the results and conclusions.展开更多
文摘The concept of intraductal papillary neoplasm of the bile duct(IPNB)has gained recognition as a discrete entity[1,2],possessing many features including multiplicity[3,4],mucin production[3],slow progression[3,5],various morphology[6,7],easy sloughing and seeding[8],and having unique risk factors[2,9-11].We have previously proposed a morphologic classification[6]and a progression model of IPNB[12].
基金Supported by National Natural Science Foundation of China(Grant No.51575150)
文摘The theoretical research of cable-driven mechanisms is developed with its broad applications. The first prototype of cable-driven mechanisms is RoboCrane, which was developed by the National Institute of Standards and Technology (NIST). Then many excellent properties were developed and they have a variety of applications such as aerospace, aircraft and automobile industries [1]. Example application for RoboCrane in the field of aircraft mainte- nance is equipped with a quick-change mechanism to remove the robot arm remotely.
文摘Coffee is one of the world's favorite and most popular beverages,the third most popular beverage after water and tea.For many people,it is an indispensable habit before going to work and a socialization tool for the rest of the day.In general,the average consum ption varies from 2 to6 cups per day.What are the health implications?Given this consum ption,the benefits are actually greater than the risks.This is the conclusion of a careful study published in the New England Journal of Medicine(van Dam et al.,2020).
文摘Only when the foundation is strong will the state be safe and stable.THE concept that"the people are the foundation of a state"is the best expression of the people-centered philosophy of ancient China.Past Chinese sages and philosophers reached this conclusion in their study of state governance amid the rise and fall of dynasties over thousands of years.Based on the belief that the people's support of state power is vital for its success,this precept has inspired policies and practices aimed at nurturing,benefiting and enriching the people throughout Chinese history.
文摘There are errors in Figure 1D1 on page 94.Specifically,RAB22A-induced autophagosomes were inadvertently marked in Figure 1D.We have revised Figure 1 to correct the errors.Of note,the errors do not impact the conclusion of this article.We apologize for the errors and for any resulting confusion.
文摘The authors examined the original data of their work and noticed misuse of images in fig.1 and fig.3(as shown below on the upper panels,red box).The correct images are shown on the lower panels(red box).The authors sincerely apologize for the mistake and confirm the change does not affect the scientific conclusion of the published work.
基金funded by the F.R.S.-FNRS for the “EOS: The Excellence of Science-Join-t-against-Osteoarthritis”, grant number 30480119by a research grant from the Osteoarthritis Foundation and by the University of Liege (Fonds Léon Fredericq and Fonds Speciaux à la Recherche)funded by Versus Arthritis senior fellowship 21937。
文摘Abnormal subchondral bone remodeling leading to sclerosis is a main feature of osteoarthritis(OA), and osteomodulin(OMD), a proteoglycan involved in extracellular matrix mineralization, is associated with the sclerotic phenotype. However, the functions of OMD remain poorly understood, specifically in vivo. We used Omd knockout and overexpressing male mice and mutant zebrafish to study its roles in bone and cartilage metabolism and in the development of OA. The expression of Omd is deeply correlated with bone and cartilage microarchitectures affecting the bone volume and the onset of subchondral bone sclerosis and spontaneous cartilage lesions. Mechanistically, OMD binds to RANKL and inhibits osteoclastogenesis, thus controlling the balance of bone remodeling. In conclusion, OMD is a key factor in subchondral bone sclerosis associated with OA. It participates in bone and cartilage homeostasis by acting on the regulation of osteoclastogenesis. Targeting OMD may be a promising new and personalized approach for OA.
文摘In the original version of this article,we published a figure showing a gap in the confidence intervals for body and tail due to data paucity for mid stages of moult progress.Here,we amended this problem adding data from the 2023 moulting season,during which we obtained 139 moult records from 98 individuals.The final sample size used for plotting these results are shown in the caption below.This amendment corroborates the conclusion already stated:body moult does not seem to be under physiological constraints,although primary moult appears to be tightly controlled to reduce aerodynamic losses.
文摘Gravitational waves propagating at nanohertz frequencies?Do they exist?Yes.Four observational networks,from China,Australia,Europe-India,and USA,respectively,simultaneously answered on June 29,releasing results from their independent observations in the extremely low waveband of nanohertz.Consistent with each other,the results arrive at a common conclusion:our planet is immersed in a wavy spacetime ruffled by overlapping low-tone ripples.FAST,the Five-hundred-meter Aperture Spherical radio Telescope of China,is among the many giant telescopes that have played a key role in the search for this low-pitch voice.They are not the real detectors,though.
文摘The special issue deals with the Cretaceous-Tertiary deserts in southwestern China and relevant sedimentological problems about deserts. The study area is located between 101°10'- 107°00'E and 28°00'-30°40′ N. The ancient desert study is so little in China that there has not been a systematic report about it up to now. Based on the study in many ways on Cretaceous-Tertiary deserts in southwestern China, plentiful data have been obtained. Though it is still a bit rough, the study is a good beginning of the ancient desert study in China. The main ideas and conclusions are summarized as follows.
基金Supported by the National Natural Science Foundation of China under Grant No 60972071the Natural Science Foundation of Zhejiang Province under Grant Nos Y6100421 and LQ12F02012.
文摘Most recently,Liu and Chen[Chin.Phys.Lett.30(2013)079901]used the tool of information theory to analyze the security of our two improved versions of the MX protocol[Chin.Phys.Lett.30(2013)040305],and they found out that our two improved versions still have the information leakage problem.After revisiting them with the tool of information theory again,with respect to the security,we draw the same conclusion as Liu and Chen.In addition,we point out that how to use a single quantum state as the sole quantum resource to design a bidirectional quantum secure direct communication protocol without information leakage is still a big challenge that needs to be solved.
文摘Looking through any exercise science journals today,in fact any science journals including many top Science Citation Index(SCI) journals,one can easily find examples of the wide-spread "p【0.05/significance" abuse phenomenon,i.e., if the p value from a statistical/hypothesis test is less than 0.05(or 0.01 sometimes),a conclusion that "the results/ findings are significant" is then drawn.The abuse is so severe that it is already seriously threatening the integrity of scientific inquiry.
基金the National Natural Science Foundation of China under Grant No.19789201the Ministry of Science and Technology of China under project 95-Yu-34.
文摘The linear instability analysis of the present paper shows that the thermocapillary convection in a half floating zone of larger Prandtl number has a steady instability mode ωi = 0 and m = 1 for a fat liquid bridge V = 1.2 with small geometrical aspect ratio A = 0.6. This conclusion is different from the usual idea of hydrothermal instability, and implies that the instability of the system may excite a steady and axial asymmetric state before the onset of oscillation in the case of large Prandtl number.
文摘The authors regret that Fig.7b in our original article was incorrectly published,which is the same as Fig.6b due to an unintentional and random error.The correct Fig.7b is shown as follows(Reusability of the immobilized laccase).The change does not affect the results and conclusions.