Objective The aim of the study was to evaluate the coverage of the prostate when prostatic implanted fiducial markers are used to verify setup of the patients in comparison to the pelvic bones while using conebeam com...Objective The aim of the study was to evaluate the coverage of the prostate when prostatic implanted fiducial markers are used to verify setup of the patients in comparison to the pelvic bones while using conebeam computed tomography(CBCT). Methods Seventeen patients with prostate cancer were included. For each patient, daily online CBCT was done. CT planning was matched with CBCT with the help of fiducial markers(3–5 markers) and another matching with done the help of pelvic bony landmarks. Registration of clinical target volume(CTV) 1 including prostate plus seminal vesicles and CTV2 including prostate only was done and were used to confirm the target volume during the process of matching. Delineation of the rectum on every CBCT was done. Two automatic margin representing planning target volume(PTV) were created. PTV1 was generated by adding 1 cm in all directions(PTV1a) and 0.7 cm in the posterior direction(PTV1b). PTV2 was generated by adding 0.5 cm in all directions(PTV2a) and 0.3 cm in the posterior direction(PTV2b). PTV1a was prescribed to receive 46 Gy in conventional fractionation with a boost dose of 30 Gy to PTV1b. The same dose was prescribed to PTV2a and PTV2b. Calculation of the percentage of intersection between CTV1and CTV2 created on CBCT with the original CTV scan was done. A comparison between the two CTVs(CTV1and CTV2) mean dose and the original delineated CTV was done. Then a comparison to the mean dose of the original CTV of PTV1a, PTV2a(CTV1a and CTV2a), and for PTV1b and PTV2b(CTV1b and CTV2b). Calculation of the mean rectal dose and also V60, V70 and V74 was done on the delineated rectum on every CBCT, and then a comparison to the planned original rectal dose. Results The created CTV1and CTV2 intersection percentage with the original CTV1and CTV2 significantly increased by 85%(range, 65%–95%, P < 0.05), when fiducial markers were used. The main difference of the received mean dose was significantly less in comparison to pelvic bone alignment(0.03% to 2% vs 0.03% to 11.6% for PTV1a, P < 0.006;0.01% to 1.8% vs 0.03% to 10.2% for PTV2a, P < 0.014;0.08 to 2.11 vs 0.04 to 11.29 for PTV1b, P < 0.015 and 0.01 to 1.79 vs 0.01 to 9.69 for PTV2b, P < 0.004). With the use of less PTV margins, significant decrease of the rectal mean dose, V60, V70 and V74 by P < 0.004, P < 0.004, P < 0.0005 and P < 0.009, respectively. Reduction of the CTV1a and CTV1b mean dose by 1.13% and 0.28% in comparison to the initial CTV1a and CTV2a.Conclusion A significant improvement of prostatic cancer patients alignment when fiducial markers are used, with more homogenous dose distribution, and with significant decrease in PTV margins. The delivered rectal dose is significantly less allowing prostate dose escalation.展开更多
<strong>Objectives: </strong>Odontoma is the most common type of odontogenic tumors. Many studies have analyzed the statistical associations between odontoma location and patient age and sex, according to ...<strong>Objectives: </strong>Odontoma is the most common type of odontogenic tumors. Many studies have analyzed the statistical associations between odontoma location and patient age and sex, according to the histological tumor type. However, few studies have assessed odontoma morphological characteristics using cone-beam computed tomography (CBCT). We aimed to evaluate the association between odontoma location and size. <strong>Methods:</strong> We performed CBCT on patients with odontomas (19 patients;10 women, 9 men;average age, 12.6 [range, 6 - 34] years) according to the pathology type at a university hospital between April 2008 and February 2017. The locations of the lesions were noted, and their sizes were measured on CBCT images. Buccolingual, mesiodistal, and vertical diameters of the lesions were recorded on the same slice with the greatest diameters on axial, coronal, and sagittal CBCT images. <strong>Results: </strong>Altogether, 9 (47.4%) and 10 (52.6%) odontomas were located in the mandible and maxilla, respectively. There was no significant difference in the mesiodistal and vertical diameters on the CBCT image between the mandibular and maxillary groups when the odontoma size was compared with location (p < 0.05). However, the average diameters in only the buccolingual diameter were significantly greater in the maxilla. There were no significant differences between the two groups according to sex, age, or histological type. <strong>Conclusions: </strong>These data suggest that the sizes of odontomas in the maxilla are affected by bone expansion in the buccolingual direction, but they may be invariable in most settings. Three-dimensional assessment across the age groups suggests a lack of variation in size.展开更多
目的探讨新疆地区维吾尔族与汉族患者上颌窦相关线性距离的差异性。方法选取2014年6月-2015年6月新疆医科大学第一附属医院维吾尔族及汉族CBCT影像,测量上颌窦垂直向及近远中向线性距离并进行比较。结果汉族患者上颌窦近远中径的平均距...目的探讨新疆地区维吾尔族与汉族患者上颌窦相关线性距离的差异性。方法选取2014年6月-2015年6月新疆医科大学第一附属医院维吾尔族及汉族CBCT影像,测量上颌窦垂直向及近远中向线性距离并进行比较。结果汉族患者上颌窦近远中径的平均距离右侧为(29.1±5.31)mm,左侧为(29.0±4.92)mm;维吾尔族患者右侧为(30.6±4.98)mm,左侧为(30.7±4.74)mm,差异有统计学意义(P<0.05)。女性患者上颌窦近远中径中,汉族患者右侧为(28.9±4.14)mm,左侧为(29.1±4.59)mm;维吾尔族患者右侧为(31.0±4.78)mm,左侧为(31.1±4.70)mm,差异有统计学意义(P<0.05)。汉族患者上颌窦颊腭径的平均距离右侧为(22.5±4.58)mm,左侧为(23.0±4.63)mm;维吾尔族患者右侧为(22.59±4.46)mm,左侧为(23.4±4.55)mm,差异无统计学意义(P>0.05)。汉族患者窦底至牙槽嵴顶的平均高度(residual bone high,RBH)右侧为(9.2±3.86)mm,左侧为(9.2±3.73)mm;维吾尔族患者右侧RBH的平均高度为(9.5±3.53)mm,左侧为(9.1±3.29)mm。汉族缺牙患者右侧RBH为(7.9±4.08)mm,左侧为(6.9±3.41)mm;维吾尔族患者右侧RBH为(7.8±4.46)mm,左侧为(7.7±3.76)mm,差异均无统计学意义(P>0.05)。结论维吾尔族患者上颌窦解剖结构中除上颌窦内壁近远中径大于汉族外,其余结构均基本一致。展开更多
文摘Objective The aim of the study was to evaluate the coverage of the prostate when prostatic implanted fiducial markers are used to verify setup of the patients in comparison to the pelvic bones while using conebeam computed tomography(CBCT). Methods Seventeen patients with prostate cancer were included. For each patient, daily online CBCT was done. CT planning was matched with CBCT with the help of fiducial markers(3–5 markers) and another matching with done the help of pelvic bony landmarks. Registration of clinical target volume(CTV) 1 including prostate plus seminal vesicles and CTV2 including prostate only was done and were used to confirm the target volume during the process of matching. Delineation of the rectum on every CBCT was done. Two automatic margin representing planning target volume(PTV) were created. PTV1 was generated by adding 1 cm in all directions(PTV1a) and 0.7 cm in the posterior direction(PTV1b). PTV2 was generated by adding 0.5 cm in all directions(PTV2a) and 0.3 cm in the posterior direction(PTV2b). PTV1a was prescribed to receive 46 Gy in conventional fractionation with a boost dose of 30 Gy to PTV1b. The same dose was prescribed to PTV2a and PTV2b. Calculation of the percentage of intersection between CTV1and CTV2 created on CBCT with the original CTV scan was done. A comparison between the two CTVs(CTV1and CTV2) mean dose and the original delineated CTV was done. Then a comparison to the mean dose of the original CTV of PTV1a, PTV2a(CTV1a and CTV2a), and for PTV1b and PTV2b(CTV1b and CTV2b). Calculation of the mean rectal dose and also V60, V70 and V74 was done on the delineated rectum on every CBCT, and then a comparison to the planned original rectal dose. Results The created CTV1and CTV2 intersection percentage with the original CTV1and CTV2 significantly increased by 85%(range, 65%–95%, P < 0.05), when fiducial markers were used. The main difference of the received mean dose was significantly less in comparison to pelvic bone alignment(0.03% to 2% vs 0.03% to 11.6% for PTV1a, P < 0.006;0.01% to 1.8% vs 0.03% to 10.2% for PTV2a, P < 0.014;0.08 to 2.11 vs 0.04 to 11.29 for PTV1b, P < 0.015 and 0.01 to 1.79 vs 0.01 to 9.69 for PTV2b, P < 0.004). With the use of less PTV margins, significant decrease of the rectal mean dose, V60, V70 and V74 by P < 0.004, P < 0.004, P < 0.0005 and P < 0.009, respectively. Reduction of the CTV1a and CTV1b mean dose by 1.13% and 0.28% in comparison to the initial CTV1a and CTV2a.Conclusion A significant improvement of prostatic cancer patients alignment when fiducial markers are used, with more homogenous dose distribution, and with significant decrease in PTV margins. The delivered rectal dose is significantly less allowing prostate dose escalation.
文摘<strong>Objectives: </strong>Odontoma is the most common type of odontogenic tumors. Many studies have analyzed the statistical associations between odontoma location and patient age and sex, according to the histological tumor type. However, few studies have assessed odontoma morphological characteristics using cone-beam computed tomography (CBCT). We aimed to evaluate the association between odontoma location and size. <strong>Methods:</strong> We performed CBCT on patients with odontomas (19 patients;10 women, 9 men;average age, 12.6 [range, 6 - 34] years) according to the pathology type at a university hospital between April 2008 and February 2017. The locations of the lesions were noted, and their sizes were measured on CBCT images. Buccolingual, mesiodistal, and vertical diameters of the lesions were recorded on the same slice with the greatest diameters on axial, coronal, and sagittal CBCT images. <strong>Results: </strong>Altogether, 9 (47.4%) and 10 (52.6%) odontomas were located in the mandible and maxilla, respectively. There was no significant difference in the mesiodistal and vertical diameters on the CBCT image between the mandibular and maxillary groups when the odontoma size was compared with location (p < 0.05). However, the average diameters in only the buccolingual diameter were significantly greater in the maxilla. There were no significant differences between the two groups according to sex, age, or histological type. <strong>Conclusions: </strong>These data suggest that the sizes of odontomas in the maxilla are affected by bone expansion in the buccolingual direction, but they may be invariable in most settings. Three-dimensional assessment across the age groups suggests a lack of variation in size.
文摘目的探讨新疆地区维吾尔族与汉族患者上颌窦相关线性距离的差异性。方法选取2014年6月-2015年6月新疆医科大学第一附属医院维吾尔族及汉族CBCT影像,测量上颌窦垂直向及近远中向线性距离并进行比较。结果汉族患者上颌窦近远中径的平均距离右侧为(29.1±5.31)mm,左侧为(29.0±4.92)mm;维吾尔族患者右侧为(30.6±4.98)mm,左侧为(30.7±4.74)mm,差异有统计学意义(P<0.05)。女性患者上颌窦近远中径中,汉族患者右侧为(28.9±4.14)mm,左侧为(29.1±4.59)mm;维吾尔族患者右侧为(31.0±4.78)mm,左侧为(31.1±4.70)mm,差异有统计学意义(P<0.05)。汉族患者上颌窦颊腭径的平均距离右侧为(22.5±4.58)mm,左侧为(23.0±4.63)mm;维吾尔族患者右侧为(22.59±4.46)mm,左侧为(23.4±4.55)mm,差异无统计学意义(P>0.05)。汉族患者窦底至牙槽嵴顶的平均高度(residual bone high,RBH)右侧为(9.2±3.86)mm,左侧为(9.2±3.73)mm;维吾尔族患者右侧RBH的平均高度为(9.5±3.53)mm,左侧为(9.1±3.29)mm。汉族缺牙患者右侧RBH为(7.9±4.08)mm,左侧为(6.9±3.41)mm;维吾尔族患者右侧RBH为(7.8±4.46)mm,左侧为(7.7±3.76)mm,差异均无统计学意义(P>0.05)。结论维吾尔族患者上颌窦解剖结构中除上颌窦内壁近远中径大于汉族外,其余结构均基本一致。
