Rare earth elements have unique physical, magnetic, luminescent and catalytic properties. They have been successfully used as medicine and probes in luminescent resonance energy transfer (LRET) for bioassays, as well ...Rare earth elements have unique physical, magnetic, luminescent and catalytic properties. They have been successfully used as medicine and probes in luminescent resonance energy transfer (LRET) for bioassays, as well as reagents for diagnosis in magnetic resonance imaging (MRI). In this progress report, we will focus on recent progress on how rare earth amino complexes bind to DNA and change DNA structure, especially on DNA B-Z transition induced by rare earth amino acid complex and its potential impact on Alzheimer’s disease (AD).展开更多
Protein misfolding is a general causation of classical conformational diseases and many pathogenic changes that are the result of structural conversion.Here I review recent progress in clinical and computational appro...Protein misfolding is a general causation of classical conformational diseases and many pathogenic changes that are the result of structural conversion.Here I review recent progress in clinical and computational approaches for each stage of the misfolding process,aiming to present readers an outline for swift comprehension of this field.展开更多
基金Project supported by the NSFC (20831003, 90813001, 20903086)Funds from CAS
文摘Rare earth elements have unique physical, magnetic, luminescent and catalytic properties. They have been successfully used as medicine and probes in luminescent resonance energy transfer (LRET) for bioassays, as well as reagents for diagnosis in magnetic resonance imaging (MRI). In this progress report, we will focus on recent progress on how rare earth amino complexes bind to DNA and change DNA structure, especially on DNA B-Z transition induced by rare earth amino acid complex and its potential impact on Alzheimer’s disease (AD).
文摘Protein misfolding is a general causation of classical conformational diseases and many pathogenic changes that are the result of structural conversion.Here I review recent progress in clinical and computational approaches for each stage of the misfolding process,aiming to present readers an outline for swift comprehension of this field.
