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Study on the Textual Coherence Function of Conjunctions in Political Texts and Their Translation Reconstruction
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作者 Goya Guli Kader Jingwen Qiao Aixia Yang 《Journal of Contemporary Educational Research》 2024年第1期25-30,共6页
The assessment of translation quality in political texts is primarily based on achieving effective communication.Throughout the translation process,it is essential to not only accurately convey the original content bu... The assessment of translation quality in political texts is primarily based on achieving effective communication.Throughout the translation process,it is essential to not only accurately convey the original content but also effectively transform the structural mechanisms of the source language.In the translation reconstruction of political texts,various textual cohesion methods are often employed,with conjunctions serving as a primary means for semantic coherence within text units. 展开更多
关键词 Political texts conjunctionS Textual cohesion Chinese to Russian translation
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PHASE STRUCTURE FACTOR AND INTERFACE CONJUNCTION FACTOR OF CAST IRON AND ITS COMPOSITION DESIGN 被引量:3
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作者 Z.L.Li,Z.L.Liu ,F.Y.Li,X.P.Yang and Z.G.Gu Departmentof Materials Science and Engineering ,Liaoning Institute of Technology,Jinzhou 121001 ,China 《Acta Metallurgica Sinica(English Letters)》 SCIE EI CAS CSCD 1999年第4期401-407,共7页
Theempiricalelectrontheory of solidsand molecules( EET) and theimproved TFDtheory wereapplied tocalculatethe phasestructurefactorsand interfaceconjunction factorsofcom mon alloying elementsincastiron. Akind of Si- M... Theempiricalelectrontheory of solidsand molecules( EET) and theimproved TFDtheory wereapplied tocalculatethe phasestructurefactorsand interfaceconjunction factorsofcom mon alloying elementsincastiron. Akind of Si- Mo- Cu ductileiron with rareearth Mg asnodularizer was designed accordingtothese valenceelectron structure parameters. Actual applicationtestsshow thatthelongevity of thisiron is 1.5 timesof thatof high manganesesteel. This accordance of theoretical results and actual effectsshows the composition design methodcan beused in othercastiron research. 展开更多
关键词 phasestructure factor interface conjunction factor ductile iron wear resistance composition design
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Research on the Occurrences of Causality Conjunctions in Korean Based on Corpus
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作者 李岩 胡翠月 《海外英语》 2019年第21期267-269,共3页
Corpus is a kind of database that may contain texts in a single language(monolingual corpus)or text data in multiple languages(multilingual corpus).Most of the words can be involved in such a database,so it is provide... Corpus is a kind of database that may contain texts in a single language(monolingual corpus)or text data in multiple languages(multilingual corpus).Most of the words can be involved in such a database,so it is provided with significant realistic meaning for language learners.Also,the use of causality conjunction in Korean plays a more important guiding role in listening,speaking,reading and writing of Korean.However,the status with regard to the application of causality conjunction in Korean is not optimistic and the problems such as the improper use of language,lack of knowledge about conjunction by learners,short of professional Korean teaching consciousness by teachers and others are being,thereby seriously hindering the learning interests of Korean learners and educational progress.Thus,in accordance with research status at home and abroad,this paper carries out indepth analysis on the basic theory of corpus and Korean conjunction as well as the application of causality conjunction in Korean based on the corpus.And it can be found that the research on the application of causality conjunction in Korean based on corpus is with important value for both the flexible use of language and the improvement of comprehensive application ability of language. 展开更多
关键词 CORPUS conjunction ERROR analysis KOREAN CAUSALITY
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The Path of Grammaticalization for Coordinate Conjunctions and its Universality 被引量:1
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作者 Ma Qinghua 《宏观语言学》 2007年第1期82-103,共22页
From the study of polysemy of coordinate conjunctions, it can be found that there are grammaticalization processes from coordination to transition and from coordination to succession. It is a general evolutionary proc... From the study of polysemy of coordinate conjunctions, it can be found that there are grammaticalization processes from coordination to transition and from coordination to succession. It is a general evolutionary process in connective structures to go from non-specific semantic relationship to specific semantic relationship. This was caused by the cognitive tendency of approximately substituting typical functions for atypical functions. 展开更多
关键词 conjunction COORDINATION transition SUCCESSION GRAMMATICALIZATION UNIVERSALITY
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Conjunction and Teaching Reading Skills in English 被引量:2
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《基础教育外语教学研究》 2005年第4期-,共5页
Conjunction contributes to organizing and managing stretches of discourse, indicating the way the information is arranged. Successfully identifying these discourse markers is of great benefit to the reader to extract ... Conjunction contributes to organizing and managing stretches of discourse, indicating the way the information is arranged. Successfully identifying these discourse markers is of great benefit to the reader to extract the required information from what he/she reads, especially for the candidates who are tested for their reading abilities in a given time, for these markers give clues to the reader and make the perception easier and save a lot of time. To teach students to explore reading skills and read su... 展开更多
关键词 conjunction Teaching reading skills APPLICATION
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On the conjunction practical stability and controllability of large-scale impulsive control systems
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作者 Dilan GHEN Jitao SUN 《控制理论与应用(英文版)》 EI 2005年第2期181-185,共5页
We studied the conjunction practical stability and controllability of large-scale impulsive control systems by using the comparison systems and vector Lyapunov fimctions. Then the less conservative sufficient conditio... We studied the conjunction practical stability and controllability of large-scale impulsive control systems by using the comparison systems and vector Lyapunov fimctions. Then the less conservative sufficient conditions for conjunction practical stability and controllability of large-scale impulsive control system were obtained. 展开更多
关键词 Large-scale impulsive dynamic system Impulsive control conjunction practical stability CONTROLLABILITY
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The Development of Successive Conjunctions of Chinese
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作者 SUN Yong-fang 《Journal of Literature and Art Studies》 2019年第7期669-674,共6页
The paper explored the development of successive conjunctions from Archaic Chinese to Contemporary Chinese from a macroscopic perspective.Data statistics and diachronic study method were adopted in this paper,and the ... The paper explored the development of successive conjunctions from Archaic Chinese to Contemporary Chinese from a macroscopic perspective.Data statistics and diachronic study method were adopted in this paper,and the results indicated that a quantity of new successive conjunctions have been produced both in Archaic Chinese and Mid-ancient Chinese,and at the same time a very large proportion of the old successive conjunctions were superseded by the new.Those which appeared in very few types of corpus and have low frequency of use are more likely to be eliminated.In Contemporary Chinese,the successive conjunction system tends to be stable and concise. 展开更多
关键词 successive conjunction DEVELOPMENT DIACHRONIC study CHINESE
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English Connector as Binding Term for Conjunction and Relative Pronoun
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作者 Japen Sarage 《Sino-US English Teaching》 2015年第9期660-666,共7页
As grammatical words, conjunction and relative pronoun play a similar role. They join clauses, phrases, and even words. The terms independent and dependent clauses have become popular for quite a long time. When the c... As grammatical words, conjunction and relative pronoun play a similar role. They join clauses, phrases, and even words. The terms independent and dependent clauses have become popular for quite a long time. When the concept of clause and sentence meets at the presence of NP (Noun Phrase) and VP (Verb Phrase), there is a right to consider construction as an S or a sentence leaving the conjunction and relative pronoun as means of uniting device and leaving every NP-VP construction as equal units. By employing an embedding theory, we can see hidden parts of a sentence and their roles in other sentences. This article tries to see if it is still necessary to distinguish between dependent and independent clauses. 展开更多
关键词 CONNECTOR conjunction relative pronoun
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The Cohesion with Conjunction in the Press Release Discourse --On Press Release Education First, 26 September, 2012, US
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作者 Cui can 《International English Education Research》 2014年第3期197-202,共6页
Conjunction occupies an important part in discourse analysis, especially in the connecting analysis. The application of conjunction can achieve cohesion. However, according to the definition of register and genre, it ... Conjunction occupies an important part in discourse analysis, especially in the connecting analysis. The application of conjunction can achieve cohesion. However, according to the definition of register and genre, it is hard to find the total or completed function of these conjunctions in press release. The reason why this kind of phenomenon comes cross should be discussed in this paper. For doing this research, the researcher chooses one discourse which was found at www. globaleducationfirst.com as the material and select the conjunction out to prove the function of connection in application. As a kind of research, the aim or target is more important because as all paper goes, the purpose should be concentrated on. Why a style like news broadcasting or press release has so little conjunction functions as, for example, addition, means and, or contradictive but, however, and yet, or condition/f and so on. Some of them functions as internal, but others external. Whether it is the deliberate consideration or free formation by the editor is finally should be discussed, and from this point of view, conjunction' s function in press release reaches the target of cohesion 展开更多
关键词 conjunction internal external register and genre press release discourse connection COHESION
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Kepler’s Conjunction for Two Strong Earthquakes in Türkiye in February 2023
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作者 Alexander N. Safronov 《Open Journal of Earthquake Research》 2023年第2期27-43,共17页
This work is devoted to the study of the relationship between strong earthquakes and planetary configurations using the example of two consecutive strong earthquakes that occurred in Türkiye (Turkey), on February... This work is devoted to the study of the relationship between strong earthquakes and planetary configurations using the example of two consecutive strong earthquakes that occurred in Türkiye (Turkey), on February 6, 2023. It is shown that at the time of the earthquakes, linear alignment of the planets along the Jupiter-Venus-Sun line was observed, that is, the astronomical trigger belonged to the generalized Kepler conjunction scheme (gKc), when the Earth does not participate in the linearization scheme. It is shown that for the first earthquake that occurred at 01:17 UTC, the ratio of the distances between Jupiter-Earth and Jupiter-Mars was close to an integer value equal to 5.993. For the second earthquake that occurred on the same day at 10:25 UTC, no integer resonance ratios were detected, however, it was found that the terrestrial e UTC line at the time of the earthquake passed through the position of Mercury. Recall that the 12-hour line of the eUTC chart is always oriented towards the Sun. The conclusions of the work once again confirm the correctness of the theories of Archimedes and Kepler and convince us of the existence of a gravitational phenomenon that does not depend on the distances and masses of planets, has a pronounced inertial and wave character and does not fit into the general theory of relativity, developed in the last century by Albert Einstein. 展开更多
关键词 Earthquake Archimedes Lever Kepler conjunction INERTIA Gravitational Waves Titius-Bode Law Interference
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CALL FOR PAPERS Workshop on Intelligence and Security Informatics (WISI’06) in conjunction with the Pacific Asia Conference on Knowledge Discovery and Data Mining (PAKDD’06)
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《复杂系统与复杂性科学》 EI CSCD 2005年第1期84-86,共3页
Important Dates Submission due November 15, 2005 Notification of acceptance December 30, 2005 Camera-ready copy due January 10, 2006 Workshop Scope Intelligence and Security Informatics (ISI) can be broadly defined as... Important Dates Submission due November 15, 2005 Notification of acceptance December 30, 2005 Camera-ready copy due January 10, 2006 Workshop Scope Intelligence and Security Informatics (ISI) can be broadly defined as the study of the development and use of advanced information technologies and systems for national and international security-related applications. The First and Second Symposiums on ISI were held in Tucson,Arizona,in 2003 and 2004,respectively. In 2005,the IEEE International Conference on ISI was held in Atlanta,Georgia. These ISI conferences have brought together academic researchers,law enforcement and intelligence experts,information technology consultant and practitioners to discuss their research and practice related to various ISI topics including ISI data management,data and text mining for ISI applications,terrorism informatics,deception detection,terrorist and criminal social network analysis,crime analysis,monitoring and surveillance,policy studies and evaluation,information assurance,among others. We continue this stream of ISI conferences by organizing the Workshop on Intelligence and Security Informatics (WISI’06) in conjunction with the Pacific Asia Conference on Knowledge Discovery and Data Mining (PAKDD’06). WISI’06 will provide a stimulating forum for ISI researchers in Pacific Asia and other regions of the world to exchange ideas and report research progress. The workshop also welcomes contributions dealing with ISI challenges specific to the Pacific Asian region. 展开更多
关键词 SECURITY in conjunction with the Pacific Asia Conference on Knowledge Discovery and Data Mining CALL FOR PAPERS Workshop on Intelligence and Security Informatics ASIA
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The 4th International Exhibition on Refractories, Industrial Ceramics and Furnaces(RCF Expo'2003)Beijing, China, April 15-17, 2003In conjunction with China Refractories Seminar' 2003-Technology and Markets
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《China's Refractories》 CAS 2003年第1期44-44,共1页
Organizers and Sponsors: China Association of Refractories Industry The Chinese Society for Metals The Chinese Ceramic Society
关键词 2003 Industrial Ceramics and Furnaces conjunction with China Refractories Seminar Technology and Markets The 4th International Exhibition on Refractories April 15-17 China on with
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Application of Conjunction in English Teaching
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作者 Jian Yang 《Sino-US English Teaching》 2006年第7期48-51,共4页
This paper discusses the application of conjunction in English teaching. Conjunction, which is in the framework of Systematic Functional Grammar, can be specifically applied in English reading and writing to help stud... This paper discusses the application of conjunction in English teaching. Conjunction, which is in the framework of Systematic Functional Grammar, can be specifically applied in English reading and writing to help students' better grasp of English. It is beneficial for English teachers to teach some English linguistic knowledge to students in language teaching. 展开更多
关键词 Systematic Functional Grammar conjunction English teaching
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ZTE USA Announces Its First Corporate Partnership and Consumer Marketing Push in Conjunction with the Houston Rockets
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作者 ZTE Corporation 《ZTE Communications》 2013年第3期61-61,共1页
5 October 2013, Houston--The Houston Rockets and ZTE USA, the fastest-growing smartphone provider in the United States, announced that ZTE will be the official smartphone of the Houston Rockets for the 2013-14 NBA sea... 5 October 2013, Houston--The Houston Rockets and ZTE USA, the fastest-growing smartphone provider in the United States, announced that ZTE will be the official smartphone of the Houston Rockets for the 2013-14 NBA season. This is the first partnership of its kind for ZTE globally and the first big consumer marketing push in the United States since the company entered the country 15 years ago. 展开更多
关键词 ZTE USA Announces Its First Corporate Partnership and Consumer Marketing Push in conjunction with the Houston Rockets PUSH USA
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A Case Study of Inter-sentence Conjunctions in Chinese/English Legal Parallel Texts
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作者 Yan Xi 《宏观语言学》 2009年第1期122-131,共10页
The present study is a contrastive study of inter-sentence conjunctions in Chinese/English legal parallel texts. Conjunction is one of the five cohesive devices put forward by Halliday and Hasan (1976). Many scholars ... The present study is a contrastive study of inter-sentence conjunctions in Chinese/English legal parallel texts. Conjunction is one of the five cohesive devices put forward by Halliday and Hasan (1976). Many scholars have applied their model of cohesion to the study of English and Chinese languages. As for the use of conjunction in Chinese and English, most scholars believe that there are more cases of conjunction in the English legal texts than in the Chinese ones because it is generally considered that Chinese is predominantly paratactic and English mainly hypotactic. Besides, up to now little detailed contrastive study has been done on conjunctions in Chinese/English non-literary texts. 展开更多
关键词 conjunction CHINESE and ENGLISH LEGAL parallel texts HYPOTAXIS PARATAXIS
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The Effect of BCG-PSN on T-cell Subsets and Cytokines in Vernal Conjunctivitis 被引量:6
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作者 HU Jun +3 位作者 (胡军) CHEN Huan (陈欢) 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 2002年第1期77-79,共3页
The effects of BCG PSN on T cell subsets and cytokines in vernal conjunctivitis were observed. The level of total IgE was quantitatively determined before and after treatment with BCG PSN by allergen diagnostic ins... The effects of BCG PSN on T cell subsets and cytokines in vernal conjunctivitis were observed. The level of total IgE was quantitatively determined before and after treatment with BCG PSN by allergen diagnostic instrument in vitro . The content of T cell subsets of peripheral blood and cytokine were determined by using indirect immune fluorescence method, and IL 4 and INF γ were quantified by ELISA. The results showed that the level of total IgE was substantially reduced ( P <0.01) after treatment in the BCG PSN group. Meanwhile, CD + 8 was decreased, CD + 4 and CD + 4/CD + 8 ratio elevated with significant differences ( P <0.05) as compared with pre treatment results. The changes in total IgE, CD + 8 ,CD + 4 and CD + 4/CD + 8 ratio after treatment also presented significant differences ( P <0.05) between BCG PSN group and routine treatment group. The level of IL 4 in serum declined ( P <0.05) after treatment in the BCG PSN group, and INF γ went up ( P <0 05). IL 4 and INF γ in serum showed significant differences ( P <0.05) between two groups after treatment. It is concluded that BCG PSN has a bi directional immunoregulating effect. It can bring CD + 4 and CD + 8 into homeostasis, thereby preventing the occurrence of anaphylaxis. At the same time, BCG PSN can restrain Th 2, decrease the synthesis of IL 4, switch the balance of Th l/Th 2 to Th 1 side, boost up the predominance of Th 1 relatively, which is propitious to perennial stabilization and recovery of vernal conjunctivitis. 展开更多
关键词 BCG PSN vernal conjunctivitis T cell subsets CYTOKINE
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Effects of vernal and allergic conjunctivitis on severity of keratoconus 被引量:4
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作者 Abdullah Kursat Cingu Yasin Cinar +5 位作者 Fatih Mehmet Turkcu Alparslan Sahin Seyhmus Ari Harun Yuksel Muhammed Sahin Ihsan Caca 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2013年第3期370-374,共5页
AIM: To demonstrate the effects of two different types of allergic conjunctivitis on severity of keratoconus (KC). ·METHODS: We retrospectively reviewed the medical records of 171 KC patients referred between Jun... AIM: To demonstrate the effects of two different types of allergic conjunctivitis on severity of keratoconus (KC). ·METHODS: We retrospectively reviewed the medical records of 171 KC patients referred between June 2010 and June 2011. The KC patients were divided into 3 groups as KC (group A), KC with vernal keratoconjunctivitis (VKC) (group B) and KC with allergic conjunctivitis (AC) (group C). Main outcome measures were demographic and ocular clinical features including age at presentation, gender, spherical equivalent (SE), best spectacle corrected visual acuity (BCVA), mean keratometric measurement (Km), central corneal thickness (CCT), and intraocular pressure (IOP). Groups were compared in term of study variables. · RESULTS: The median age at presentation was significantly lower in group B (P 【0.001). According to the median SE (P =0.003), BCVA(P =0.022), Km(P 【0.001), CCT (P =0.015) and Amsler-Krumeich classification (P 【 0.001), KC was more severe in group B. There was no significant difference in terms of IOP and corrected IOP among the groups (P =0.44), however there were 4 patients who had increased corrected IOP developed after topical corticosteroid use in group B. The differences among the groups persisted even after controlling for age and gender. · CONCLUSION: Our findings demonstrated a more severe KC in VKC patients despite their younger age which suggests evaluation of VKC patients as a separate group in keratoconus disease. 展开更多
关键词 KERATOCONUS vernal keratoconjunctivitis allergic conjunctivitis intraocular pressure
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Effect of diluted povidone iodine in adenoviral keratoconjunctivitis on the rate of subepithelial corneal infiltrates 被引量:2
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作者 Rana Altan-Yaycioglu Nedime Sahinoglu-Keskek +2 位作者 Handan Canan Muge Coban-Karatas Burak Ulas 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2019年第9期1420-1425,共6页
AIM: To evaluate the clinical characteristics of adenoviral keratoconjunctivitis, the management modalities, as well as the incidence of subepithelial corneal infiltrates(SEI).METHODS: Patients with characteristic cli... AIM: To evaluate the clinical characteristics of adenoviral keratoconjunctivitis, the management modalities, as well as the incidence of subepithelial corneal infiltrates(SEI).METHODS: Patients with characteristic clinical symptoms and signs, who presented to our clinic within the first week of symptoms and received the diagnosis of adenoviral keratoconjunctivitis between January 2013 and April 2016, were included in the study. A total of 211 patients were included in the study. Patients were evaluated for the incidence of clinical signs, late complications, management preferences, and the effect of diluted povidone-iodine(d-PVP-I) 2%. RESULTS: Patients’ mean age was 33.03±14.76 y. We observed an increase in the number of cases according to the years. At presentation and/or early follow-up, the clinical signs were conjunctival hyperemia(100%), conjunctival follicules(79.1%), edema of the eyelids(39.3%), chemosis(16.1%), pseudomembrane formation(16.6%), and corneal epitheliopathy(29.9%). During late follow-up 13.3% patients developed conjunctival subepithelial fibrosis, and 39.8% developed SEI. A significant decrease in the incidence of SEI development was observed in patients who used d-PVP-I 2%(P=0.032;33.3% vs 45.9%, respectively in patients who received d-PVP-I 2% and who did not).CONCLUSION: Adenoviral keratoconjunctivitis has a tremendous effect on patient’s comfort and abilities in short-term. Additionally, almost half of the patients develop visual problems related to SEI. According to our clinical experience, using d-PVP-I 2% in the first days of adenoviral keratoconjunctivitis might be helpful in reducing the risk of SEI as a complication. 展开更多
关键词 conjunctIVITIS CORNEAL OPACITY infectious KERATOconjunctIVITIS KERATOconjunctIVITIS POVIDONE-IODINE viral conjunctIVITIS
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The efficacy and safety of besifloxacin for acute bacterial conjunctivitis: a Meta-analysis 被引量:3
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作者 Jun-Jie Wang Xin-Yi Gao +1 位作者 Hong-Zhuo Li Shan-Shuang Du 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2019年第6期1027-1036,共10页
AIM: To evaluate the relative efficacy and safety of besifloxacin for treatment of acute bacterial conjunctivitis.METHODS: A comprehensive search in PubMed, EMBASE Web of Science, Cochrane Central Database and CNKI wa... AIM: To evaluate the relative efficacy and safety of besifloxacin for treatment of acute bacterial conjunctivitis.METHODS: A comprehensive search in PubMed, EMBASE Web of Science, Cochrane Central Database and CNKI was undertaken for randomized controlled trials(RCTs) comparing besifloxacin with other treatments or placebo. The primary outcome measures were clinical resolution, rates of bacterial eradication, individual clinical outcomes, cure rates, and bacterial eradication rates of different kinds of pathogens. Safety outcomes were the number of adverse effects(AEs). The final search was performed on August 2018.RESULTS: Eight RCTs were included. Five studies compared the efficacy and safety of besifloxacin with placebo, 2 studies compared besifloxacin with moxifloxacin, and 1 study compared besifloxacin with gatifloxacin. A total of 3105 patients met the inclusion criteria. Besifloxacin presented higher efficacy and safety than did placebo in clinical resolution, rates of bacterial eradication, individual clinical outcomes, cure rates, bacterial eradication rates of different kinds of pathogens and the number of AEs. There was no significant difference between besifloxacin and moxifloxacin or gatifloxacin in the comparison items mentioned above.CONCLUSION: Besifloxacin is highly effective and safe for treatment of acute bacterial conjunctivitis. Further comparative trials regarding the effect of besifloxacin for treatment of acute bacterial conjunctivitis will aid in treatment decisions. 展开更多
关键词 besifloxacin ACUTE BACTERIAL conjunctIVITIS META-ANALYSIS RANDOMIZED CONTROLLED trials
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Semaphorin 3A controls allergic and inflammatory responses in experimental allergic conjunctivitis 被引量:5
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作者 Junmi Tanaka Hideo Tanaka +8 位作者 Nobuhisa Mizuki Eiichi Nomura Norihiko Ito Naoko Nomura Masayuki Yamane Tomonobu Hida Yoshio Goshima Hiroshi Hatano Hisashi Nakagawa 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2015年第1期1-10,共10页
AIM: To assess the efficacy of topical Semaphorin 3A(SEMA3A) in the treatment of allergic conjunctivitis.METHODS: Experimental allergic conjunctivitis(EAC)mice model induced by short ragweed pollen(SRW) in 4-week-old ... AIM: To assess the efficacy of topical Semaphorin 3A(SEMA3A) in the treatment of allergic conjunctivitis.METHODS: Experimental allergic conjunctivitis(EAC)mice model induced by short ragweed pollen(SRW) in 4-week-old of BALB/c mice, mice were evaluated using haematoxylin and eosin(H&E) staining, immunofluor-escence and light microscope photographs. Early phase took the samples in 24 h after instillation and late phase took the samples between 4 to 14 d after the start of treatment. The study use of topical SEMA3A(10 U, 100 U,1000 U) eye drops and subconjunctival injection of SEMA3 A with same concentration. For comparison, five types of allergy eyedrops were quantified using clinical characteristics.· RESULTS: Clinical score of composite ocular symptoms of the mice treated with SEMA3 A were significantly decreased both in the immediate phase and the late phase compared to those treated with commercial ophthalmic formulations and non-treatment mice. SEMA3 A treatment attenuates infiltration of eosinophils entering into conjunctiva in EAC mice. The score of eosinophil infiltration in the conjunctiva of SEMA3 A 1000 U-treated group were significantly lower than low-concentration of SEMA3 A treated groups and non-treated group. SEMA3 A treatment also suppressed T-cell proliferation in vitro and decreased serum total Ig E levels in EAC mice. Moreover, treatment of SEMA3 A suppressed Th2-related cytokines(IL-5, IL-13 and IL-4)and pro-inflammatory cytokines(IFN-γ, IL-17 and TNF-α)release, but increased regulatory cytokine IL-10 concentration in the conjunctiva of EAC mice.CONCLUSION: SEMA3 A as a biological agent, showed the beneficial activity in ocular allergic processes with the less damage to the intraocular tissue. It is expected that SEMA3 A may be contributed in patients with a more severe spectrum of refractory ocular allergic diseases including allergic conjunctivitis in the near future. 展开更多
关键词 Semaphorin 3A experimental allergic conjunctivitis eosinophil infiltration serum total Ig E cytokines INSTILLATION subconjunctival administration
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