Loss of synapse and functional connectivity in brain circuits is associated with aging and neurodegeneration,however,few molecular mechanisms are known to intrinsically promote synaptogenesis or enhance synapse functi...Loss of synapse and functional connectivity in brain circuits is associated with aging and neurodegeneration,however,few molecular mechanisms are known to intrinsically promote synaptogenesis or enhance synapse function.We have previously shown that MET receptor tyrosine kinase in the developing cortical circuits promotes dendritic growth and dendritic spine morphogenesis.To investigate whether enhancing MET in adult cortex has synapse regenerating potential,we created a knockin mouse line,in which the human MET gene expression and signaling can be turned on in adult(10–12 months)cortical neurons through doxycycline-containing chow.We found that similar to the developing brain,turning on MET signaling in the adult cortex activates small GTPases and increases spine density in prefrontal projection neurons.These findings are further corroborated by increased synaptic activity and transient generation of immature silent synapses.Prolonged MET signaling resulted in an increasedα-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid/N-methyl-Daspartate(AMPA/NMDA)receptor current ratio,indicative of enhanced synaptic function and connectivity.Our data reveal that enhancing MET signaling could be an interventional approach to promote synaptogenesis and preserve functional connectivity in the adult brain.These findings may have implications for regenerative therapy in aging and neurodegeneration conditions.展开更多
When charged bodies come up close to each other,the field energy is diffused and their states are regulated under bidirectional field coupling.For biological neurons,the diversity in intrinsic electric and magnetic fi...When charged bodies come up close to each other,the field energy is diffused and their states are regulated under bidirectional field coupling.For biological neurons,the diversity in intrinsic electric and magnetic field energy can create synaptic connection for fast energy balance and synaptic current is passed across the synapse channel;as a result,energy is pumped and exchanged to induce synchronous firing modes.In this paper,a capacitor is used to connect two neural circuits and energy propagation is activated along the coupling channel.The intrinsic field energy in the two neural circuits is exchanged and the coupling intensity is controlled adaptively using the Heaviside function.Some field energy is saved in the coupling channel and is then sent back to the coupled neural circuits to reach energy balance.Therefore the circuits can reach possible energy balance and complete synchronization.It is possible that the diffusive energy of the coupled neurons inspires the synaptic connections to grow stronger for possible energy balance.展开更多
随着分布式电源(distributed generation,DG)的容量变化,微电网原有的供电结构发生改变,使得潮流大小、方向和功率结构发生变化,对快速检测和定位微电网中的短路故障区域提出了挑战。在MATLAB/Simulink中搭建低压交流微电网模型;通过高...随着分布式电源(distributed generation,DG)的容量变化,微电网原有的供电结构发生改变,使得潮流大小、方向和功率结构发生变化,对快速检测和定位微电网中的短路故障区域提出了挑战。在MATLAB/Simulink中搭建低压交流微电网模型;通过高尺度小波能量谱算法对微电网与大电网公共连接点(point of common coupling,PCC)处检测到的电流进行分解,提取适应不同容量情况的短路故障特征值,实现了不同容量下微电网短路故障的早期检测;利用小波能量谱特征结合基于正交最小二乘法(orthogonal least square,OLS)的径向基函数(radial basis function,RBF)神经网络算法提出一种适用于不同容量微电网的短路故障区域定位方法,并进行仿真验证;在此基础上设计并网模式微电网短路故障保护硬件系统,并进行实验验证。结果表明,所设计的保护系统能够快速、准确地同时实现并网模式下交流微电网短路故障的早期检测与区域定位。展开更多
基金supported by NIH/NIMH grant R01MH111619(to SQ),R21AG078700(to SQ)Institute of Mental Health Research(IMHR,Level 1 funding,to SQ and DF)institution startup fund from The University of Arizona(to SQ)。
文摘Loss of synapse and functional connectivity in brain circuits is associated with aging and neurodegeneration,however,few molecular mechanisms are known to intrinsically promote synaptogenesis or enhance synapse function.We have previously shown that MET receptor tyrosine kinase in the developing cortical circuits promotes dendritic growth and dendritic spine morphogenesis.To investigate whether enhancing MET in adult cortex has synapse regenerating potential,we created a knockin mouse line,in which the human MET gene expression and signaling can be turned on in adult(10–12 months)cortical neurons through doxycycline-containing chow.We found that similar to the developing brain,turning on MET signaling in the adult cortex activates small GTPases and increases spine density in prefrontal projection neurons.These findings are further corroborated by increased synaptic activity and transient generation of immature silent synapses.Prolonged MET signaling resulted in an increasedα-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid/N-methyl-Daspartate(AMPA/NMDA)receptor current ratio,indicative of enhanced synaptic function and connectivity.Our data reveal that enhancing MET signaling could be an interventional approach to promote synaptogenesis and preserve functional connectivity in the adult brain.These findings may have implications for regenerative therapy in aging and neurodegeneration conditions.
基金Project supported by the National Natural Science Foundation of China(Grant No.12062009)the Gansu National Science of Foundation,China(Grant No.20JR5RA473)。
文摘When charged bodies come up close to each other,the field energy is diffused and their states are regulated under bidirectional field coupling.For biological neurons,the diversity in intrinsic electric and magnetic field energy can create synaptic connection for fast energy balance and synaptic current is passed across the synapse channel;as a result,energy is pumped and exchanged to induce synchronous firing modes.In this paper,a capacitor is used to connect two neural circuits and energy propagation is activated along the coupling channel.The intrinsic field energy in the two neural circuits is exchanged and the coupling intensity is controlled adaptively using the Heaviside function.Some field energy is saved in the coupling channel and is then sent back to the coupled neural circuits to reach energy balance.Therefore the circuits can reach possible energy balance and complete synchronization.It is possible that the diffusive energy of the coupled neurons inspires the synaptic connections to grow stronger for possible energy balance.
文摘随着分布式电源(distributed generation,DG)的容量变化,微电网原有的供电结构发生改变,使得潮流大小、方向和功率结构发生变化,对快速检测和定位微电网中的短路故障区域提出了挑战。在MATLAB/Simulink中搭建低压交流微电网模型;通过高尺度小波能量谱算法对微电网与大电网公共连接点(point of common coupling,PCC)处检测到的电流进行分解,提取适应不同容量情况的短路故障特征值,实现了不同容量下微电网短路故障的早期检测;利用小波能量谱特征结合基于正交最小二乘法(orthogonal least square,OLS)的径向基函数(radial basis function,RBF)神经网络算法提出一种适用于不同容量微电网的短路故障区域定位方法,并进行仿真验证;在此基础上设计并网模式微电网短路故障保护硬件系统,并进行实验验证。结果表明,所设计的保护系统能够快速、准确地同时实现并网模式下交流微电网短路故障的早期检测与区域定位。
