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不同病情乙型肝炎患者HBV-DNA定量、两对半检测结果差异
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作者 陈静 金灿灿 +2 位作者 周皓鹏 张茜蕙 梅辉 《中国医药科学》 2024年第5期161-164,168,共5页
目的分析乙型肝炎患者乙型肝炎病毒(HBV)-DNA定量检测与两对半检测结果的相关性,并观察不同病情HBV-DNA阳性率和两对半检测结果差异。方法选取江苏省泰兴市人民医院2021年4月至2023年4月收治的375例乙型肝炎患者病例为研究资料。比较不... 目的分析乙型肝炎患者乙型肝炎病毒(HBV)-DNA定量检测与两对半检测结果的相关性,并观察不同病情HBV-DNA阳性率和两对半检测结果差异。方法选取江苏省泰兴市人民医院2021年4月至2023年4月收治的375例乙型肝炎患者病例为研究资料。比较不同乙肝两对半检测[乙肝表面抗原(HBsAg)、乙肝表面抗体(HBsAb)、乙肝e抗原(HBeAg)、乙肝e抗体(HBeAb)、乙肝核心抗体(HBcAb)]结果患者HBV-DNA定量检测结果差异,将患者根据HBV-DNA定量检测结果分为阳性组和阴性组,比较乙肝两对半结果差异,使用Pearson相关性分析;将患者根据疾病类型分为肝炎组、肝硬化组和肝癌组,比较三组患者乙肝两对半和HBV-DNA定量检测结果差异。结果不同乙肝两对半类型患者HBV-DNA阳性率比较,差异有统计学意义(P<0.05);HBV-DNA阳性组患者HBsAg、HBeAg水平高于HBV-DNA阴性组,HBsAb、HBeAb、HBcAb水平低于HBV-DNA阴性组,差异有统计学意义(P<0.05);HBsAg、HBeAg水平与HBV-DNA呈正相关(P<0.05),HBsAb、HBeAb、HBcAb水平与HBV-DNA呈负相关(P<0.05);不同疾病类型患者乙肝两对半类型HBV-DNA阳性率比较,差异有统计学意义(P<0.05),不同疾病类型患者HBV-DNA定量检测结果比较,差异有统计学意义(P<0.05)。结论乙型肝炎患者HBV-DNA定量检测与两对半检测结果有相关性,不同乙肝两对半类型间及不同疾病类型间HBV-DNA均有差异,HBV-DNA定量检测联合两对半检测可较好地反映病毒复制和疾病进展情况,为临床治疗提供指导。 展开更多
关键词 乙型肝炎 乙肝两对半 hbv-dna定量 相关性分析
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HBV-DNA病毒载量在不同HBV感染产妇产后血清、唾液、乳汁中的变化及与肝功能的相关性研究
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作者 程苗 袁果 +2 位作者 郭宾 郑艳冰 张静 《临床医学工程》 2024年第2期203-204,共2页
目的 观察不同HBV感染产妇的HBV-DNA病毒载量及其与肝功能的相关性。方法 102例HBV产妇根据HBV血清标志物分为三组,比较各组的HBV-DNA载量以及ALT、 AST水平,分析HBV-DNA载量与肝功能的相关性。结果 产妇血清、唾液、乳汁中的HBV-DNA载... 目的 观察不同HBV感染产妇的HBV-DNA病毒载量及其与肝功能的相关性。方法 102例HBV产妇根据HBV血清标志物分为三组,比较各组的HBV-DNA载量以及ALT、 AST水平,分析HBV-DNA载量与肝功能的相关性。结果 产妇血清、唾液、乳汁中的HBV-DNA载量,以及血清中ALT、 AST水平由高到低依次为A组、 B组、 C组(P <0.05)。不同HBV感染产妇的血清、唾液、乳汁HBV-DNA载量与ALT、 AST水平均呈正相关(P <0.05)。结论 随着HBV感染程度的加深,产妇血清、唾液、乳汁中的HBV-DNA病毒载量呈上升趋势,产后血清、唾液及乳汁中HBV-DNA病毒载量均与肝功能密切相关。 展开更多
关键词 hbv-dna 病毒载量 血清 唾液 乳汁 肝功能
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Mechanical properties and acoustic emission characteristics of soft rock with different water contents under dynamic disturbance 被引量:1
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作者 Yujing Jiang Lugen Chen +4 位作者 Dong Wang Hengjie Luan Guangchao Zhang Ling Dong Bin Liang 《International Journal of Coal Science & Technology》 EI CAS CSCD 2024年第3期135-148,共14页
Uniaxial compression tests and cyclic loading acoustic emission tests were conducted on 20%,40%,60%,80%,dry and saturated muddy sandstone by using a creep impact loading system to investigate the mechanical properties... Uniaxial compression tests and cyclic loading acoustic emission tests were conducted on 20%,40%,60%,80%,dry and saturated muddy sandstone by using a creep impact loading system to investigate the mechanical properties and acoustic emission characteristics of soft rocks with different water contents under dynamic disturbance.The mechanical properties and acoustic emission characteristics of muddy sandstones at different water contents were analysed.Results of experimental studies show that water is a key factor in the mechanical properties of rocks,softening them,increasing their porosity,reducing their brittleness and increasing their plasticity.Under uniaxial compression,the macroscopic damage characteristics of the muddy sandstone change from mono-bevel shear damage and‘X’type conjugate bevel shear damage to a roadway bottom-drum type damage as the water content increases.Dynamic perturbation has a strengthening effect on the mechanical properties of samples with 60%and less water content,and a weakening effect on samples with 80%and more water content,but the weakening effect is not obvious.Macroscopic damage characteristics of dry samples remain unchanged,water samples from shear damage and tensile–shear composite damage gradually transformed into cleavage damage,until saturation transformation monoclinic shear damage.The evolution of acoustic emission energy and event number is mainly divided into four stages:loading stage(Ⅰ),dynamic loading stage(Ⅱ),yield failure stage(Ⅲ),and post-peak stage(Ⅳ),the acoustic emission characteristics of the stages were different for different water contents.The characteristic value of acoustic emission key point frequency gradually decreases,and the damage degree of the specimen increases,corresponding to low water content—high main frequency—low damage and high water content—low main frequency—high damage. 展开更多
关键词 Dynamic disturbance Soft rock Cyclic loading Acoustic emission Water content
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CHB血清核心抗体与HBV-DNA、HBsAg、肝脏组织纤维化分期相关性及临床意义 被引量:1
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作者 姚挺英 柳丽娟 +1 位作者 廖柏涛 魏玉仙 《临床输血与检验》 CAS 2024年第1期117-123,共7页
目的探讨慢性乙型肝炎(CHB)患者血清核心抗体(HBcAb)与乙肝病毒脱氧核糖核酸(HBV-DNA)、乙肝表面抗原(HBsAg)、肝脏组织纤维化分期相关性及临床意义。方法选取我院2018年1月—2022年12月收治的CHB患者作为研究对象,根据纤维化严重程度... 目的探讨慢性乙型肝炎(CHB)患者血清核心抗体(HBcAb)与乙肝病毒脱氧核糖核酸(HBV-DNA)、乙肝表面抗原(HBsAg)、肝脏组织纤维化分期相关性及临床意义。方法选取我院2018年1月—2022年12月收治的CHB患者作为研究对象,根据纤维化严重程度分为轻度组(S0~S1期,50例)、中重度组(S2~S4期,150例),比较两组患者临床资料和实验室指标,应用Spearman/Pearson分析HBcAb与HBV-DNA、HBsAg、肝脏组织纤维化分期相关性;运用LASSO回归筛选变量;诊断效能分析采用受试者工作特征曲线(ROC)。结果单因素分析显示,中重度组病程长于轻度组,肝脏炎症分级分布较轻度组严重,ALT、AST、总胆红素(TBIL)、碱性磷酸酶(ALP)、层粘连蛋白、Ⅲ型前胶原N端肽、透明质酸、Ⅳ型胶原、HBcAb高于轻度组,HBV-DNA、HBsAg低于轻度组(P<0.05);HBCAb与肝纤维化呈正相关,HBVDNA、HBsAg与肝脏组织纤维化分期呈负相关(P<0.05);将单因素分析P<0.05的13个变量进行LASSO回归分析筛选出4个变量肝脏炎症分级、HBcAb、HBV-DNA、HBsAg,其是中重度肝纤维化相关影响因素(P<0.05);肝脏炎症分级、HBcAb、HBV-DNA、HBsAg联合诊断中重度肝脏组织纤维化的AUC优于任一单一项目。结论HBCAb与肝纤维化呈正相关,HBV-DNA和HBSAg与肝纤维化负相关,以上指标均是中重度肝纤维化相关影响因素,具有一定诊断价值,为临床预测中重度肝纤维化提供一定参考。 展开更多
关键词 CHB 核心抗体 hbv-dna HBSAG 肝脏组织 纤维化分期
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基于新型Contention网络的滚动轴承早期故障诊断方法研究
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作者 赵俊豪 郑煜 +1 位作者 王英 王凯 《机械设计与制造工程》 2024年第3期87-91,共5页
针对滚动轴承早期故障诊断问题,为了同时建模振动信号中的高频和低频特征,实现高精度诊断,提出了一种新的模型Contention。它以一种互补的方式集成了空洞卷积和自注意力机制的优点,具有同时捕捉高频和低频信息的能力。为了验证其诊断能... 针对滚动轴承早期故障诊断问题,为了同时建模振动信号中的高频和低频特征,实现高精度诊断,提出了一种新的模型Contention。它以一种互补的方式集成了空洞卷积和自注意力机制的优点,具有同时捕捉高频和低频信息的能力。为了验证其诊断能力,首先,在完整信息原则下将振动信号连续构造成数据集;其次,搭建Contention网络并训练,其最终测试集准确度可达100%,t-SNE显示随网络层次的深入特征被明显聚类;最后,设置对照实验,将该模型与传统RNN、CNN、Transformer模型对比,证明该模型具备突出的诊断能力。 展开更多
关键词 contention网络 空洞卷积 自注意力机制 滚动轴承 早期故障诊断
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阿拉尔市某医院HBsAg阳性孕妇血清标志物模式分布与HBV-DNA载量分析
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作者 岳帆 侯向萍 +2 位作者 谭玉梅 李琼 叶佳 《分子诊断与治疗杂志》 2024年第9期1784-1787,1792,共5页
目的分析阿拉尔市某医院的乙型肝炎病毒表面抗原(HBsAg)阳性孕妇乙型肝炎病毒(HBV)感染血清标志物模式与HBV-DNA载量之间的关系,为监控孕期HBV感染和预防阻断HBV母婴传播提供理论依据。方法选取2021年10月至2023年10月期间在新疆生产建... 目的分析阿拉尔市某医院的乙型肝炎病毒表面抗原(HBsAg)阳性孕妇乙型肝炎病毒(HBV)感染血清标志物模式与HBV-DNA载量之间的关系,为监控孕期HBV感染和预防阻断HBV母婴传播提供理论依据。方法选取2021年10月至2023年10月期间在新疆生产建设兵团第一师阿拉尔医院产科建档及生产的HBsAg阳性孕妇为研究对象,通过磁微粒化学发光法检测孕妇五项HBV血清标志物包括测HBsAg和乙肝病毒表面抗体(HBsAb)、乙肝病毒e抗原(HBeAg)、乙肝病毒e抗体(HBeAg)以及乙肝病毒核心抗体(HBcAb),并利用荧光定量PCR检测HBV-DNA载量,分析HBV-DNA载量以及孕妇HBV感染模式对新生儿的影响。结果共纳入145例HBsAg阳性孕妇,HBV感染模式以感染模式Ⅱ[HbsAg(+)、HBeAb(+)和HBcAb(+)]为主,占62.76%。HBV-DNA阳性(>0.5×10^(3)IU/mL)阳性率为63.45%(92/145),不同HBV感染模式的HBsAg阳性孕妇HBV-DNA阳性率及载量分布情况比较差异有统计学意义(χ^(2)=16.532、64.367,P<0.05),主要表现为感染模式Ⅰ比例随HBV-DNA载量升高而增高。同时,HBV-DNA阳性组随HBeAg浓度升高而比例增高,而HBV-DNA阴性组正好相反,Spearman相关分析表明HBsAg阳性孕妇的HBeAg浓度与HBV DNA载量呈现明显正相关性(r=0.327,P<0.05)。不同HBV感染模式的HBsAg阳性孕妇的新生儿脐带血HBV阳性率比较差异有统计学意义(χ^(2)=16.851,P=0.002),同时HBsAg阳性孕妇的新生儿脐带血HBV阳性率随着HBV-DNA载量增高而明显增高,差异有统计学意义(χ^(2)=15.062,P=0.005)。结论HBsAg阳性孕妇血清标志物模式与HBV-DNA病毒载量密切相关,产前筛查对孕产妇及新生儿的乙肝预防及干预有重要意义,是母婴传播防控的重点。 展开更多
关键词 乙型肝炎表面抗原 乙型肝炎病毒 hbv-dna 母婴传播
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乙肝患者HBV-DNA载量与血清标志物水平的相关性及其对抗病毒疗效的预测价值
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作者 隋娟 钟芳芳 郑秀霞 《中国民康医学》 2024年第10期148-150,154,共4页
目的:观察乙型肝炎(简称乙肝)患者HBV-DNA载量与血清标志物[乙肝表面抗原(HBsAg)、乙肝病毒e抗原(HBeAg)、乙肝病毒核心抗体(HBcAb)、HBcAb-免疫球蛋白M(IgM)]水平的相关性及其对抗病毒疗效的预测价值。方法:选取2020年7月至2022年7月... 目的:观察乙型肝炎(简称乙肝)患者HBV-DNA载量与血清标志物[乙肝表面抗原(HBsAg)、乙肝病毒e抗原(HBeAg)、乙肝病毒核心抗体(HBcAb)、HBcAb-免疫球蛋白M(IgM)]水平的相关性及其对抗病毒疗效的预测价值。方法:选取2020年7月至2022年7月该院收治的154例乙肝患者进行前瞻性研究,测定其入院时、抗病毒治疗1个月后HBV-DNA载量与血清标志物水平。采用Pearson相关性分析,分析乙肝患者入院时HBV-DNA载量与血清标志物水平的相关性;比较抗病毒治疗6个月不同疗效患者抗病毒治疗1个月时HBV-DNA载量与血清标志物水平;采用受试者工作特征(ROC)曲线分析抗病毒治疗1个月HBV-DNA载量与血清标志物水平单项及联合检测对抗病毒治疗6个月后疗效的预测价值。结果:Pearson相关性分析结果显示,入院时,乙肝患者HBVDNA载量与血清HBsAg、HBeAg、HBcAb、HBcAb-IgM水平均呈正相关(r>0,P<0.05);抗病毒治疗6个月后完全应答患者治疗1个月时HBV-DNA载量和血清HBsAg、HBeAg、HBcAb、HBcAb-IgM水平均低于未完全应答患者,差异有统计学意义(P<0.05);ROC曲线分析结果显示,乙肝患者抗病毒治疗1个月后HBV-DNA载量与血清HBsAg、HBeAg、HBcAb、HBcAb-IgM水平联合检测对抗病毒治疗6个月后的疗效预测价值[曲线下面积(AUC)=0.905]高于五者单项检测(AUC=0.779、0.802、0.792、0.739、0.831)。结论:乙肝患者HBV-DNA载量与血清HBsAg、HBeAg、HBcAb、HBcAb-IgM水平均呈正相关,且乙肝患者抗病毒治疗1个月后HBV-DNA载量与血清HBsAg、HBeAg、HBcAb、HBcAb-IgM水平联合检测对抗病毒治疗6个月后的疗效预测价值高于五者单项检测。 展开更多
关键词 hbv-dna载量 血清标志物 抗病毒疗效 检测 预测 价值
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血清肝纤维化指标、HBV-DNA病毒载量联合检验在乙型肝炎肝纤维化中的评估价值
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作者 赵石磊 刘晓莉 张成伟 《黔南民族医专学报》 2024年第3期277-279,共3页
目的:探究血清肝纤维化指标、HBV-DNA病毒载量联合检验在乙型肝炎肝纤维化中的评估价值。方法:选取2022年1月至2023年5月本院收治的100例乙型肝炎肝纤维化患者作为观察组,并选择同期100例慢性乙型肝炎患者作为对照组。分别采用化学发光... 目的:探究血清肝纤维化指标、HBV-DNA病毒载量联合检验在乙型肝炎肝纤维化中的评估价值。方法:选取2022年1月至2023年5月本院收治的100例乙型肝炎肝纤维化患者作为观察组,并选择同期100例慢性乙型肝炎患者作为对照组。分别采用化学发光法和荧光定量PCR法检测两组患者肝纤维化指标及HBV-DNA水平,并比较分析其与乙型肝炎肝纤维化的关系。结果:观察组透明质酸(HA)、层粘连蛋白(LN)、Ⅲ型前胶原(PCⅢ)、Ⅳ型胶原(Ⅳ-C)水平均显著高于对照组(P<0.05);HBV-DNA水平显著低于对照组(P<0.05)。结论:HBV在慢性乙型肝炎患者具有高度复制性,在肝纤维化阶段复制水平下降。随着乙肝的进一步发展,肝纤维化指标水平逐渐升高。联合检测肝纤维化指标和HBV-DNA病毒载量对临床诊断乙型肝炎肝纤维化有一定的参考价值。 展开更多
关键词 肝纤维化指标 hbv-dna 联合检验 乙型肝炎肝纤维化
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HBV感染相关性肝细胞癌患者血甲胎蛋白、转氨酶水平与HBV-DNA载量和病情进展的关系
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作者 段丽娟 高照伟 +1 位作者 赵芳 武伟龙 《罕少疾病杂志》 2024年第10期57-59,共3页
目的探讨乙型肝炎病毒(HBV)感染相关性肝细胞癌(HCC)患者血甲胎蛋白(AFP)、转氨酶水平与HBV-DNA载量和病情进展的关系。方法回顾性分析2022年1月至2023年4月本院收治的50例HBV感染相关性HCC患者资料并设为HCC组,另筛选同期HBV相关肝硬化... 目的探讨乙型肝炎病毒(HBV)感染相关性肝细胞癌(HCC)患者血甲胎蛋白(AFP)、转氨酶水平与HBV-DNA载量和病情进展的关系。方法回顾性分析2022年1月至2023年4月本院收治的50例HBV感染相关性HCC患者资料并设为HCC组,另筛选同期HBV相关肝硬化(LC)和慢性乙型肝炎(CHB)患者资料各30例设为LC组和CHB组,比较三组血AFP及转氨酶水平;比较HCC组不同HBV-DNA载量患者AFP及转氨酶水平差异,并分析肝癌组患者AFP及转氨酶水平与病情进展的关系。结果HCC组患者AFP和丙氨酸氨基转移酶(ALT)水平均高于CHB组和LC组(P<0.05);50例HCC患者中,中低分化及Ⅲ~Ⅳ期患者血AFP和ALT水平高于高分化及Ⅰ~Ⅱ期患者(P<0.05);HBV-DNA高载量患者血AFP和ALT水平高于低载量患者(P<0.05),且患者HBV-DNA载量与其血AFP和ALT水平呈正相关(P<0.05)。结论HBV感染相关性HCC患者血AFP和ALT水平显著提升,且血AFP和转氨酶水平与HBV-DNA载量、肿瘤分期分化程度关系密切,二者对临床评估HBV感染相关性HCC病情进展有一定提示作用。 展开更多
关键词 乙型肝炎病毒感染相关性肝细胞癌 甲胎蛋白 转氨酶 hbv-dna载量 病情进展
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Digital twin driven and intelligence enabled content delivery in end-edge-cloud collaborative 5G networks
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作者 Bo Yi Jianhui Lv +2 位作者 Xingwei Wang Lianbo Ma Min Huang 《Digital Communications and Networks》 SCIE CSCD 2024年第2期328-336,共9页
The rapid development of 5G/6G and AI enables an environment of Internet of Everything(IoE)which can support millions of connected mobile devices and applications to operate smoothly at high speed and low delay.Howeve... The rapid development of 5G/6G and AI enables an environment of Internet of Everything(IoE)which can support millions of connected mobile devices and applications to operate smoothly at high speed and low delay.However,these massive devices will lead to explosive traffic growth,which in turn cause great burden for the data transmission and content delivery.This challenge can be eased by sinking some critical content from cloud to edge.In this case,how to determine the critical content,where to sink and how to access the content correctly and efficiently become new challenges.This work focuses on establishing a highly efficient content delivery framework in the IoE environment.In particular,the IoE environment is re-constructed as an end-edge-cloud collaborative system,in which the concept of digital twin is applied to promote the collaboration.Based on the digital asset obtained by digital twin from end users,a content popularity prediction scheme is firstly proposed to decide the critical content by using the Temporal Pattern Attention(TPA)enabled Long Short-Term Memory(LSTM)model.Then,the prediction results are input for the proposed caching scheme to decide where to sink the critical content by using the Reinforce Learning(RL)technology.Finally,a collaborative routing scheme is proposed to determine the way to access the content with the objective of minimizing overhead.The experimental results indicate that the proposed schemes outperform the state-of-the-art benchmarks in terms of the caching hit rate,the average throughput,the successful content delivery rate and the average routing overhead. 展开更多
关键词 Digital twin IoE content delivery CACHING ROUTING
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Surface and Content Validity of the Mentoring Function Scale for Novice Nurses
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作者 Aimi Furukawa Yasuko Hosoda 《Open Journal of Nursing》 2024年第8期401-411,共11页
This study aimed to examine the surface and content validity of the Mentoring Function Scale for Novice Nurses, used to assess the mentoring of entry-level nurses, and to refine the scale items. In Study 1, six nurse ... This study aimed to examine the surface and content validity of the Mentoring Function Scale for Novice Nurses, used to assess the mentoring of entry-level nurses, and to refine the scale items. In Study 1, six nurse education researchers, selected using convenience sampling, with five or more years of nursing experience and experience teaching novice nurses, were invited to an expert meeting in July 2015. A group interview was conducted that lasted approximately 120 minutes. Study 2 examined the content validity index. Between September and November 2015, we distributed a self-administered questionnaire survey to 11 participants selected by convenience sampling. The participants included five nurse education researchers with a minimum of five years of nursing experience and experience teaching novice nurses, as well as six clinical nurses with a master’s degree or higher. Finally, 81 questionnaire items were retained from the initial 125 items. The 81-item Mentoring Function Scale for Novice Nurses had higher content validity than the original scale. To further increase the scale’s applicability, future studies should assess its reliability, construct validity, and criterion-related validity. 展开更多
关键词 Novice Nurses Mentoring Function Surface and content Validity Item-Level content Validity Index
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A Survey of Digital Content Required for STD Prevention Education Taught by School Nurses
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作者 Tomoko Nakamura 《Health》 2024年第4期350-370,共21页
Purpose: In recent years, there has been concern in Japan about the increase in STDs among adolescents aged 15 - 19. In order to prevent STDs and guide adolescents toward desirable sexual behavior, this study’s goal ... Purpose: In recent years, there has been concern in Japan about the increase in STDs among adolescents aged 15 - 19. In order to prevent STDs and guide adolescents toward desirable sexual behavior, this study’s goal was to examine the actual state of STD prevention education taught by school nurses as part of the school curriculum, as well as the kinds of digital content they wish to have for teaching on the subject. Method: An anonymous, self-administered questionnaire was distributed by email and leaflet. Targeting the 100 valid responses received from the surveyed school nurses, descriptive statistics were made for each survey item and comparisons were made between the early- and mid-career groups based on years of experience. Results: 70.0% of respondents reported teaching about STDs in Health & Physical Education classes. School nurses in the early-career group used ready-made materials, while the mid-career group used both ready-made and self-made materials. 95% of respondents reported that they had little or no knowledge of STDs, while 84% reported that they were “good” or “fairly good” at teaching classes on sexuality. Both groups reported difficulty with the topics of “phimosis” and “nocturnal emissions” in the physiological category, “sexual behavior” in the “sex-adjacent” category, and “sexual and reproductive issues” in the psychosocial category. Respondents expressed a need for digital content covering the topics of “sexual violence”, “sexual abuse”, “sexually transmitted diseases”, and “how to turn down sex”. The mid-career group desired digital content for more items than the early-career group, with significant differences in the pathogens involved in sexually transmitted diseases and sex-adjacent items. 32.0% of respondents answered that they had done self-study for sex education classes in the past three years, and both groups desired self-study on “sexually transmitted diseases”, with the mid-career group significantly higher than the early-career group on “cervical cancer & HPV”, “emergency contraceptives”, and “media literacy”. Conclusion: Health & Physical Education is the main subject that covers STDs, and pre-existing materials are commonly used. It is expected that this is due to nurses’ busy schedules and the fact that only one school nurse is assigned to each school. The data collected suggested that nurse teachers want categorized digital content that can be used in the classes they are responsible for, rather than educational content on topics they are not comfortable with. In addition, given the changing environment surrounding sex, it was clear that they wish to understand the realities and needs of the high school students they teach, and desire self-study opportunities to improve their teaching methods. 展开更多
关键词 High School Students Sexually Transmitted Diseases Digital content School Nurses
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Quantitative characterizations of anisotropic dynamic properties in organic-rich shale with different kerogen content
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作者 Jian-Yong Xie Yan-Ping Fang +4 位作者 Xing-Hua Wu Jian'er Zhao Jun-Cheng Dai Jun-Xing Cao Ji-Xin Deng 《Petroleum Science》 SCIE EI CAS CSCD 2024年第2期855-865,共11页
Understanding the quantitative responses of anisotropic dynamic properties in organic-rich shale with different kerogen content(KC)is of great significance in hydrocarbon exploration and development.Conducting control... Understanding the quantitative responses of anisotropic dynamic properties in organic-rich shale with different kerogen content(KC)is of great significance in hydrocarbon exploration and development.Conducting controlled experiments with a single variable is challenging for natural shales due to their high variations in components,diagenesis conditions,or pore fluid.We employed the hot-pressing technique to construct 11 well-controlled artificial shale with varying KC.These artificial shale samples were successive machined into prismatic shape for ultrasonic measurements along different directions.Observations revealed bedding perpendicular P-wave velocities are more sensitive to the increasing KC than bedding paralleling velocities due to the preferential alignments of kerogen.All elastic stiffnesses except C_(13)are generally decreasing with the increasing KC,the variation of C_(1) and C_(33)on kerogen content are more sensitive than those of C_(44)and C_(66).Apparent dynamic mechanical parameters(v and E)were found to have linear correlation with the true ones from complete anisotropic equations independent of KC,which hold value towards the interpretation of well logs consistently across formations,Anisotropic mechanical parameters(ΔE and brittlenessΔB)tend to decrease with the reducing KC,withΔB showing great sensitivity to KC variations.In the range of low KC(<10%),the V_(P)/V_(S) ratio demonstrated a linearly negative correlation with KC,and the V_(P)/V_(S) ratio magnitude of less than 1.75may serve as a significant characterization for highly organic-rich(>10%)shale,compilation of data from natural organic rich-shales globally verified the similar systematic relationships that can be empirically used to predict the fraction of KC in shales. 展开更多
关键词 Elastic properties Organic shale ANISOTROPY Kerogen content Physical modeling
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Longitudinal dependence of the forecast accuracy of the ionospheric total electron content in the equatorial zone
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作者 Artem Kharakhashyan Olga Maltseva 《Geodesy and Geodynamics》 EI CSCD 2024年第5期528-541,共14页
The longitudinal dependence of the behavior of ionospheric parameters has been the subject of a number of works where significant variations are discovered.This also applies to the prediction of the ionospheric total ... The longitudinal dependence of the behavior of ionospheric parameters has been the subject of a number of works where significant variations are discovered.This also applies to the prediction of the ionospheric total electron content(TEC),which neural network methods have recently been widely used.However,the results are mainly presented for a limited set of meridians.This paper examines the longitudinal dependence of the TEC forecast accuracy in the equatorial zone.In this case,the methods are used that provided the best accuracy on three meridians:European(30°E),Southeastern(110°E)and American(75°W).Results for the stations considered are analyzed as a function of longitude using the Jet Propulsion Laboratory Global Ionosphere Map(JPL GIM)for 2015.These results are for 2 h ahead and 24 h ahead forecast.It was found that in this case,based on the metric values,three groups of architectures can be distinguished.The first group included long short-term memory(LSTM),gated recurrent unit(GRU),and temporal convolutional networks(TCN)models as a part of unidirectional deep learning models;the second group is based on the recurrent models from the first group,which were supplemented with a bidirectional algorithm,increasing the TEC forecasting accuracy by 2-3 times.The third group,which includes the bidirectional TCN architecture(BiTCN),provided the highest accuracy.For this architecture,according to data obtained for 9 equatorial stations,practical independence of the TEC prediction accuracy from longitude was observed under the following metrics(Mean Absolute Error MAE,Root Mean Square Error RMSE,Mean Absolute Percentage Error MAPE):MAE(2 h)is 0.2 TECU approximately;MAE(24 h)is 0.4 TECU approximately;RMSE(2 h)is less than 0.5 TECU except Niue station(RMSE(2 h)is 1 TECU approximately);RMSE(24 h)is in the range of 1.0-1.7 TECU;MAPE(2 h)<1%except Darwin station,MAPE(24 h)<2%.This result was confirmed by data from additional 5 stations that formed latitudinal chains in the equatorial part of the three meridians.The complete correspondence of the observational and predicted TEC values is illustrated using several stations for disturbed conditions on December 19-22,2015,which included the strongest magnetic storm in the second half of the year(min Dst=-155 nT). 展开更多
关键词 IONOSPHERE Total electron content Forecasting BiGRU BiLSTM BiTCN Temporal convolution
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Selection and application of four QTLs for grain protein content in modern wheat cultivars
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作者 Zihui Liu Xiangjun Lai +4 位作者 Yijin Chen Peng Zhao Xiaoming Wang Wanquan Ji Shengbao Xu 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2024年第8期2557-2570,共14页
The grain protein content(GPC)is the key parameter for wheat grain nutritional quality.This study conducted a resampling GWAS analysis using 406 wheat accessions across eight environments,and identified four previousl... The grain protein content(GPC)is the key parameter for wheat grain nutritional quality.This study conducted a resampling GWAS analysis using 406 wheat accessions across eight environments,and identified four previously reported GPC QTLs.An analysis of 87 landraces and 259 modern cultivars revealed the loss of superior GPC haplotypes,especially in Chinese cultivars.These haplotypes were preferentially adopted in different agroecological zones and had broad effects on wheat yield and agronomic traits.Most GPC QTLs did not significantly reduce yield,suggesting that high GPC can be achieved without a yield penalty.The results of this study provide a reference for future GPC breeding in wheat using the four identified QTLs. 展开更多
关键词 BREEDING grain protein content haplotype selection and application WHEAT
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A Study on the Correlation between Salivary Cortisol Content and Anxiety and Depression in Pregnant and Postpartum Women
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作者 Qiuping Wang Shujuan Luo +1 位作者 Jinrui Zhang Yujuan Fan 《Open Journal of Obstetrics and Gynecology》 2024年第2期250-258,共9页
Objective: To analyze the correlation between salivary cortisol content and anxiety and depression in pregnant and postpartum women. Method: 300 pregnant and postpartum women who were admitted from January 2021 to Dec... Objective: To analyze the correlation between salivary cortisol content and anxiety and depression in pregnant and postpartum women. Method: 300 pregnant and postpartum women who were admitted from January 2021 to December 2021 were selected as the research subjects. They were all tested with the Hamilton Anxiety Scale (HAMA) and the Edinburgh Postnatal Depression Scale (EPDS). 40 pregnant women with anxiety and depression were selected as the observation group, and 50 normal pregnant women were selected as the control group, adopting logistic regression analysis to investigate the correlation between salivary cortisol and postpartum anxiety and depression during pregnancy. Result: The salivary cortisol levels in the observation group were significantly higher than those in the control group before bedtime, after waking up the next day, 15 minutes after waking up, 30 minutes after waking up, 60 minutes after waking up, and 1 hour before lunch (p < 0.05). Maternal depression and anxiety were not related to age, weight, gestational age, negative events, or history of adverse pregnancy and childbirth (p > 0.05). Maternal depression and anxiety are closely related to salivary cortisol levels and educational background (p Conclusion: There is a close correlation between anxiety and depression and an increase in cortisol levels, suggesting that the salivary cortisol awakening response during pregnancy has a predictive effect on the occurrence of postpartum depression. 展开更多
关键词 Salivary Cortisol content ANXIETY DEPRESSION MATERNAL
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Multi-omics analysis reveals the pivotal role of phytohormone homeostasis in regulating maize grain water content
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作者 Yuanliang Liu Manman Li +5 位作者 Jianju Liu Suining Deng Yan Zhang Yuanfeng Xia Baoshen Liu Mingliang Xu 《The Crop Journal》 SCIE CSCD 2024年第4期1081-1092,共12页
Grain water content(GWC)is a key determinant for mechanical harvesting of maize(Zea mays).In our previous research,we identified a quantitative trait locus,qGWC1,associated with GWC in maize.Here,we examined near-isog... Grain water content(GWC)is a key determinant for mechanical harvesting of maize(Zea mays).In our previous research,we identified a quantitative trait locus,qGWC1,associated with GWC in maize.Here,we examined near-isogenic lines(NILs)NILL and NILH that differed at the qGWC1 locus.Lower GWC in NILL was primarily attributed to reduced grain water weight(GWW)and smaller fresh grain size,rather than the accumulation of dry matter.The difference in GWC between the NILs became more pronounced approximately 35 d after pollination(DAP),arising from a faster dehydration rate in NILL.Through an integrated analysis of the transcriptome,proteome,and metabolome,coupled with an examination of hormones and their derivatives,we detected a marked decrease in JA,along with an increase in cytokinin,storage forms of IAA(IAA-Glu,IAA-ASP),and IAA precursor IPA in immature NILL kernels.During kernel development,genes associated with sucrose synthases,starch biosynthesis,and zein production in NILL,exhibited an initial up-regulation followed by a gradual down-regulation,compared to those in NILH.This discovery highlights the crucial role of phytohormone homeostasis and genes related to kernel development in balancing GWC and dry matter accumulation in maize kernels. 展开更多
关键词 Grain water content Maize kernel Phytohormone homeostasis
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Predictability of the upper ocean heat content in a Community Earth System Model ensemble prediction system
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作者 Ting Liu Wenxiu Zhong 《Acta Oceanologica Sinica》 SCIE CAS CSCD 2024年第1期1-10,共10页
Upper ocean heat content(OHC)has been widely recognized as a crucial precursor to high-impact climate variability,especially for that being indispensable to the long-term memory of the ocean.Assessing the predictabili... Upper ocean heat content(OHC)has been widely recognized as a crucial precursor to high-impact climate variability,especially for that being indispensable to the long-term memory of the ocean.Assessing the predictability of OHC using state-of-the-art climate models is invaluable for improving and advancing climate forecasts.Recently developed retrospective forecast experiments,based on a Community Earth System Model ensemble prediction system,offer a great opportunity to comprehensively explore OHC predictability.Our results indicate that the skill of actual OHC predictions varies across different oceans and diminishes as the lead time of prediction extends.The spatial distribution of the actual prediction skill closely resembles the corresponding persistence skill,indicating that the persistence of OHC serves as the primary predictive signal for its predictability.The decline in actual prediction skill is more pronounced in the Indian and Atlantic oceans than in the Pacific Ocean,particularly within tropical regions.Additionally,notable seasonal variations in the actual prediction skills across different oceans align well with the phase-locking features of OHC variability.The potential predictability of OHC generally surpasses the actual prediction skill at all lead times,highlighting significant room for improvement in current OHC predictions,especially for the North Indian Ocean and the Atlantic Ocean.Achieving such improvements necessitates a collaborative effort to enhance the quality of ocean observations,develop effective data assimilation methods,and reduce model bias. 展开更多
关键词 ocean heat content prediction skill retrospective forecast experiment
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Experimental and numerical analyses of the effect of fibre content on the close-in blast performance of a UHPFRC beam
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作者 Junbo Yan Qiyue Zhang +4 位作者 Yan Liu Yingliang Xu Zhenqing Shi Fan Bai Fenglei Huang 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第1期242-261,共20页
Limited research has been conducted on the influences of fiber content on close-in blasting characteristics for ultrahigh-performance fiber-reinforced concrete(UHPFRC)beams.This paper aims to address this knowledge ga... Limited research has been conducted on the influences of fiber content on close-in blasting characteristics for ultrahigh-performance fiber-reinforced concrete(UHPFRC)beams.This paper aims to address this knowledge gap through experimental and mesoscale numerical methods.Experiments were conducted on ten UHPFRC beams built with varying steel fiber volumetric fractions subjected to close-in explosive conditions.Additionally,this study considered other parameters,such as the longitudinal reinforcement type and ratio.In the case of UHPFRC beams featuring normal-strength longitudinal reinforcement of diametersΦ12,Φ16,andΦ20,a reduction in maximum displacement by magnitudes of19.6%,19.5%,and 17.4%was observed,respectively,as the volumetric fractions of fiber increased from1.0%to 2.5%.In addition,increasing the longitudinal reinforcement ratio and using high-strength steel longitudinal reinforcement both significantly reduced the deformation characteristics and increase the blasting resistances of UHPFRC beams.However,the effects on the local crushing and spalling damage were not significant.A mesoscale finite element model,which considers the impacts of fiber parameters on UHPFRC beam behaviors,was also established and well correlated with the test findings.Nevertheless,parametric analyses were further conducted to examine the impacts of the steel fiber content and length and the hybrid effects of various types of microfibers and steel fibers on the blasting performance of UHPFRC beams. 展开更多
关键词 Blast performance Close-in blast Fiber content Mesoscale approach UHPFRC beams
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Research on the Legal Framework of Content Regulations for Network Platforms
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作者 Zhang Yin Liao Xinyue 《Contemporary Social Sciences》 2024年第1期137-155,共19页
In the era of the Internet,various network platforms have evolved into new hubs for information dissemination.Currently,China has established a platform-centered content regulation framework,wherein platforms proactiv... In the era of the Internet,various network platforms have evolved into new hubs for information dissemination.Currently,China has established a platform-centered content regulation framework,wherein platforms proactively enforce content regulations in accordance with legal censorship obligations.Additionally,platform policies and user agreements augment their authority in content regulation.The platforms can achieve cost-effective and highly efficient content regulation by leveraging their strategic advantages enabled by their own technical capabilities and extensive coverage.The platform self-regulation model,however,still faces challenges.First,accurately evaluating content remains a formidable task;second,ensuring effective platform publicity through self-regulation poses difficulties;third,users may potentially face disadvantages due to the platform’s right of self-regulation;and fourth,digital copyright owners face challenges when defending digital copyright disputes under the safe harbor rule.Therefore,it is imperative to establish,review,and revise the legal framework for content regulation of network platforms in order to enhance the efficiency of their governance systems.The formulation of the legal framework for content regulation of network platforms may encompass the following aspects:rationalizing obligations pertaining to platform content regulations,enhancing supervision over platform self-regulation,and establishing a dual-track responsibility system for digital copyright content regulation.This will ensure a harmonious balance among public interests,users’personal rights and interests,and commercial benefits through regulating the content on network platforms. 展开更多
关键词 content regulations platform self-regulation legal framework
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