After peripheral nerve injury, the process of Wallerian degeneration is initiated in the distal stump of injured nerves. Wallerian degeneration in peripheral nerves involves axonal degeneration and degradation of the ...After peripheral nerve injury, the process of Wallerian degeneration is initiated in the distal stump of injured nerves. Wallerian degeneration in peripheral nerves involves axonal degeneration and degradation of the myelin sheath in Schwann cells. This provides the necessary conditions for axonal regeneration and remyelination. After nerve injury, macrophages are also recruited to the distal nerve stump and, together with Schwann cells, play a role in the clearance of myelin debris.展开更多
Obstructive sleep apnea syndrome （OSAS） is a respiratory disease characterized by the upper airway collapses and reopens repeatedly during sleep. Though the nerve control plays a key role in the upper airway collaps...Obstructive sleep apnea syndrome （OSAS） is a respiratory disease characterized by the upper airway collapses and reopens repeatedly during sleep. Though the nerve control plays a key role in the upper airway collapse, it has been considered in previous studies only with lumped parameter models. Based on a finite element model including airway and surrounding structures, the effect of nerve control on the upper airway collapse was studied with fluid-structure interaction method. Spring elements were used to simulate the function of the muscle group. The simulation results show that the nerve control reduces the deformation of airway successfully and avoids the risk of OSAS.展开更多
文摘After peripheral nerve injury, the process of Wallerian degeneration is initiated in the distal stump of injured nerves. Wallerian degeneration in peripheral nerves involves axonal degeneration and degradation of the myelin sheath in Schwann cells. This provides the necessary conditions for axonal regeneration and remyelination. After nerve injury, macrophages are also recruited to the distal nerve stump and, together with Schwann cells, play a role in the clearance of myelin debris.
基金supported by Beijing Natural Sciences Foundation(Nos.7133248 and 3122020)
文摘Obstructive sleep apnea syndrome （OSAS） is a respiratory disease characterized by the upper airway collapses and reopens repeatedly during sleep. Though the nerve control plays a key role in the upper airway collapse, it has been considered in previous studies only with lumped parameter models. Based on a finite element model including airway and surrounding structures, the effect of nerve control on the upper airway collapse was studied with fluid-structure interaction method. Spring elements were used to simulate the function of the muscle group. The simulation results show that the nerve control reduces the deformation of airway successfully and avoids the risk of OSAS.
