Adoptive cell therapy using chimeric antigen receptor T (CAR-T) cells, which is a promising cancer immunotherapy strategy, has been developing very rapidly in recent years. CAR-T cells are genetically modified T cells...Adoptive cell therapy using chimeric antigen receptor T (CAR-T) cells, which is a promising cancer immunotherapy strategy, has been developing very rapidly in recent years. CAR-T cells are genetically modified T cells that can specifically recognize tumor specific antigens on the surface of tumor cells, and then effectively kill tumor cells. At present, exciting results are being achieved in clinical applications of CAR-T cells for patients with hematological malignancies. The research and development of CAR-T cells for various targets and for the treatment of solid tumors have become a hot topic worldwide, so an increasing number of investigational new drug applications (INDAs) and new drug applications (NDAs) of CAR-T cell products are expected to be submitted in future. The quality control and nonclinical research of these products are of great significance in ensuring the safety and effectiveness of these products;however, they also present great challenges and difficulties. This article discusses the general principles of and key issues regarding the quality control and nonclinical research of CAR-T cell products based on their product characteristics and on relevant guidelines for gene and cell therapy products.展开更多
On the basis of reviewing the development history of drilling engineering technology over a century, this paper describes the technical and scientific background of downhole control engineering, discusses its basic is...On the basis of reviewing the development history of drilling engineering technology over a century, this paper describes the technical and scientific background of downhole control engineering, discusses its basic issues, discipline frame and main study contents, introduces the research progress of downhole control engineering in China over the past 30 years, and envisions the development direction of downhole control engineering in the future. The author proposed the study subject of well trajectory control theory and technology in 1988, and further proposed the concept of downhole control engineering in 1993. Downhole control engineering is a discipline branch, which applies the perspectives and methods of engineering control theory to solve downhole engineering control issues in oil and gas wells; meanwhile, it is an application technology field with interdisciplinarity. Downhole control engineering consists of four main aspects; primarily, investigations about dynamics of downhole system and analysis methods of control signals; secondly, designs of downhole control mechanisms and systems, research of downhole parameters collections and transmission techniques; thirdly, development of downhole control engineering products; fourthly, development of experimental methods and the laboratories. Over the past 30 years, the author and his research group have achieved a number of progress and accomplishments in the four aspects mentioned above. As a research field and a disciplinary branch of oil and gas engineering, downhole control engineering is stepping into a broader and deeper horizon.展开更多
This paper analyses the fragmenting principle of static blasting agent (SBA) and the action of its cutting fragmentation. Using SBA for sterming material proved very useful and advantageous. Here we analyse in detail ...This paper analyses the fragmenting principle of static blasting agent (SBA) and the action of its cutting fragmentation. Using SBA for sterming material proved very useful and advantageous. Here we analyse in detail the cutting action of pre- stress and stress wave in pre-stressing force blasting.展开更多
So far, most theories of economics and management are under the same premisethat the natural resources are never exhausted and regenerated repeatedly. The magic of technologybrought by industrial revolution endowed hu...So far, most theories of economics and management are under the same premisethat the natural resources are never exhausted and regenerated repeatedly. The magic of technologybrought by industrial revolution endowed human with power that they can do anything they want. Italso turns natural resources into industrial energy and enhances the development of human societyand civilization. Human uses direct comparison of input and output and the satisfaction degree ofdemands to measure the production activities, the economic benefit and management performance,regardless of the change of ecology that serves as the natural resources. However, since theecological environment has been changing worse recently and natural disaster happened frequentlyhuman's dream of conquering the nature has been broken. The nature implements reprisal against humanagain and again, and human is faced with the development limit because of the environmentalrestriction.展开更多
软着陆探测是重要的地外天体探测方式,制导、导航与控制(Guidance,Navigation and Control,GNC)是地外天体软着陆成功的关键。首先梳理了国内外月球、火星和小天体等地外天体软着陆任务发展现状;在此基础上,总结了地外天体软着陆任务典...软着陆探测是重要的地外天体探测方式,制导、导航与控制(Guidance,Navigation and Control,GNC)是地外天体软着陆成功的关键。首先梳理了国内外月球、火星和小天体等地外天体软着陆任务发展现状;在此基础上,总结了地外天体软着陆任务典型GNC方案及自主导航与控制技术主要进展;最后,针对未来的地外天体精确定点软着陆任务,提出了需要重点关注和发展的自主导航与控制关键技术,为未来技术发展提供借鉴和参考。展开更多
Based on the research on domestic and international automatic technical development in fossil power plant,the paper analyses the recent situation of the coordinate control system between turbine and boiler of domestic...Based on the research on domestic and international automatic technical development in fossil power plant,the paper analyses the recent situation of the coordinate control system between turbine and boiler of domestic fossil Power Plant,provides the development thought of coordinate control system between turbine and boiler,and describes the application prospect in control system of fossil power plant combining with the application experience.展开更多
文摘Adoptive cell therapy using chimeric antigen receptor T (CAR-T) cells, which is a promising cancer immunotherapy strategy, has been developing very rapidly in recent years. CAR-T cells are genetically modified T cells that can specifically recognize tumor specific antigens on the surface of tumor cells, and then effectively kill tumor cells. At present, exciting results are being achieved in clinical applications of CAR-T cells for patients with hematological malignancies. The research and development of CAR-T cells for various targets and for the treatment of solid tumors have become a hot topic worldwide, so an increasing number of investigational new drug applications (INDAs) and new drug applications (NDAs) of CAR-T cell products are expected to be submitted in future. The quality control and nonclinical research of these products are of great significance in ensuring the safety and effectiveness of these products;however, they also present great challenges and difficulties. This article discusses the general principles of and key issues regarding the quality control and nonclinical research of CAR-T cell products based on their product characteristics and on relevant guidelines for gene and cell therapy products.
文摘On the basis of reviewing the development history of drilling engineering technology over a century, this paper describes the technical and scientific background of downhole control engineering, discusses its basic issues, discipline frame and main study contents, introduces the research progress of downhole control engineering in China over the past 30 years, and envisions the development direction of downhole control engineering in the future. The author proposed the study subject of well trajectory control theory and technology in 1988, and further proposed the concept of downhole control engineering in 1993. Downhole control engineering is a discipline branch, which applies the perspectives and methods of engineering control theory to solve downhole engineering control issues in oil and gas wells; meanwhile, it is an application technology field with interdisciplinarity. Downhole control engineering consists of four main aspects; primarily, investigations about dynamics of downhole system and analysis methods of control signals; secondly, designs of downhole control mechanisms and systems, research of downhole parameters collections and transmission techniques; thirdly, development of downhole control engineering products; fourthly, development of experimental methods and the laboratories. Over the past 30 years, the author and his research group have achieved a number of progress and accomplishments in the four aspects mentioned above. As a research field and a disciplinary branch of oil and gas engineering, downhole control engineering is stepping into a broader and deeper horizon.
文摘This paper analyses the fragmenting principle of static blasting agent (SBA) and the action of its cutting fragmentation. Using SBA for sterming material proved very useful and advantageous. Here we analyse in detail the cutting action of pre- stress and stress wave in pre-stressing force blasting.
文摘So far, most theories of economics and management are under the same premisethat the natural resources are never exhausted and regenerated repeatedly. The magic of technologybrought by industrial revolution endowed human with power that they can do anything they want. Italso turns natural resources into industrial energy and enhances the development of human societyand civilization. Human uses direct comparison of input and output and the satisfaction degree ofdemands to measure the production activities, the economic benefit and management performance,regardless of the change of ecology that serves as the natural resources. However, since theecological environment has been changing worse recently and natural disaster happened frequentlyhuman's dream of conquering the nature has been broken. The nature implements reprisal against humanagain and again, and human is faced with the development limit because of the environmentalrestriction.
文摘软着陆探测是重要的地外天体探测方式,制导、导航与控制(Guidance,Navigation and Control,GNC)是地外天体软着陆成功的关键。首先梳理了国内外月球、火星和小天体等地外天体软着陆任务发展现状;在此基础上,总结了地外天体软着陆任务典型GNC方案及自主导航与控制技术主要进展;最后,针对未来的地外天体精确定点软着陆任务,提出了需要重点关注和发展的自主导航与控制关键技术,为未来技术发展提供借鉴和参考。
文摘Based on the research on domestic and international automatic technical development in fossil power plant,the paper analyses the recent situation of the coordinate control system between turbine and boiler of domestic fossil Power Plant,provides the development thought of coordinate control system between turbine and boiler,and describes the application prospect in control system of fossil power plant combining with the application experience.
