Comparative analysis of conventional laparoscopic surgery and single-incision laparoscopic surgery in gastric cancer treatment:Outcomes and prognosis

BACKGROUND Gastric cancer surgery has advanced with minimally invasive techniques.This study compares outcomes between single-incision laparoscopic surgery plus one port(SILS+1)and conventional laparoscopic surgery(CLS)in treating gastric cancer.AIM To explore the curative effect of SILS+1 and CLS on gastric cancer and their influences on prognosis.METHODS A total of 93 patients with gastric cancer undergoing radical gastrectomy in the hospital were retrospectively analyzed between September 2019 and September 2022.According to different surgical methods,they were divided into SILS+1 group(n=56)and CLS group(n=37).The perioperative indexes,pain degree[visual analogue scale(VAS)]and stress response[C-reactive protein(CRP),white blood cell count(WBC)]in the two groups were compared.The postoperative complications,recurrence rate and mortality at 1 year after surgery were recorded.RESULTS Intraoperative blood loss was significantly lower in the SILS+1 group(76.53±8.12 mL)compared to the CLS group(108.67±12.34 mL,P<0.001),and the total incision length was also significantly shorter in the SILS+1 group(5.29±1.01 cm vs 9.45±2.34 cm,P<0.001).SILS+1 patients experienced faster recovery,with shorter times to first flatus(1.94±0.43 days vs 3.23±0.88 days,P<0.001)and ambulation(2.76±0.58 days vs 4.10±0.97 days,P<0.001).Postoperative pain,as measured by VAS scores,was significantly lower in the SILS+1 group on postoperative days 1,2,and 3(P<0.001).Additionally,stress markers(CRP and WBC)were significantly lower in the SILS+1 group on the first postoperative day(CRP:6.41±1.63 mg/L vs 7.82±1.88 mg/L,P<0.001;WBC:6.34±1.50×109/L vs 7.09±1.61×109/L,P=0.024).The complication rate in the SILS+1 group was also significantly lower than in the CLS group(8.93%vs 27.03%,P=0.020).However,there was no significant difference in recurrence rates between the two groups after one year(3.57%vs 8.11%,P>0.05).CONCLUSION SILS+1 and CLS have the comparable lymph node clearance effect in patients with gastric cancer.However,SILS+1 is more beneficial to reduce intraoperative blood loss,relieve pain,alleviate stress response,reduce the incidence of complications and promote rapid postoperative recovery.

Observation on the Effect of Non-Invasive Ventilator Combined with Conventional Therapy in the Treatment of Chronic Obstructive Pulmonary Disease Complicated with Respiratory Failure

Objective:To explore the clinical effect of a non-invasive ventilator combined with conventional therapy in the treatment of patients with chronic obstructive pulmonary disease(COPD)combined with respiratory failure.Methods:68 patients with COPD combined with respiratory failure treated in our hospital from September 2021 to October 2023 were selected as the research subjects.Using the random number table method,they were divided into a control group and an experimental group of 34 cases each.The control group received conventional symptomatic treatment,and the experimental group received non-invasive ventilator treatment based on the control group.The clinical effects,blood gas indicators(partial pressure of carbon dioxide(PaCO_(2)),partial pressure of oxygen(PaO_(2)),arterial oxygen saturation(SaO_(2))),lung function(forced expiratory volume in 1 second(FEV1),forced vital capacity(FVC),6 min walking distance),complications,and inflammatory factor levels(c-reactive protein(CRP),interleukin-6(IL-6),neutrophil-to-lymphocyte ratio(NLR))of the two groups of patients were observed.Results:(1)The clinical efficacy of the patients in the experimental group(33/97.06%)was more significant as compared with the control group(25/73.53%)(P<0.05);(2)After treatment,the clinical efficacy of the two groups of patients in terms of FEV1,FEV1/FVC,6-minute walking distance,PaO_(2)and SaO_(2)all increased in the experimental group as compared to that of the control group(P<0.05);(3)After treatment,the PaCO_(2),CRP,IL-6,and NLR of the two groups of patients decreased,and the decrease in the experimental group was higher than that of the control group(P<0.05);(4)The patients’complication rate in the experimental group(2/5.88%)was lower as compared to that of the control group(9/26.46%)(P<0.05).Conclusion:Non-invasive ventilators combined with conventional therapy achieved good clinical results in treating patients with COPD and respiratory failure.

适于机械化的高粱杂交种吉杂176的选育及栽培技术

吉杂176是吉林省农业科学院以自选不育系吉2062A为母本,以恢复系吉R139为父本组配的矮秆高粱杂交种,该品种属于中早熟品种,株高147 cm,穗长27.4 cm,中紧穗、纺锤形,穗粒重73.2 g,千粒重30.7 g,生育期114 d;籽粒淀粉含量较高,粗脂肪含量低,单宁含量0.86%。2019—2020年,该品种参加国家春播早熟区新品种区域试验,2年试验平均产量为8777 kg/hm^(2),比对照品种四杂25平均增产10.02%。该品种具有红粮优势,红壳红粒,中矮秆,适于酿造,产量高,适应性好,抗性强,适宜于吉林省中西部地区、黑龙江省第一积温带及内蒙古自治区的中东部地区进行机械化推广应用。

Effect of experimental warming on soil respiration under conventional tillage and no-tillage farmland in the North China Plain

Understanding the response of soil respiration to global warming in agro-ecosystem is crucial for simulating terrestrial carbon （C） cycle. We conducted an infrared warming experiment under conventional tillage （CT） and no-tillage （NT） farmland for winter wheat and summer maize rotation system in North China Plain （NCP）. Treatments include CT with and without warming （CTW and CTN）, NT with and without warming （NTW and NTN）. The results indicated that warming had no sig- nificant effect on soil moisture in irrigated farmland of NCP （P〉0.05）. The elevated average soil temperature of 1.1-116℃ in crop growing periods could increase annual soil CO2 emission by 10.3% in CT filed （P〉0.05）, but significantly increase it by 12.7% in NT field （P〈0.05）, respectively. The disturbances such as plowing, irrigation and precipitation resulted in the obvious soil CO2 emission peaks, which contributed 36.6-40.8% of annual soil cumulative CO2 emission. Warming would enhance these soil CO2 emission peaks; it might be associated with the warming-induced increase of autotrophic respiration and heterotrophic respiration. Compared with un-warming treatments, dissolved organic carbon （DOC） and soil microbial biomass carbon （MBC） in warming treatments were significantly increased by 11.6-23.4 and 12.9-23.6%, respectively, indicating that the positive responses of DOC and MBC to warming in both of two tillage systems. Our study highlights that climate warming may have positive effects on soil C release in NCP in association with response of labile C substrate to warming.

Capsule endoscopy compared with conventional colonoscopy for detection of colorectal neoplasms

Colon capsule endoscopy(CCE) may be a means to overcome the low adherence to colorectal cancer screening. The device is an ingestible capsule with a video camera at both ends that can take photographs as it progresses through the gastrointestinal tract.PillCam colon(PCC1) may be used for structural evaluation of the large bowel following an adequate cleaning procedure.PCC1 measures 11 mm×31 mm and has dual cameras that enable the device to acquire video images from both ends with a wide coverage area,automatic light control and a frame rate of four frames per second.The system includes a sensor array and data recorder connected to the patient during the procedure.The recorded data are downloaded to the Given Imaging Rapid workstation for review of the colon video.The second generation of PillCam Colon(PCC2) is similar to PCC1 and incorporates new developments.The angle of view has been increased to 172 degrees.It has an adaptive frame rate,alternating from 35 frames per second while in motion to 4 images when virtually stationary.The new RAPIDsoftware now includes a simple graphic interface tool for polyp size estimation.The procedure of bowel cleansing until capsule ingestion is similar to that used for traditional colonoscopy.However it is more rigorous as the bowel cleanliness for capsule colonoscopy has to be excellent or at least good to result in an adequate sensi-tivity of the method.Briefly,it consists of 3.5-4 L of split dose polyethylene glycol.Oral NaP boosters are administered after 1-2 h if the capsule has entered the small bowel.Sodium phosphate(NaP) seems to be a necessary adjunct to the regimen because the total transit time is doubled without NaP.The cleansing level was considered to be good to excellent in 72%-88%in studies with PCC1.The sensitivity for significant polyps(>6 mm or more than 3 polyps>3 mm) ranged from 63%-88% with specificities between 64%-94%.PCC2 showed an improved sensitivity of 89%and a specificity of 76%. CCE seems to be a safe and effective method of visualizing the colonic mucosa through colon fluids without the need for sedation or insufflation of air.The sensitivity of CCE to detect polyps,advanced adenomas and cancer is lower compared to optical colonoscopy but improvements will be made in the near future.With an increased recording duration,even a panenteric examination of the whole gastrointestinal tract may be possible.

Differentiation of Soil Fauna Populations in Conventional Tillage and No-Tillage Red Soil Ecosystems

In a field experiment, the populations of major soil fauna groups including earthworms, enchytraeids,arthropods and nematodes were examined in conventional tillage (CT) and no-tillage (NT) red soil ecosystems to evaluate their responses to tillage disturbance. Earthworms, macrry and micro-arthropods were stimulated under NT with earthworms showing the highest population increase by four times, while enchytraeids and nematodes favored CT system, predicting certain adaptability of these animals to plow-disturbed soil environment. On the basis of relative response index it was found that soil fauna was more sensitive to tillage than soil resource base (C and N pools) and microflora. The population structure of soil fauna was also affected by tillage treatments. Analysis on nematode trophic groups showed that bacteria-feeding and plant parasitic nematodes were more abundant in CT soil whereas the proportions of fungivores and omnivorepredators increased in NT soil. Possible reasons for the differentiation in both size and structure of the fauna population were discussed and the ecological significance involved in these changes was emphasized.

Three-dimensional MR and axial CT colonography versus conventional colonoscopy for detection of colon pathologies

AIM： To evaluate the sensitivity and specificity of MR colonography （MRC） and CT performance in detecting colon lesions, and to compare their sensitivity and specificity with that of conventional colonoscopy. METHODS： Forty-two patients suspected of having colonic lesions, because of rectal bleeding, positive fecal occult blood test results or altered bowel habits, underwent the examinations. After insertion of a rectal tube, the colon was filled with 1000-1500 mL of a mixture of 9 g/L NaCI solution, 15-20 mL of 0.5 mmol/L gadopentetate dimeglumine and 100 mL of iodinized contrast material. Once colonic distension was achieved, three-dimensional gradient-echo （3D-GRE） sequences for MR colonography and complementary MR images were taken in all cases. Immediately after MR colonography, abdominal CT images were taken by spiral CT in the axial and supine position. Then all patients were examined by conventional colonoscopy （CC）. RESULTS： The sensitivity and specificity of MRC for colon pathologies were 96.4% and 100%, respectively. The percentage of correct diagnosis by MRC was 97.6%. The sensitivity and specificity of CT for colon pathologies were 92.8%, 100%, respectively. The percentage of correct diagnosis by CT was 95.2%. CONCLUSION： In detecting colon lesions, MRC achieved a diagnostic accuracy similar to CC. However, MRC is minimally invasive, with no need for sedation or analgesics during investigation. There is a lower percentage of perforation risk, and all colon segments can be evaluated due to multi-sectional imaging availability; intramural, extra-intestinal components of colonic lesions, metastasis and any additional lesions can be evaluated easily. MRC and CT colonography are new radiological techniques that promise to be highly sensitive in the detection of colorectal mass and inflammatory bowel lesions.

Endoscopic diagnosis of cervical esophageal heterotopic gastric mucosa with conventional and narrow-band images

AIM: To compare the diagnostic yield of heterotopic gastric mucosa (HGM) in the cervical esophagus with conventional imaging (CI) and narrow-band imaging (NBI).

A new nonlinear empirical strength criterion for rocks under conventional triaxial compression

The failure criterion of rocks is a critical factor involved in reliability design and stability analysis of geotechnical engineering.In order to accurately evaluate the triaxial compressive strength of rocks under different confining pressures,a nonlinear empirical strength criterion based on Mohr-Coulomb criterion was proposed in this paper.Through the analysis of triaxial test strength of 11 types of rock materials,the feasibility and validity of proposed criterion was discussed.For a further verification,six typical strength criteria were selected,and the prediction results of each criterion and test results were statistically analyzed.The comparative comparison results show that the prediction results obtained by applying this new criterion to 97 conventional triaxial compression tests of 11 different rock materials are highly consistent with the experimental data.Statistical analysis was executed to assess the application of the new criterion and other classical criteria in predicting the failure behavior of rock.This proposed empirical criterion provides a new reference and method for the determination of triaxial compressive strength of rock materials.

Anterior vs conventional approach right hepatic resection for large hepatocellular carcinoma:A systematic review and meta-analysis

AIM To compare the clinical outcomes of right hepatectomy for large hepatocellular carcinoma via the anterior and conventional approach.METHODS We comprehensively performed an electronic search of Pub Med, EMBASE, and the Cochrane Library for randomized controlled trials(RCTs) or controlled clinical trials(CCTs) published between January 2000 and May 2017 concerning the anterior approach(AA) and the conventional approach(CA) to right hepatectomy. Studies that met the inclusion criteria were included, and their outcome analyses were further assessed using a fixed or random effects model.RESULTS This analysis included 2297 patients enrolled in 16 studies(3 RCTs and 13 CTTs). Intraoperative blood loss [weighted mean difference =-255.21; 95% confidence interval(95%CI):-371.3 to-139.12; P < 0.0001], intraoperative blood transfusion [odds ratio(OR) = 0.42; 95%CI: 0.29-0.61; P < 0.0001], mortality(OR = 0.59; 95%CI: 0.38-0.92; P = 0.02), morbidity(OR = 0.77; 95%CI: 0.62-0.95; P = 0.01), and recurrencerate(OR = 0.62; 95%CI: 0.47-0.83; P = 0.001) were significantly reduced in the AA group. Patients in the AA group had better overall survival(hazard ratio [HR] = 0.71; 95%CI: 0.50-1.00; P = 0.05) and disease-free survival(HR = 0.67; 95%CI: 0.58-0.79; P < 0.0001) than those in the CA group.CONCLUSION The AA is safe and effective for right hepatectomy for large hepatocellular carcinoma and could accelerate postoperative recovery and achieve better survival outcomes than the CA.

An efficient synthesis of benzofuran derivatives under conventional/non-conventional method

l-Methyl-3-ethyl imidazolium bromide[meim]Br/basic alumina（Al2O3） has been found to promote the cyclocondensation of chloroacetone/chloroethyl acetate with salicylaldehydes under conventional as well as microwave irradiation to yield benzofuran derivatives.

Theory, technology and prospects of conventional and unconventional natural gas

The development of natural gas in China has entered a golden and leap-forward stage, which is a necessary bridge to clean energy. This in-depth study on the status quo, theory, technology and prospect of natural gas development shows:(1) The global remaining proven recoverable reserves of natural gas are 186×1012 m3, and the reserves-production ratio is 52.4, indicating a solid resource base for long-term and rapid development.(2) Ten formation and distribution laws of conventional and unconventional natural gas reservoirs have been proposed. In terms of exploration geology, the theory of conventional "monolithic" giant gas fields with different gas sources, and an unconventional gas accumulation theory with continuous distribution of "sweet areas" in different lithologic reservoirs have been established; in terms of development geology, a development theory of conventional structural gas reservoirs is oriented to "controlling water intrusion", while a development theory of unconventional gas is concentrated on man-made gas reservoirs.(3) With the geological resources(excluding hydrates) of 210×1012 m3 and the total proven rate of the resources less than 2% at present, the natural gas in China will see a constant increase in reserve and production; by 2030, the proven geological reserves of natural gas are expected to reach about(6 000-7 000)×108 m3, the production of conventional and unconventional natural gas each will reach about 1 000×108 m3, and the gas consumption will reach 5 500×108 m3. The dependence on imported natural gas may be 64% by 2030, and 70% by 2050.(4) Ten measures for future development of natural gas have been proposed, including strengthening exploration in large-scale resource areas, increasing the development benefits of unconventional gas, and enhancing the peak adjusting capacity of gas storage and scale construction of liquified natural gas.

Yttrium-90 transarterial radioembolization versus conventional transarterial chemoembolization for patients with hepatocellular carcinoma：a systematic review and meta-analysis

Objective: To compare the effects and safety of conventional transarterial chemoembolization(c TACE) and yttrium-90 transarterial radioembolization [TARE(90 Y)] for hepatocellular carcinoma(HCC)Methods: Nine high-quality observational studies, one low bias-risk randomized controlled trial(RCT), and one moderate biasrisk RCT included 1,652 patients [c TACE, 1,124; TARE(90 Y), 528], from whom data were extracted for this systematic review and meta-analysis.Results: The extracted study outcomes included 1-year and 2-year overall survival(OS) rates, objective responses(ORs), and serious adverse events(AEs). 1-year OS rates: OR = 0.939, 95 % CI: 0.705-1.251, P = 0.66. 2-year OS rates: overall pooled OR =0.641, 95% CI: 0.382-1.075, P = 0.092; observational study subgroup OR = 0.575, 95% CI: 0.336-0.984, P = 0.043; RCT subgroup OR* = 0.641, 95% CI: 0.382-1.075, P = 0.346. OR: overall pooled OR = 0.781, 95% CI: 0.454-1.343, P = 0.371; m RECIST subgroup OR = 0.584, 95 % CI: 0.349-0.976, P = 0.040; WHO subgroup OR = 1.065; 95% CI: 0.500-2.268, P = 0.870. Serious AEs: overall pooled RR = 1.477, 95% CI: 0.864-2.526, P = 0.154; RCT subgroup RR = 0.680, 95% CI: 0.325-1.423, P = 0.306; observational study subgroup RR = 1.925; 95 % CI: 0.978-3.788, P = 0.058.Conclusions: TARE(90 Y) increased 2-year OS rates in the observational subgroup and resulted in better OR rates, according to m RECIST criteria, in comparison with c TACE. Furthermore, a lower risk of AEs was observed for TARE(90 Y) than for c TACE.

Colonography by CT,MRI and PET/CT combined with conventional colonoscopy in colorectal cancer screening and staging

Colorectal cancer (CRC) remains a leading cancer killer worldwide. But the disease is both curable and preventable at an early stage. Regular CRC cancer screening has been shown to reduce the risk of dying from CRC. However, the importance of large-scale screening is only now starting to be appreciated. This article reviews a variety of imaging procedures available for detecting ulcerative colitis (UC) and Crohn's disease (CD), polyps and CRC in their early stage and also presents details on various screening options. Detecting, staging and re-staging of patients with CRC also require multimodality, multistep imaging approaches. Staging and re-staging with conventional colonoscopy (CC), computer tomography colonography (CTC), magnetic resonance colonography (MRC) and positron emission tomography/computer tomography colonography (PET/CTC) are of paramount importance in determining the most appropriate therapeutic method and in predicting the risk of tumor recurrence and overall prognosis. The advantages and limitations of these modalities are also discussed.

Time-dependent Diffusion Coefficient and Conventional Diffusion Constant of Nanoparticles in Polymer Melts by Mode-coupling Theory

Time-dependent diffusion coefficient and conventional diffusion constant are calculated and analyzed to study diffusion of nanoparticles in polymer melts. A generalized Langevin equa- tion is adopted to describe the diffusion dynamics. Mode-coupling theory is employed to calculate the memory kernel of friction. For simplicity, only microscopic terms arising from binary collision and coupling to the solvent density fluctuation are included in the formalism. The equilibrium structural information functions of the polymer nanocomposites required by mode-coupling theory are calculated on the basis of polymer reference interaction site model with Percus-Yevick closure. The effect of nanoparticle size and that of the polymer size are clarified explicitly. The structural functions, the friction kernel, as well as the diffusion coefficient show a rich variety with varying nanoparticle radius and polymer chain length. We find that for small nanoparticles or short chain polymers, the characteristic short time non-Markov diffusion dynamics becomes more prominent, and the diffusion coefficient takes longer time to approach asymptotically the conventional diffusion constant. This constant due to the microscopic contributions will decrease with the increase of nanoparticle size, while increase with polymer size. Furthermore, our result of diffusion constant from mode- coupling theory is compared with the value predicted from the Stokes-Einstein relation. It shows that the microscopic contributions to the diffusion constant are dominant for small nanoparticles or long chain polymers. Inversely, when nanonparticle is big, or polymer chain is short, the hydrodynamic contribution might play a significant role.

Difference between grid connections of large-scale wind power and conventional synchronous generation

In China, regions with abundant wind energy resources are generally located at the end of power grids. The power grid architecture in these regions is typically not sufficiently strong, and the energy structure is relatively simple. Thus, connecting large-capacity wind power units complicates the peak load regulation and stable operation of the power grids in these regions. Most wind turbines use power electronic converter technology, which affects the safety and stability of the power grid differently compared with conventional synchronous generators. Furthermore, fluctuations in wind power cause fluctuations in the output of wind farms, making it difficult to create and implement suitable power generation plans for wind farms. The generation technology and grid connection scheme for wind power and conventional thermal power generation differ considerably. Moreover, the active and reactive power control abilities of wind turbines are weaker than those of thermal power units, necessitating additional equipment to control wind turbines. Hence, to address the aforementioned issues with large-scale wind power generation, this study analyzes the differences between the grid connection and collection strategies for wind power bases and thermal power plants. Based on this analysis, the differences in the power control modes of wind power and thermal power are further investigated. Finally, the stability of different control modes is analyzed through simulation. The findings can be beneficial for the planning and development of large-scale wind power generation farms.

Omics Technologies Reveal Abundant Natural Variation in Metabolites and Transcripts among Conventional Maize Hybrids

In this report we have evaluated metabolite and RNA profiling technologies to begin to understand the natural variation in these biomolecules found in commercial-quality, conventional (non-GM) maize hybrids. Our analyses focus on mature grain, the article of commerce that is most typically subjected to the rigorous studies involved in the comparative safety assessment of GM products. We have used a population of conventionally-bred maize hybrids that derive from closely related inbred parents grown under standard field conditions across geographically similar locations. This study highlights the large amount of natural variation in metabolites and transcripts across conventional maize germplasm grown under normal field conditions, and underscores the critical need for further extensive studies before these technologies can be seriously considered for utility in the comparative safety assessment of GM crops.

Phenolic Acids Content and Nutritional Quality of Conventional, Organic and Biodynamic Cultivations of the Tomato CXD271BIO Breeding Line (Solanum lycopersicum L.)

This study was undertaken to evaluate the influence of growing systems (conventional, organic and biodynamic performed with two types of manuring) on some nutritional traits of the tomato breeding line CXD271BIO (Solanum lycopersicum L.). Experimental fields were in the same geographical area and the cultivations were performed over five years. The content of macronutrients, minerals (Ca, K, Mg, P, Na), trace elements (Fe, Zn, Cu, Mn) and phenolic acids (chlorogenic, caffeic, p-coumaric and ferulic acids) was determined. The biodynamic A growing system showed the highest protein and carbohydrates content compared to the other growing systems. Data on minerals and trace elements content showed significant differences (mainly in Ca, Na, Fe and Zn content) between conventional and biodynamic tomatoes, whereas no major impact of the fertilization among organic and the two biodynamic growing systems was observed. Appreciable differences in phenolic acids biosynthesis were observed, with the year of harvest showing a marked effect especially on chlorogenic, p-cumaric and ferulic acids content. Conversely, the cultivation system did not show major influence. Principal Components Analysis (PCA), performed on mineral and phenolic acids content, substantiated the large effect of the year of harvest, also suggesting an effect of the conventional cultivation system.

Short-term efficacy and influencing factors of conventional chemotherapy combined with irinotecan in patients with advanced gastric cancer

BACKGROUND Gastric cancer is one of the most common cancers worldwide, with a 5-year survival rate of only 20%. The age of onset of gastric cancer is in line with the general rule of cancer. Most of them occur after middle age, mostly between 40and 60 years old, with an average age of about 50 years old, and only 5% of patients are under 30 years old. The incidence of male is higher than that of female.AIM To investigate the short-term efficacy and influencing factors of chemotherapy combined with irinotecan in patients with advanced gastric cancer.METHODS Eighty patients with advanced gastric cancer who were treated in our hospital from January 2019 to January 2022 were selected. The patients were divided into an observation group(n = 40) and control group(n = 40) by the envelope method.The control group was given preoperative routine chemotherapy. The observation group was treated with irinotecan in addition to the chemotherapy given to the control group. The short-term efficacy of treatment in the two groups, as well as tumor marker levels and quality of life before and after treatment were evaluated.RESULTS The short-term treatment effect in the observation group was better than that in the control group(P < 0.05), and the total effective rate was 57.50%. The age and proportion of tumor node metastasis(TNM) stage IV patients with ineffective chemotherapy in the observation group were(65.12 ± 5.71) years and 52.94%,respectively, which were notably higher than those of patients with effective chemotherapy(P < 0.05), while the Karnofsky Performance Scale score was(67.70± 3.83) points, which was apparently lower than that of patients with effective chemotherapy(P <0.05). After 3 mo of treatment, the SF-36 scale scores of physiological function, energy, emotional function, and mental health in the observation group were 65.12 ± 8.14, 54.76 ± 6.70, 47.58 ± 7.22,and 66.16 ± 8.11 points, respectively, which were considerably higher than those in the control group(P < 0.05). The incidence rates of grade Ⅲ-Ⅳ diarrhea and grade Ⅲ-Ⅳ thrombocytopenia in the observation group were 32.50% and 25.00%, respectively, which were markedly higher than those in the control group(P < 0.05).CONCLUSION Chemotherapy combined with irinotecan in patients with advanced gastric cancer has a good short-term efficacy and can significantly reduce serum tumor markers and improve the quality of life of patients. The efficacy may be affected by the age and TNM stage of the patients, and its long-term efficacy needs further study.

Conventional and Enhanced Canonical Quantizations, Application to Some Simple Manifolds

It is well known that the representations over an arbitrary configuration space related to a physical system of the Heisenberg algebra allow to distinguish the simply and non simply-connected manifolds [arXiv:quant-ph/9908.014, arXiv:hep-th/0608.023]. In the light of this classification, the dynamics of a quantum particle on the line is studied in the framework of the conventional quantization scheme as well as that of the enhanced quantization recently introduced by J. R. Klauder [arXiv:quant-ph/1204.2870]. The quantum action functional restricted to the phase space coherent states is obtained from the enhanced quantization procedure, showing the coexistence of classical and quantum theories, a fundamental advantage offered by this new approach. The example of the one dimensional harmonic oscillator is given. Next, the spectrum of a free particle on the two-sphere is recognized from the covariant diffeomorphic representations of the momentum operator in the configuration space. Our results based on simple models also point out the already-known link between interaction and topology at quantum level.