Immunotherapy is revolutionizing the clinical management of cancer patients by modulating T cells and natural killer cells.Dendritic cells(DCs)have the capacity to orchestrate the expansion and function of these effec...Immunotherapy is revolutionizing the clinical management of cancer patients by modulating T cells and natural killer cells.Dendritic cells(DCs)have the capacity to orchestrate the expansion and function of these effector cells both in lymphoid and non-lymphoid tissues of cancer patients.Distinct subtypes of DCs have various capacities to prime and activate different T cell responses.Here,we review conventional type 1 dendritic cells(cDC1s)and their crucial role in protective anti-tumor immunity.Targeting cDC1s as a cancer vaccine against the development of hepatocellular carcinoma will be discussed.展开更多
基金supported by the Natural Science Foundation of China(No.81571620)the Chinese Academy of Medical Sciences Innovative Medicine(No.2016-I2M-1-007).
文摘Immunotherapy is revolutionizing the clinical management of cancer patients by modulating T cells and natural killer cells.Dendritic cells(DCs)have the capacity to orchestrate the expansion and function of these effector cells both in lymphoid and non-lymphoid tissues of cancer patients.Distinct subtypes of DCs have various capacities to prime and activate different T cell responses.Here,we review conventional type 1 dendritic cells(cDC1s)and their crucial role in protective anti-tumor immunity.Targeting cDC1s as a cancer vaccine against the development of hepatocellular carcinoma will be discussed.
