Clinical efficacy of angina pectoris after pci in patients with coronary heart disease complicated with type 2 diabetes by Yiqi Yangyin and Huatan Tongluo recipe

Objective:To evaluate the clinical efficacy of Yiqi Yangyin and Huatan Tongluo Recipe in improving the symptoms of angina pectoris and cardiac function in patients with coronary heart disease complicated with type 2 diabetes after PCI.Methods Sixty-two patients with coronary heart disease complicated with type 2 diabetes after PCI were randomly divided into treatment group and control group,with 31 patients in each group.Both groups were treated with western medicine.The treatment group added Yiqi Yangyin and Huayu Tongluo Recipe granules.The changes of metabolic equivalent(METs),angina symptoms,TCM symptoms,BNP,hypersensitive C-reactive protein(hs-CRP),Interleukin-6(IL-6),Tumor necrosis factor-(TNF-α)and left ventricular ejection fraction(LVEF)were analyzed after 1 course of treatment and Corrected TIMI Frame Count(CTFC)after six month.Results The improvement of METS and LVEF in the treatment group was better than that in the control group(P<0.05);the improvement of BNP,hs-CRP,IL-6,TNF-αand CTFC in the treatment group was better than that in the control group;the curative effect of angina pectoris in the treatment group was better than that in the control group;the effective rate of TCM syndrome improvement in the treatment group was better than that in the control group.Conclusion Yiqi Yangyin and Huatan Tongluo Recipe can effectively alleviate angina pectoris symptoms in patients with coronary heart disease complicated with type 2 diabetes after PCI,suggesting cardiac function,inhibiting inflammatory response,and improving microcirculation disturbance.

Psychosocial Adaptation Level and Work Participation Rate of Young and Middle-aged Patients with Coronary Heart Disease after PCI

[Objectives]The research aimed to understand the psychosocial adjustment to illness of young and middle-aged patients with coronary heart disease after PCI and their participation situation in work.[Methods]210 young and middle-aged patients aged 18-59 years with coronary heart disease treated by PCI in a tertiary hospital of Suzhou from July of 2020 to November of 2022 were selected,and general information of patients in three days after operation was registered.Self-report psychosocial adjustment to illness scale(PAIS-SR)was used to investigate the psychosocial adjustment to illness of patients in 1,3 and 6 months after operation and the participation rate of work.[Results]The psychosocial adjustment to illness of young and middle-aged patients with coronary heart disease after PCI was different in gender,age,education level,marital status,hypertension,diabetes,postoperative cardiac color Doppler ultrasound results(left ventricular ejection fraction)and the number of stents(P<0.05).[Conclusions]The psychosocial adjustment to illness of young and middle-aged patients with coronary heart disease after PCI needs to be improved.The psychosocial adjustment to illness of men is higher than that of women.The older the age is,the lower the psychosocial adjustment to illness is.The psychosocial adjustment to illness of patients with high educational background is higher than those with low educational background,while the psychosocial adjustment to illness of married people is higher than unmarried people.The psychosocial adjustment to illness of patients with hypertension and/or diabetes is lower.

PCI compared with medical therapy in elderly patients with chronic symptomatic coronary artery disease

Objective The aim of this study was to assess quality of results of elderly patients with coronary disease after medical or revascularisation therapy. Methods In this study, we enrolled 103 patients aged 75 years or older with chronic angina in which 47 patients were assigned coronary angiography and revascularisation and 56 patients with optimised medical therapy. The primary endpoint was quality of life after 6 months, as assessed by questionnaire and the presence of major adverse cardiac events (death, non fatal myocardial infarction, or hospital admission for acute coronary syndrome with or without the need for revascularisation). Results After 6 months follow up, angina severity decreased and measures of quality of life increased in both treatment groups( P <0.05 ); however, these improvements were significantly greater after revascularisation( P <0.01 ). Major adverse cardiac events occurred in 30 ( 53.6% ) of patients in the medical group and 9 ( 19.1% ) in the invasive group ( P <0.01 ).Conclusions Patients aged 75 years or older with angina benefit more from revascularisation than from optimised medical therapy in terms of symptom relief and quality of life. Therefore, these patients should be offered invasive assessment despite their high risk profile followed by revascularisation if feasible.

Research Progress on the Depression Status and Nursing Intervention in Patients after Percutaneous Coronary Intervention

Percutaneous coronary intervention(PCI)is an effective treatment method for myocardial ischemic necrosis.Postoperative depression caused by PCI stress will adversely affect the prognosis of patients.This article reviews the current status and influencing factors of postoperative depression after PCI and summarizes the corresponding nursing interventions,to provide a literature reference to implement effective nursing interventions for depressed patients after clinical PCI.

Arterial hypertension and electrocardiographic diagnosis of left ventricular hypertension in the group of geriatric patients with coronary heart disease living in the far north

As a result of research, high prevalence of arterial hypertension has been identified in the group of patients with coronary heart disease aged 60 and older. Most often, occurring form of arterial hypertension among geriatric patients is isolated systolic arterial hypertension (ISAH). The comparison of two ethnic groups of the population has showed higher levels of systolic and diastolic blood pressure (SBP and DBP) in the group of patients of non-indigenous nationality, rather than Yakut patients. Correlation was recorded in the group of non-indigenous patients as they age. Significant increase in the level of SBP was identified in the group of senile and long-livers than in the elderly. Detection of ECG signs of LVH showed the lowest specificity of Cornell voltage criterion comparing to Sokolow-Lyon criterion with its more often occurrence. ECG-signs of left ventricle hypertrophy are significantly more often established by Sokolow-Lyon criterion for men, Cornell voltage—for women. Correlation has been found between the presence of LVH and combination of Cornell voltage criterion with both Gubner-Ungerleider and Sokolow-Lyon criteria.

Efficacy and safety of traditional Chinese medicine in the treatment of coronary heart disease complicated with anxiety and/or depression after PCI:A systematic review and meta-analysis

Objective:The clinical efficacy and safety of traditional Chinese medicine in the treatment of anxiety and/or depression after PCI for coronary heart disease were systematically evaluated.Methods:The databases of CNKI,Wanfang,VIP,CMB,PubMed,Web of Science,PubMed,Web of Science and Cochrane Library were searched by computer,and the Chinese and English randomized controlled trials(RCTs)of traditional Chinese medicine in the treatment of anxiety and/or depression after PCI of coronary heart disease published from the database to November 2020 were included.The Cochrane bias risk tool and the modified Jadad scale were used to evaluate the quality of the included literature,and the RevMan 5.3 and Stata 16.0 software were used for Meta-analysis.Results:A total of 23 RCTs were included,including 1837 subjects,including 917 cases in the treatment group of traditional Chinese medicine,920 cases in the control group,the baseline situation between groups was consistent,comparable.Meta-analysis results show that TCM treatment improves the total clinical effective rate[OR=2.34,95%CI(1.61,3.40),P<0.00001],and the efficacy of TCM syndrome[OR=5.19,95%CI(2.74,9.86),P<0.00001],reduce Hamilton anxiety scale HAMA score[SMD=-0.96,95%CI(-1.78,-0.14),P=0.02],Hamilton Depression Scale HAMD score[SMD=-1.10,95%CI(-1.79,-0.41),P=0.002],SAS self-rating scale score[SMD=-1.20,95%CI(-1.75,-0.65),P<0.0001],SDS self-rating scale score[SMD=-1.14,95%CI(-1.62,-0.65),P<0.00001]and other indicators are better than the control group,and the difference is statistically significant(P<0.05).Conclusion:The combination of traditional Chinese medicine intervention and conventional western medicine treatment after PCI can further improve the clinical efficacy of patients with anxiety and/or depression after PCI of coronary heart disease and has good safety.Due to the general quality of the literature included in this study,the above conclusions need to be further confirmed by high-quality randomized controlled double-blind clinical trials.

Relationship between the Self-Efficacy and Mental Health of Elderly Patients with Coronary Heart Disease in Rural Hebei Province

Objective:To investigate the self-efficacy and mental health of elderly patients with coronary heart disease(CHD)in rural Hebei Province as well as to analyze the relationship between them.Methods:From June 2021 to December 2021,480 elderly patients with CHD from rural areas,who had been discharged by the Department of Cardiology from three tertiary hospitals in three cities with different economic levels in Hebei Province for more than a year,were selected as the research subjects.The general self-efficacy scale(GSES)and symptom self-rating scale(SCL-90)were used to investigate the self-efficacy and mental health of these patients.SPSS 25.0 was used for data analysis.Results:The total mean self-efficacy score of elderly patients with CHD in rural Hebei Province was 17.18±4.68,which is lower than the international norm(t=-32.067,P=0.000)and the national norm(t=-28.783,P=0.000);the total average SCL-90 score was 148.64±55.13,which is higher than the national norm for adults and the reference norm for ordinary elderly people;except for hostility and psychosis,the other dimensions were significantly higher than the national norm for adults(P<0.05);except for psychosis,the other dimensions were significantly higher than the reference norm for ordinary elderly people(P<0.05);the self-efficacy score was found to be negatively correlated with the total SCL-90 score and the score for each dimension(P<0.05).Conclusion:Elderly CHD patients with higher self-efficacy in rural Hebei Province have higher mental health level.It is suggested that the mental health of elderly patients with CHD in rural areas can be improved by improving their self-efficacy.

A Readmission Risk Prediction Model for Elderly Patients with Coronary Heart Disease

Objective:To analyze the independent risk factors and establish a risk prediction model by investigating the readmission of elderly patients with coronary heart disease(CHD)within 1 year after discharge.Methods:A total of 480 CHD patients,who were hospitalized in the Affiliated Hospital of Hebei University from October 2019 to December 2020,were included in this study.A general data scale,mental health status scale,the Clinical Frailty Scale,Pittsburgh Sleep Quality Index,as well as the Family Adaptability and Cohesion Evaluation Scale were used to collect data.According to the number of readmissions due to CHD within 1 year after discharge,the patients were divided into two groups:the readmission group(n=212)and the no readmission group(n=268).General data,laboratory examination indicators,frailty,mental health status,sleep status,as well as family intimacy and adaptability were compared between the two groups.Logistic regression was used to analyze the independent risk factors for the readmission of these patients,and R software was used to construct a line diagram model for predicting readmission of elderly patients with CHD.Results:Five factors including body mass index(OR=1.045),low density lipoprotein(OR=1.123),frailty(OR=1.946),mental health(OR=1.099),as well as family intimacy and adaptability(OR=0.928)were included to construct the risk prediction model for the readmission of elderly patients with CHD within 1 year after discharge.The ROC curve showed that the area under the curve for predicting readmission of elderly patients with CHD was 0.816;Hosmer-Lemeshow goodness of fit test showed X2=1.456 and P=0.989;the maximum Youden index corresponding to the predicted value of risk was 0.526.The results showed that the model could accurately predict the risk of readmission in elderly patients with CHD within 1 year after discharge.Conclusion:This study constructed a line diagram model based on five independent risk factors of the readmission of elderly patients with CHD:body mass index,low density lipoprotein,frailty,mental health status,as well as family intimacy and adaptability.This model has good discrimination,accuracy,and predictive efficiency,providing reference for the early prevention and intervention of readmission in elderly patients with CHD recurrence.

Based on data mining to explore the medication rule of Professor Shao Zheng-bin in the treatment of coronary heart disease combined with type2 diabetes mellitus after PCI

Objective:To explore the clinical medication rule of Shao Zhengbin in the treatment of coronary heart disease with type 2 diabetes mellitus after PCI by using data mining technology.Methods:Shao Zhengbin was collected from January 2016 to may 2019 in the outpatient department of the First Affiliated Hospital of Anhui University of traditional Chinese medicine to treat patients with coronary heart disease combined with type 2 diabetes mellitus after PCI.The data base was established with Microsoft Excel 2016,SPSS statistic 24.0,SPSS modeler 18.0 computer software,and drug frequency analysis,high-frequency drug association rule analysis and clustering were carried out Analysis and factor analysis.Results:of the 133 prescriptions included in the study,86 Chinese herbs were involved,and the top 10 drugs were dangshen,Huangjing,Danshen,Gualou,chuanxiong,fried Atractylodes rhizome,Poria cocos,Fushen and Chenpi respectively;12 drug associations were generated by association analysis,including Huangjing,Huangjing,chuanxiong,dandelion,Dangshen and banpi;12 drug associations were obtained by cluster analysis,including Huangjing,huangxiong,Gualou and Huangqi There are 7 clustering formulas,such as Xia,Danshen,Fuling,Gualou,etc.Conclusion:Shao Zhengbin is good at the treatment of coronary heart disease combined with type 2 diabetes mellitus after PCI.

Feasibility of percutaneous coronary intervention via transulnar artery approachin selective patients with coronary heart disease

Objective To probe the clinic feasibility of percutaneous coronary intervention(PCI) via transulnar artery approach (PCI TRU).Methods Fourty patients with unstable ischemic manifestation(male 34,female 6;age 59.3 ±9.10 years)whose radial artery of right hand was thin with a weak pulse that was not suitable to transradial artery PCI while whose ulnar artery was thick with a strong pulse based on their larger diameter in ulnar artery as compared with those in radial artery ( 3.30 ±0.22mm vs 2.43 ±0.33 mm, P <0.05 ) by the investigation of vessel echography,but revesered Allen’s test for radial and ulnar artery was positive,were selected as the subjects for PCI TRU. The radio of ulnar artery versus radial artery was 1.35:1.00 and the time of Allen’s test in ulnar artery side was shorter than that in radial artery side ( 2.70 ±0.36 s vs 4.68 ±0.52s , P <0.05 ) before PCI. The efficiency of PCI TRU was evaluated. The time of manipulative duration for each procedure of PCI TRU was recorded. The time of Allen’s test, luminal diameter (mm) , cross area of vessel lumin (mm 2), blood velocity (Vs max), blood resistance (RI) in ulnar artery and radial artery and the level of blood oxygen in finger (PaO 2、SatO 2) were measured and recorded , respectively , as well were compared quantitatively before and after 1 month of procedure . Results Fourty eight lesion segments of 42 vessels in all patients were angioplasticized successfully via TRU by 6F guiding catheter including 23 segments of type B1 , 14 segments of type B2 and 11 segments of type C. PCI TRU in all of 40 patients was performed successfully. Fourty eight stents were implanted including 2 lesions of intrastent restenosis angioplasticized with cutting balloon technique before re stenting . The average time of manipulative duration of guiding catheters engaging in osicum of target coronary, crossing the vessel lesions of guidewire, dilatation and implantation of stents,and under X ray fluoroscopy were 4.30 ±0.59 min , 2.52 ±0.40min , 2.66 ±0.40 min ,and 25.9 ±0.49 min , respectively, and the total time of the whole procedure was 56.6 ±14.8 min . When the ulnar introducer was taken off, the access site in ulnar artery was suppressed by tourniquet with no bleeding in the access site and no limitation of physical activation under maintaining infusion of heparin immediately after procedure . There was no significant change in the diameter of ulnar artery and the time of Allen’s test after 1 month of PCI procedure as compared with those before procedure ( 3.22 ±0.48mm vs 3.26 ±0.22 mm , P >0.05 ; 2.96 ±0.98 s vs 2.72 ±0.47 s , P >0.05 ). No significant change was found in the parameters of blood velocity , cross area of vessel lumin, blood resistance and the level of blood oxygen in finger after 1 month of PCI procedure. The average total hospital stay was 5.21 ±0.43 days. Following up 1 month, no complications such as occlusion of ulnar artery, abnormal sensitivity and movement disability were found in right hands in all patients.Conclusions The ulnar artery might be selected as one approach of antebrachial artery for PCI in the patients with coronary heart disease whose radial artery was difficulty as access vessels of PCI, while reversed Allen’s test for radial and ulnar artery are positive and the luminal diameter of ulnar artery was larger than that of radial artery.

Change and significance of fibrinolysis in coronary heart disease patients with angina pactoris

Objectives To study change and the clinical significance of fibrinolysis in coronary heart disease(CHD) patients with angina pactoris(AP).Methods Levels of plas-min plasminogen activator inhibitor-1(PAI-1),tissue-type plasminogen activator(t-PA),fibrinogen(FIB) in 110 CHD patients with AP and 20 normal cases as control group were analyzed in the same ways.Results Levels of PAI-1,FIB in CHD patients with AP were significantly higher than those in control cases,and those of t-PA were significantly lower than control cases;Levels of PAI-1,FIB in UA patients with UA heart events were significantly higher than those in patients with SA,and those of t-PA were significantly lower than patients with SA;Levels of PAI-1,FIB in patients with AP events were significantly higher than those in patients without AP events,and those of t-PA were significantly lower than patients without AP events.Conclusions There was abnormal of fibrinolysis function in CHD patients with AP, specially in patients with UA or with AP events,the abnormal of fibrinolysis might be play an important rule in coronary heart disease(CHD) patients with angina pactoris.

冠心病病人PCI术后1年出血危险因素的模型构建和验证

目的:基于LASSO-Logistic回归分析冠心病病人经皮冠状动脉介入(PCI)术后1年出血的危险因素,并建立Nomogram预测模型,以便临床采取及时、有效的干预方案。方法:选取2021年1月—12月在我院行PCI术的226例冠心病病人为研究对象,依据PCI术后1年是否出血分为出血组、未出血组。采用LASSO-Logistic回归筛选PCI术后1年出血的危险因素,进一步构建Nomogram预测模型。利用受试者工作特征(ROC)曲线、校准曲线验证Nomogram预测模型的价值。结果:PCI术后1年226例冠心病病人出血发生率为11.95%;年龄≥60岁、有消化道病史、慢性肾功能不全、使用血管闭合器、球囊扩张次数、支架术后抗血小板药物停药模式(PARIS)评分、支架术后双重抗血小板治疗病人出血并发症预测(PRECISE-DAPT)评分为PCI术后1年出血的危险因素(P<0.05);Nomogram预测模型预测PCI术后1年出血的ROC曲线下面积为0.959。结论:年龄≥60岁、有消化道病史、慢性肾功能不全、使用血管闭合器、球囊扩张次数、PARIS评分、PRECISE-DAPT评分为冠心病病人PCI术后1年出血的危险因素,基于LASSO-Logistic回归分析建立的Nomogram预测模型对PCI术后1年出血具有一定预测价值,临床应筛查高危人群并实施严格观察,制定合理治疗措施,以降低出血风险。

二级预防概念下的预防管理对冠心病PCI术后患者心脏康复及抗血小板效果的影响研究

目的:探究二级预防概念下的预防管理对冠心病经皮冠状动脉治疗(PCI)术后患者心脏康复及抗血小板效果的影响。方法:选择2021年2月—2022年1月河南省胸科医院收治的160例冠心病PCI患者作为研究对象,采用随机数表法分为对照组和试验组,每组各80例。对照组患者采用常规护理,试验组患者在对照组的基础上采用联合二级预防概念下的预防管理,比较两组患者干预前、干预4个月后心脏康复和抗血小板效果情况。结果:干预4个月后,试验组患者左心室射血分数(LVEF)水平高于对照组患者,左心室舒张末期内径(LVEDD)水平、美国纽约心脏病学会(NYHA)分级均低于对照组患者,差异有统计学意义(t=8.583、8.695、6.455,P<0.05)。干预4个月后,试验组患者血小板最大聚焦率(MPAR)、血将P2Y12反应单位(PRU)水平均低于对照组患者,差异有统计学意义(t=8.573、8.661,P<0.05)。结论:基于二级预防理念对冠心病PCI术后患者进行预防管理,可有效提高患者抗血小板效果,改善其心脏康复水平。

厄贝沙坦对冠心病PCI术后患者临床疗效的影响

目的:观察厄贝沙坦对冠心病经皮冠状动脉介入术(PCI)术后患者的临床疗效。方法:选取2021年1月—2023年12月江南大学附属医院收治的120例冠心病PCI术后患者,随机分为A组(n=60)与B组(n=60)。A组予以常规治疗,B组予以常规治疗+厄贝沙坦治疗,对比两组患者的心绞痛发作情况(发作频率、持续时间)、血脂水平[甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)]、心功能指标[左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)、左室射血分数(LVEF)]、氧化应激水平[超氧化物歧化酶(SOD)、丙二醛(MDA)]及临床疗效。结果:两组治疗后的心绞痛发作频率、持续时间均减少,且B组少于A组,差异有统计学意义(P<0.05)。两组治疗后的TG、TC、HDL-C、LDL-C均改善,且B组优于A组,差异有统计学意义(P<0.05)。两组治疗后的LVEDD、LVESD、LVEF均改善,且B组优于A组,差异有统计学意义(P<0.05)。两组治疗后的SOD、MDA均改善,且B组优于A组,差异有统计学意义(P<0.05)。B组总有效率高于A组,差异有统计学意义(P<0.05)。结论:厄贝沙坦在冠心病PCI术后患者中的应用效果较好,可减少心绞痛发作频率及持续时间,改善血脂水平、心功能指标及氧化应激水平,总有效率高。

经皮冠状动脉介入治疗(PCI)患者的中医证型分布及预后危险因素:系统评价和meta分析

目的探讨经皮冠状动脉介入治疗(PCI)中医证候分布及相关风险因素,并评估现有研究的报告质量,以期为未来的标准化研究提供指导。方法分别在Pub Med、Cochrane Library和Web of Science等英文数据库,以及中国知网(CNKI)、维普(VIP)和万方数据库等中文数据库中检索PCI相关论文。论文检索的时间跨度从数据库建立至2023年10月1日。使用Stata 12和Python(V 3.9)进行统计分析。采用观察性研究报告规范(STROBE)声明评估纳入研究的报告质量。结果共筛选出1356篇文章,纳入40项横断面研究,涉及10270名参与者。PCI前最常见的中医证候为气滞血瘀证(n=261,36.45%),PCI后1–2周最常见的中医证候为痰瘀互结证(n=109,27.18%),PCI后6个月至1年最常见的中医证候为气虚血瘀证(n=645,37.03%)。吸烟[比值比(OR)=1.15,95%置信区间(CI)(0.83–1.47),I^(2)=24.7%,P=0.257]、寒凝气滞证[OR=4.62,95%CI(1.37–7.86),I^(2)=61.6%,P=0.074]及低密度脂蛋白(LDL)升高[OR=1.38,95%CI(0.92–1.85),I^(2)=12.2%,P=0.286]是再狭窄的风险因素。高血压[OR=7.26,95%CI(3.54–14.88),I^(2)=91.6%,P=0.001]和超重[即身体质量指数(BMI)>23][OR=1.20,95%CI(1.07–1.35),I^(2)=85.3%,P=0.009]是伴发焦虑的显著风险因素。结论本系统评价和meta分析显示,不同中医证型患者PCI术后特点和危险因素不同,未来需要更多相对高质量的研究,以提供更多的支持性证据。

有氧康复训练联合体外反搏对高龄冠心病患者PCI术后康复及侧支循环和内皮功能的影响

目的探究有氧康复训练联合体外反搏对高龄冠心病患者经皮冠状动脉介入治疗(percutaneous coronary intervention,PCI)手术后康复情况,及其对侧支循环和内皮功能的影响。方法以2021年1—12月进行PCI治疗的208例高龄冠心病患者为研究对象,所有患者随机分为对照组和观察组,每组48例,对照组患者采用常规护理联合体外反搏,观察组患者则采用有氧康复训练联合体外反搏,干预前后比较两组患者心肺功能指标、内皮功能和侧支循环指标、运动耐量指标,评估患者干预后的生活质量。结果干预3个月后,观察组患者的氧阈下代谢当量峰值摄氧量、峰值氧脉搏、无氧阈摄氧量和无氧阈下代谢当量等肺功能指标均显著高于对照组患者(P<0.05);观察组患者的心室射血分数、心输出量和最大心率等心功能指标显著高于对照组患者(P<0.05);观察组患者的血流介导肱动脉内皮依赖性舒张功能、肱动脉皮非依赖性舒张功能等内皮功能指标及脉侧支循环评分均显著高于对照组患者(P<0.05);观察组患者心率血压乘积、自认疲劳分级及Borg评分运动耐量指标显著低于对照组患者,运动时间显著长于对照组患者,差异有统计学意义(P<0.05);观察组患者的各项生活质量量表评分也显著高于对照组患者(P<0.05)。结论对实施PCI的高龄冠心病患者采用有氧康复训练联合体外反搏,有利于促进患者术后的心肺功能恢复,改善其心脏侧支循环和内皮功能,提高其运动耐量和生活质量,该种科学有效的康复训练措施具有重要的临床应用价值。

调卫和营宣痹方辅助干预冠心病PCI术后再发心绞痛的临床疗效观察

【目的】观察调卫和营宣痹方与常规西药联合治疗对冠心病经皮冠状动脉介入(PCI)术后再发心绞痛的治疗效果。【方法】将90例冠心病PCI术后再发心绞痛寒凝心脉证患者随机分为对照组和治疗组,每组各45例。对照组给予常规西药治疗,治疗组在对照组的基础上联合调卫和营宣痹方治疗,疗程为12周。观察2组患者治疗前后中医证候积分、心绞痛疗效积分、西雅图心绞痛量表(SAQ)评分以及左心室射血分数(LVEF)、室间隔厚度(IVS)的变化情况,并评定2组患者的临床疗效和用药安全性。【结果】(1)脱落情况方面,研究过程中,对照组和治疗组各有1例患者脱落,最终对照组和治疗组各有44例患者纳入疗效统计。(2)疗效方面,治疗12周后,治疗组的总有效率为93.18%(41/44),对照组为81.82%(36/44),组间比较(χ2检验),治疗组的疗效明显优于对照组(P<0.05)。(3)心绞痛疗效积分方面,治疗后,2组患者的心绞痛发作次数评分、持续时间评分、疼痛程度评分、硝酸甘油使用量评分及总积分均较治疗前明显降低(P<0.05),且治疗组治疗后的各项评分及总积分均明显低于对照组(P<0.05)。(4)SAQ评分方面,治疗后,2组患者SAQ量表的身体活动受限程度(PL)、心绞痛稳定状态(AS)、心绞痛发作情况(AF)、治疗满意程度(TS)、疾病认知程度(DS)评分均较治疗前明显升高(P<0.05),且治疗组治疗后SAQ量表的各项评分均明显高于对照组(P<0.05)。(5)中医证候积分方面,治疗后,2组患者的胸痛、胸闷、气短、乏力、口唇紫暗等证候积分均较治疗前明显降低(P<0.05),且治疗组治疗后的各项中医证候积分均明显低于对照组(P<0.05)。(6)心脏彩超指标方面,治疗后,2组患者的LVEF均较治疗前有所改善(P<0.05),而2组患者的IVS治疗前后均无明显变化(P>0.05);治疗后组间比较,治疗组的LVEF改善幅度明显优于对照组(P<0.05)。(7)安全性方面,治疗过程中,治疗组的不良事件发生率为2.27%(1/44),对照组为18.18%(8/44),组间比较,差异无统计学意义(P>0.05);且2组患者的血、尿、大便常规及肝功能、肾功能、心电图等安全性指标均无明显变化。【结论】在常规西药治疗基础上联合调卫和营宣痹方治疗,能有效缓解冠心病PCI术后再发心绞痛寒凝心脉证患者的临床症状,改善患者的中医证候及左心室射血分数,临床疗效显著。

PCI术后冠心病病人心理弹性的纵向研究

目的:探讨经皮冠状动脉介入(PCI)术后冠心病病人心理弹性的变化趋势及影响因素。方法:采用一般资料调查表、10条目简易心理弹性量表、医学应对方式及正负性情绪量表对2021年10月—2022年10月在广西南宁市某三级甲等医院住院并行PCI术的180例冠心病病人进行纵向调查。结果:PCI术后冠心病病人在住院期间、术后1个月、术后3个月、术后6个月的10条目简易心理弹性得分依次为(23.77±4.61)分、(27.02±4.04)分、(26.60±3.65)分、(27.61±3.62)分。PCI术后冠心病病人心理弹性发展变化趋势受体质指数、饮酒史、病变冠状动脉数的影响(P<0.05);正性情绪、负性情绪、屈服应对对心理弹性变化趋势有影响;负性情绪对心理弹性的影响随时间变化而减弱;正性情绪、面对应对、回避应对、屈服应对对心理弹性的影响不随时间的变化而变化。结论:PCI术后冠心病病人术后6个月内的心理弹性趋势呈缓慢上升态势,体质指数、饮酒史、病变冠状动脉数影响其增长速率。正性情绪、负性情绪、屈服应对影响病人的心理弹性变化,其中正性情绪对心理弹性具有正向预测,负性情绪、屈服应对对其具有负向预测。负性情绪对心理弹性的影响会随着时间的延长而逐渐减弱。

参附注射液对冠心病PCI围手术期患者冠脉微循环的影响

目的观察参附注射液对冠心病经皮冠状动脉介入治疗(PCI)围手术期患者冠脉微血管障碍(CMD)的影响。方法将拟行PCI术患者60例按随机数字表法分为对照组与观察组各30例。对照组行标准化治疗,观察组在此基础上,在术前和术后1周静脉滴注参附注射液,比较观察两组患者造影帧数(TIMI)、血流储备分数(FFR)和治疗后4周内发生主要心血管不良事件的比例。结果与对照组相比,观察组TIMI明显降低,FFR显著增高(P<0.01),且冠脉再狭窄、无复流、心力衰竭等心血管不良事件发生率更低(P<0.05)。结论在围手术期,给予冠心病PCI术患者静脉滴注参附注射液可以减轻冠脉微循环障碍,改善患者预后。

探索PERMA模型联合Cox-IMCHB模式对冠心病患者PCI术后健康状况及心理健康水平的影响

目的 探索PERMA模型联合Cox-IMCHB模式对冠心病PCI术后患者健康状况及心理健康水平的影响。方法 选择2023年3—5月本院心血管内科及全科医疗科收治的冠心病PCI术后患者200例作为研究对象,按简单随机抽样法分为观察组和对照组两组,每组各100例。对照组予以常规入院护理与宣教,观察组予以PERMA模型联合Cox-IMCHB模式进行护理与宣教。采用焦虑自评量表(SAS)、抑郁自评量表(SDS)比较患者出院后3个月心理健康水平;比较两组患者BMI、吸烟较少支数、低密度脂蛋白胆固醇(LDL-C)、收缩压(SBP)、舒张压(DBP)变化评判患者健康状况。结果 观察组健康状况及心理健康水平均优于对照组,差异有统计学意义(P<0.05);观察组吸烟减少支数、BMI、低密度脂蛋白胆固醇、血压均优于对照组,差异有统计学意义(P<0.05)。结论 PERMA模型联合Cox-IMCHB模式可一定程度上改善冠心病患者PCI术后健康状况及心理健康水平。