Molecular dynamics method was used to establish composite wall/inorganic nanopores of three pore sizes, three shale oil systems, five CO_(2)-cosolvent systems, and pure CO_(2) system. The process of CO_(2)-cosolvent d...Molecular dynamics method was used to establish composite wall/inorganic nanopores of three pore sizes, three shale oil systems, five CO_(2)-cosolvent systems, and pure CO_(2) system. The process of CO_(2)-cosolvent displacement of crude oil in shale nanopores and carbon storage was simulated and the influencing factors of displacement and storage were analyzed. It is shown that the attraction of the quartz wall to shale oil increases with the degree of hydroxylation. The higher the degree of quartz hydroxylation, the more difficult it is to extract the polar components of shale oil. Nanopore size also has a great impact on shale oil displacement efficiency. The larger the pore size, the higher the shale oil displacement efficiency. The closer the cosolvent molecules are to the polarity of the shale oil, the higher the mutual solubility of CO_(2) and shale oil. The more the non-polar components of shale oil, the lower the mutual solubility of CO_(2) and shale oil with highly polar cosolvent. Ethyl acetate is more effective in stripping relatively high polar shale oil, while dimethyl ether is more effective in stripping relatively low polar shale oil. Kerogen is highly adsorptive, especially to CO_(2). The CO_(2) inside the kerogen is not easy to diffuse and leak, thus allowing for a stable carbon storage. The highest CO_(2) storage rate is observed when dimethyl ether is used as a cosolvent, and the best storage stability is observed when ethyl acetate is used as a cosolvent.展开更多
The solubility and sorption of oil by uncontaminated clay loam and silt loam soils were studied from water and cosolvent/water solutions using batch techniques. The data obtained from the dissolution and sorption expe...The solubility and sorption of oil by uncontaminated clay loam and silt loam soils were studied from water and cosolvent/water solutions using batch techniques. The data obtained from the dissolution and sorption experiments were used to evaluate the applicability of the cosolvent theory to oil as a complex mixture. Aqueous solubility and soil-water distribution coeffcients (Kd,w, L/kg) were estimated by extrapolating from cosolvent data, with a log-linear cosolvency model, to the volume fraction of cosolve...展开更多
The solubility data of compounds in supercritical fluids and the correlation between the experimental solubility data and predicted solubility data are crucial to the development of supercritical technologies. In the ...The solubility data of compounds in supercritical fluids and the correlation between the experimental solubility data and predicted solubility data are crucial to the development of supercritical technologies. In the present work, the solubility data of silymarin(SM) in both pure supercritical carbon dioxide(SCCO2) and SCCO2 with added cosolvent was measured at temperatures ranging from 308 to 338 K and pressures from 8 to 22 MPa. The experimental data were fit with three semi-empirical density-based models(Chrastil, Bartle and Mendez-Santiago and Teja models) and a back-propagation artificial neural networks(BPANN) model. Interaction parameters for the models were obtained and the percentage of average absolute relative deviation(AARD%) in each calculation was determined. The correlation results were in good agreement with the experimental data. A comparison among the four models revealed that the experimental solubility data were more fit with the BPANN model with AARDs ranging from 1.14% to 2.15% for silymarin in pure SCCO2 and with added cosolvent. The results provide fundamental data for designing the extraction of SM or the preparation of its particle using SCCO2 techniques.展开更多
The effect of cosolvent cyclohexane, chloroform, and acetonitrile on the keto-enol tautomeric equilibrium of ethyl acetoacetate in supercritical CO2 was studied by UV-Vis spectroscopy over the pressure range from 76 t...The effect of cosolvent cyclohexane, chloroform, and acetonitrile on the keto-enol tautomeric equilibrium of ethyl acetoacetate in supercritical CO2 was studied by UV-Vis spectroscopy over the pressure range from 76 to 110 bar at 308.15 K. It was found that the equilibrium constant decreases with increasing polarity of the cosolvents.展开更多
The objective of the present study was to examine the influence of cosolvent system and micro-emulsion formulation on in-vitro skin permeation of gabapentin, furthermore, to characterize the physicochemical properties...The objective of the present study was to examine the influence of cosolvent system and micro-emulsion formulation on in-vitro skin permeation of gabapentin, furthermore, to characterize the physicochemical properties of drug-loaded oil-in-water (o/w) and water-in-oil (w/o) cremophor 40-based microemulsions in comparison to the blank counterparts. The cosolvent system prepared by homogenous mixing is composed of ethanol-water and propylene glycol-water mixture (90:10, 80:20, 70:30 v/v) respectively. The microemulsion consisted of coconut oil, water and mixture of cremophor 40 (surfactant) and ethanol (cosurfactant) and was prepared by aqueous phase titration method. Physicochemical properties of microemulsions were determined using reported procedures. Transdermal flux for gabapentin was studied in-vitro using modified Franz diffusion cells. The physicochemical properties of drug-loaded microemulsions and their blank counterparts were generally alike, however, slight variation in pH and viscosity was observed probably due to the intrinsic properties of the drug. The ethanol-water system (70:30 v/v) gave higher flux for gabapentin when compared to propylene glycol-water system (70:30 v/v). The w/o microemulsion formulations resulted in, higher flux for gabapentin when compared to o/w formulations. FTIR spectra of the untreated stratum corneum, when compared to cosolvent system and microemulsion treated stratum corneum, suggest the mechanism of permeation to be disruption of lipid bilayers and keratin denaturation of the stratum corneum. The results show that incorporation of gabapentin into microemulsions did not change the microemulsion type. The in vitro permeation data obtained from experimental work suggest that the cosolvent system (ethanol-water 70:30 v/v) and w/o microemulsion formulations respectively, can be successfully used as potential vehicles in developing transdermal therapeutic systems for gabapentin.展开更多
The morphology of active layer in bulk heterojunction(BHJ) organic solar cells is decisive to the device performance. Previous works have shown that the solvent engineering is an effective method to optimize the morph...The morphology of active layer in bulk heterojunction(BHJ) organic solar cells is decisive to the device performance. Previous works have shown that the solvent engineering is an effective method to optimize the morphology of active layer. However, screening the proper solvent is a tedious task, and we know very little about how to select a proper solvent for a particular system, especially for polymer/nonfullerene blend systems. Here, we combined the spectroscopic analysis in various solvent mixtures during film-forming process to reveal the relationship among the cosolvent characteristics, film-forming kinetics and film morphology. In this article, P3 HT/O-IDTBR blend was selected as model system due to being facile synthesized under a large-scale. Chlorobenzene(CB) was selected as main solvent, and the cosolvents were grouped into three categories according to its boiling point(bp) compared to CB.The cosolvents with lower bp, like chloroform(CF), can facilitate a faster film-forming process, reducing the domain size but sacrificing the crystallinity of both components. For the cosolvents with higher bp,like o-dichlorobenzene(DCB) and 1,2,4-trichlorobenzene(TCB), the self-organization process of P3 HT and O-IDTBR is separated and its duration was extended, constructing highly crystalline nanointerpenetrating network. However, the cosolvents with very high bp, such as chlornaphthalene(CN),would residue in film and keep P3 HT and O-IDTBR self-organizing for longer time, leading to larger phase separation. This work systematically investigated the effect of cosolvent on the film-forming kinetics, and proposed a guideline of how to select a proper cosolvent according to the crystallinity and domain size of active layer.展开更多
A remarkable rate enhancement technique has been devised for a typical nucleophilic displacement reaction by using triphase catalytic materials based on tetraoctylammonium exchange forms of hectorite clay. Pseudo-firs...A remarkable rate enhancement technique has been devised for a typical nucleophilic displacement reaction by using triphase catalytic materials based on tetraoctylammonium exchange forms of hectorite clay. Pseudo-first order rate constants (kobs) for the conversion of 1-bromobutane to the corresponding chloride under triphase conditions using the clay catalyst in the presence of various polar cosolvents have been observed. The results here have shown that the addition of a cosolvent increases the catalytic activity of the triphase system by several fold. In addition, the results have demonstrated that each cosolvent has a unique concentration for achieving an optimum reaction rate.展开更多
Transdermal drug delivery not only has contributed immensely to medical practice, but has enjoyed enormous interest in the field of cosmetic and pharmaceutical industries. Nevirapine, a non‐nucleoside reverse transcr...Transdermal drug delivery not only has contributed immensely to medical practice, but has enjoyed enormous interest in the field of cosmetic and pharmaceutical industries. Nevirapine, a non‐nucleoside reverse transcriptase inhibitor (NNRTI) is used clinically for the treatment of HIV‐ 1 infection. The aim of the present study is to investigate the influence of cosolvents (glycerol, propylene glycol, ethanol, polyethylene glycol 400) and surfactants (polysorbate 20, polysorbate 80, sodium lauryl sulfate, sodium cholate and cetrimide) on the dermal permeability coefficient of nevirapine by utilizing established and recognized mathematical model that employs partition coefficient as one of its molecular descriptors. The partition coefficient of nevirapine is determined in chloroform-water system at room temperature using the shake flask method. The results show that all the cosolvents used in this study decrease the partition coefficient of nevirapine. The same decrease in the partition coefficient of nevirapine is observed with all the surfactants investigated. The order of dermal enhancement potential of the vehicles studied based on the predicted permeability coefficient is glycerol > propylene glycol > ethanol > polyethylene glycol 400 for the cosolvents while tween 20 > tween 80 > sodium lauryl sulfate > sodium cholate > cetrimide for the surfactants. The maximum predicted flux through skin was obtained by multiplying the predicted permeability coefficient and the drug aqueous solubility. As the rate of penetration into the skin is quantitatively assessed by the use of permeability coefficient, the findings suggest that for dermal formulation of nevirapine, glycerol and tween 20 are the most preferred vehicles out of the vehicles investigated. Furthermore, the results of the correlation coefficients obtained by plotting permeability coefficient or maximum predicted flux, versus logarithm partition coefficient indicate that permeability coefficient can be a more reliable parameter to predict transdermal absorption of nevirapine than flux.展开更多
We report a carbon/carbon capacitor based on micro/mesoporous carbon electrodes with cost-effective and eco-friendly aqueous choline bis(trifluoromethylsulfonyl)imide(Ch TFSI)electrolyte with a cosolvent enabling low-...We report a carbon/carbon capacitor based on micro/mesoporous carbon electrodes with cost-effective and eco-friendly aqueous choline bis(trifluoromethylsulfonyl)imide(Ch TFSI)electrolyte with a cosolvent enabling low-temperature operation down to-30℃.For this purpose,a Mg O-templated hierarchical carbon(MP98B)with an average mesopore diameter of 3.5 nm was prepared by pyrolysis of magnesium citrate hydrate at 900℃.To reach lower temperatures,the melting point and viscosity of the aqueous electrolyte were reduced by mixing water(W)with an organic solvent(methanol,M,or isopropanol,I)of high dielectric constant and low viscosity.5 mol kg^(-1)(5 m)Ch TFSI in an optimized volume fraction of cosolvent,M_(0.75)W_(0.25),and I_(0.75)W_(0.25),showed the highest conductivity;the higher conductivity in M_(0.75)W_(0.25)(22.8 and 3.1 m S cm^(-1) at 20 and-30℃,respectively)than in I_(0.75)W_(0.25)(8.5 and0.5 m S cm^(-1)at 20 and-30℃,respectively)is attributed to the lower viscosity of the M_(0.75)W_(0.25)solution.The electrochemical stability window(ESW)of 5 m Ch TFSI in M_(0.75)W_(0.25)and I_(0.75)W_(0.25)(1.6 V)on an MP98B electrode was determined by applying the S-method.Meanwhile,by adjusting the mass ratio of the two electrodes,a MP98B/MP98B capacitor using the 5 m electrolyte in M_(0.75)W_(0.25)could operate with a good life span up to 1.6 V while exhibiting a better charge propagation,greater specific capacitance,and higher specific energy than in I_(0.75)W_(0.25).展开更多
Griseofulvin (GF) is an antifungal drug whose pharmaceutical activity can be improved by reducing particle size. In this study the rapid expansion of supercritical solution (RESS) was employed to micronize GF.Carbon d...Griseofulvin (GF) is an antifungal drug whose pharmaceutical activity can be improved by reducing particle size. In this study the rapid expansion of supercritical solution (RESS) was employed to micronize GF.Carbon dioxide with cosolvent acetone was chosen as a supercritical mixed solvent. The solubility of GF in super-critical CO2 with cosolvent acetone was measured using a dynamic apparatus at pressures between 12 and 32 MPa,temperatures at 313, 323 and 333 K and cosolvent concentration at 1.5, 3.0, 4.5 and 6.0% (by mole). The effect of pre-expansion pressure, extraction temperature, spraying distance, nozzle size and concentration of cosolvent on the precipitated particles was investigated. The results show that the mean particle size of griseofulvin precipitated by RESS was less than 1.2μm. An increase in pre-expansion pressure, extraction temperature, spraying distance and concentration of cosolvent resulted in a decrease in particle size under the operating condition studied. With the decrease of nozzle diameter the particle size reduces. The crystallinity and melting point of the original material and the processed particle by RESS were tested by X-ray diffraction (XRD) and differential scanning calorimetry (DSC).No evident modification in the crystal habit was found under the experimental conditions tested. The morphology of particles precipitated was analyzed bY scanning electron microscopy (SEM).展开更多
The poor aqueous solubility of drugs is a challenging problem faced by pharmaceutical scientists in drug formulation. Cosolvency and micellization techniques have been severally used to enhance the solubility of poorl...The poor aqueous solubility of drugs is a challenging problem faced by pharmaceutical scientists in drug formulation. Cosolvency and micellization techniques have been severally used to enhance the solubility of poorly aqueous soluble drugs. Mirtazapine, a tetracyclic antidepressant used for the treatment of moderate to severe depression and anxiety, has very poor aqueous solubility. The objective of the study was to investigate the effect of solubilizing agents (cosolvents and surfactants) on the aqueous solubility of mirtazapine while envisaging that any significant improvement in its aqueous solubility could contribute towards alleviating the withdrawal symptoms often associated with the drug. The solubility of mirtazapine was determined at room temperature in aqueous mixtures of cosolvents (propylene glycol and polyethylene glycol 400) and surfactants (polysorbate 20, polysorbate 80 and sodium lauryl sulfate). An exponential increase in mirtazapine solubility was observed when total drug solubility in water-cosolvent system was plotted against cosolvent fraction volume. Polyethylene glycol 400 gave larger solubilization capacity (σ) when compared to propylene glycol. With the surfactants, linear relationship between the total solubility of the drug in water-surfactant mixtures and surfactant concentration was noted. Sodium lauryl sulfate showed the largest solubilization power (k) when compared to the nonionic surfactants (polysorbate 20 and polysorbate 80 respectively). A linear relationship between standard free energy and partition coefficient was also observed. The result of the study shows that aqueous solubility of mirtazapine is significantly improved by cosolvency and micellization and therefore there exists the possibility of improving the withdrawal symptoms often experienced with the drug. It also suggests that large free energy is required for drugs with high partition coefficients to permeate the biological membrane.展开更多
The preparation of ethanol-diesel fuel blends and their emission characteristics were investigated. Results showed the absolute ethanol can dissolve in diesel fuel at an arbitrary ratio and a small quantity of water(0...The preparation of ethanol-diesel fuel blends and their emission characteristics were investigated. Results showed the absolute ethanol can dissolve in diesel fuel at an arbitrary ratio and a small quantity of water(0.2%) addition can lead to the phase separation of blends. An organic additive was synthesized and it can develop the ability of resistance to water and maintain the stability of ethanol-diesel-trace amounts of water system. The emission characteristics of 10%, 20%, and 30% ethanol-diesel fuel blends, with or without additives, were compared with those of diesel fuel in a direct injection(DI) diesel engine. The experimental results indicated that the blend of ethanol with diesel fuel significantly reduced the concentrations of smoke, hydrocarbon(HC), and carbon monoxide(CO) in exhaust gas. Using 20% ethanol-diesel fuel blend with the additive of 2% of the total volume, the optimum mixing ratio was achieved, at which the bench diesel engine testing showed a significant decrease in exhaust gas. Bosch smoke number was reduced by 55%, HC emission by 70%, and CO emission by 45%, at 13 kW/1540 r/min. However, ethanol-diesel fuel blends produced a few ppm acetaldehydes and more ethanol in exhaust gas.展开更多
Two-dimensional(2D)nanomaterials have aroused immense attention in extensive applications due to their intriguing physical and chemical properties.However,there is a formidable challenge to prepare few-layered and fun...Two-dimensional(2D)nanomaterials have aroused immense attention in extensive applications due to their intriguing physical and chemical properties.However,there is a formidable challenge to prepare few-layered and functionalized 2D nanomaterials in an effective and universal way.Herein,we developed an integrated strategy of glucose-assisted mechanochemical exfoliation and cosolvent-intensified sonication exfoliation to effectively exfoliate and functionalize 2D materials.Taking exfoliation of boron nitride(BN)as an example,the production yield and functionalization ratio of BN nanosheets(BNNSs)reached 47.5%and 25.8 wt.%,188%and 16%higher than that of BNNSs without sonication exfoliation,respectively.The introduction of glucose not only augmented the friction force between adjacent BN layers to promote the efficiency of ball-milling-driven exfoliation supported by density functional theory calculation,but also reacted with active edges of BNNSs for functionalization.Afterwards,cosolventintensified sonication exfoliation strongly stabilized exfoliated BNNSs,obviously boosting the exfoliation yield.This proposed method is universal for preparing various 2D nanomaterials like molybdenum disulfide,tungsten disulfide,and graphene nanosheets.The thin plate structure and high functionalization ratio enabled the release of property superiorities of 2D nanomaterials.Our work offers a promising prototype to realize mass production of functionalized 2D nanomaterials.展开更多
Precipitation polymerizations of divinylbenzene(DVB) in pure supercritical carbon dioxide,and parallel runs with presence of a cosolvent were carried out.The results showed that use of acetone as the cosolvent contr...Precipitation polymerizations of divinylbenzene(DVB) in pure supercritical carbon dioxide,and parallel runs with presence of a cosolvent were carried out.The results showed that use of acetone as the cosolvent contributed greatly to the formation of the monodisperse microspheres.PDVB microspheres,with obviously higher uniformity than reported up to date,were achieved using 6-7 mL of acetone in a reactor of 50 mL with DVB concentration of 0.4 mol/L under 16 MPa,a much lower pressure than previously reported without use of cosolvent.展开更多
基金Supported by National Natural Science Foundation of China(52304021,52204031)Natural Science Foundation of Sichuan Province(2022NSFSC0205)National Science and Technology Major Project of China(2017ZX05049006-010).
文摘Molecular dynamics method was used to establish composite wall/inorganic nanopores of three pore sizes, three shale oil systems, five CO_(2)-cosolvent systems, and pure CO_(2) system. The process of CO_(2)-cosolvent displacement of crude oil in shale nanopores and carbon storage was simulated and the influencing factors of displacement and storage were analyzed. It is shown that the attraction of the quartz wall to shale oil increases with the degree of hydroxylation. The higher the degree of quartz hydroxylation, the more difficult it is to extract the polar components of shale oil. Nanopore size also has a great impact on shale oil displacement efficiency. The larger the pore size, the higher the shale oil displacement efficiency. The closer the cosolvent molecules are to the polarity of the shale oil, the higher the mutual solubility of CO_(2) and shale oil. The more the non-polar components of shale oil, the lower the mutual solubility of CO_(2) and shale oil with highly polar cosolvent. Ethyl acetate is more effective in stripping relatively high polar shale oil, while dimethyl ether is more effective in stripping relatively low polar shale oil. Kerogen is highly adsorptive, especially to CO_(2). The CO_(2) inside the kerogen is not easy to diffuse and leak, thus allowing for a stable carbon storage. The highest CO_(2) storage rate is observed when dimethyl ether is used as a cosolvent, and the best storage stability is observed when ethyl acetate is used as a cosolvent.
基金the National Basic Research Program of China (No. 2004CB418504)
文摘The solubility and sorption of oil by uncontaminated clay loam and silt loam soils were studied from water and cosolvent/water solutions using batch techniques. The data obtained from the dissolution and sorption experiments were used to evaluate the applicability of the cosolvent theory to oil as a complex mixture. Aqueous solubility and soil-water distribution coeffcients (Kd,w, L/kg) were estimated by extrapolating from cosolvent data, with a log-linear cosolvency model, to the volume fraction of cosolve...
基金supported financially by the Subject Chief Scientist Program (10XD14303900) from Science and Technology Commission of Shanghai Municipalitythe Special Research Fund for the Doctoral Program of Higher Education of China (20123107110005)
文摘The solubility data of compounds in supercritical fluids and the correlation between the experimental solubility data and predicted solubility data are crucial to the development of supercritical technologies. In the present work, the solubility data of silymarin(SM) in both pure supercritical carbon dioxide(SCCO2) and SCCO2 with added cosolvent was measured at temperatures ranging from 308 to 338 K and pressures from 8 to 22 MPa. The experimental data were fit with three semi-empirical density-based models(Chrastil, Bartle and Mendez-Santiago and Teja models) and a back-propagation artificial neural networks(BPANN) model. Interaction parameters for the models were obtained and the percentage of average absolute relative deviation(AARD%) in each calculation was determined. The correlation results were in good agreement with the experimental data. A comparison among the four models revealed that the experimental solubility data were more fit with the BPANN model with AARDs ranging from 1.14% to 2.15% for silymarin in pure SCCO2 and with added cosolvent. The results provide fundamental data for designing the extraction of SM or the preparation of its particle using SCCO2 techniques.
基金This work was financially support by National Basic Research Project(G2000048010).
文摘The effect of cosolvent cyclohexane, chloroform, and acetonitrile on the keto-enol tautomeric equilibrium of ethyl acetoacetate in supercritical CO2 was studied by UV-Vis spectroscopy over the pressure range from 76 to 110 bar at 308.15 K. It was found that the equilibrium constant decreases with increasing polarity of the cosolvents.
文摘The objective of the present study was to examine the influence of cosolvent system and micro-emulsion formulation on in-vitro skin permeation of gabapentin, furthermore, to characterize the physicochemical properties of drug-loaded oil-in-water (o/w) and water-in-oil (w/o) cremophor 40-based microemulsions in comparison to the blank counterparts. The cosolvent system prepared by homogenous mixing is composed of ethanol-water and propylene glycol-water mixture (90:10, 80:20, 70:30 v/v) respectively. The microemulsion consisted of coconut oil, water and mixture of cremophor 40 (surfactant) and ethanol (cosurfactant) and was prepared by aqueous phase titration method. Physicochemical properties of microemulsions were determined using reported procedures. Transdermal flux for gabapentin was studied in-vitro using modified Franz diffusion cells. The physicochemical properties of drug-loaded microemulsions and their blank counterparts were generally alike, however, slight variation in pH and viscosity was observed probably due to the intrinsic properties of the drug. The ethanol-water system (70:30 v/v) gave higher flux for gabapentin when compared to propylene glycol-water system (70:30 v/v). The w/o microemulsion formulations resulted in, higher flux for gabapentin when compared to o/w formulations. FTIR spectra of the untreated stratum corneum, when compared to cosolvent system and microemulsion treated stratum corneum, suggest the mechanism of permeation to be disruption of lipid bilayers and keratin denaturation of the stratum corneum. The results show that incorporation of gabapentin into microemulsions did not change the microemulsion type. The in vitro permeation data obtained from experimental work suggest that the cosolvent system (ethanol-water 70:30 v/v) and w/o microemulsion formulations respectively, can be successfully used as potential vehicles in developing transdermal therapeutic systems for gabapentin.
基金supported by the National Natural Science Foundation of China (51773203, 51903211)the Fundamental Research Funds for the Central Universities (D5000200273)。
文摘The morphology of active layer in bulk heterojunction(BHJ) organic solar cells is decisive to the device performance. Previous works have shown that the solvent engineering is an effective method to optimize the morphology of active layer. However, screening the proper solvent is a tedious task, and we know very little about how to select a proper solvent for a particular system, especially for polymer/nonfullerene blend systems. Here, we combined the spectroscopic analysis in various solvent mixtures during film-forming process to reveal the relationship among the cosolvent characteristics, film-forming kinetics and film morphology. In this article, P3 HT/O-IDTBR blend was selected as model system due to being facile synthesized under a large-scale. Chlorobenzene(CB) was selected as main solvent, and the cosolvents were grouped into three categories according to its boiling point(bp) compared to CB.The cosolvents with lower bp, like chloroform(CF), can facilitate a faster film-forming process, reducing the domain size but sacrificing the crystallinity of both components. For the cosolvents with higher bp,like o-dichlorobenzene(DCB) and 1,2,4-trichlorobenzene(TCB), the self-organization process of P3 HT and O-IDTBR is separated and its duration was extended, constructing highly crystalline nanointerpenetrating network. However, the cosolvents with very high bp, such as chlornaphthalene(CN),would residue in film and keep P3 HT and O-IDTBR self-organizing for longer time, leading to larger phase separation. This work systematically investigated the effect of cosolvent on the film-forming kinetics, and proposed a guideline of how to select a proper cosolvent according to the crystallinity and domain size of active layer.
文摘A remarkable rate enhancement technique has been devised for a typical nucleophilic displacement reaction by using triphase catalytic materials based on tetraoctylammonium exchange forms of hectorite clay. Pseudo-first order rate constants (kobs) for the conversion of 1-bromobutane to the corresponding chloride under triphase conditions using the clay catalyst in the presence of various polar cosolvents have been observed. The results here have shown that the addition of a cosolvent increases the catalytic activity of the triphase system by several fold. In addition, the results have demonstrated that each cosolvent has a unique concentration for achieving an optimum reaction rate.
文摘Transdermal drug delivery not only has contributed immensely to medical practice, but has enjoyed enormous interest in the field of cosmetic and pharmaceutical industries. Nevirapine, a non‐nucleoside reverse transcriptase inhibitor (NNRTI) is used clinically for the treatment of HIV‐ 1 infection. The aim of the present study is to investigate the influence of cosolvents (glycerol, propylene glycol, ethanol, polyethylene glycol 400) and surfactants (polysorbate 20, polysorbate 80, sodium lauryl sulfate, sodium cholate and cetrimide) on the dermal permeability coefficient of nevirapine by utilizing established and recognized mathematical model that employs partition coefficient as one of its molecular descriptors. The partition coefficient of nevirapine is determined in chloroform-water system at room temperature using the shake flask method. The results show that all the cosolvents used in this study decrease the partition coefficient of nevirapine. The same decrease in the partition coefficient of nevirapine is observed with all the surfactants investigated. The order of dermal enhancement potential of the vehicles studied based on the predicted permeability coefficient is glycerol > propylene glycol > ethanol > polyethylene glycol 400 for the cosolvents while tween 20 > tween 80 > sodium lauryl sulfate > sodium cholate > cetrimide for the surfactants. The maximum predicted flux through skin was obtained by multiplying the predicted permeability coefficient and the drug aqueous solubility. As the rate of penetration into the skin is quantitatively assessed by the use of permeability coefficient, the findings suggest that for dermal formulation of nevirapine, glycerol and tween 20 are the most preferred vehicles out of the vehicles investigated. Furthermore, the results of the correlation coefficients obtained by plotting permeability coefficient or maximum predicted flux, versus logarithm partition coefficient indicate that permeability coefficient can be a more reliable parameter to predict transdermal absorption of nevirapine than flux.
基金financially supported by the National Science Centre(MAESTRO project UMO-2016/22/A/ST4/00092)。
文摘We report a carbon/carbon capacitor based on micro/mesoporous carbon electrodes with cost-effective and eco-friendly aqueous choline bis(trifluoromethylsulfonyl)imide(Ch TFSI)electrolyte with a cosolvent enabling low-temperature operation down to-30℃.For this purpose,a Mg O-templated hierarchical carbon(MP98B)with an average mesopore diameter of 3.5 nm was prepared by pyrolysis of magnesium citrate hydrate at 900℃.To reach lower temperatures,the melting point and viscosity of the aqueous electrolyte were reduced by mixing water(W)with an organic solvent(methanol,M,or isopropanol,I)of high dielectric constant and low viscosity.5 mol kg^(-1)(5 m)Ch TFSI in an optimized volume fraction of cosolvent,M_(0.75)W_(0.25),and I_(0.75)W_(0.25),showed the highest conductivity;the higher conductivity in M_(0.75)W_(0.25)(22.8 and 3.1 m S cm^(-1) at 20 and-30℃,respectively)than in I_(0.75)W_(0.25)(8.5 and0.5 m S cm^(-1)at 20 and-30℃,respectively)is attributed to the lower viscosity of the M_(0.75)W_(0.25)solution.The electrochemical stability window(ESW)of 5 m Ch TFSI in M_(0.75)W_(0.25)and I_(0.75)W_(0.25)(1.6 V)on an MP98B electrode was determined by applying the S-method.Meanwhile,by adjusting the mass ratio of the two electrodes,a MP98B/MP98B capacitor using the 5 m electrolyte in M_(0.75)W_(0.25)could operate with a good life span up to 1.6 V while exhibiting a better charge propagation,greater specific capacitance,and higher specific energy than in I_(0.75)W_(0.25).
文摘Griseofulvin (GF) is an antifungal drug whose pharmaceutical activity can be improved by reducing particle size. In this study the rapid expansion of supercritical solution (RESS) was employed to micronize GF.Carbon dioxide with cosolvent acetone was chosen as a supercritical mixed solvent. The solubility of GF in super-critical CO2 with cosolvent acetone was measured using a dynamic apparatus at pressures between 12 and 32 MPa,temperatures at 313, 323 and 333 K and cosolvent concentration at 1.5, 3.0, 4.5 and 6.0% (by mole). The effect of pre-expansion pressure, extraction temperature, spraying distance, nozzle size and concentration of cosolvent on the precipitated particles was investigated. The results show that the mean particle size of griseofulvin precipitated by RESS was less than 1.2μm. An increase in pre-expansion pressure, extraction temperature, spraying distance and concentration of cosolvent resulted in a decrease in particle size under the operating condition studied. With the decrease of nozzle diameter the particle size reduces. The crystallinity and melting point of the original material and the processed particle by RESS were tested by X-ray diffraction (XRD) and differential scanning calorimetry (DSC).No evident modification in the crystal habit was found under the experimental conditions tested. The morphology of particles precipitated was analyzed bY scanning electron microscopy (SEM).
文摘The poor aqueous solubility of drugs is a challenging problem faced by pharmaceutical scientists in drug formulation. Cosolvency and micellization techniques have been severally used to enhance the solubility of poorly aqueous soluble drugs. Mirtazapine, a tetracyclic antidepressant used for the treatment of moderate to severe depression and anxiety, has very poor aqueous solubility. The objective of the study was to investigate the effect of solubilizing agents (cosolvents and surfactants) on the aqueous solubility of mirtazapine while envisaging that any significant improvement in its aqueous solubility could contribute towards alleviating the withdrawal symptoms often associated with the drug. The solubility of mirtazapine was determined at room temperature in aqueous mixtures of cosolvents (propylene glycol and polyethylene glycol 400) and surfactants (polysorbate 20, polysorbate 80 and sodium lauryl sulfate). An exponential increase in mirtazapine solubility was observed when total drug solubility in water-cosolvent system was plotted against cosolvent fraction volume. Polyethylene glycol 400 gave larger solubilization capacity (σ) when compared to propylene glycol. With the surfactants, linear relationship between the total solubility of the drug in water-surfactant mixtures and surfactant concentration was noted. Sodium lauryl sulfate showed the largest solubilization power (k) when compared to the nonionic surfactants (polysorbate 20 and polysorbate 80 respectively). A linear relationship between standard free energy and partition coefficient was also observed. The result of the study shows that aqueous solubility of mirtazapine is significantly improved by cosolvency and micellization and therefore there exists the possibility of improving the withdrawal symptoms often experienced with the drug. It also suggests that large free energy is required for drugs with high partition coefficients to permeate the biological membrane.
文摘The preparation of ethanol-diesel fuel blends and their emission characteristics were investigated. Results showed the absolute ethanol can dissolve in diesel fuel at an arbitrary ratio and a small quantity of water(0.2%) addition can lead to the phase separation of blends. An organic additive was synthesized and it can develop the ability of resistance to water and maintain the stability of ethanol-diesel-trace amounts of water system. The emission characteristics of 10%, 20%, and 30% ethanol-diesel fuel blends, with or without additives, were compared with those of diesel fuel in a direct injection(DI) diesel engine. The experimental results indicated that the blend of ethanol with diesel fuel significantly reduced the concentrations of smoke, hydrocarbon(HC), and carbon monoxide(CO) in exhaust gas. Using 20% ethanol-diesel fuel blend with the additive of 2% of the total volume, the optimum mixing ratio was achieved, at which the bench diesel engine testing showed a significant decrease in exhaust gas. Bosch smoke number was reduced by 55%, HC emission by 70%, and CO emission by 45%, at 13 kW/1540 r/min. However, ethanol-diesel fuel blends produced a few ppm acetaldehydes and more ethanol in exhaust gas.
基金supported by the National Natural Science Foundation of China(Nos.52022061,52103099,51973138,and U21A2090).
文摘Two-dimensional(2D)nanomaterials have aroused immense attention in extensive applications due to their intriguing physical and chemical properties.However,there is a formidable challenge to prepare few-layered and functionalized 2D nanomaterials in an effective and universal way.Herein,we developed an integrated strategy of glucose-assisted mechanochemical exfoliation and cosolvent-intensified sonication exfoliation to effectively exfoliate and functionalize 2D materials.Taking exfoliation of boron nitride(BN)as an example,the production yield and functionalization ratio of BN nanosheets(BNNSs)reached 47.5%and 25.8 wt.%,188%and 16%higher than that of BNNSs without sonication exfoliation,respectively.The introduction of glucose not only augmented the friction force between adjacent BN layers to promote the efficiency of ball-milling-driven exfoliation supported by density functional theory calculation,but also reacted with active edges of BNNSs for functionalization.Afterwards,cosolventintensified sonication exfoliation strongly stabilized exfoliated BNNSs,obviously boosting the exfoliation yield.This proposed method is universal for preparing various 2D nanomaterials like molybdenum disulfide,tungsten disulfide,and graphene nanosheets.The thin plate structure and high functionalization ratio enabled the release of property superiorities of 2D nanomaterials.Our work offers a promising prototype to realize mass production of functionalized 2D nanomaterials.
基金This research is financial supported by National Natural Science Foundation of China(No.20904016)Natural Science Foundation of Shandong Province(No.Y2008F30)Doctoral Foundation of Shandong Province,China (No.2007BS04036)
文摘Precipitation polymerizations of divinylbenzene(DVB) in pure supercritical carbon dioxide,and parallel runs with presence of a cosolvent were carried out.The results showed that use of acetone as the cosolvent contributed greatly to the formation of the monodisperse microspheres.PDVB microspheres,with obviously higher uniformity than reported up to date,were achieved using 6-7 mL of acetone in a reactor of 50 mL with DVB concentration of 0.4 mol/L under 16 MPa,a much lower pressure than previously reported without use of cosolvent.