Colorectal cancer screening in countries of European Council outside of the EU-28

AIM: To provide an update on colorectal cancer(CRC) screening programmes in non-European Union(EU)-28 Council of Europe member states as of December 2015. METHODS: The mission of the Council of Europe is to protect and promote human rights in its 47 member countries. Its 19 non-EU member states are Albania, Andorra, Armenia, Azerbaijan, Bosnia and Herzegovina, Republika Srpska, Georgia, Iceland, Liechtenstein, Republic of Moldova, Monaco, Montenegro, Norway, Russian Federation, San Marino, Serbia, Switzerland, FYR of Macedonia, Turkey, and Ukraine(EU-19). The main data source were GLOBOCAN, IARC, WHO, EUCAN, NORDCAN, ENCR, volume X of the CI5, the ministerial and Public Health Agency websites of the individual countries, Pub Med, EMBASE, registries of some websites and the www.cochranelibrary.com, Scopus, www.clinicaltrials.gov, www.clinicaltrialsregister.eu, Research gate, Google and data extracted from screening programme results. RESULTS: Our results show that epidemiological data quality varies broadly between EU-28 and EU-19 countries. In terms of incidence, only 30% of EU-19 countries rank high in data quality as opposed to 86% of EU-28 states. The same applies to mortality data, since 52% of EU-19 countries as against all EU-28 countries are found in the high ranks. Assessment of the method of collection of incidence data showed that only 32% of EU-19 countries are found in the top three quality classes as against 89% of EU-28 countries. For the mortality data, 63% of EU-19 countries are found in the highest ranks as opposed to all EU-28 member states. Interestingly, comparison of neighbouring countries offering regional screening shows, for instance, that incidence and mortality rates are respectively 38.9 and 13.0 in Norway and 29.2 and10.9 in Sweden, whereas in Finland, where a national organised programme is available, they are respectively 23.5 and 9.3. CONCLUSION: Cancer screening should be viewed as a key health care tool, also because investing in screening protects the weakest in the population, decreases the social burden of cancer, and reduces all types of health care costs, including those for radical surgery, long-term hospitalisation, and chemotherapy.

44%of steep slope cropland in Europe vulnerable to drought

Steep-slope cropland plays a vital role in food production,economic development,ecosystem diversity,and Eu-ropean cultural heritage.However,these systems are susceptible to extreme weather events.The 2022 summer drought significantly impacted European agriculture,but the specific effects on steep-slope crops remain uncer-tain.Clarifying this is essential for comprehending similar future events and for implementing effective water management strategies to ensure the sustainability of steep-slope agriculture and associated ecosystem services.This study quantitatively analyzes the spatial distribution of twelve major European steep-slope(>12%)crops and assesses agricultural drought severity during the 2022 events using open-access spatial data.The satellite-based Vegetation Health Index(VHI)is utilized to identify critical hotspots.Results show that olive grove is the most widespread crop in steep slope agriculture(34%of total area),followed by wheat(24%),maize(16%),and vineyard(11%).Almost half of the steep-slope agriculture in Europe suffered drought during summer 2022.Vineyards were hardest affected at 79%,primarily in northern Portugal,northern Spain,southern France,and central Italy.Sunflowers followed at 62%,mainly in Spain,central Italy,southern France,and northern Roma-nia.Olive groves ranked third at 59%,with the most impact in northern Portugal,southern and central Spain,and southern Italy.Maize was also significantly affected at 54%.In this paper,we therefore highlight the need to increase steep-slope agriculture resilience by improving water management and promoting sustainable land practices.

Temporal Variability of Tropospheric NO_(2) over Cities in the United States,Western Europe and China from 2005 to 2022

Anthropogenic Nitrogen oxides(NO_(x)=NO_(2)+NO)emissions are highly concentrated in urban area,and the weekly cycles,seasonal patterns and long-term trends of tropospheric NO_(2) columns over cities differ from region to region due to different emission sectoral compositions and human activities.In this study,we used satellite observed tropospheric NO_(2) column data to compare the longand short-term NO_(2) column density time series over cities in the United Sates(the U.S.),western Europe and China.The results showed that in all the targeted cities,the outbreak of the Corona Virus Disease in 2019(COVID-19)moved the December peak of the city-level NO_(2)columns forward to November and October or even earlier in 2020 and 2021.On weekly level,cities in the U.S.show the lowest NO_(2) columns ratio on weekend/work day,then come the western European cities,and a weak weekly pattern is seen in Chinese cities.For all the cites,we find a higher weekend/work day NO_(2) ratio in cold seasons than in warm seasons,indicating a higher contribution from NOx emission sectors of residential,industry and power plants in the warm seasons.In the long-term,NO_(2) columns over the U.S.and western European cities declined by a fraction twice that of the regional mean level from 2004 to 2021.In China,NO_(2) columns started to decrease since 2012,at a similar rate between the city and regional level.This work confirms the importance to quantify and control NOx emissions from cities.

How Marie Sklodowska-Curie Doctoral Networks Can Support European Refractory Ecosystem in Context of The European Green Deal

The movement of the Iron&Steelmaking(I&S)industry towards Net-Zero emissions and digitalized processes through disruptive,breakthrough technologies will be achieved through the use of Hydrogen.The biggest challenge for the refractory industry is to continue to meet the performance expectations while,at the same time,moving to a more sustainable production direction.The complexity and urgency of these technological changes,highlighted by the European Green Deal,requires ambitious,international,interdisciplinary and intersectoral projects,bringing together institutes from across the global value chain,to carry out cutting edge research.The European Union,through its flagship doctoral training program,MSCA,has,and continues to support research and development as well as the promotion of the refractory industry in Europe.An introduction to two MSCA projects and some of the results achieved are highlighted within this article.

Analysis and Commentary:“Council of Europe Convention on Preventing and Combating Violence Against Women and Domestic Violence”

On May 11, 2011, 13 mem- bers of the Council of Europe signed a legally binding international in-strument, the Council of Europe Convention on Preventing and Combating Violence Against Women and Domestic Violence, as part of a program to protect and aid women. The Convention aims to increase aware- ness and understanding among the general public of the different mani- festations of all forms of violence and their consequences on children,

The Quality Evaluation of Two Chinese Leading Wheat Varieties in Europe Laboratory

[Objective] The objective was to research the quality evaluation of Chinese wheat variety which analyzed in Europe laboratory, discuss the quality analysis standard of different countries. [Method] Two leading varieties （Yangnong19, Jimai22） of Huanghuai wheat area from China were analyzed in Cra-w （Walloon Agricultural Research Centre）. [Result] Yannong19 corresponds to amuchstronger flour with a far better gluten quality. It could be used for bread making. It could also be used to produce good quality gluten. Jimai22 is not suitable for bread making but would probably be better for noodles production. [Conclusion] Protein results which come from NIR instrument are over estimating the content. This is probably due to the fact that Europe instruments are calibrated with European wheat.

Epidemiology of hepatitis C in Croatia in the European context

We analyzed prevalence, risk factors and hepatitis C virus(HCV) genotype distribution in different population groups in Croatia in the context of HCV epidemiology in Europe, with the aim to gather all existing information on HCV infection in Croatia which will be used to advise upon preventive measures. It is estimated that 35000-45000 of the Croatian population is chronically infected with HCV. Like in other European countries, there have been changes in the HCV epidemiology in Croatia over the past few decades. In some risk groups(polytransfused and hemodialysis patients), a significant decrease in the HCV prevalence was observed after the introduction of routine HCV screening of blood/blood products in 1992. Injecting drug users(IDUs) still represent a group with the highest risk for HCV infection with prevalence ranging from 29% to 65%. Compared to the prevalence in theCroatian general population(0.9%), higher prevalence rates were found in prison populations(8.3%-44%), human immunodeficiency virus-infected patients(15%), persons with high-risk sexual behavior(4.6%) and alcohol abusers(2.4%). Low/very low prevalence was reported in children and adolescents(0.3%) as well as in blood donors(0%-0.009%). In addition, distribution of HCV genotypes has changed due to different routes of transmission. In the general population, genotypes 1 and 3 are most widely distributed(60.4%-79.8% and 12.9%-47.9%, respectively). The similar genotype distribution is found in groups with high-risk sexual behavior. Genotype 3 is predominant in Croatian IDUs(60.5%-83.9%) while in the prison population genotypes 3 and 1 are equally distributed(52.4% and 47.6%). Data on HCV prevalence and risk factors for transmission are useful for implementation of preventive measures and HCV screening.

Epidemiology of hepatitis E in South-East Europe in the "One Health" concept

The significance of hepatitis E virus(HEV)as an important public health problem is rising.Until a decade ago,cases of HEV infection in Eur-ope were mainly confined to returning travelers,but nowadays,hepatitis E represents an emerging zoonotic infection in many European countries.The aim of this manuscript is to perform a systematic review of the published literature on hepatitis E distribution in humans,animals and environmental samples("One Health"concept)in the South-Eastern European countries.Comparison of the available data showed that the anti-HEV seroprevalence in the South-Eastern Europe varies greatly,depending on the population studied,geographical area and methods used.The IgG seroprevalence rates in different population groups were found to be 1.1%-24.5%in Croatia,up to 20.9%in Bulgaria,5.9-%17.1%in Romania,15%in Serbia,up to 9.7%in Greece and 2%-9.7%in Albania.Among possible risk factors,older age was the most significant predictor for HEV seropositivity in most studies.Higher seroprevalence rates were found in animals.HEV IgG antibodies in domestic pigs were detected in 20%-54.5%,29.2%-50%,38.94%-50%and 31.1%-91.7%in Serbia,Bulgaria,Romania and Croatia,respectively.In wild boars seroprevalence rates were up to 10.3%,30.3%and 31.1%in Romania,Slovenia and Croatia,respectively.A high HEV RNA prevalence in wild boars in some countries(Croatia and Romania)indicated that wild boars may have a key role in the HEV epidemiology.There are very few data on HEV prevalence in environmental samples.HEV RNA was detected in 3.3%and 16.7%surface waters in Slovenia and Serbia,respectively.There is no evidence of HEV RNA in sewage systems in this region.The available data on genetic characterization show that human,animal and environmental HEV strains mainly belong to the genotype 3.

Spatial distribution of the potential forest biomass availability in Europe

Background: European forests are considered a crucial resource for supplying biomass to a growing bio-economy in Europe. This study aimed to assess the potential availability of forest biomass from European forests and its spatial distribution. We tried to answer the questions(i) how is the potential forest biomass availability spatially distributed across Europe and(ii) where are hotspots of potential forest biomass availability located?Methods: The spatial distribution of woody biomass potentials was assessed for 2020 for stemwood, residues(branches and harvest losses) and stumps for 39 European countries. Using the European Forest Information SCENario(EFISCEN) model and international forest statistics, we estimated the theoretical amount of biomass that could be available based on the current and future development of the forest age-structure, growing stock and increment and forest management regimes. We combined these estimates with a set of environmental(site productivity, soil and water protection and biodiversity protection) and technical(recovery rate, soil bearing capacity) constraints, which reduced the amount of woody biomass that could potentially be available. We mapped the potential biomass availability at the level of administrative units and at the 10 km × 10 km grid level to gain insight into the spatial distribution of the woody biomass potentials.Results: According to our results, the total availability of forest biomass ranges between 357 and 551 Tg dry matter per year. The largest potential supply of woody biomass per unit of land can be found in northern Europe(southern Finland and Sweden, Estonia and Latvia), central Europe(Austria, Czech Republic, and southern Germany),Slovenia, southwest France and Portugal. However, large parts of these potentials are already used to produce materials and energy. The distribution of biomass potentials that are currently unused only partially coincides with regions that currently have high levels of wood production.Conclusions: Our study shows how the forest biomass potentials are spatially distributed across the European continent, thereby providing insight into where policies could focus on an increase of the supply of woody biomass from forests. Future research on potential biomass availability from European forests should also consider to what extent forest owners would be willing to mobilise additional biomass from their forests and at what costs the estimated potentials could be mobilised.

Creation of a Geo-Spatial Database to Analyse Railways in Europe (1830-2010). A Historical GIS Approach

The GIS is a tool that allows us to study the logic of the distribution of phenomena that occur on the Earth’s surface. In this article, we propose exploring its potential for historical research over long periods. Here, we present a Historical GIS (HGIS) of the railways of Europe for the period 1830-2010. This is a response to the need to carry out spatialtemporal analyses in order to evaluate the territorial impact of the railway and its influence on the distribution of population. The main objectives of this work are: to publicise the existence of this spatial database;to explain the approach followed in order to produce it;and to highlight some of the results that have already been achieved by using it. To date, the possibilities offered by HGIS have hardly been explored in research into the territorial impact of the railway. Similarly, until now, little work has been done in this area at the European scale. The most innovative aspects of this HGIS therefore lie in the methodology used and the subject treated.

The Last 15,000 Years: Climate-Controlled and “Rare-Event”-Triggered/Rise and Fall of Holocene Cultures in the Near/Middle East and in Central Europe—Evidence and Background

Pushed by the results of a preceding publication on the possibly Quaternary Jebel Waqf as Suwwan Meteorite Crater, Jordan [5], where an amazing coincidence of Rapid Climate Changes (RCCs) with Rise and Fall of Neolithic and Bronze Age Cultures became evident for the Near/Middle East, this paper deals with the same subject, however, relating to the complete Holocene period in the same area and, additionally, in Central Europe as well. By application of modern climatic data [6] comprising isotope analysis (δ18O, 14C, 10Be), acid and aerosol events, and greenhouse gases (CO2, CH4) Greenland ice cores as well as other astro-/geophysical and geological parameters, an overwhelming coincidence/relation/interdependence of both natural and cultural evidences becomes obvious throughout the last 15,000 years across the Northern Hemisphere. Apart from solar output and other astrophysical processes, most important climate- and Earth-related parameters are Mega-Volcanism (i.e.Santorini Greece: ~3640 yr cal. B. P.), Impact Events (i.e. during Mesolithic: ~9600 yr cal. B. P), rapid oceanic current change (DO-Events), and Plate Tectonics (possibly Atlantis-Event: ~11,500 yr cal. B.P. = Pleistocene/Holocene boundary). The most essential parameter is a significant temperature change related to more or less restricted latitude realms of the Northern Hemisphere. Thus, glacier advance/retreat controls the mobility of peoples (i.e. Nations' Migration, Teutonic Empires) and the access to ore deposits (Au, Ag, Cu, Sn, Zn, Pb, Fe) located in Alpine Mountain Ranges (i.e. End-Neolithic, Early Bronze Age). Myths like the Gilgamesh Epos and John Apocalypse convincingly reveal realistic contents relating to natural hazards like tsunamis, impact and flooding events. They unmisunderstandably make obvious that Myths may provide valuable contributions, especially to Geosciences. Some of the controlling parameters interrelate with others or present a kind of hierarchy: Mega-Volcanism/impact events à ejecta à wildfires, heat storms à cosmic winter, sint winter à stop of photosynthesis à mass extinction environmental pollution à greenhouse effects. Significant events (21 cases in total) occurred on i.e.

Archaeological Mineralogy and the Dawn of Gemmology:Prehistoric(7th-5th Millennium BC)Gem Minerals and Gold from the Balkans（South-East Europe）

The territory of the Balkan Peninsula in SE Europe is reviewed, from the point of gemmology, as the cradle of gem and decorative minerals and metals in European prehistory. During the local Neolithic period (end of 7 th -6 th millennium BC), as material for tools or for beads, nephrite (with the earliest known Balkan nephrite culture), jadeite-omphacite and quartz (different varieties) were introduced to make pendants and idols. Large quantities of copper and gold artifacts are known since the Chalcolithic period (5 th millennium BC)(unique for the region;the largest in number of gold artifacts is the Varna I Chalcolithic necropolis in Bulgaria). The gemmological materials in the Balkans are known for malachite, antigorite serpentinite, turquoise, rock crystal, carnelian, jasper, jet and obsidian. In the Varna I necropolis (mid 5 th millennium BC) are recorded the first known complex faceted carnelian beads with 32 facets, as well as some of the most important gemmological techniques and procedures such as faceting, tumbling, annealing, miniaturization and standardization. As pigments for pottery, cinnabar, graphite and gold were used in different prehistoric sites. The earliest salt production in the Balkans is known from sites in Romania and Bulgaria, and because of its trade, salt is positively linked to a population rich with prestigious goods. The introduced possible Chalcolithic weight unit “van”(2 carats) is supposed to be the earliest known in prehistoric times.

Research on representative brand and operation mode of second-hand clothing in Europe

In order to study the current situation and operation mode of second-hand clothing brand in Europe,this paper makes a field investigation on the second-hand clothing shops in European countries.Through classification of the inspected shops,five representative brands with certain popularity and influence and different operation modes in Europe are selected out from high-grade antique boutiques,non-profit charity organizations,professional retailers and middle-grade consignment shops in the second-hand clothing market.This paper analyzes and discusses the development history of stores,the source of goods,the form of stores,and the operation mode,so as to provide a reference for the development and standardization of the second-hand clothing market in China.

On division management for environmental system of China: lessons from European local sustainable development

The concept of sustainable development, after being brousht forward, has become a shibboleth in the world, at national and local levels. In Europe, this concept is implemented from the local to tha nation, even to the Continent. The local sustainable development mainly consists in two factors： one is the renovating method continually invented by European Secretariot of ICLEI, and the other is that the local authorities towards sustainability are co-operated by the European Sustainable Cities and Towns Campaign. The coo-budget method is the outcome of tbese factors, For our country is a big country, on rapid progression of indastrialization and urbanization, with a large population and scarce resoarces per capita, it is practically significance to study us soon as possible the methodology. Experience from European local sustainable development may help us to resolve the handicap of departraent division in local a, tbority.

Regulation on the Protection of Fossils Issued by the State Council of the People's Republic of China:Scientists' Researches Protected Legally—Further Explanation

With large-scale engineering projects being carried out in China, a large number of fossil localities have been discovered and excavated by responsible agencies, but still some important fossils of great value have been removed and smuggled into foreign countries. In the last three years, more than 1345 fossil specimens have been intercepted by Customs in Shenzhen, Shanghai, Tianjin, Beijing and elsewhere, and more than 5000 fossils, most of which are listed as key fossils,

Ecological Risk Assessment of Amphibian Chytridiomycosis from Europe to China

[Objective] Chytridiomycosis has become one of the important infectious diseases of amphibians around the world since 1998. So far, amphibian chytridiomycosis has led to regional extinction of nearly 200 kinds of amphibians and reduced 50% of amphibian populations in the world. In recent years, amphibian chytridiomycosis occurs frequently in Europe. For instance, amphibian chytridiomycosis cases have been found successively in Spain, Germany and Italy, especially in Germany. Currently, with the development of prosperous world trade, the spread of chytrid fungus through trade between countries has posed a huge poten- tial threat to the ecological security of amphibians in China. [ Method] According to entry-exit inspection and quarantine standards of the people＇s Republic of China, in this paper, release assessment, contact exposure assessment and consequence assessment technologies were integrated to obtain the risk assessment result of chytrid fungus from Europe and the possibility assessment result of the colonization and dissemination of chytrid fungus after the introduction. [ Result] The risk assessment result of chytrid fungus from Europe to China was identified as ＂moderate＂, and the possibility assessment result of the colonization and dissemination of chytrid fungus after the introduction was identified as ＂high＂. [ Conclusion] The importation of amphibians from Europe to China exhibits a certain risk. The intro- duction of chytrid fungus in China will cause a high risk of colonization and dissemination.

A Study of Precipitation Climatology and Its Variability over Europe Using an Advanced Regional Model (WRF)

In recent years long-term precipitation trends on a regional scale have been given emphasis due to the impacts of global warming on regional hydrology. In this study, regional precipitation trends are simulated over the Europe continent for a 60-year period in 1950-2010 using an advanced regional model, WRF, to study extreme precipitation events over Europe. The model runs continuously for each year during the period at a horizontal resolution of 25 km with initial/ boundary conditions derived from the National Center for Environmental Prediction (NCEP) 2.5 degree reanalysis data sets. The E-OBS 0.25 degree rainfall observation analysis is used for model validation. Results indicate that the model could reproduce the spatial annual rainfall pattern over Europe with low amounts (250 - 750 mm) in Iberian Peninsula, moderate to large amounts (750 - 1500 mm) in central, eastern and northeastern parts of Europe and extremely heavy falls (1500 - 2000 mm) in hilly areas of Alps with a slight overestimation in Alps and underestimation in other parts of Europe. The regional model integrations showed increasing errors (mean absolute errors) and decreasing correlations with increasing time scale (daily to seasonal). Rainfall is simulated relatively better in Iberian Peninsula, northwest and central parts of Europe. A large spatial variability with the highest number of wet days over eastern, central Europe and Alps (~200 days/year) and less number of wet days over Iberian Peninsula (≤150 days/year) is also found in agreement with observations. The model could simulate the spatial rainfall climate variability reasonably well with low rainfall days (1 - 10 mm/days) in almost all zones, heavy rainfall events in western, northern, southeastern hilly and coastal zones and extremely heavy rainfall events in northern coastal zones. An increasing trend of heavy rainfall in central, southern and southeastern parts, a decreasing trend in Iberian Peninsula and a steady trend in other zones are found. Overall, the simulated rainfall climatology was reproduced well for the low and heavy rainfall followed by very heavy and extremely heavy rainfall in Europe and the simulation is better in the Iberian west coast, central northern Europe and Alps Mountains.

Asian Society of Andrology Executive Council (2001--2004)

PresidentDr. Shao-Zhen QianAsian Journal of AndrologyShanghai Institute of Materia MedicaChinese Academy of Sciences294 Taiyuan Road, Shanghai 200031CHINATel: + 86-21-6431 1833 ext 207Fax: + 86-21-6474 2629e-mail: szqian@mail. shcnc.ac.cn

Pediatric Cardiac Surgical Patterns of Practice and Outcomes in Europe and China:An Analysis of the European Congenital Heart Surgeons Association Congenital Heart Surgery Database

Background:The European Congenital Heart Surgeons Association(ECHSA)Congenital Heart Surgery Database(CHSD)was founded in 1999 and is open for worldwide participation.The current dataset includes a large amount of surgical data from both Europe and China.The purpose of this analysis is to compare patterns of practice and outcomes among pediatric congenital heart defect surgeries in Europe and China using the ECHSA-CHSD.Methods:We examined all European(125 centers,58,261 operations)and Chinese(13 centers,23,920 operations)data in the ECHSA-CHSD from 2006-2018.Operative mortality,postoperative length of stay,median patient age and weight were calculated for the ten benchmark operations for China and Europe,respectively.Results:Benchmark procedure distribution frequencies differed between Europe and China.In China,ventricular septal defect repair comprised approximately 70%of procedures,while Norwood operations comprised less than one percent of all procedures.Neonatal cardiac procedures were rare in China overall.For procedures in STAT mortality category 1,Chinese centers had lower operative mortality rates,while procedures in categories 3 and 5 mortality is lower in European centers.Operative mortality over the time period decreased from 3.89%to 1.64%for the whole cohort,with a sharper decline in China.This drop coincides with an increase of submitted procedures over this 13-year-period.Conclusion:Chinese centers had higher programmatic volume of congenital heart surgeries,while European centers have a more complex case mix.Palliation for patients with functionally univentricular heart was performed less commonly in China.These comparison of patterns of practice and outcomes demonstrate opportunities for continuing bidirectional transcontinental collaboration and quality improvement.